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5th Anniversary Congress of IDDST-2007
Serial II: Advances and Challenges Toward Major Diseases |
Preliminary Program
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DAY 1-Morning: Wednesday, November 07, 2007 |
Time: 09: am-12:00 am |
09:00 am-09:30 am |
Opening Ceremony |
Time |
Session 1: Keynote Forum |
Session Chair: |
Dr. Chao Chen, Professor of Northwest University, Xi' an, Director of National Engineering Research Center for Miniaturized Detection Systems, China |
09:30 am-10:00 am |
Title: Fascinating Insights in Chemistry, Biology and Medicine by NMR
Dr. Richard R. Ernst, Nobel Prize Laureate in Chemistry 1991
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10:00 am-10:30 am |
Title: Embracing Cross-Border Alliances to Expand and Advance Drug Discovery
Activities
Dr. Bharatt M. Chowrira, Vice President, Sirna Therapeutics, Executive Director, Worldwide Licensing & External Research, Merck and Co., Inc., USA
|
10:30 am-11:00 am |
Title: TBD
Dr. William A. Haseltine, Former Chairman and CEO of Human Genome Sciences, USA
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11:00 am-11:30 am |
Title: A HTP Yeast System for Studying the Effects of the Human CYP SNPs on Drug Metabolism and Toxicity
Dr. Chao Chen, Professor of Northwest University, Xi' an, Director of National Engineering Research Center for Miniaturized Detection Systems, China
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11:30 am-12:00 am |
Speech Opportunity Available |
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| DAY 1-Afternoon: Wednesday, November 07, 2007 |
Time: 01:30 pm-05:30 pm |
Time |
Session 2: Anti-Cancer/Tumors Drug Discovery & Development and Current Status of the Innovative Therapeutics (Part I) |
Session Chair: |
Dr. Kailash C. Chadha, Department of Molecular & Cellular Biology, Roswell Park Cancer Institute; Associate Research Professor, Department of Medicine State University of New York, USA |
| Co-Chair: |
Dr. Moshe Szyf, Department of Pharmacology and Therapeutics, McGill University, Canada |
01:30 pm-01:50 pm |
Title: Inhibiting Human Prostate Cancer Metastasis by Targeting the p38 MAP Kinase-HSP27 Pathway.
Dr. Raymond Bergan, Department of Medicine, Center for Drug Discovery and Chemical Biology, Robert H. Lurie Cancer Center of Northwestern University, USA
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01:50 pm-02:10 pm |
Title: Functions, Mechanisms of Action, and Regulation of Histone Deacetylases
Dr. Edward Seto, H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, USA
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02:10 pm-02:30 pm |
Title: Physiological Role of Prostate-Specific Antigen (PSA): Modulator of Angiogenic Growth Factors Expression
Dr. Kailash C. Chadha, Department of Molecular & Cellular Biology, Roswell Park Cancer Institute; Associate Research Professor, Department of Medicine State University of New York, USA
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02:30 pm-02:50 pm |
Title: Identification of Selective Anti-pancreatic Cancer Inhibitors Using Synthetic Lethal Chemical Screening
Dr. Xiaodong Cheng, Associate Professor, Department of Pharmacology & Toxicology, University of Texas Medical Branch, USA
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02:50 pm-03:10 pm |
Title: Survival of Tumors: Investigation of Mitochondrial Function, Structure and Composition in Human Lung Cancer
Dr. Rodrigue Rossignol, French National Institute for Medical and Scientific Research and Universit¨¦ Victor Segalen Bordeaux 2, France
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03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:45 pm |
Title: Tumor Suppressor BARD1 Expression in Cancer: Biomarker of Cancer and Target for Treatment
Dr. Irmgard Irminger-Finger, Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, University Hospitals Geneva, Switzerland
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03:45 pm-04:05 pm |
Title: Targeting Cancer by Immunotherapy: Current Challenges
Dr. R¨¦jean Lapointe, Tumour Immunology Laboratory, Montreal Cancer Institute; Department of Medicine, Universit¨¦ de Montr¨¦al, Canada
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04:05 pm-04:25 pm |
Title: MBD2 a Master Regulator of Cancer Metastasis; Novel Therapeutic Opportunities
Dr. Moshe Szyf, Department of Pharmacology and Therapeutics, McGill University, Canada |
04:25 pm-04:45 pm |
Title: A Novel Target for Breast and Prostate Cancer Intervention
Dr. Uri Nir, Faculty of Life Sciences, Bar-Ilan University,Israel
|
04:45 pm-05:05 pm |
Title: Deacetylation of cortactin by SIRT1 promotes ovarian and breast cancer cell migration
Dr. Xiaohong Zhang, MDC11, Department Pathology & Cell Biology, USF College of Medicine, USA |
Time |
Session 3: CNS Drug Discovery & Development |
Session Chair: |
