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2008 iBio
(May 18-22, 2008,Hangzhou,China)
CEMD-2008
( Oct.22-28, 2008, Beijing & Xi'an, China )
WCV 2008
( Dec.1-5, 2008, Foshan, China)
WCG 2008
(Dec. 5-7, 2008, Foshan, China)
 
 
Scientific Program

    Congress Dates : October 18-22, 2008     Beijing Loong Palace Hotel & Resort, Beijing
    Exhibition Dates : October 18-20, 2008


2008 IDDST Final Program

Time: October 18-22, 2008

Venue: Loong Palace Hotel, Beijing, China

 

Morning of October 18


Opening Ceremony & Keynote Forum

For Detail Track Info: Click here



Morning of October 19


Plenary Lectures

-- From Novel Targets to Billion Dollar Molecules

Special Symposium Sponsored by ACS-Medichem Division



Afternoon of October 18, Afternoon of October 19


Track I: Applicable and Frontier Scientific Methodologies and Models

-Great Thoughts for Deciphering Human Disorders

For Detail Track Info: Click here, Session 1-20


Morning of October 20


Track II: How Advanced Medicinal Chemistry Help Your prototype molecules to Blockbusters

-Listen to Successful Case Story from Big Phmarmas and Enjoy the Voice of ACS Medichem

For Detail Track Info: Click here, Session 21-25



Morning of October 20


Track III: Translational Cutting-Edge Technologies

-Speeding Discovery Process with Niches

For Detail Track Info:
Click here, Session 26-35



Morning of October 20, Afternoon of October 21, Morning of October 22


Track IV: Therapeutics Development for Major and Rare Diseases

-Delivering Promises for Future Drugs

For Detail Track Info: Click here, Session 36-55



Morning of October 22


Track V: Nature Product Based Drug Discovery

-Mining 5000 Year Nature Pool

For Detail Track Info: Click here, Session 56-60



Morning of October 22


Track VI: Drug R & D Partnering in China

-Integrating Resources and Talents from the East To Slow Your Money Burning Rate Increase pipeline successful percentage

For Detail Track Info: Click here, Session 61-65

Time

Activities

Oct.18, 2008
Saturday
08:20-11:50

Opening Ceremony

08:20-08:40

Group Photo

09:00-09:05

Chair's Opening Remark
09:05-09:35

VIP's Address

 Keynote Forum
09:40-09:45 Welcome and Introduction
Dr. Jing-Shan Hu
, Director of Licensing & External Research, Merck & Co., Inc., USA

09:45-10:10

Title: The Secret Life of Enzymes: An Aggressive Strategy for Drug Discovery
Prof. K. Barry Sharpless, Professor, The Scripps Research Institute, 2001 Nobel Prize Laureate in Chemistry, USA

10:10-10:35

Title: Innovation in Drug Discovery
Dr. Joel C Barrish, Vice President, Immunology and Metabolic Diseases Chemistry, Bristol-Myers Squibb, USA

10:35-11:00

Title: Roche R&D Center ( China ) Ltd.: A New Way of Drug Discovery
Dr. Andreas Claudius Tschirky, General Manager of Roche R&D Center China (RRDCC), China

11:00-11:25

Title: Principal Questions for Therapeutic Antibody Discovery
Dr. Wenyan David Shen, Executive Director and Head, Biologics Research and GlycoFi, Merck & Co., Inc., USA

11:25-11:50

Title: Predicting Seasonal and Pandemic Influenza Evolution via Homologous Recombination
Dr. Henry L. Niman, President & Founder, Recombinomics, Inc., USA


The Main Scientific Program will take place from 09:00-17:00 during October 18-22, 2008. 500+ Research and Industrial Presentations divided into six tracks with sixty-five sessions in total. The ten sessions offered will run concurrently per half day.

Click following session number for detailed program:

 

Track I: Drug Discovery Sciences ¡øTOP
-Great Thoughts for Deciphering Human Disorders
 

Time

Sessions

Oct.18, 2008
Saturday
13:30-15:25

Track I-1: ¡°Omics¡±, Molecular Genetics to System Biology and Drug Discovery
£­Place:
Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Christian Pasquali, Professor, Geneva Research Center, Merck Serono International S.A.,
Switzerland
13:30-13:55

Keynote Speech
Title:
Principals for Omic Medicine
Dr. Ira L. Goldknopf,
Director of Proteomics, Power3 Medical Products, Inc., USA

13:55-14:20

Title: A Chemical Proteomics Approach to Phosphatidylinositol 3-Kinase Signaling in Macrophages
Dr. Christian Pasquali, Professor, Geneva Research Center, Merck Serono International S.A.,
Switzerland

14:20-14:45

Title: Genomewide Identification of Gene-gene Interactions Associated with the Susceptibility to Disease
Dr. Sara Marsal Barril
, Senior Consultant in Rheumatology, Rheumatology Unit, Hospital Universitari Vall d'Hebron, Spain

14:45-15:10

Title: Steps toward Broad-spectrum Therapeutics: Discovering Virulence-associated Genes Present in Diverse Pathogens
Dr. Murray Wolinsky, Team Leader, Bioscience Division, Los Alamos National Laboratory, USA

15:10-15:25 Coffee Break

Oct.18, 2008
Saturday
15:25-17:30

Track I-2: Regenerative Medicine and Drug Discovery
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Christophe Labie, Head, Neurobiology Group, Sanofi-aventis, Inc., France
15:25-15:50

Keynote Speech
Title:
Artificial Cells Containing Stem Cells for Regenerative Medicine

Dr. Thomas Ming Swi Chang,
Director, Artificial Cells & Organs Research Centre, McGill
University, Canada

15:50-16:15 Title: Regenerative Approaches for Adult Brain Diseases: Enhancement of Brain Neurogenesis to Replace Lost Neurons
Dr. Christophe Labie, Head, Neurobiology Group, Sanofi-aventis, Inc., France
16:15-16:40

Title: Transdifferentiation of Bone Marrow Stromal Cells into Neuronal Cells and Its Application for Regenerative Medicine
Dr. Masaaki Kitada, Associate Professor, Department of Stem Cell Biology and Histology, Tohoku Univeristy Graduate School of Medicine, Japan

16:40-17:05

Title: The Discovery and Development of Botanic Drug Ph-3 Based on Regenerative Medicine: From Discovery to Clinical Trial
Dr. Rong-Tsun Wu
, Professor & Director, Research Center for Drug Discovery, Institute of
Biopharmaceutical Science, National Yang-Ming University, Taiwan

17:05-17:30 Panel Discussion

Oct.18, 2008
Saturday
13:30-17:30

Track I-3: Molecular/Cell Biology and Drug Discovery
£­Place:
Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Michael R. Briggs,Senior Director and Head of Cell & Molecular Biology,Vertex Pharmaceuticals, Inc., USA

Co-Chair:

Dr. Meir Wetzler, Chief, Leukemia Section, Roswell Park Cancer Institute, USA
13:30-13:55

Keynote Speech
Title:
Finding Novel Cancer Drugs that Address Unmet Medical Needs

Dr. Michael R. Briggs,
Senior Director and Head of Cell & Molecular Biology, Vertex Pharmaceuticals, Inc., USA

13:55-14:20

Title: P25/CDK5 Inhibitors for AD Therapeutics
Dr. Ilho Ha, Director, BioScience Center Hanwha Chemical R & D Institute Hanwha Chemical Co., Korea

14:20-14:45 Title: DNA Polymerase Inhibitors for HBV Therapy
Dr. Howard Li, Vertex Pharmaceuticals, Inc., USA
14:45-15:10

Title:Arsenic Trioxide - Teaching an Old Drug New Tricks
Dr. Meir Wetzler, Chief, Division of Leukemia, Department of Medicine, University of New York at Buffalo, USA

15:10-15:25 Coffee Break
15:25-15:50

Title: ¦Â Peptide, A Potential New Anti-metastasis Peptide: Expression and Anti-metastasis Ability
Dr. Yinkun Liu,
Deputy Director, Liver Cancer Institute of Fudan University, China

15:50-16:15

Title: Wisdom: Grid Computing Enabled Identification of Active Molecules Against Targets Implicated in Malaria
Dr. Ana Lucia Da Costa,
CNRS, Clermont-Ferrand, France

16:15-16:40

Title: The Mosquito Sodium Channel: Adaptive Changes of Amino Acid and Codon Biases in the Evolution of Pyrethroid Resistance
Dr. Nannan Liu, Associate Professor, Department of Entomology and Plant Pathology, Auburn University, Auburn, USA

16:40-17:05

Title: Novel Technologies for Expediting Drug Discovery Research
Dr. Keming Song, R&D Manager, Sigma-Aldrich Corporation, USA

17:05-17:30

Title: KH902, A Potentially Better Therapy for Neovascular Age-Related Macular Degeneration
Dr. Dechao Michael Yu, CEO, Kanghong Biotech Co. Ltd., China

Oct.18, 2008
Saturday
13:30-15:25

Track I-4: Immunology and Drug Discovery
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Prakash Nagarkatti, Associate Dean for Basic Science, University of South Carolina School of Medicine, USA
13:30-13:55

Keynote Speech
Title:
Use of Cannabinoids as Novel Anti-inflammatory Drugs through Potential Targeting of CB2 Receptors
Dr. Prakash Nagarkatti,
Associate Dean for Basic Sciences, University of South Carolina School of Medicine, USA

13:55-14:20 Title: Development and Validation of New Multiplex Panels for Cell Signaling and Neuroscience
Dr. Geraldine Wee,
Asia Marketing Manager (Drug Discovery), Bioscience Division, Millipore Singapore, Singapore
14:20-14:45

Title: Cytokine Profile of T Cells in Pregnancy
Dr. Marie-Pierre Piccinni
,
Professor, University of Florence, Italy

14:45-15:10

Title: Cholera Toxin B Subunit-based Fusion Proteins: An Approach to Design New Adjuvanted Vaccines
Dr. Ana Paula de Mattos Areas, Natural and Human Sciences Center, Federal University of ABC, Brazil

15:10-15:25 Coffee Break

Oct.18, 2008
Saturday
15:25-17:40

Track I-5: Microbiology, Virology and Drug Discovery
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Natarajan Ranganathan, Interim CEO, Kibow Biotech, USA

Co-Chair:

Dr. Grace Wong, Founder, President & CSO, ActoKine Therapeutics, USA
15:25-15:45 Keynote Speech
Title:
Discovering Enteric Dialysis ?The Gut Based Uremia Therapy for Chronic Kidney Failure Applications

Dr. Natarajan Ranganathan, Interim CEO, Kibow Biotech, USA
15:45-16:05

Title: Efficient Selection of Monoclonal Antibodies to Rabies Virus Using Ribosome Display Technology
Dr. Xiao-Ling Zhao, Associate Professor, Institute of Health and Enviramental Medicine, China

16:05-16:25

Title: IIdentification of AK-1 for Protection against Radiation Damage and Ak-2 & Ak-8 for Protection against a Broad-spectrum Viral Infection
Dr. Grace Wong, Founder, President & CSO, ActoKine Therapeutics, USA

16:25-16:45

Title: Generic Vaccines against Threat Pathogens
Dr. Jian Song, Staff Scientist, Los Alamos National Laboratory, USA

16:45-17:05 Title: Low Cost Integral Aproaches for Pertussis Vaccines for Neonates, Infants and Adolecents Developed at Instituto Butantan - Brazil
Dr. Luciana C. C. Leite, Vice President, Centro de Biotecnologia, Instituto Butantan, Brasil
17:05-17:25

Title: Designs and Efficacies of Broad-spectrum and Virus-specific Approaches Using Uucleic Acid-based Aagents against Influenza A Viruses
Dr. Jonathan P. Wong, Research Scientist, Chemical & Biological Defence Section, Defence R & D Canada - Suffield (DRDC Suffield), Canada

17:25-17:40

Panel Discussion

Oct.18, 2008
Saturday
13:30-17:40

Track I-6: Oncology and Drug Discovery
£­Place: Taihang Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Mitzi Nagarkatti, Deputy Director of Cancer, University of South Carolina, USA

Co-Chair:

Dr. M Asif Chaudry,University Department of Surgery Royal Free & University College London, UK

13:30-13:50

Keynote Speech
Title:
Tumor-Selective Anticancer Drugs from Amphiphilic Organophosphazenes

Dr. Youn Soo Sohn,
Distinguished Professor, Department of Chemistry, Division of Nano Science, Ewha Womans University, Korea

¡¡13:50-14:10

Title: Multiple Target Tyrosine Kinase Inhibitors
Dr. Tang Peng Cho, Chief Scientific Officer, Shanghai Hengrui Pharmaceuticals, China

14:10-14:30

Title: Targeting the Cannabinoid System as a Novel Therapeutic Modality to Treat Cancers of the Immune System
Dr. Mitzi Nagarkatti,
Deputy Director of Cancer, University of South Carolina, USA

14:30-14:50

Title: Fragment Based Drug Discovery Using Rational Design
Dr. Harren Jhoti,
Chief Executive Officer & Founder, Astex Therapeutics, Cambridge, UK

14:50-15:10

Title: A Human Tumor Genome Project: From Sequence to Structure, Function and Possibly Drug Targets
Dr. Laszlo Homolya,
Senior Scientist, Research Group for Membrane Biology, Semmelweis
University, Hungarian Academy of Sciences, Hungary

15:10-15:25 Coffee Break
15:25-15:45

Title: Targeting Multidrug Resistant Cancer
Dr. Gergely Szakacs,
Professor, Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

15:45-16:05

Title: Target Therapy in Cancer
Dr. Valentina Tzekova, Professor, University Hospital "Queen Joanna", Bulgaria

16:05-16:25

Title: Identification of Cyano Indenopyrazine Derivatives as a Novel Series of Potent Ubiquitin-Specific Protease Inhibitors
Dr. Fr¨¦d¨¦ric Colland, Director, Biological Research, Hybrigenics Pharma, France

16:25-16:45

Title: Phage Display: A Magic Tool for Cancer Biology
Dr. Zonghai Li, Associate Professor, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai, China

16:45-17:05
Title: Multifunctional Antibody Treatment Targeting EpCAM in GI Cancer
Dr. M Asif Chaudry,
University Department of Surgery Royal Free & University College London, UK
17:05-17:40
Panel Discussion

Oct.18, 2008
Saturday
13:30-17:00

Track I-7: Neurology and Drug Discovery
£­Place: Song Shan Room A, 1F, South Wing, LPHR

Session Chair:

Dr. Sabina Janciauskiene, Associate Professor, Department of Clinical Sciences, Lund University, Sweden

Co-Chair:

Dr. Xueqing Wang, Associate Research Investigator, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, USA
13:30-13:55

Title: Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases): What Can Be Learned by Studies on Cu(II)-peptide Complexes
Dr. Gianni Valensin,
Professor, Director of the NMR Centre of the University of Siena, Italy

13:55-14:20

Title: Opioid Antagonist Treatment and Alcohol Consumption: Role of Dose, Gender and
Pharmacologic Strategy

Dr. Jorge Ju¨¢rez,
Professor, Universidad de Guadalajara, M¨¦xico

14:20-14:45

Title: TCA Cycle May Play an Important Role for Protection Against Epileptic Seizures
Dr. Hiro-aki Yamamoto,
Associate Professor, University of Tsukuba, Japan

14:45-15:10

Title: Innovation in Neuroscience£ºThe Useful Tools for Drug Discovery
Dr. Yi Wang, Training Manager and Field Application Scientist, Millipore Corp, China

15:10-15:25 Coffee Break
15:25-15:50

Title: Neurovascular Dysfunction in Dementia: Cholinesterase Inhibitors
Dr. Sabina Janciauskiene, Associate Professor, Department of Clinical Sciences, Lund University, Sweden

15:50-16:15

Title: Thiazol-2(3H)-ylidene-1-ethanones: Potent, Selective Cannabinoid CB2 Agonist as Novel Pain Therapeutics
Dr. Xueqing Wang
, Associate Research Investigator, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, USA

16:15-16:40

Title: Ion Channel Modulators for Treatment of Neuropsychiatric Disorders
Dr. Kewei Wang, ChangJiang Professor, Department of Neurobiology and Neuroscience Research Institute, Peking University School of Medicine, China

¡¡16:40-17:00 Panel Discussion

Oct.18, 2008
Saturday
13:30-15:25

Track I-8: Hepatology and Drug Discovery
£­Place: Song Shan Room B, 1F, South Wing, LPHR

Session Chair:


Dr. Michael S Roberts,
Professor, University of Queensland, Australia

Co-Chair:

Dr. Hanry Yu, Associate Professor, National University of Singapore, Singapore
13:30-13:55 Keynote Speech
Title: Drug Structure-Hepatic Pharmacokinetic Relationships in Normal and Diseased Livers
Dr. Michael S Roberts,
Professor, University of Queensland, Australia
13:55-14:20

Title: 3D Cellular Models for Hepatotoxicity
Dr. Hanry Yu,
Associate Professor, National University of Singapore, Singapore

14:20-14:45

Title: Cyclic Arg-Gly-Asp Peptide-Labeled Liposomes Fpr Targeting Drug Therapy of Hepatic Fibrosis in Rats
Dr. Jiyao Wang,
Professor & Chair, GI & Hepatology, Shanghai Medical College, Fudan University, China

14:45-15:10

Title: Replicative HBV Transgenic Mice and Its Use in Drug Evaluation
Mr. Xue-Rui Yi, The Liver Center of PLA, The 458 Hospital in Guangzhou, Guangzhou, China

15:10-15:25 Coffee Break

Oct.18, 2008
Saturday
15:25-17:40

Track I-9: Pharmacology, Toxicology and Pathology in Drug Discovery
£­Place: Song Shan Room B, 1F, South Wing, LPHR

Session Chair:

Dr. Tian Yang, Research Leader, Roche Pharmaceuticals, USA
15:25-15:50

Keynote Speech
Title: De-risk Adverse Drug Reaction Potential in Drug Discovery and Development
Dr. Tian J Yang,
Research Leader, Roche Pharmaceuticals, USA

15:50-16:15

Title: Clays and Their Beneficial Effects upon Skin
Dr. Carmen del Hoyo Mart¨ªnez,
Professor, University of Salamanca, Spain

16:15-16:40

Title: Pharmacoepidemiology Studies about Drugs and Herbal Medicine during Breastfeeding, How to Protect Neonate and Infant from Harmful Compounds during Breastfeeding
Dr. Raphael Serreau, Physician Specialist, Necker Hospital in Paris, France

16:40-17:05

Title: In Vitro Anti-tumor Activity of Novel Nucleoside Analogs with an Optically Active Bicyclo Heptane Sugar Moiety
Dr. Tanase Constantin, Professor, National Institute for Chemical-Pharmaceutical Research & Development, Romania

17:05-17:30 Title: Novel Nucleoside Analogs with an Oxabicyclo [3,3,0] Octane Modified Sugar Moiety -
Preclinical Study on Tumor Cells

Dr. Gina Manda,
Senior Scientist, Victor Babes National Institute, Romania
17:30-17:40

Panel Discussion

Time

Activities
Oct.18, 2008
Saturday
18:30-20:30

18:30-20:30

Welcome Banquet
Sponsored by Roche!

Oct.19, 2008
Sunday
13:30-15:45

Track I-10: Protein/Peptide Sciences, and Protein-Protein Interactions
£­Place: Huang Shan Room A, 2F, South Wing, LPHR

Session Chair:

Dr. David Craik, Professor, Institute for Molecular Bioscience, University of Queensland, Australia
13:30-14:00

Keynote Speech
Title:
Pharmaceutical Applications of Cyclotides: Macrocyclic Knotted Plant Proteins
Dr. David Craik, Professor, Institute for Molecular Bioscience, University of Queensland, Australia

14:00-14:30

Title: Peroxisome: Biogenesis, Biogenesis Disorders, Pathogenic Genes, and Restoration of Dysfunctions
Dr. Yukio Fujiki, Professor, Department of Biology, Faculty of Sciences, Kyushu University Graduate School, Fukuoka, Japan

14:30-15:00

Title: Synthetic Peptides Derived from Tumor Suppressor p53 Inhibit the Excision of UV-Induced DNA Damages
Dr. Yin-Chang Liu, Director, Institute of Molecular Medicine, National Tsing-Hua University, Taiwan

15:00-15:30

Title:Design of Functional Peptide-Nanoparticle Complexes with Potential Applications in Targeted Drug Delivery
Dr. Bengt-Harald Jonsson, Division of Molecular Biotechnology, Department of Physics,
Chemistry and Biology, Linkoping University, Sweden

15:30-15:45 Coffee Break

Oct.19, 2008
Sunday
15:45-17:30

Track I-11: Cytokine Based Drug Discovery
£­Place: Huang Shan Room A, 2F, South Wing, LPHR

Session Chair:

Dr. Jian-Dong Li, Professor, University of Rochester Medical Center, USA
15:45-16:15 Keynote Speech
Title:
Discovery of Novel Anti-inflammatory and Anti-heart Failure Drugs
Dr. Jian-Dong Li,
Professor, University of Rochester Medical Center, USA
16:15-16:45

Title: Compounds that Affect the Activity of Hemichannels and or Gap Junction Channels as New Tolls to Modulate the Strength of Immune Responses
Dr. Juan C. Saez, Full Professor, Department of Physiological Sciences, Catholic University of Chile, Chile

16:45-17:15

Title: Advancements in Obesity Management: Adipocytokine-Based Drug Discovery
Dr. Nasser M. Al-Daghri, Assistant Professor, College of Science, Biochemistry Department, King Saud University, Kingdom of Saudi Arabia

17:15-17:30

Panel Discussion

Oct. 19, 2008
Sunday
13:30-17:40

Track I-12: Molecular Targets and Biomarker in Drug Discovery
£­Place: Huang Shan Room B, 2F, South Wing, LPHR