Dr. Amardeep Kumar, Senior Registrar, Mental health, Central Northern Adelaide Health Services (CNAHS), Adelaide, Australia |
Co-Chair: |
Dr. Yuqing Li, Associate Professor Center for Neurodegeneration and Experimental Therapeutics (CNET) Department of Neurology, School of Medicine, University of Alabama at Birmingham, USA |
01:30 pm-01:50 pm |
Title: Myoblast Transplantation: A Potential Treatment for Several Recessive Muscular Dystrophies
Dr. Jacques P. Tremblay, Unit¨¦ de G¨¦n¨¦tique Humaine, Centre de Recherche, Centre Hospitalier Universit¨¦ Laval, Canada
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01:50 pm-02:10 pm |
Title: S111- a Post Absorption/metabolism TCM Drug, Its Anti-depression Effect and a Transcriptomic Study
Dr. William Jia, Associate Professor, Brain Research Center, Faculty of Medicine, University of British Columbia, Canada
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02:10 pm-02:30 pm |
Title: Serendipitous Clinical Observation and It's Implication for the Development of Innovative CNS Drugs
Dr. Amardeep Kumar, Senior Registrar, Mental health, Central Northern Adelaide Health Services (CNAHS), Adelaide, Australia
|
02:30 pm-02:50 pm |
Title: Discovery and Development of Myostatin Inhibitors to Prevent Muscle Atrophy Caused by Neuromuscular Disorders
Dr. Kunihiro Tsuchida, Division for Therapies against Intractable Diseases,Institute for Comprehensive Medical Sciences (ICMS), Fujita Health University, Japan
|
02:50 pm-03:10 pm |
Title: Prokineticin Signaling: A Potential Therapeutic Target for Neuroblastoma
Dr. Elly SW Ngan, Research Assistant Professor, Department of Surgery, University of Hong Kong, China |
03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:45 pm |
Title: Spine Disc Degeneration and Regeneration Animal Model Using Fluoroscope Guidance and Smart Hydrogel
Dr. Hee-Jeong Im Sampen, Assistant Professor Department of Biochemistry, Department of Internal Medicine, Department of Orthopedic Surgery, Rush University Medical Center, USA
|
03:45 pm-04:05 pm |
Title: Pathophysiology and Experimental Therapeutics of Dystonia
Dr. Yuqing Li, Associate Professor Center for Neurodegeneration and Experimental Therapeutics (CNET) Department of Neurology, School of Medicine, University of Alabama at Birmingham, USA
|
04:05 pm-04:25 pm |
Title: Auditory Noise Improves Cognitive Performance in ADHD Children: Neurocomputational Modeling of Dopamine and Implication for Treatment
Dr. Sverker Sikstrom, Lund University Cognitive Science (LUCS), Sweden
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04:25 pm-04:45 pm |
Title: Brain Tumour Diagnosis and Prognosis through Intelligent Software Agents
Dr. Horacio Gonzalez-Velez, University of Edinburgh, Institute for Computing Systems Architecture, UK |
04:45 pm-05:05 pm |
Title: Therapeutic Approach in Alzheimer's Disease
Dr. Beka Solomon, Department of Molecular Microbiology & Biotechnology George S. Wise Faculty of Life Sciences Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel |
Time |
Session 4: (Part One) Anti-Infectious Drug Discovery & Development (I)
(Part Two) RNAi & Gene: Applications in Drug Discovery and Therapeutics
|
Session Chair: |
Dr. Dmitry Samarsky, Vice President, Technology Development, RXi Pharmaceuticals Corp., USA |
Co-Chair: |
Dr. Brain Johnston, Stanford University School of Medicine, USA |
| (Part One) Anti-Infectious Drug Discovery & Development (I) |
01:30 pm-02:00 pm |
Title: Rational Design and Anti-toxin Agents Against Pathogenic Bacteria
Dr. Maurizio Pellecchia, Professor, Burnham Institute for Medical Research, USA |
02:00 pm-02:30 pm |
Title: Design of Antimicrobial Agents based on Acyl-Lysine Oligomers that Mimic Host Defense Peptides
Dr. Amram Mor, Department of Biotechnology and Food Engineering, Technion¡ªIsrael Institute of Technology, Israel |
02:30 pm-03:00 pm |
Title: Therapeutic Discovery for Treating Preterm Birth
Dr. Yiping Han, Associate Professor, Case Western Reserve University, USA
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| (Part Two) RNAi & Gene: Applications in Drug Discovery and Therapeutics |
03:00 pm-03:20 pm |
Title: RNAi-Based Therapeutics- The Promise and Challenges
Dr. Bharatt M. Chowrira, Vice President, Sirna Therapeutics, Executive Director, Worldwide Licensing & External Research, Merck and Co., Inc., USA |
03:20 pm-03:40 pm |
Title: Development and Optimization of Novel RNAi Therapeutics Platforms
Dr. Dmitry Samarsky, Vice President, Technology Development, Rxi Pharmaceuticals Corp., USA
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| 03:40 pm-04:00 pm |
Title: Optimization of shRNA Features for Targeting Hepatitis c Virus
Dr. Brain Johnston, Stanford University School of Medicine, USA |
04:00 pm-04:20 pm |
Tilte: Inactivation of the catalytic ribonucleoprotein human RNase P and its role in transcription of small noncoding RNA genes
Dr. Nayef Jarrous, Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
|