Session Chair:

Dr. Nitin Saksena, Head, Retroviral Genetics Division, Westmead Millennium Institute, Australia

Co-Chair:

Dr. Fei Huang, Associate Director, Oncology Clinical Biomarker, Bristol-Myers Squibb, USA
13:30-13:55

Keynote Speech
Title:
The Use of Human Tissues for Biomarkers and Drug Discovery Research: Practical, Regulatory, and Ethical Concerns
Dr. Charles F. Saller,
President & CEO, ABS, Inc., USA

13:55-14:20

Title: The Glycosphingolipid, Globotriaosyl Ceramide Provides New Therapeutic Approaches to Both Cancer Treatment and HIV Therapy
Dr. Clifford A. Lingwood, Hospital for Sick Children, Toronto, Canada

14:20-14:45

Title: Lysophosphatidic Acid Induces Ovarian Cancer Cell Migration via Activation of AMP-
Activated Protein Kinase

Dr. Pann-Ghill Suh
,
Professor, Department of Life Science, Postech, Korea

14:45-15:10

Title: A Human Tumor Genome Project: From Sequence to Structure, Function and Possibly Drug Targets
Dr. Peter W. Gunning, Head, Oncology Research Unit; Conjoint Professor, University of Sydney, Australia

15:10-15:25 Coffee Break
15:25-15:50

Title: Integrating Biomarkers for Accelerated Drug Development--A Case Study of Dasatinib
Dr. Fei Huang,
Associate Director, Oncology Clinical Biomarker, Bristol-Myers Squibb, USA

15:50-16:15

Title: PAK1 Interacts with* ?catenin and is Required for the Regulation of the ?catenin Signalling Pathway by Gastrins
Dr. Hong He, Senior Research Fellow, Department of Surgery University of Melbourne, Australia

16:15-16:40

Title: Novel Human Proteins-Future Drug Candidates for Controlling Human Immunodeficiency Virus (HIV)
Dr. Nitin Saksena,
Head, Retroviral Genetics Division, Westmead Millennium Institute, Australia

16:40-17:05

Title: Transcription Factor Nrf2 as A Molecular Target for the Cytoprotection Against Oxidative Damage
Dr. Mi-Kyoung Kwak
, Assistant Professor, School of Pharmacy, Lab of Pharmacology, Yeungnam University, South Korea

17:05-17:30

Title: Biomarker Application in Oncology Clinical Development
Dr. Michael M. Shi, Director and Biomarker Project Leader, Exploratory Oncology Development, Novartis Pharmaceuticals Corporation, USA

17:30-17:40

Panel Discussion

Oct. 19, 2008
Sunday
13:30-15:25

Track I-13: Protein to Cell Based Assay Technologies
£­Place: Huang Shan Room C, 2F, South Wing, LPHR

Session Chair:

Dr. Michael Duszenko, Professor, Department of Biochemistry University of Tuebingen, Germany
13:30-13:55 Keynote Speech
Title:
Advancing Drug Discovery with Invitrogen Cell-Based Discovery Systems and Services

Dr. Thomas Livelli, Vice President, Cellular Assay Systems, Invitrogen Discovery Assays and Services, USA
13:55-14:20

Title: Drug Development to Cure Sleeping Sickness in Africa
Dr. Michael Duszenko, Professor, Department of Biochemistry University of Tuebingen, Germany

14:20-14:45

Title: Electrophoretic Separation of Hydrophobic Membrane Proteins Using Iso-electric Focusing
Dr. Kashino Yasuhiro, Assistant Professor, Graduate School of Life Science, University of Hyogo, Japan

14:45-15:10

Title: Physical Biotechnology Development and Its Biomedical Applications
Dr. Chunghsuan (Winston) Chen, Distinguished Research Fellow & Director, The Genomics Research Center, Taiwan

15:10-15:25 Coffee Break

Oct. 19, 2008
Sunday
15:25-17:40

Track I-14: Nuclear Receptors and Drug Discovery
£­Place: Huang Shan Room C, 2F, South Wing, LPHR

Session Chair:

Dr. Jiake Xu, Associate Professor and Head, Molecular Orthopedic Lab, School of Surgery and Pathology, the University of Western Australia, Australia
15:25-15:50

Keynote Speech
Title:
NF-kB Modulators in Osteolytic Bone Diseases

Dr. Jiake Xu, Associate Professor and Head, Molecular Orthopedic Lab, School of Surgery and Pathology, the University of Western Australia, Australia

15:50-16:15

Title:Estrogen Receptor Beta May be a Novel Target for the Beneficial Effects of Naturally-occurring Steroids, Therapeutics, and Selective Estrogen Receptor Modulators
Dr. Alicia A. Walf, Graduate Research Associate, University at Albany, USA

16:15-16:40

Title: Androgen Receptor and Its Coactivators in Prostate Cancer: Novel Targets for Androgen-independent Disease
Dr. Peng Lee, Assistant Professor of Pathology, NYU Langone Medical Center and VA New York Harbor Healthcare System, USA

16:40-17:05

Title: Progesterone and Its Metabolites as Therapeutic Targets
Dr. Cheryl A. Frye, Professor of Psychology, University at Albany, USA

17:05-17:30 Title: Target-selective Degradation of Proteins and Oligosaccharides by Light-Activated Hybrid Molecules for Molecular-targeted Photodynamic Therapy
Dr. Kazunobu Toshima, Full Professor, Department of Applied Chemistry, Keio University, Japan
17:30-17:40

Panel Discussion

Oct. 19, 2008
Sunday
13:30-15:45

Track I-15: Proteinase and Kinases in Drug Discovery
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Rohan Teasdale, Group Leader, Institute for Molecular Bioscience, The University of Queensland, Australia
13:30-13:55 Keynote Speech
Title:
Parterning Your Research in Drug Discovery: Kinase, Kinase Assay and Kinase Inhibitor Screening Services
Dr. Fang Zhang,
Asia Technical Support Team Manager, Millipore Corp, China
13:55-14:20

Title: Defining Organelle Proteomes
Dr. Rohan Teasdale, Group Leader, Institute for Molecular Bioscience, The University of Queensland, Australia

14:20-14:45

Title: Anticancer Drug Discovery Based on Zinc- dependent Metalloproteinase as Target
Dr. Wen-Fang Xu, Professor, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, China

14:45-15:10

Title: Protein Kinase D Signaling in Health and Disease
Dr. Johan Van Lint,
Professor of Medical Biochemistry, Department of Molecular Cell Biology, Faculty of Medicine, Katholieke University Leuven, Belgium

15:10-15:35 Title: Targeting Cyclin A: An Alternative More Selective Approach for CDKs Inhibition
Dr. Kontopidis George
, Assistant Professor of Biochemistry and Head of Biochemistry Veterinary School, University of Thessaly, Greece
15:35-15:45

Coffee Break

Oct. 19, 2008
Sunday
15:45-17:40

Track I-16: Targeting Signaling Pathways
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Xiaoyan Jiang, Senior Scientist, BC Cancer Research Centre, Canada

Co-Chair:

Dr. Cheng-Jung Lai, Director, Molecular and Cellular Oncology, Curis, Inc., MA, USA
15:45-16:05 Keynote Speech
Title:
AHI -1: A Novel Oncogene and Potential Therapeutic Target in the BCR - ABL Signaling Pathway

Dr. Xiaoyan Jiang,
Senior Scientist, BC Cancer Research Centre, Canada
16:05-16:25

Title: CU-0101, a Potent, Small Molecule, Multi-targeted Inhibitor of HDAC, EGFR and Her-2, Has Potent Antitumor Activity in vivo Xenograft Models
Dr. Cheng-Jung Lai, Director, Molecular and Cellular Oncology, Curis, Inc., MA, USA

16:25-16:45

Title: Treatment of Acute Pancreatitis: Targeting Inositol Trisphosphate Receptors
Dr. Ole H. Petersen, Professor, MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, UK

16:45-17:05

Title: Biomarker and Drug Discovery with High Density Functional Protein Microarrays
Dr. Timothy Wong, Regional Business Manager, Discovery Sciences & Proteomics, Asia Pacific Invitrogen Corporation, Hongkong, China

17:05-17:30 Title: Targeting Cancer Signaling Network Using a Systems Biology Approach
Dr. Prahlad T. Ram
, Assistant Professor, Department of Systems Biology, M.D. Anderson Cancer Center, Housto, USA
17:30-17:40

Panel Discussion

Oct. 19, 2008
Sunday
13:30-17:00

Track I-17: G Protein-Coupled Receptors in Drug Discovery
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Xiang-Qun (Sean) Xie, Professor, Dept of Pharmaceutical Sciences, School of Pharmacy; Drug Discovery Institute; Dept of Computational Biology and Structural Biology, University of Pittsburgh, USA

Co-Chair:

Dr. Marta Filizola, Assistant Professor, Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, USA
13:30-14:00

Keynote Speech
Title:
Hit Validation and Functional Selectivity Profiling Using ChemiscreenTM GPCR Cell Lines
Dr. Blaine N. Armbruster, Product Manager - GPCR Drug Discovery, Millipore Corp, USA

14:00-14:30

Title: In Silico and In Vitro Chemical Genomics Screens for GPCR Drug Discovery
Dr. Xiang-Qun (Sean) Xie,Professor, Dept of Pharmaceutical Sciences, School of Pharmacy; Drug Discovery Institute; Dept of Computational Biology and Structural Biology, University of Pittsburgh, USA

14:30-15:00

Title: Modern Molecular Modeling and Simulations to Explore Activation Pathways of G-Protein Coupled Receptors
Dr. Marta Filizola
, Assistant Professor, Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, USA

15:00-15:15

Coffee Break

15:15-15:45

Title: A Confocal Fluorescence Imaging Method for High Throughput Drug Screening
Dr. Zhuan Zhou, Professor and Senior Investigator, Laboratory of Cellular Biophysics, Institute of Molecular Medicine, Peking University, China

15:45-16:15

Title: Exploring Adipocyte Expressed GPCRs as Potential Novel Therapeutics For Treating
Metabolic Diseases

Dr. Yang Li, Principal Scientist, Amgen Inc., USA

16:15-16:45

Title: Universal Structural Principles Applicable in Molecular Modeling of Integral Membrane Proteins
Dr. Siavoush Dastmalchi,
Associate Professor, School of Pharmacy and Biotechnology Research
Center, Tabriz University of Medical Sciences, Iran

16:45-17:00 Panel Discussion

Oct. 19, 2008
Sunday
13:30-15:50

Track I-18: Preclinical and Clinical Trials and Outsourcing
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Sponsored by SAS Institute Inc.