04:20 pm-04:40 pm |
Title: Diving into the DNA Dumpster: SINE B2 Repeat Transcription is Responsible for the Organization of the Growth Hormone Gene Locus in Mouse Development
Dr. Victoria V. Lunyak, Department of Medicine, Division of Endocrinology and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, USA |
04:40 pm-05:05 pm |
Title: miRNAs as Potential Biomarkers in Colorectal Cancer
Dr. Jingfang Ju, Mitchell Cancer Institute-USA Mobile, AL, USA |
|
Day 1-Evening: Wednesday, November 07, 2007 |
Time |
Plenary Lecture by Nobel Prize Laureate |
08:10 pm-08:40 pm |
Title: The Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and onto Drug Targeting
Dr. Aaron Ciechanover, Nobel Prize Laureate in Chemistry in 2004 |
Day 2-Morning: Thursday, November 08, 2007 |
Time: 09: am-12:10 am |
Time |
Session 5: Liver Disease Drug Discovery & Development and Innovative Therapeutics |
Session Chair: |
Dr. David H Vanthiel, Professor of Medicine/Surgery, Director of Hepatology and Medical Director Liver Transplantation in Rush University Chicago, IL Medical Center and St.Luke's Medical Center, USA |
Co-Chair: |
Dr. Bangyan Stiles, Assistant Professor, USC School of Pharmacy, USA |
09:00 am-09:20 am |
Title: Protective Effect of Fructose 1, 6-Bisphosphate on Hepatic Injury
Dr. Jarbas Rodrigues de Oliveira, Director of laboratory Biophysics cellular and inflammation ¨CPontif¨ªcia Universidade Cat¨®lica do Rio Grande do Sul, Brazil
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09:20 am-09:40 am |
Title: Inhibition of Activation of the Liver and Pancreas Stellate Cells as A Novel Strategy for Fibrosis Treatment, Effect of Halofuginone
Dr. Mark Pines, Director, Institute of Animal Sciences, The Volcani Center, Israel |
09:40 am-10:00 am |
Title: Advances in the Treatment of Hepatitis C and B Virus Infections with Novel Molecules.
Dr. David H Vanthiel, Professor of Medicine/Surgery, Director of Hepatology and Medical Director Liver Transplantation in Rush University Chicago, IL Medical Center and St.Luke's Medical Center, USA
|
10:00 am-10:20 am |
Title: B-L-2¡ä, 3¡ä-Didehydro-2¡ä, 3¡ä-dideoxy-N4-hydroxycytidine: A New Strong and Selective Inhibitor of Hepatitis B Virus Replication
Dr. Eckart Matthes, Max-Delbr¨¹ck-Centrum f¨¹r Molekulare Medizin, Berlin, Germany |
10:20 am-10:40 am |
Title: Treatment of Hepatitis C after Liver Transplantation-Is There Hope?
Dr. Sandeep Mukherjee, Associate Professor, Department of Internal Medicine, Section of Gastroenterology and Hepatology, University of Nebraska Medical Center, USA
|
10:40 am-11:00 am |
Title: Discovery of New Therapeutic Targets Using Liver Pten Deletion Animal Model
Dr. Bangyan Stiles, Assistant Professor,USC School of Pharmacy, USA |
11:00 am-11:20 am |
Title: New Approaches to the Management of ThrombocytopEnia and the Syndrome of Heparin- Induced Thrombocytopenia (HIT)
Dr. Magdalene M George, Director of Hepatology clinic research, Liver Transplantation in Rush University Chicago, IL Medical Center and St.Luke¡¯s Medical Center, USA |
11:20 am-11:40 am |
Title: Advances in Treatment of Nonalcoholic Steatohepatitis: Molecular Approach and Possibly Drugs Targets
Dr. Claudia PMS de Oliveira, Departament of Gastroenterology, University of Sao Paulo - School of Medicine, Brazil |
11:40 am-12:00 am |
PANEL DISCUSSION
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Time |
Session 6: New & Emerging Biomarkers & Drug Targets |
Session Chair: |
Dr. Glenn McConkey, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK |
Co-Chair: |
Dr. Armando Bartolazzi , St. Andrea University Hospital, Rome, Italy; Cellular and Molecular Tumor Pathology Laboratory, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden |
09:00 am-09:20 am
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Title: Biomarkers and Drug Development: Practical US Experience
Dr. Gregory M. Hockel, Vice President, Regulatory Affairs
PharmaNet, LLC, USA
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09:20 am-09:40 am |
Title: IXPC gene silencing as an important biomarker in lung and bladder cancer progression
Dr. Gan Wang, Associate Professor, Institute of Environmental Health Sciences, Wayne State University, Detroit, USA
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09:40 am-10:00 am |
Title: Targeting Parasitic Diseases and Design of Novel Inhibitors as Antimalarial Agents
Dr. Glenn McConkey, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, UK |
10:00 am-10:20 am |
Title: Novel Mictotubule-drugs as Anti-cancer, Non-toxic, Orally Available Agents
Dr. Harish C. Joshi, Director, Laboratory of Drug Discovery, Design & Research, Department of Cell Biology Emory University School of Medicine, Atlanta, USA
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10:20 am-10:40 am |
Title: Development of Functional Magnetic Nanobeads for Drug Target Screening
Dr. Satoshi Sakamoto, Assistant Professor, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