Session Chair:

Dr. Song Xuemei, President of Venture Pharma Service (VPS) CRO Group, China
13:30-14:00

Keynote Speech
Title:
Optimize Your Clinical Data Management Using SAS Solutions

Mr. Jeff Sun, Sr. Technical Consultant, Global Health & Life Sciences, SAS Institute Inc., USA

14:00-14:25

Title: China Preclinical Services Outsourcing: Crouching Tiger Hidden Dragon
Dr. R. Stephen Porter, CSO, Medicilon/MPI Preclinical Research-Shanghai, USA

14:25-14:50

Title: Reporting Randomized Controlled Trials in Journal and Conference Abstracts
Dr. Giovanni Dondi dall'orologio,
Associate Professor, Division of Conservative Dentistry
Department of Dental Sciences, University of Bologna, Italy

14:50-15:15

Title: Venturepharm a Full-Service Provider to World Pharmaceutical Life Science Industry
Dr. Song Xuemei, President of Venture Pharma Service (VPS) CRO Group, China

15:15-15:40 Title: Bayesian Adaptive Dose-finding Trial Designs for Drug Combinations
Dr. Guosheng Yin, Associate Professor, Department of Biostatistics, M. D. Anderson Cancer Center, The University of Texas, USA
15:40-15:50

Coffee Break

Oct. 19, 2008
Sunday
15:50-17:40

Track I-19: Laboratory Animals in Drug Discovery
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Lang Zhuo, Team Leader and Principal Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore
15:50-16:15 Keynote Speech
Title:
The Cotton Rat Sigmodon Hispidus as a Model of Human Infectious Diseases

Dr. Marina S. Boukhvalova, Senior Scientist, Virion Systems, Inc., USA
16:15-16:40

Title: Discovering New and More Efficient Drugs for Infectious and Chronic Disease by Using the Collaborative Cross Mouse Population
Dr. Fuad A. Iraqi
, Senior Researcher, Department of Human Microbiology, Sackler Faculty of Medicine, Israel

16:40-17:05

Title: Profiling Compound Neurotoxicity and Efficacy by Molecular Retinal Imaging in Transgenic Mice
Dr. Lang Zhuo, Team Leader and Principal Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore

17:05-17:30

Title: A Novel Approach for the Screening of Psychotropic Drugs under Simulated Clinical Conditions
Dr. Natalia N. Kudryavtseva (Kudriavtseva),
Head of Neurogenetics of Social Behavior Sector
in the Institute of Cytology and Genetics SD RAS, Russia

17:30-17:40

Panel Discussion

Time
Events
Oct. 19, 2008
Sunday
19£º00-20:00

19:00-20:00

Cocktail Party
Sponsored by Bioduro !
 
 
 
Track II: Frontiers in Medicinal Chemistry ¡øTOP
-Build Better Drug Molecules at Atomic-Level
 
Special Symposium Sponsored by ACS-Medichem Division

Medicinal Chemistry Part 1: Plenary Lectures

-- New Interventions in Drug Discovery: From Bench to Clinic

Medicinal Chemistry Part II: Parallel Sessions

Time

Sessions

Oct.19, 2008
Sunday
09:00-12:00

Plenary Lectures on Medicinal Chemistry
-New Interventions in Drug Discovery: From Bench to Clinic
-Place: Huang Shan Room, 2F, South Wing, LPHR

¡¡09:00-09:05

Chair¡®s Welcome & Introduction

¡¡Chair:

Dr. Yanping Xu, Head of Discovery Chemistry Research and Technology, Lilly Research Laboratories, Lilly Corporate Center, USA

09:05-09:35

Title: The Discovery and Development of SPRYCEL (Dasatinib)
Dr. Joel C. Barrish, Vice President of Immunology Chemistry and Chemical Synthesis, Bristol-Myers Squibb, USA

09:35-10:05

Title: Discovery of Potent and Selective 11B-HSD-1 Inhibitors
Dr. Wenqing Yao, Senior Scientist, Incyte, Inc., USA

10:05-10:35

Title: Discovery of Taranabant, a Novel Cannabinoid-1 Receptor Inverse Agonist for the Treatment
of Obesity

Dr. Linus S. Lin, Senior Research Fellow, External Basic Research, Merck Research Laboratories, USA

10:35-11:05

Title: A Next Generation Oral Anticoagulant: The Discovery of Apixaban, a Potent, Selective and Orally Bioavailable Factor Xa Inhibitor
Dr. Donald Pinto, Research Fellow, Bristol Myers Squibb Pharmaceutical Co., USA

11:05-11:35

Title: The Power of Collaboration: From Butterfly Wings to ALIMTA
Dr. Chuan (Joe) Shih, Distinguished Lilly Scholar, Eli Lilly and Company, USA

11:35-12:00

Panel Discussion
Panelists: Dr. Chuan (Joe) Shih (Lilly); Dr. Joel C. Barrish (BMS);
Dr. Yanping Xu (Lilly); Dr. Wenqing Yao (Incyte); Dr. Linus S. Lin (Merck)

Oct.20, 2008
Monday
08:30-11:40

Track II-1: Drug Discovery through Alliance and Outsourcing: Opportunities and Challenges
£­Place: Huang Shan Room A, 2F, South Wing, LPHR

Session Chair:

Dr. Linus S. Lin, Senior Research Fellow, External Basic Research, Merck Research Laboratories, USA

Co-Chair:

Dr. Shuhui Chen, Chief Scientific Officer, WuXi PharmaTech Co., Ltd., China

08:30-09:00

Title: Integrated Services for Therapeutic Programs Offered at WuXi AppTec
Dr. Shuhui Chen, Chief Scientific Officer, WuXi PharmaTech Co., Ltd., China

09:00-09:30

Title: Lilly R&D Strategies in China: Managing Partnerships and Risk to Maximize Value
Dr. Peter Lander, Head of Discovery Chemistry in Asia, Eli Lilly and Company, China

09:30-10:00

Title: Chemistry Service Beyond SynthesisTM: Building a Fully Integrated R&D Pharmaceutical Chemistry Service Company
Dr. Boliang Lou, Chairman and Chief Executive Officer, Pharmaron, Inc., USA

10:00-10:30

Title: From Simple Building Blocks to Strategic Research Partnerships
Dr. Frederik Deroose, Head of External Collaborations & Outsourcing Services, Johnson & Johnson Pharmaceutical Research & Development, Belgium

10:30-11:00

Title: Bring Value to Its Customers: A Chinese Startup CRO's Approach
Dr. Yuntao (Michael) Song, CEO, Beijing PharmaSciences Co., Ltd., China

11:00-11:40

Panel Discussion

Oct.20, 2008
Monday
08:30-12:00

Track II-2: Modeling, SAR and Synthesis
£­Place: Huang Shan Room B, 2F, South Wing, LPHR

Session Chair:

Dr. Puwen Zhang, Group Leader, Medicinal Chemistry Team, Wyeth Research, USA

Co-Chair:

Dr. Yujia Dai, Research Investigator, Abbott Laboratories, USA

08:30-08:55

Keynote Speech
Title:
Advances in the Art of Library Design: Diversity is Dead, Pragmatism Lives
Dr. Dora M. Schnur,
Principal Scientist, Pharmaceutical Research Institute, Bristol-Myers Squibb,USA

08:55-09:20

Title: Multitargeted Receptor Tyrosine Kinase Inhibitors for Cancer Treatment
Dr. Yujia Dai,
Research Investigator, Abbott Laboratories, USA

09:20-09:45

Title: Design of Novel Inhibitors of Phosphoinositide-3-kinase (PI3K)
Dr. Jackie Kendall,
Senior Research Fellow, Auckland Cancer Society Research Centre, New Zealand

09:45-10:10

Title: Novel, Potent, and Selective Non-steroidal Progesterone Receptor Modulators Discovery of Tanaproget and Analogs
Dr. Puwen Zhang,
Group Leader, Medicinal Chemistry Team, Wyeth Research, USA

10:10-10:25 Coffee Break
10:25-10:50

Title: Pharmacophores / Virtual Screening and 5-HT Ligands
Dr. Ronan Bureau,
Professor, University of Caen, France

10:50-11:15

Title: Novel Inhibitors of Orotidine Monophosphate Decarboxylase as Antimalarial Agents
Dr. Lakshmi P. Kotra,
Associate Professor, The University of North Carolina at Greensboro, USA

¡¡11:15-11:40

Title: 3D/4D Classification of Drugs
Dr. Vladimir A. Potemkin, Head of Organic Chemistry Department, Head of Laboratory of Theoretical Problems of Organic Chemistry of Russian Academy of Sciences, Russia

11:40-12:00

Panel Discussion

Oct.20, 2008
Monday
08:30-10:25

Track II-3: Combinatorial and High Throughput Synthetic Chemistry
£­Place: Huang Shan Room C, 2F, South Wing, LPHR

Session Chair:

Dr. Mark Engel, Chairman, Excel PharmaStudies, China

08:30-08:55 Keynote Speech
Title:
Changing Trends in Clinical Work Being Placed in China
Dr. Mark Engel,
Chairman, Excel PharmaStudies, China
08:55-09:20

Title: Preparation of Compound Collections for Lead Finding through Parallel Synthesis and
Combinatorial Chemistry Techniques

Dr. Joan-Carles Fern¨¤ndez,
Senior Project Leader, Barcelona Science Park, Spain

09:20-09:45

Title: Enaminones: Easily Avaliable and Versatile Key-intermedates in Combinatorial Synthesis of Functionalized Heterocycles
Dr. Jurij Svete,
Professor, University of Ljubljana, Slovenia

09:45-10:10

Title: The Application of ¡°Molecular Architecture¡± Strategy in Drug Discovery-Total Synthesis and Process Development of Synthetic Epothilones
Dr. Yue Chen,
Professor, College of Pharmacy and The State Key Laboratory of Elemento-organic Chemistry, Nankai University, China

10:10-10:25 Coffee Break

Oct.20, 2008
Monday
10:25-12:00

Track II-4: Target Identification and Lead Optimization
£­Place: Huang Shan Room C, 2F, South Wing, LPHR

Session Chair:

Dr. Xin-Jie Chu, Senior Principal Scientist, Discovery Chemistry, Roche, USA

10:25-10:50

Keynote Speech
Title:
Discovery and Pharmacological Evaluation of Agonists of GPR119

Dr. Graeme Semple,
Vice President, Arena Pharmaceuticals Inc., San Diego, USA

10:50-11:15

Title: Optimizing Ligands of Promiscuous Targets - A Case Study for P-glycoprotein Inhibitors
Dr. Gerhard F. Ecker,
Professor, University of Vienna, Austria

11:15-11:40

Title: Discovery of Novel Cyclin-dependent Kinase Inhibitor R547 as Anti-Cancer Agent
Dr. Xin-Jie Chu,
Senior Principal Scientist, Discovery Chemistry, Roche, USA

11:40-12:00

Panel Discussion

Oct.20, 2008
Monday
08:30-12:10

Track II-5: Case Studies of Better Drugs through Medicinal Chemistry and New Synthesis
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Mr. Ken Li, General Manager, Chiralquest Shanghai, China

Co-Chair:

Dr. X. Shawn Qian, Associate Director, Medicinal Chemistry, Cytokinetics, Inc., USA