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10:40 am-11:00 am |
Title: Galectin-3 thyrotest in the preoperative characterization of thyroid nodules
Dr. Armando Bartolazzi, St. Andrea University Hospital, Rome, Italy; Cellular and Molecular Tumor Pathology Laboratory, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden
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Title: G-quadruplex Structures of Nucleic Acids as Potential Targets for Drug Design
Dr. Anh Tuan Phan, Division of Physics & Applied Physics, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore |
11:20 am-11:40 am |
Title: PI3K-AKT Network as a Therapeutic Target For Human Diseases
Dr. Masayuki Noguchi, Professor, Division of Cancer, BiologyInstitute for Genetic Medicine, Hokkaido University, Japan |
11:40 am-12:00 am |
Title: The Replication Combing Assay: A sensitive and quantitative assay for monitoring the efficacy of drugs on DNA replication
Dr. Aaron Bensimon, Founder and CEO of Genomic Vision, Paris, France |
Time |
Session 7:
Anti-Cancer/Tumors Drug Discovery & Development and Current Status of the Innovative Therapeutics (Part II) |
Session Chair: |
Dr. M Asif Chaudry, University College London, UK |
Co-Chair: |
Dr. James S. Norris, Professor and Chairman Department of Microbiology and Immunology, Medical University of South Carolina Charleston, USA |
09:00 am-09:20 am |
Title: Tumor Targeting with an AB.Fab
Dr. Mark S. Dennis, Senior Scientist, Department of Antibody Engineering, Genentech, Inc., South San Francisco, USA |
09:20 am-09:40 am |
Title: Chelating Agents as Treatments for Colon Cancer? The Gastrin-Iron Story
Dr. Graham Baldwin, University of Melbourne Department of Surgery, Australia
|
09:40 am-10:00 am |
Title: Immunotherapy for Gastrointestinal Malignancy: Current Experience and Future Challenges
Dr. M Asif Chaudry, University College London, UK |
10:00 am-10:20 am |
Title: A Novel Tumor Suppressor that Inhibits EGFR Signaling
Dr. Noriko Gotoh, Associate Professor, Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Japan |
10:20 am-10:40 am |
Title: Thymosin ¦Â4: A Novel Therapeutic Target for Colorectal Cancer
Dr. Yeu Su, Institute of Biopharmaceutical Science, National Yang-Ming University, Taiwan, China |
10:40am-11:00 am |
Title: Cancer Chemoprevention and Biomarkers
Dr. Jianyu Rao, Department of Pathology and Laboratory Medicine, UCLA, USA |
11:00 am-11:20 am |
Title: Sensitizing cells to Radiation and Chemotherapy using Sphingolipid Modifiers
Dr. James S. Norris, Professor and Chairman Department of Microbiology and Immunology, Medical University of South Carolina Charleston, USA |
11:20am-11:40 am |
Title: N-hydroxy-N-(4-butyl-2-methylphenol) Formamidine (HET0016), a Novel Anti-angiogenic and Anti-tumoral Drug
Dr. Austin Meng Guo, Senior Bioscientific Staff/Assistant Scientist, Henry Ford Health System, Eye Care Services Research, USA
|
11:40 am-12:00 am |
Title: Antihypertensives as Novel Antineoplastics: The Use of Angiotensin Blockade Therapies in Pancreatic Ductal Adenocarcinoma
Dr. Hwyda Arafat, Assistant Professor, Departments of Surgery Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, USA
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| Day 2-Afternoon: Thursday, November 08, 2007 |
Time: 01:30 pm-05:30 pm |
Time |
Session 8: Inflammatory Disease and Severe Autoimmune Disease Drug Discovery & Development |
Session Chair: |
Dr. Zhikang Peng, Associate Professor, Dept of Pediatrics and Child Health and Dept of Immunology, University of Manitoba, Canada |
Co-Chair: |
Dr. Bjarne Bogen, Professor of Medicine, University of Oslo, Norway |
01:30 pm-01:50 pm |
Title: A Novel Treatment of Autoimmune Diseases Using Bi-functional Peptide Inhibitors: Blocking the Immunological Synapse Formation
Dr. Teruna J. Siahaan, Department of Pharmaceutical Chemistry, Kansas, USA
|
01:50 pm-02:10 pm |
Title: The Proteasome Inhibitor Bortezomib for Treatment of Lupus-like Disease in Mouse Models
Dr. Reinhard E. Voll, Nikolaus-Fiebiger Center of Molecular Medicine, IZKF-N2 and Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen,Germany
|
02:10 pm-02:30 pm |
Title: Cytokine Peptide-based Virus-like Particle Vaccines in the Down-regulation of Allergic and Autoimmune Responses
Dr. Zhikang Peng, Associate Professor, Dept of Pediatrics and Child Health and Dept of Immunology, University of Manitoba, Canada
|
02:30 pm-02:50 pm |
Title: Potential Therapeutic Applications of Cyclotides
Dr. Norelle L. Daly, Institute for Molecular Bioscience, University of Queensland, Australia |
02:50 pm-03:10 pm |
Title: IL-27 Signaling as a Target for Autoimmune Disease Treatment
Dr. Hiroki Yoshida, Department of Biomolecular Sciences, Saga Medical School, Japan |
03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:45 pm |
Title: The Airway Smooth Muscle as a Target for Asthma Therapy