08:30-08:55

Keynote Speech
Title:
Risk-sharing, Integrated Medicinal Chemistry Programs

Mr. John V. Oyler, MBA, Chief Executive Officer & President, BioDuro, Inc., USA

08:55-09:20

Title: Building the Leadership in Chiral Technology, Product and Business
Dr. Ken Li, General Manager, Chiralquest Shanghai, China

09:20-09:45

Title: Addressing the Analytical Challenges of Biopharmaceutical Drug Development with UPLC®Technology
Dr. Dorothy J. Phillips, Director, Strategic Marketing, Waters Corporation, USA

09:45-10:10 Title: Discovery of Mitotic Kinesin Inhibitors as Novel Anticancer Agents
Dr. X. Shawn Qian,
Associate Director, Medicinal Chemistry, Cytokinetics, Inc., USA
10:10-10:20 Coffee Break
¡¡10:20-10:45 Title: Discovery of Novel HIV-1 Inhibitors Using a Cell-based High Throughput Screening Strategy
Dr. Yun He,
Vice President of Research, BioDuro (Beijing) Co. Ltd, China
10:45-11:10

Title: Process Research on the Microtubule Dynamics Inhibitor Eribulin Mesylate (E7389), a Halichondrin B Analog
Dr. Bryan M. Lewis, Associate Director, Department of Process Research, Eisai Research Institute, Andover, Massachusetts, USA

11:10-11:35

Title: Saffron: The New Era of Antioxidants and Free Radical Scavengers
Dr. Muslim Ali,
Professor, Biological Sciences, Faculty of Science, Kuwait University, Kuwait

¡¡11:35-12:00 Title: Predictive Computation of Ligand Binding Affinity for Pharmaceutical Proteins
Dr. Hideaki Fujitani, Fujitsu Laboratories Ltd., Japan
11:40-12:00 Panel Discussion
 
 
 
Track III: Drug Discovery Technologies ¡øTOP
-Speeding Discovery Process with Niches
 

Time

Sessions

Oct.20, 2008
Monday
08:30-10:00

Track III-1: RNAi, MicroRNA, and Non-Coding RNA Technologies
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Xingwang Fang, Senior Manager, Applied Biosystems, USA

08:30-09:00

Keynote Speech
Title:
Identification and Characterization of Dicer-regulated Noncoding RNAs
Dr. Kai-Fu Tang,
Professor, Chongqing University of Medical Sciences, China

09:00-09:30

Title: Peforming Small RNA and Whole Transcriptome Gene Expression Analysis Using the SoLiD Next Generation Sequencing Platform
Dr. Xingwang Fang,
Senior Manager, Applied Biosystems, USA

09:30-10:00

Title: RNAi-based High-throughput Analysis of Fruit Fly Drosophila Melanogaster Immune Response
Dr. Mika Ramet,
Professor, Institute of Medical Technology, University of Tampere, Finland

Oct.20, 2008
Monday
10:00-12:00

Track III-2: Computer Aided Drug Design and Fragment-based Discovery
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Kam Y. J. Zhang, Director of Structural Biology, Plexxikon, Inc., USA

10:00-10:20

Keynote Speech
Title:
Identification of NVP-AUY922-Structure Based Discovery of Hsp90 Inhibitors for the Treatment of Cancer
Dr. Martin J. Drysdale,
Deputy Research Director, Vernalis (R&D) Ltd., UK

10:20-10:40

Title: Scaffold-based Discovery of a Novel Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Anti-melanoma Activity
Dr. Kam Y. J. Zhang,
Director of Structural Biology, Plexxikon, Inc., USA

10:40-11:00

Title: ADDock: An Anchor-dependent Molecular Docking Process for Docking Flexible Small
Molecules in Rigid Protein Receptors

Dr. Thy-Hou Lin,
Professor, National Tsing Hua University, Taiwan

11:00-11:20

Title: A Computer-assisted Decision Support System for Recovering Elements of Study Phase III: Dosage Adaptation to Prevent Adverse Drug Events While Checking Therapeutic Effectiveness
Dr. Christophe Obez,
Faculty of Medicine of Marseilles, France

11:20-11:40

Title: Integrating Biomolecular Network Information in Computational Models
Dr. Johannes HGM van Beek, Project Leader, Centre for Integrative Bioinformatics VU & VU
University Medical Centre, Amsterdam, the Netherlands

¡¡11:40-12:00

Panel Discussion

Oct.20, 2008
Monday
08:30-12:00

Track III-3: Multiple Read-Out Options, Biochips, Microarray, Electrophoresis, Lab-on-Chips and Lab Automation
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Markus Beck, Research Assistant, Nanotechnology Group, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland

Co-Chair:

Dr. Lai-Kwan Chau, Professor, National Chung Cheng University, Taiwan

08:30-09:00

Keynote Speech
Title:
A Cell-based Microfluidic System for Lead and Delivery Optimization
Dr. Shankar Sundaram,
Vice President, CFD Research Corporation, USA

09:00-09:30

Title: High Density Fluorescence Readout with Structured Evanescent Wave Excitation
Dr. Markus Beck, Research Assistant, Nanotechnology Group, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland

09:30-10:00

Title: Integration of Genomics, Proteomics and Transcriptomics for Cardiovascular Drugs Pharmacogenomics
Dr. G¨¦rard Siest, Professor, Universit?Henri Poincar? Nancy, France

10:00-10:15

Coffee Break

10:15-10:45

Title: Fast and Sensitive Immunoanalysis Using Optical Microfluidic Sensor
Dr. Jaebum Choo,
Vice-Dean, Department of Applied Chemistry, Hanyang University, South Korea

¡¡10:45-11:15

Title: Noble Metal Nanoparticles in Biomolecular Detection
Dr. Lai-Kwan Chau,
Director, Center for Nano Bio-Detection, National Chung Cheng University, Taiwan

11:15-11:45 Title: Developments of Glucose Biosensing Chip Techniques and Their Future Perspectives
Dr. Hideaki Nakamura,
Assistant Professor, Tokyo University of Technology, Japan
¡¡11:45-12:00

Panel Discussion

Oct.20, 2008
Monday
08:30-12:00

Track III-4: High Throughput/Content and Virtual Screening
£­Place: Heng Shan Room A, 1F, South Wing, LPHR

Session Chair:

Dr. Gary Reznik, Applications Sciences Group Leader, PerkinElmer LAS, Downers Grove, IL, USA

Co-Chair:

Dr. Rentian Feng, Research Assistant Professor, Division of Hematology/Oncology, University of Pittsburgh, USA

08:30-09:00

Keynote Speech
Title:
Cost- and API-Sparing in Vitro PK Screening for Formulation Ingredients for Practically Insoluble Drug Candidates
Dr. Alex Avdeef,
President & CSO, pION, Inc., USA

09:00-09:30

Title: Flexophore, a Pharmacophore Descriptor Beyond Chemical Similarity
Dr. Modest von Korff
,
Senior Research Informatician, Actelion Ltd, Switzerland

09:30-10:00

Title: A High Throughput Approach for Searching Heterogeneous Catalytic Materials
Dr. Norbert Steinfeldt,
Superrisor Leibniz Institute for Catalysis at the University Rostock, Germany

10:00-10:15 Coffee Break
10:15-10:45 Title: AlphaLISA ?- A Novel Scalable Homogenous HTS and Ultra-HTS Technology for Biomarker Detection
Dr. Gary Reznik, Applications Sciences Group Leader, PerkinElmer LAS, Downers USA
¡¡10:45-11:15

Title: Development of High-Throughput Assays for Biotin Protein Lipase: Technologies for Antibiotic Drug Discovery
Dr. Steven Polyak,
University of Adelaide, Australia

11:15-11:45

Title:A Novel Multiplex Drug Screening Assay for Identification of Potential Compounds with Anti-myeloma Activity
Dr. Rentian Feng, Research Assistant Professor, Division of Hematology/Oncology, University of Pittsburgh, USA

¡¡11:45-12:00 Panel Discussion

Oct.20, 2008
Monday
08:30-10:30


International Nanomedicine Symposium
(Track III-5-7)

International Nanomedicine Symposium

International Academy of Nanomedicine (IANM)
IDDST


Time: October 20, 2008
Place: Loong Palace Hotel, Beijing, China

Chiming Wei, MD, PhD, Symposium Organizer

Track III-5: Asian-Pacific Network of Nanomedicine
£­Place: Taihang Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Gert Storm, Professor, Utrecht University, The Netherlands

Co-Chair:

Dr. Kenichi Yoshikawa, Professor, Department of Physics, Kyoto University, Kyoto, Japan

08:30-08:35 Welcome and Introduction
Dr. Chiming Wei,
FACC, FAHA, FCCP, FAAN, USA
08:35-08:55 Title: Nanomedicine Research in Turkey
Dr. G¨¹rer G. Budak, Director Assistant Professor, Gazi University, Ankara, Turkey
08:55-09:15 Title: Current Trends in Nanomedicine Research in India
Dr. N.K. Jain, Professor, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, India
09:15-09:35 Title: Nanomedicine Research in China
Dr. Yuliang Zhao, Chinese Academy of Science, Beijing, China
09:35-09:55 Title: Higher Order Structure of DNA is One of the Decisive Factors for Radiosensitivity
Dr. Yuko Yoshikawa, Professor, Faculty of Education for Future Generations, International Pacific University, Okayama, Japan
09:55-10:15 Title: Intelligent Surgical Instruments Project
Dr. Hideo Fujimoto, Professor, Nagoya Institute of Technology, Nagoya, Japan
10:15-10:30 Coffee Break

Oct.20, 2008
Monday
10:30-12:00

Track III-6: International Network of Nanomedicine
£­Place:
Taihang Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Hideo Fujimoto, Professor, Nagoya Institute of Technology, Nagoya, Japan

Co-Chair:

Dr. Chiming Wei, FACC, FAHA, FCCP, FAAN, USA

10:30-10:50

Title: MediTrans: An Integrated EC-sponsored (FP6) Project on Targeted Nanomedicines
Dr. Gert Storm, Professor, Utrecht University, The Netherlands

10:50-11:10

Title: On/Off Switching of the Higher-Order Structure in DNA
Dr. Kenichi Yoshikawa, Professor, Department of Physics, Kyoto University, Kyoto, Japan

11:10-11:30

Title: Sentinel Node Detection with Dual Nuclear/Fluorescent Imaging System Using Silica Nanoparticles
Dr. Keon Wook Kang, Associate Professor,* Seoul National University, College of Medicine, Seoul, Korea

11:30-11:50 Title: Updates in Romanian Nanomedicine Research
Dr. Raoul Vasile Lupusoru, Faculty of Medicine, "Gr.T. Popa" University of Medicine and Pharmacy, Romania
11:55-12:10

Panel Discussion

Oct.20, 2008
Monday
13:30-17:30

Track III-7: Nanotechnologies in Drug Discovery
£­Place: Taihang Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Julia Y. Ljubimova, Director of Molecular Oncology, Cedars-Sinai Medical Center, USA

Co-Chair:

Dr. Diana Shu-Lian Chow, Director, Institute for Drug Education and Research (IDER), College of Pharmacy, University of Houston, USA