Dr. Blanca Camoretti-Mercado, Associate Professor, Section of Pulmonary and Critical Care, Department of Medicine, The University of Chicago, USA |
03:45 pm-04:05 pm |
Title: Increased Immunogenicity of Vaccines by Targeting Antigen Presenting Cells
Dr. Bjarne Bogen, Professor of Medicine, University of Oslo, Norway |
04:05 pm-04:25 pm |
Title: Targeting Histone Deacetylases in Acute and Chronic Inflammatory Disease
Dr. Matthew J. Sweet, Institute for Molecular Bioscience and Cooperative Research Centre for Chronic Inflammatory Diseases, University of Queensland, Australia
|
04:25 pm-04:45 pm |
Title: A Novel Inhibitor of CD8 T-cells: YourDex (r)
Dr. Bent Jakobsen, Senior Vice President Research, MediGene Limited, UK |
04:45 pm-05:05 pm |
PANEL DISCUSSION |
Time |
Session 9: Innovative Metabolic Diseases Drug Discovery & Development |
Session Chair: |
Dr. Gary J. Grover, Director of Pharmacology, Eurofins Scientific, Associate Professor of Physiology and Biophysics, Robert Wood Johnson Medical School, New Jersey, USA |
Co-Chair: |
Dr. Subrata Chakrabarti, Professor, Department of Pathology, University of Western Ontario, Canada |
01:30 pm-01:50 pm |
Title: RNA Interference for Target Identification and Validation
Dr. Ruojing Yang, Senior research biologist, Merck & Co. Metabolic diseases division
|
01:50 pm-02:10 pm |
Title: Role of a Novel Nuclear Oxysterol in Lipid Metabolism, Potential Usage in the Therapy of Hyperlipidemia
Dr. Shunlin Ren, Associate Professor,McGuire Research Institute/Virginia Commonwealth University, USA
|
02:10 pm-02:30 pm |
Title: Gastrin-releasing Peptide Receptor (GRPR) Signaling Pathway as a Potential Molecular Target for Cancer, Inflammatory and Neurological Disorders
Dr. G. Schwartsmann, Professor, Medicine Federal University Porto Alegre, Brazil
|
02:30 pm-02:50 pm |
Title: The Role of Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) in Human Ovarian Regulation
Dr. Donna Seto-Young, Director of Endocrinology Research Laboratory, Associate Professor of Medicine, Albert Einstein College of Medicine, Beth Israel Medical Center, Division of Enocrinology & Metabolism, USA |
02:50 pm-03:10 pm |
Title: Gonadotropin-Inhibitory Hormone (GnIH): Discovery, Mode of Action, Functional,
Significance and Prospective Application to Reproductive Dysfunction
Dr. Kazuyoshi Tsutsui, Professor, Laboratory of Integrative Brain Sciences, Department of Biology, Waseda University, Japan |
03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:45 pm |
Title: Effects of Insulin Resistance on Coronary In-stent Restenosis
Dr. Kazuaki Nishio, Showa University, Tokyo, Japan
|
03:45 pm-04:05 pm |
Title: Understanding Endothelial Cell Signaling to Identify Potential Future Treatment Strategies for Vascular Diseases in Diabetes
Dr. Subrata Chakrabarti, Professor, Department of Pathology, University of Western Ontario, Canada
|
04:05 pm-04:25 pm |
Title: Evaluating Current and Future Anti-obesity Pharmacotherapy in the Context of Historical Controversies
Dr. David W Haslam, Clinical Director, & immediate former Chair of National Obesity Forum., Chair of Foundations Charity,.UK |
04:25 pm-04:45 pm |
Title: The Endocannabinoid System: a Therapeutic Target for Reducing Obesity and Cardiometabolic Risk Factors?
Dr. Marie-Paule GONTHIER, Laboratoire de Biochimie et G¨¦n¨¦tique Mol¨¦culaire, Universit¨¦ de La R¨¦union, FRANCE
|
04:45 pm-05:05 pm |
PANEL DISCUSSION |
Time |
Session 10: Stem Cell Research & Tissue Engineering to New Therapeutics |
Session Chair: |
Dr. R¨¦gis ROCHE, Laboratoire de Biochimie et G¨¦n¨¦tique Mol¨¦culaire, Universit¨¦ de La R¨¦union , FRANCE |
Co-Chair: |
Dr. Haval Shirwan, Department of Microbiology and Immunology, Molecular Immunomodulation Program, Institute for Cellular Therapeutics, University of Louisville, USA |
01:30 pm-02:00 pm |
Title: Human Embryonic Stem Cells in Genetic Research
Dr. Nissim Benvenisty, Department of Genetics, The Hebrew University, Jerusalem, Israel
|
02:00 pm-02:30 pm |
Title: In the Heart of the Adipose Tissue
Dr. R¨¦gis ROCHE, Laboratoire de Biochimie et G¨¦n¨¦tique Mol¨¦culaire, Universit¨¦ de La R¨¦union , FRANCE
|
02:30 pm-03:00 pm |
Title: An EX Vivo Model of Human Oesophageal Epithelium
Dr. Wayne A. Phillips, Peter MacCallum Cancer Centr, Australia
|
03:00 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:55 pm |
Title: Therapeutic Potentials of Dopaminergic Neurons Derived from Human Embryonic Stem Cells
Dr. Xianmin Zeng, Assistant Professor and Director, North Bay CIRM Shared Research Laboratory for Stem Cells and Aging, Buck Institute for Age Research, USA |
03:55 pm-04:25 pm |
Title: ProtEx™ Technology as a Practical Alternative to Gene Therapy for Immunomodulation
Dr. Haval Shirwan, Department of Microbiology and Immunology, Molecular Immunomodulation Program, Institute for Cellular Therapeutics, University of Louisville, USA |
04:25 pm-04:55 pm |
Title: Clinical Applications Using Cultured Autologous Osteoblasts.
Dr. Seok-Jung Kim, Department of Orthopedic Surgery, College of Medicine, the Catholic University of Korea, Korea
|
04:55 pm-05:05 pm |
PANEL DISCUSSION |
|
Day 3-Morning: Friday, November 09, 2007 |
Time: 09: am-12:20 am |
Time |
Session 11: Anti-Infectious Drug Discovery & Development (II) |
Session Chair: |
Dr. Li Huang, Research Scientist, Duke University Medical Center, USA |
Co-Chair: |
Dr. Joachim Hauber, Professor of Virology, Heinrich-Pette-Institute for Experimental Virology and Immunology, Germany |
09:00 am-09:20 am |
Title: Antibiotics targeting ribosomes vs. smart pathogens
Dr. Ada Yonath, professor, Structural Biology, Weizmann Institute Rehovot, Israel
|
09:20 am-09:40 am |
Title: Novel approach for screening new antibiotics by activating dormant genes in bacteria
Dr. Kozo Ochi, The National Food Research Institute, Japan |
09:40 am-10:00 am |
Title: Global Grid-computing Initiative to Discover Novel Dengue and Hepatitis C Antivirals
Dr. Stanley J. Watowich, Associate Professor, University of Texas Medical Branch, USA
|
10:00 am-10:20 am |
Title: Development and Characterization of A Safe and Efficient Avian Influenza H5N1 Virus Entry System for Virological and Antiviral studies
Dr. XiaoJian Yao, Assistant Professor, University of Manitoba, CA |
10:20 am-10:40 am |
Title: New RNA-binding Peptidomimetic Structures that Repress HIV Viral Replication by Specifically Inhibiting Transcriptional Activation
Dr. Yu Chen, research scientist, Department of Chemistry and Department of Biochemistry, University of Washington, USA |
10:40 am-11:00 am |
Title: Small Molecules with Novel Mechanisms of Action and Potent Anti-HIV-1 Activity Against Multiple Genetic Subtypes of HIV-1
Dr. Li Huang, Research Scientist, Duke University Medical Center, USA
|
11:00 am-11:20am |
Title: Experimental Therapies for HIV Infection
Dr. Joachim Hauber, Professor of Virology, Heinrich-Pette-Institute for Experimental Virology and Immunology, Germany |
11:20 am-11:40 am |
Title: Identification of Novel and Effective Antiviral Treatment and zstablishment of Disease Pathogenesis: A journey of Global Gene Expression of dengue virus infection.
Dr. Irene Bosch, Assistant Professor of Medicine, University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, USA |
11:40 am-12:00 am |
PANEL DISCUSSION |
Time |
Session 12: Better Drugs by Mastering Medicinal Chemistry |
Session Chair: |
Dr. Snehasikta Swarnakar, Scientist and Head, Dept. of Physiology, Indian Institute of Chemical Biology, India |
Co-Chair: |
Dr. Weishuo Fang, professor, IMM/CAMS, as well as an adjunct professor in College of Pharmacy, Wuhan University, China |
09:00 am-09:30 am
Keynote speaker |
Title: New Thrombin Inhibitors: Molecular Design and Experimental Discovery
Dr. Vladimir Sulimov, Head of the Lab at Research Computer Center, Moscow State University, Russia
|
09:30 am-10:00 am |
Title: Optimization of Antitumor Effects of Taxol Analogues through Modulating Their Interactions with b-Tubulin and P-glycoprotein
Dr. Weishuo Fang, professor, IMM/CAMS, as well as an adjunct professor in College of Pharmacy, Wuhan University, China |
10:00 am-10:30 am |
Title: Cancer Immunotherapy Rebirth
Dr. Georges Math¨¦, leading cancer researcher, Instltut de Cancerologle et d ImmunogenetNue, Hopltal Paul-Brousse, France |
10:30 am-10:45 am |
TEA BREAK |
10:45 am-11:15 am |
Title: A Multidisciplinary Approach leading to the Discovery of a novel RSV Fusion Inhibitor
Dr. Jean Francois Bonfanti, Team Leader, Tibotec¡¡Pharmaceutical Co. Ltd, France |
11:15 am-11:45 am |
Title: Targeting Matrix Metalloproteinases for prevention of Gastric Inflammation
Dr. Snehasikta Swarnakar, Scientist and Head, Dept. of Physiology, Indian Institute of Chemical Biology, India |
11:45 am-12:05 am |
PANEL DISCUSSION |
Time |
Session 13:
(Part One) Development of Novel Drug Delivery Systems
(Part Two) Combinatorial Chemistry & High Throughput Screening |
Session Chair: |
Dr. Gang Zheng, Associate Professor of Medical Biophysics, University of Toronto, Canada |
Co-Chair: |