13:30-14:00

Keynote Speech
Title:
Nanotechnology in Cancer Treatment
Dr. M. G. Krukemeyer,
Professor, University of Muenster, Germany

14:00-14:30

Title: Biodegradable Drug Delivery Nanoconjugate Able Synergistically Inhibit Several Molecular Targets to Treat Malignant Tumors
Dr. Julia Y. Ljubimova,
Director of Molecular Oncology, Cedars-Sinai Medical Center, USA

14:30-15:00

Title: Polymalic Acid-based Nanovehicles
Dr. Eggehard Holler,
Senior Scientist and Professor, Universitaet Regensburg, Germany

15:00-15:15

Coffee Break

15:15-15:45

Title: Approaches of Nanomedicine Formulations in Cancer Therapy for Achieving Significant
Impacts on Pharmacokinetics and Biodistributions

Dr. Diana Shu-Lian Chow,
Director, Institute for Drug Education and Research (IDER), College of Pharmacy, University of Houston, USA

15:45-16:15 Title: Nanotargeted Radiopharmaceuticals for Tumor Imaging and Therapeutics
Dr. Gann Ting,
Visiting Professor, National Institute of Cancer Research and Center of Nanomedicine, National Health Research Institute, Taiwan
16:15-16:45 Title: In Vivo Targeting Potential of Gelatin Nanoparticles with Biotinylated EGF Conjugation Delivered by Inhalation in Mice Lung Cancer Model
Dr. Feng-Huei Lin, Director & Professor, Institute of Biomed. Eng., National Taiwan University, Taipei, Taiwan
16:45-17:15 Title: Integrated Molecular Targeting of Cell Surface Receptors and Selective Destruction of Breast Cancer Cells Using Nano-particles
Dr. Balaji Panchapakesan,
Assistant Professor, Department of Electrical and Computer Engineering, University of Delaware Newark, USA
17:15-17:30

Panel Discussion

Oct.20, 2008
Monday
13:30-15:50

Track III-8: LC, LC-MS, NMR and X-ray Crystallography in Drug Discovery
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Wulff Niedner, Dionex Corporation, Dornierstr, Germering, Germany

13:30-13:55

Keynote Speech
Title:
Addressing the Analytical Problems of Drug Discovery and Global Systems Biology Using Ultra High Resolution LC and Exact Mass MS (MS)
Dr. Robert Plumb,
Head of Analytical Technologies, Pharmaceutical Market Development, Waters Corporation, USA

13:55-14:20

Title: Speeding up Pharmaceutical UHPLC Method Development with an Integrated, Ultrafast Automated Method Scouting Solution
Dr. Wulff Niedner, Dionex Corporation, Dornierstr, Germering, Germany

14:20-14:45

Title: Metal(II) Complexes of Polyether Ionophore Antibiotics: Coordination Mode, X-ray Structures and Biological Properties
Dr. Mariana Mitewa,
Full Professor, Department of Analytical Chemistry, Sofia University "St. Kl. Ohridsky"

14:45-15:10

Title: Crystal Structure of the Transcriptional Regulator AcrR from Escherichia Coli
Dr. Edward W. Yu, Assistant Professor, Department of Physics & Astronomy, Iowa State University, USA

15:10-15:35 Title: Bicyclic Peroxides in the G-factor Series; Fe(II) and Ru(II) Induced Transformations in
Relation to Their Potential Biological Activities

Dr. Michel Baltas,
Director of the Laboratory, University Paul Sabatier, France
15:35-15:50

Coffee Break

Oct.20, 2008
Monday
15:50-17:30

Track III-9: Translational Medicines
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. James C. Crabbe, Professor of Biochemistry; Dean of the Faculty of Creative Arts, Technologies and Science, University of Bedfordshire, UK.

15:50-16:15 Keynote Speech
Title:
Speeding Drug Discovery Using Bayesian Design and Novel Algorithms for Microarray
Analysis and Protein Folding Simulations

Dr. M. James C. Crabbe,
Professor of Biochemistry; Dean of the Faculty of Creative Arts, Technologies and Science, University of Bedfordshire, UK.
16:15-16:40 Title: Tailor-made Chemotherapy and Gene Therapy Based on Biomarkers Non-small Cell Lung Cancer
Dr. Cheng-long Huang,
Associate Professor, Second Department of Surgery, Faculty of Medicine, Kagawa University, Japan
16:40-17:05

Title: Adjuvant Fatty Acid Therapeutic Approaches Based on Lipid Models Constructed for Tumors and Cancer
Dr. Louise Louw,
Professor, University of the Free State, South Africa

17:05-17:30

Title: Mass Spectrometry for Neuropathic Pain Research
Dr. Pascal Vachon
, Associate Professor, Department of Veterinary Biomedicine, University of Montreal, Canada

Oct.20, 2008
Monday
13:30-15:25

Track III-10: Safety Evaluation Tech: From ADME-Tox Screening to Clinical Trials
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Jinhua Zhang, Senior Scientist, Simulations Plus Inc., Lancaster, CA, USA

Co-Chair:

Dr. Ling Yang, Group Leader of Pharmaceutical Resource Development, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

13:30-13:55

Keynote Speech
Title:
In Vitro ADME and HERG Profiling in Drug Discovery
Dr. Wentao Zhang, Director, New Lead Discovery, Exelixis, Inc., USA

13:55-14:20

Title: In Silico Studies of ADMET Properties in Early Drug Discovery
Dr. Jinhua Zhang, Senior Scientist, Simulations Plus Inc., Lancaster, CA, USA

14:20-14:45

Title: Structure-Metabolism Relationships of Taxanes by Human Cytochrome P450 Enzymes
Dr. Ling Yang, Group Leader of Pharmaceutical Resource Development, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

¡¡14:45-15:10 Title: Prediction of Ligands of Promiscuous Targets - Safety Sciences on the Molecular Level
Dr. Gerhard F. Ecker,
Associate Professor, University of Vienna, Austria
¡¡15:10-15:25

Coffee Break

Oct.20, 2008
Monday
15:25-17:35

Track III-11: Novel Drug Delivery Technologies
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Lucienne Juillerat, Research Unit Leader, University Institute of Pathology, Switzerland

Co-Chair:

Dr. C.F. Van Nostrum, Associate Professor, Department of Pharmaceutics of the Utrecht University, the Netherlands

15:25-15:45

Keynote Speech
Title:
Manufacture and Characterization of Biodegradable (PLA Based) and Thermosensitive (PVCL Based) Nanoparticles for Drug Delivery Applications
Dr. Jouni Hirvonen,
Professor and Vice Dean, Faculty of Pharmacy, University of Helsinki, Finland

15:45-16:05

Title: Surface Functionalization of Super paramagnetic Nano-particles for Cell-targeted Drug Delivery
Dr. Lucienne Juillerat-Jeanneret,
Research Unit Leader, University Institute of Pathology, Switzerland

16:05-16:30

Title: In Vitro and in Vivo Evaluation of Eudragit-coated Chitosan- succinyl- prednisolone Conjugate Microspheres
Dr. Hiraku Onishi, Associate Professor, Department of Drug Delivery Research, Hoshi University, Japan

16:30-16:55

Title: Polymer Surfactant-contained Poly(N-isopropylacrylamide) (PNIPAM) Bulk/Micro Gels and Electro-spun PNIPAM Nanofibers: Potential Applications in Drug Delivery Systems
Dr. Hu Yan,
Associate Professor, Laboratory of Organic Robotics, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan

16:55-17:15

Title: Polymeric Micelles with Controlled Release Properties for Oral and Systemic Drug Delivery
Dr. C.F. Van Nostrum, Associate Professor, Department of Pharmaceutics of the Utrecht University, the Netherlands

17:15-17:35

Title: Drug Targeting to the Colon
Dr. Idris M. El-Mahdi Buokhamada, Associate Professor of Pharmaceutics & Dean, Faculty of Pharmacy, Arab Medical University, Arabia

 
 
 
Track IV: Therapeutics Development for Diseases ¡øTOP
-Delivering Promises for Future Drugs
 

Time

Sessions

Oct.20, 2008
Monday
13:30-14:20

Track IV-1: Anti-Emerging Disease Drug Discovery and Development
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Martin Schwemmle, Professor, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany

13:30-13:55 Keynote Speech
Title:
BLX-1002, a Novel Thiazolidinedione with No PPAR Affinity, Stimulates AMP-Activated Protein Kinase Activity, Raises Cytosolic Ca2+, and Enhances Glucose-Stimulated Insulin Secretion in a PI3K-Dependent Manner
Dr. Qimin Zhang,
Senior Researcher, Research Center, Karolinska Institute, Sweden
13:55-14:20

Title: Peptide-mediated Interference with the Influenza a Virus Polymerase: New Approaches to Screen for Antiviral Components
Dr. Martin Schwemmle,
Professor, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany

Oct.20, 2008
Monday
14:20-17:40

Track IV-2: CNS Disorder Drug Discovery and Development
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Mohammad S. Alavijeh, Managing Director, Pharmidex Pharmaceutical Services Ltd., UK

14:20-14:45

Keynote Speech
Title:
A Case Study for Drug Discovery and Development toward Cognitive Enhancement and Neuroprotection
Dr. Illana Gozes,
Founder and Chief Scientific Officer, Allon Therapeutics Inc.; Professor of Clinical Biochemistry; the Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Tel Aviv University, Israel

14:45-15:10

Title: CNS Drug Discovery; Assessment and Delivery of Drugs Across Blood-brain Barrier (BBB)
Dr. Mohammad S. Alavijeh,
Managing Director, Pharmidex Pharmaceutical Services Ltd., UK

15:10-15:25

Coffee Break

15:25-15:50

Title: PARP-1 Activation Mediates the Expression of Immediate Early Genes Implicated in Long- term Memory Formation
Dr. Malka Cohen-Armon,
Professor, Sackler School of Medicine, Tel-Aviv University, Israel

15:50-16:15

Title: The Purinergic System: A New Target for the Development of Novel Drugs for Acute and Chronic CNS Disorders
Dr. Maria P. Abbracchio, Professor, Department of Pharmacological Sciences, University of Milan, Italy

16:15-16:40

Title: Purinergic Receptor Ligands: State-of-the Art of the Medicinal Chemistry and Application to Neurodegenerative Diseases
Dr. Gloria Cristalli, Professor, Department of Chemical Sciences, University of Camerino, Italy

16:40-17:05

Title: A Molecular Chaperone Inducer Protects Neurons from ER Stress
Dr. Takashi Kudo
, Associate Professor, Department of Psychiatry, Osaka University Graduate School of Medicine, Japan

¡¡17:05-17:30

Title: Towards Deeper Insights into the Subsite Selective Antagonism of NMDA Receptor Ion
Channels through Comparative QSAR Study
Dr. Manish Sharma,Associate Professor and Programme Head (PG), Department of Medicinal and Pharmaceutical Chemistry TIFAC-CORE, Innovation Square, B. R. Nahata College of Pharmacy, India

¡¡17:30-17:40 Panel Discussion

Oct.20, 2008
Monday
13:30-17:40

Track IV-3: Cancer Therapeutics Discovery and Development
£­Place: Huang Shan Room C, 2F, South Wing, LPHR

Session Chair:

Dr. Jagabandhu Das, Research Fellow, Bristol-Myers Squibb Pharmaceutical Research Institute, USA

Co-Chair:

Dr. Ting-Chao Chou, Director, Preclinical Pharmacology Core, Molecular Pharmacology &
Chemistry Program, Memorial Sloan-Kettering Cancer Center, USA

13:30-13:55

Keynote Speech
Title:
Targeting ER-*36: Discovery and Preclinical Profiling of SNG-162 as a Novel Anti-breast Cancer Agent
Dr. Jin Li, Co-founder and the Chief Operating Officer, Shenogen Pharma Group, China

13:55-14:20

Title: The Discovery and Development of SUTENT*? a Multi-target Tyrosine Kinase Inhibitor Used for the Treatment of Cancers
Dr. Connie L. Sun,
Sr. Director, Poniard Pharmaceuticals, Inc., USA

14:20-14:45

Title: Discovery of the Multi-kinase Inhibitor Dasatinib (SPRYCEL) for the Treatment of Philadelphia Chromosome Positive Leukemias
Dr. Jagabandhu Das,
Research Fellow, Bristol-Myers Squibb Co., USA

14:45-15:10

Title: Circulating Tumor Cell Analysis for Cancer Therapeutics
Dr. Glenn Deng, Sr. Scientist, Genetix, USA

15:10-15:25

Coffee Break

15:25-15:50

Title: Discovery of a Daunorubicin Analogue that Exhibits Potent Antitumor Activity and Overcomes P-gp Mediated Drug Resistance
Dr. Peng George Wang, Professor, Nankai University, China

15:50-16:15

Title: The Myth and Reality in Drug Discovery
Dr. Ting-Chao Chou,
Director, Preclinical Pharmacology Core, Molecular Pharmacology & Chemistry Program, Memorial Sloan-Kettering Cancer Center, USA

16:15-16:40

Title: New Anticancer Drugs Specifically Targetting the ABC Transporters BCRP (Breast Cancer Resistance Protein/ABCG2) and MRP1 (Multidrug Resistance Protein 1/ABCC1)
Dr. Attilio Di Pietro,Fist-class Research Director, French National Center of Scientific Research, France

16:40-17:05

Title: The Kazal Motifs of RECK Protein Inhibit MMP-9 Secretion and Activity and Reduce Metastasis of Lung Cancer Cells in Vitro and in Vivo
Dr. Wen-Chun Hung,
Director, Institute of Biomedical Sciences, National Sun Yat-Sen University, Taiwan

¡¡17:05-17:30 Title: Targeting Cdk4/6 in Combination Therapy for Multiple Myeloma
Dr. Xiangao Huang, Instructor, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, USA
17:30-17:40

Panel Discussion

Oct.20, 2008
Monday
13:30-15:25

Track IV-4: Anti-HIV Drug Discovery and Development
£­Place: Huang Shan Room B, 2F, South Wing, LPHR

Session Chair: Dr. Virendra N. Pandey, Associate Professor, Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, USA

13:30-13:55

Keynote Speech
Title:
Targeting HIV Reservoir & Sanctuary Sites Using Peptide Backbone Polyethylene Glycol (PEG) Nanocarriers
Dr. Patrick J. Sinko, Associate Vice President for Research, Rutgers, the State University of New Jersey, USA

13:55-14:20

Title: Increasing Access to Life Saving Drugs
Dr. David Zakus
, Director, Centre for International Health, Associate Professor, Dalla Lana School of Public Health, Associate Professor, Department of Health Policy, Management and Evaulation, Faculty of Medicine, University of Toronto, Canada

14:20-14:45

Title: Targeting Critical Regions of HIV-1 Genome for Intervention of HIV-1 Replication
Dr. Virendra N. Pandey, Associate Professor, Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, USA

14:45-15:10

Title: Driving Drug Discovery, Development and Delivery in a Complex New World-Insights & Incentives for Sustainable Healthcare Solutions in a Global Market Place
Dr. Opul Dickson David,
Chairman and Executive Director, Community HIV/AIDS Prevention
and Treatment Programs, Uganda

15:10-15:25

Coffee Break

Oct.20, 2008
Monday
15:25-17:00

Track IV-5: Anti-HCV, Anti-HPV, Dengue Fever and Other Antiviral Drug Discovery and Development
£­Place: Huang Shan Room B, 2F, South Wing, LPHR

Session Chair: Dr. Jiancun Zhang, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, China

Co-Chair:

Dr. Chao Lin, Research Fellow and Head of HCV Virology Group, Department of Infectious Diseases, Vertex Pharmaceuticals Inc., USA

15:25-15:50

Keynote Speech
Title:
Recent Clinical Development of HCV NS3 -4A Protease Inhibitors
Dr. Chao Lin,
Research Fellow and Head of HCV Virology Group, Department of Infectious
Diseases, Vertex Pharmaceuticals Inc., USA

15:50-16:15

Title: Targeting Major Cancer, Infectious and Metabolic Diseases
Dr. Jiancun Zhang
, Guangzhou Institute of Biomedicine and Health Chinese Academy of Sciences, China

16:15-16:40

Title: Discovery of Antivirals for the Treatment of Dengue: A Showcase of Modern Drug Discovery in Tropical Diseases
Dr. Zheng Yin,
Senior Research Investigator, Chemistry, Novartis Institute for Tropical Diseases, Singapore

¡¡16:40-17:00

Panel Discussion

Oct.21, 2008
Tuesday
08:30-10:25

Track IV-6: Antifungal Drug Discovery and Development
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Lixin Zhang, Professor, Director, Center of Microbial Natural Product HTS Screening, Beijing Institute of Microbiology, Chinese Academy of Sciences, China
08:30-08:55

Keynote Speech
Title:
Counteracting the Drug Resistance Function of MDR1 for Enhanced Therapeutic Sensitivity of Fungal Pathogens by Natural Products
Dr. Lixin Zhang, Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

08:55-09:20

Title: Genetics of Caspofungin (CAS) Resistance in Aspergillus Nidulans
Dr. Gregory S. May
, Professor, Division of Pathology and Laboratory Medicine, UT M. D. Anderson Cancer Center, Houston, USA

09:20-09:45

Title: Inhibition of Fungal PLB1: A New Target for Antifungal Drug Discovery
Dr. Katrina A. Jolliffe,
Associate Professor, University of Sydney, Australia

09:45-10:10

Title: Therapy of Genital Candida Infections and Mechanisms for Failures
Dr. Per-Anders Mardh
, Professor, Department of Obstetrics and Gynecology, Lund University, Sweden

10:10-10:25

Coffee Break

Oct.21, 2008
Tuesday
10:25-12:15

Track IV-7: Cardiovascular Drug Discovery and Development
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. XingMei Han, Research Investigator, DMPK, China Novartis Institute for Biomedical Research Company, China

10:25-10:50

Keynote Speech
Title: Proteomic Analysis of Abdominal Aortic Aneurysms in Search for Drug Targets and Biomarkers
Dr. Bent Honor¨¦, Department of Medical Biochemistry, Ole Worms All? University of Aarhus, Denmark

10:50-11:15

Title: New Treatment for Hypertension: Renin Inhibitor, Aliskiren
Dr. XingMei Han, Research Investigator, DMPK, China Novartis Institute for Biomedical Research Company, China

11:15-11:40

Title: New Strategy on the Treatment and Prevention in Hypertension and Public Health ?Dietary Potassium and Cardiovascular Protection
Dr. Qing Wang, Division of Nephrology and Hypertension, CHUV ( University Hospital ), Lausanne, Switzerland

11:40-12:05

Title: The Role of Adrenomedullin in the Circulation
Dr. Bernard M Y Cheung, Professor, Department of Clinical Pharmacology, University of Birmingham, UK

12:05-12:15

Panel Discussion

Oct.21, 2008
Tuesday
08:30-10:05

Track IV-8: Neurodegenerative Drug Discovery and Development
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Cheng-Xin Gong, Head, Laboratory of Brain Metabolism, New York State Institute for Basic Research, USA
08:30-08:50

Keynote Speech
Title:
On the Significance of GABA Neurotransmission in Alzheimer Disease (AD), Does GABA Provide a Clue for New Putative Therapeutic Approaches to AD

Dr. Horst Peter Schmitt, Professor, Institute of Pathology, Department of Neuropathology, Universityof Heidelberg, Germany

08:50-09:10

Title: Hyperphosphorylation of Tau: A Promising Therapeutic Target for Alzheimer's Disease
Dr. Cheng-Xin Gong, Head, Laboratory of Brain Metabolism, New York State Institute for Basic Research, USA

09:10-09:30

Title: Ligand/Target Interaction Investigated by Molecular Simulation
Dr. Paolo Carloni,
Full Professor in Chemistry, International School for Advanced Studies (SISSA), Trieste, Italy

09:30-09:50 Title: Identification of Novel TIAF1/WOX1 Aggregates in Alzheimer’s Disease: Potential Targets for Drug Development
Dr. Nan-shan Chang, Professor, National Cheng Kung University Medical College, Taiwan;
Adjunct Professor, Upstate Medical University at Syracuse, USA
09:50-10:05

Coffee Break

Oct.21, 2008
Tuesday
10:05-12:00

Track IV-9: Metabolic Diseases Drug Discovery and Development
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Gary J. Grover, Associate Professor of Physiology and Biophysics, Robert Wood Johnson Medical School, USA

Co-Chair:

Dr. Hong Yang, Professor, University of California, Los Angeles, California, USA

10:05-10:25

Keynote Speech
Title:
Link between Energy Balance and Medullary Autonomic Regulation
Dr. Hong Yang,
Professor, University of California, Los Angeles, California, USA

10:25-10:45

Title: Pharmacological Profile of the Thyroid Hormone Receptor Antagonist NH3 in Rats
Dr. Gary J. Grover,
Associate Professor of Physiology and Biophysics, Robert Wood Johnson Medical School, USA

10:45-11:05

Title: Small Molecular ERR Agonists as New Anti-diabetes Drugs
Dr. Ke Ding,
Professor, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, China

11:05-11:25

Title: Muscle Lipid Turnover as Potential Target for Treating Insulin Resistance
Dr. Zengkui Guo,
Consultant, Endocrine Research Unit, Mayo Foundation, USA

11:25-11:45

Title: The Effects of the Natural Products from the Chinese Traditional Medicine on the Metabolic Syndrome
Dr. Guang Ning, Head, Shanghai Clinical Center for Endocrine and Metabolic Diseases, China

¡¡11:45-12:00

Panel Discussion

Oct.21, 2008
Tuesday
08:30-11:00

Track IV-10: Autoimmune Disorder Drug Discovery and Development
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Hsiou-Chi Liou, Associate Professor, Immunology in Medicine, Weill Medical College of Cornell University, USA
08:30-09:00