Dr. Sek-Wen Hui, Senior Research Scientist, Cancer Biology, Roswell Park Cancer Institute Professor, Molecular and Cellular Biophysics and Biochemistry, University at Buffalo, USA |
| (Part One) Development of Novel Drug Delivery Systems |
09:00 am-09:20 am |
Title: Delivery of Drugs and Genes by Physical Methods
Dr. Sek-Wen Hui, Senior Research Scientist, Cancer Biology, Roswell Park Cancer Institute Professor, Molecular and Cellular Biophysics and Biochemistry, University at Buffalo, USA |
09:20 am-09:40 am |
Title: Lipoprotein-like Nanocarriers for In Vivo Cancer Imaging and Treatment
Dr. Gang Zheng, Associate Professor of Medical Biophysics, University of Toronto, Canada |
09:40 am-10:00 am |
Title: Controlled release Gastro-Retentive Dosage forms for optimizing therapy of Narrow Absorption Window Drugs
Dr. Amnon Hoffman, Chairman, Dept.of Pharmaceutics, Head, Clinical Pharmacy Program, School of Pharmacy, The Hebrew University of Jerusalem, Israel |
10:00 am-10:20 am |
Title: Self-assembling Peptides as a Drug Carrier
Dr. Xiaojun Zhao, Professor and Executive Director, Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, China
|
10:20 am-10:40 am |
Title: Binding Characterization of the IL-13 Signaling Complex and Development of a Ternary TR-FRET Assay
Dr. Xiaoke Yang, Principla Scientist, Wyeth, USA |
| (Part Two )Combinatorial Chemistry & High Throughput Screening |
10:40 am-11:00 am |
Title: Solid and Solution-Phase Synthesis for Natural and Unnatural Product Library
Dr. Takashi Takahashi, Professor of Synthetic Organic Chemistry at Tokyo Institute of Technology, President of JCCF (Japan Combinatorial Chemistry Focus Group), Tokyo, Japan |
11:00 am-11:20 am |
Title: In Sillico Screening of Drugs Targeting the Prion Proteins
Dr. Paolo Carloni, Associate professor, International School for Advanced Studies (SISSA/ISAS), Italy
|
11:20 am-11:40 am |
Title: Quantitative Structure Activity Relationship (3D-CoMFA Study) on Oxindole Derivatives as Cyclin Dependent Kinase 1 (CDK1) and Cyclin Dependent Kinase 2 (CDK2) Inhibitors
Dr. Sanjeev Kumar Singh, Lecturer, Madurai Kamaraj University, India
|
11:40 am-12:00 am |
Title: Combinatorial Strategies in Pharmaceutical Science
Dr. Steve Brocchini, Professor of Chemical Pharmaceutics, the School of Pharmacy, University of London, UK
|
| Day 3-Afternoon: Friday, November 09, 2007 |
Time: 01:30 pm-05:30 pm |
Time |
Session 14: Cardiovascular and Heart Disease Drug Discovery & Development to Innovative Therapeutics
|
Session Chair: |
Dr. Levon M. Khachigian, NHMRC SPRF, Professor and Head, Transcription and Gene Targeting Laboratory, Centre for Vascular Research, University of New South Wales, Australia |
Co-Chair: |
Dr. J.W.N. Akkerman, Department of Clinical Chemistry and Haematology University Medical Center Utrecht , The Netherlands |
01:30 pm-01:55 pm |
Title: Normalizing Calcium Cycling for the Treatment of Atrial Fibrillation
Dr. Xander H.T. Wehrens, Baylor College of Medicine Houston, TX, USA
|
01:55 pm-02:20 pm |
Title: Therapeutic Opportunities in Cardiovascular Disease using Small Molecule Nucleic Acid-Based Strategies
Dr. Levon M. Khachigian, NHMRC SPRF, Professor and Head, Transcription and Gene Targeting Laboratory, Centre for Vascular Research, University of New South Wales, Australia
|
02:20pm-02:45 pm |
Title: Recombinant Sendai Virus as a Novel RNA Drug (DVC1-0101) to Treat Critical Limb Ischemia
Dr. Yoshikazu Yonemitsu, Professor, Department of Gene Therapy, Chiba University Graduate School of Medicine, Japan
|
02:45 pm-03: 10pm |
Title: A Novel Aqueous Alprostadil Formulation with Excellent Superficial Skin Penetration but without Hypersensitivity or Skin Irritation for the Treatment of Female Sexual Arousal Disorder
Dr. Ernst R. Schwarz, Professor of Medicine, David Geffen School of Medicine at UCLA Division of Cardiology, Division of Cardiothoracic Surgery, Comprehensive Transplant Program, Cedars Sinai Medical Center, Los Angeles, California, USA |
03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:50 pm |
Title: Role of the Mitochondrial F1F0 ATPase in Myocardial Ischemia: Is the Switch from Synthase to Hydrolase Activity During Ischemia Merely a Chemical Reaction Run in Reverse?
Dr. Gary J. Grover, Director of Pharmacology, Eurofins Scientific, Associate Professor of Physiology and Biophysics, Robert Wood Johnson Medical School, New Jersey, USA |
03:50 pm-04:15 pm |
Title: Secretion from Cells - Networks and Structures; Use of Cell Immunoblotting and the Atomic Force Microscope
Dr. John Evans, Department of Obstetrics and. Gynaecology, Christchurch Women's Hospital, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand |
04:15 pm-04:40 pm |
Title: Novel Causes of Hyperactive Blood Platelets
Dr. J.W.N. Akkerman, Department of Clinical Chemistry and Haematology University Medical Center Utrecht , The Netherlands
|
04:40 pm-05:00 pm |
PANEL DISCUSSION |
Time |
Session 15: Anti-Cancer/Tumors Drug Discovery & Development and Current Status of the Innovative Therapeutics (Part III) |
Session Chair: |
Dr. Christian Jaulin, Group Leader, Cancer Research Center (CRLC) of Montpellier, France |
Co-Chair: |
Dr. Robert J. Hickey, Indiana University School of Medicine, Department of Medicine, Indianapolis, Indiana, USA |
01:30 pm-02:00 pm |
Title: A Novel Anti-cancer Agents that Target HIF-1a and HIF-2a for Cancer Therapy
Dr. Naijie Jing, Associate Professor, Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, USA |
02:00 pm-02:30 pm |
Title: The Mitotic Spindle Assembly Checkpoint: A New Therapeutic Target For Histone Deacetylase Inhibitors
Dr. Christian Jaulin, Group Leader, Cancer Research Center (CRLC) of Montpellier, France |
02:30 pm-03:00 pm |
Title: Targeting IGF-I Receptor to Treat Colorectal Cancer
Dr. Shi Yu Yang, Academic Department of Surgery, Royal Free & University College Medical School, University College London, UK |
03:00 pm-03:30 pm |
Title: Identification of a Cancer Specific Signature for Cancer: Diagnostic and Therapeutic Potential
Dr. Robert J. Hickey, Indiana University School of Medicine, Department of Medicine, Indianapolis, Indiana, USA |
03:30 pm-03:45 pm |
TEA BREAK |
03:45 pm-04:15 pm |
Title: Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X-Protein : A New Therapeutic Targets for DNA Methyltransferase Inhibitors
Dr. Young Ik Lee, Metabolic Syndrome Research Div.Korea Research Institute of Bioscience and Biotechnology (KRIBB), Taejeon, Korea
|
04:15 pm-04:40 pm |
Title: AZD1152, an Aurora B Kinase Inhibitor, Demonstrates Potent Antitumour Efficacy in Preclinical Models
Dr. Xiaolin Zhang, VP, Head of Innovation Center China, AstraZeneca Global R&D, China/USA
|
04:40 pm-05:00 pm |
PANEL DISCUSSION |
Time |
Session 16: Protein and Peptide Drug Development |
Session Chair: |
Dr. Anton Fliri , Research Fellow, Pfizer Inc, USA |
Co-Chair: |
Dr. W.I.M. Van de Ven, Professor, Laboratory for Molecular Oncology, Department of Human Genetics, Belgium |
01:30 pm-01:50 pm |
Title: Analytical Challenges in Protein Therapeutics Development
Dr. Xing Wang, Senior Principal Scientist, Global Biologics, Pfizer Global Research and Development, USA |
01:50 pm-02:10 pm |
Title: GEP: a Novel Chondrogenic Growth Factor and Target in Arthritis
Dr. Chuanju Liu, Assistant Professor, Dept. of Orthopaedic Surgery
& Cell Biology, New York University School of Medicine, USA |
02:10 pm-02:30 pm |
Title: Furin: A Proven Endoproteolytic Processing Tool for Enhanced Manufacturing of Safe Recombinant Biopharmaceuticals
Dr. W.J.M. Van de Ven, Professor, Laboratory for Molecular Oncology, Department of Human Genetics, Belgium |
02:30 pm-02:50 pm |
Title: MED-SuMo : A Powerful Software to Classify Binding Sites Using 3D Surface Chemical Features and to Perform Fragment-Based Drug Design at PDB Scale
Dr. Alexandre G. de Brevern, French Institute of Health and Medical Research, France |
02:50 pm-03:10 pm |
Title: Studies on the Origin of Protein Network Topologies
Dr. Anton Fliri , Research Fellow, Pfizer Inc, USA |
03:10 pm-03:25 pm |
TEA BREAK |
03:25 pm-03:45 pm |
Title: Ribosomal synthesis of unusual peptides by reprogramming the genetic code and its application for physiologically stable peptide drugs
Dr. Hiroaki Suga, Research Center for Advanced Science and Technology, The University of Tokyo, Japan
|
03:45 pm-04:05 pm |
Title:In vivo Regulation and Inhibition of Ribonucleotide Reductase
Dr. Mingxia Huang, University of Colorado Health Sciences Center, USA
|
04:05 pm-04:25 pm |
Title: Molecular Designer Of Self-assembling Peptide Nanomaterials and Its Application In Regenerative Medicine
Dr. Xiaojun Zhao, Professor and Executive Director, Institute for Nanobiomedical Technology and Membrane Biology, Sichuan University, Chengdu, China |
04:25 pm-05:00 pm |
PANEL DISCUSSION |
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