Keynote Speech
Title:
Immunotherapy in Psoriasis: New Treatment Options in a Serious Skin Condition

Dr. Esper Boel, Corporate Vice President, Head of Biotechnology, Novo Nordisk A/S, Denmark

09:00-09:30

Title: Rel/NF-kB as Therapeutic Targets for Autoimmune Disease and Cancer
Dr. Hsiou-Chi Liou,
Associate Professor, Immunology in Medicine, Weill Medical College of Cornell University, USA

09:30-10:00

Title: Selective Silencing of Disease-associated Auto-reactive B Lymphocytes by a Chimeric Antibody Targeting Their Inhibitory Fc-gammaiib and Cd22 Receptors
Dr. Tchavdar Vassilev,
Professor, Head of Department of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Bulgaria

10:00-10:30

Title: The Key Issues in the Pathogenesis of Allergic Diseases and Drug Development Strategy
Dr. Shaoheng He,
Director, The Clinical Experiment Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

10:30-11:00

Panel Discussion

Oct.21, 2008
Tuesday
08:30-11:40

Track IV-11: MDR Drug Resistant Bacterial/Parasite Infections, TB and Malaria
£­Place: Taihang Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Zakaria Hmama, Associate Professor, Division of Infectious Disease, University of British Columbia, Canada

Co-Chair:

Dr. Yiqun (Joyce) Zhang, WHO/TDR Fellow, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, USA

08:30-09:00

Keynote Speech
Title:
Design and Synthesis of TDR17516 Analogues as Antimalarials
Dr. Yiqun (Joyce) Zhang,
WHO/TDR Fellow, Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, USA

09:00-09:30

Title: Role of Mycobacterial Lipoamide Dehydrogenase in the Pathogenesis of Tuberculosis
Dr. Zakaria Hmama, Associate Professor, Division of Infectious Disease, University of British Columbia, Canada

09:30-10:00

Title: Search for New Anthelmintic Antibiotics -NADH-fumarate Reductase Inhibitors from Microbial Origin
Dr. Kazuro Shiomi,
Professor, Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

10:00-10:15

Coffee Break

10:15-10:45

Title: Novel Aryl-thiazolidones and Their Complexes with Ruthenium: Endowed with Anti- trypanosoma Cruzi Activity
Dr. Ana Cristina Lima Leite, Professor and Director, Federal University of Pernambuco, Brazil

¡¡10:45-11:15

Title: Serrated Colonic Polyps: New Concepts Regarding the Serrated Pathway of Colon Carcinogenesis
Dr. Robert D. Odze
, Chief, Gastrointestinal Pathology Service; Associate Professor of Pathology, Brigham and Women's Hospital, Harvard medical School, USA

11:15-11:40

Panel Discussion

Oct.21, 2008
Tuesday
13:30-17:40

Track IV-12: Cell Therapeutics, Antibody & Vaccine Discovery and Development
£­Place: Wuzhi Shan Room, 2F, South Wing, LPHR

Session Chair:

Dr. Henry L. Niman, President and Founder, Recombinomics, Inc., USA

13:30-14:10

Keynote Speech
Title:
Rapid Selection and Development of Cell Lines for the Production of Therapeutic Monoclonal Antibodies
Dr. Julian F Burke,
Chief Scientific Officer, Genetix Limited, UK

14:10-14:50

Title: Clinical Pharmacology Strategies for Development of Monoclonal Antibodies-drug-drug Interaction Potential and First-in-human Dose Selection
Dr. Honghui Zhou
, Senior Director and Head, Pharmacokinetics, Modeling & Simulation, Clinical Pharmacology Sciences, Johnson & Johnson Biotechnology, Immunology & Oncology, USA

14:50-15:30

Title: The Evolution of Influenza via Recombination H5N1 and Vaccine Target Development
Dr. Henry L. Niman, President and Founder, Recombinomics, Inc., USA

15:30-15:45

Coffee Break

15:45-16:25

Title: Recombinant Viral Vector Based Dengue Vaccines
Dr. Kanakatte Raviprakash
, Senior Scientist, Viral and Ricketttsial Diseases Department, Naval Medical Research Center, USA

16:25-17:05

Title: Confronting Heterogeneity of Kinase Inhibitor Resistance in Gastrointestinal Stromal Tumor
Dr. Meijun Zhu, Senior Scientist, Brigham and Women's Hospital, Harvard Medical School, USA

¡¡17:05-17:30 Title: Transcription Factor Requirements for Induced Reprogramming: Exploring Feasibility of Protein Transduction to Reprogram Cells
Dr. Frank Edenhofer, Stem Cell Engineering Group, Institut fur. Rekonstruktive Neurobiologie, University of Bonn, Germany

17:30-17:40

Panel Discussion

 
 
 
Track V: Nature Product Based Drug Discovery ¡øTOP
-Mining 5000 Year Nature Pool
 

Time

Sessions

Oct. 21, 2008
(Tuesday)
13:30-15:25

Track V-1: Apply Cutting Edge Technologies for Modernization of TCM
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. William Jia, Associate Professor, University of British Columbia, Canada

Co-Chair:

Dr. Gary Li, Head, High Throughput Assays Biochemical Technologies Corning Incorporated, USA

13:30-13:55

Keynote Speech
Title:
A Comprehensive New Drug Research and Development Platform for Chinese Medicine
Dr. Yang Dajian,
Chief Technologist, Institute of Modern Chinese Medicine (IMCM), the Hong Kong Polytechnic University, China

13:55-14:20

Title: Bridging the Antient TCM to Modern Medicine--Post Absorption/Metabolite Drugs
Dr. William Jia,
Associate Professor, University of British Columbia, Canada

14:20-14:45

Title: Drug Discovery in Post-Human Genome Era- Induction, Deduction or Both
Dr. Jun Xu, CSO of KMS Technologies, Ltd., and Beijing Eastlinden Science & Technology Co., Ltd., China

14:45-15:10

Title: Study Alternative Medicines with Cell Based Assays Using Corning Epic Label-free System
Dr. Gary Li, Head, High Throughput Assays, Biochemical Technologies, Corning Incorporated, USA

15:10-15:25

Coffee Break

Oct. 21, 2008
(Tuesday)
15:25-17:30

Track V-2: Mining Hits and Leads Using TCM as Super Natural Compound Library
£­Place: Yimeng Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Feng Guo, Research Fellow, Shanghai Innovative Research Center of Traditional Chinese Medicine, China

15:25-15:55

Keynote Speech
Title:
Plant Phenolic Compounds

Dr. Veronika Abram,
Professor, University of Ljubljana, Slovenia

15:55-16:25

Title: How to Root out Modern New Drugs from TCM
Dr. Feng Guo,
Research Fellow, Shanghai Innovative Research Center of Traditional Chinese Medicine, China

16:25-17:05

Title: Traditional Medicine and High Throughput Screening: the Example of the Antimalarial Vietnamese Plant Extract Library
Dr. Julie Nguyen Pouplin, Oxford University Clinical Research Unit, Vietnam

17:05-17:30

Panel Discussion

Oct. 21, 2008
(Tuesday)
13:30-15:25

 

Track V-3: Rethink TCM in System Biology and Multi-Target Theory
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair: Ms. Yanhuai Liu, President of Beijing East Linden Science & Technology Co., Ltd., China

13:30-13:55

Keynote Speech
Title:
Integrative Systems Biology for the Research and Development of New TCM Drugs
Dr. Guoan Luo, Director of Modern Research Center of Traditional Chinese Medicine, Tsinghua University, Beijing, China

13:55-14:20

Title: Intellectual Property Protection of Traditional Chinese Medicine and World Traditional Medicine Patent Database
Ms. Yanhuai Liu, President of Beijing East Linden Science & Technology Co., Ltd., China

14:20-14:45

Title: Mapping the Chemogenomics Space of Natural Products
Dr. Irene Kouskoumvekaki,
Assistant Professor, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Denmark

14:45-15:10

Title: A Comparative Analysis of Gene Expression of Jasminoidin, Ursodeoxycholic Acid and Their Combination after Experimental Stroke
Dr. Jing Zhi-wei, Director, Department of Academical Management, China Academy of Chinese Medical Sciences (CACMS), Beijing, China

15:10-15:25

Coffee Break

Oct. 21, 2008
(Tuesday)
15:25-17:30

Track V-4: Develop Bioprocesses for Production of High Value Natural Medicines
£­Place: Helan Shan Room, 2F, South Wing, LPHR

Session Chair: Dr. Fabricio Medina-Bolivar, Chief Scientific Officer, Nature West, Inc., USA

15:25-15:50

Keynote Speech
Title:
Induced Biosynthesis and Biological Activities of Natural Resveratrol Analogues from Hairy Root Cultures
Dr. Fabricio Medina-Bolivar,
Chief Scientific Officer, Nature West, Inc., USA

15:50-16:15

Title: In Vitro Cultures of Crocus as Potential Producers of Natural Drugs
Dr. Tatiana A. Vlasova, Senior Research, Department of Plant Physiology, Faculty of Biology, Moscow State University, Russia

16:15-16:40

Title: Chinese Medicinal Plants and Its Sustainable Utilization
Dr. Shilin Chen, Director of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, China

16:40-17:05

Title: Novel Bioreactors for Pharmaceutical Production from Plant Cell Cultures
Dr. Chunzhao Liu, Professor of Biochemical Engineering, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering,Chinese Academy of Sciences, China

17:05-17:30

Title: Antiviral Drug Development
Dr. Ming-Liang He, Associate Professor, Stanley Ho Center for Emerging Infectious Diseases, Hong Kong, China

 
Track VI: Drug R & D Partnering in China ¡øTOP
-Integrating Resources from the East
 

Time

Sessions

Oct. 22, 2008
Wednesday
08:30-11:45

Track VI-1: Drug R & D Licensing and Partnering in China -From CRO to FTE
£­Place: Song Shan Room A, 1F, South Wing, LPHR

Session Chair: Dr. John P. Iwanicki, Principal Shareholder, Banner & Witcoff, Ltd., USA

Co-Chair:

Dr. Stella Xu, Licensing Director, Pharma Partnering Asia, Roche, USA

08:30-08:50

Title: How can Large and Small Companies Work Together
Dr. Teresa Faria,
Alliance Management, Bristol-Myers Squibb, USA

08:50-09:10

Title: A New Model in Drug Innovation: Partnership for Success
Dr. Jingshan Hu, Director of Licensing & External Research, Merck & Co., USA

09:10-09:30

Title: BHM-A Reliable and Innovative Parter of Chemistry from China
Dr. Jinchang Wu, Vice President of R & D, Beijing Honghui Meditech (BHM); Professor of Chemistry, Jilin University Center for Combinatorial Chemistry, Jilin University, China

09:30-09:50

Title: Partnering in Asia ?The Roche Pharma Approach
Dr. Stella Xu, Licensing Director, Pharma Partnering Asia, Roche, USA

09:50-10:05

Coffee Break

10:05-10:25

Title: Patents: The Sword and the Shield in a Highly Competitive Market
Dr. John P. Iwanicki, Principal Shareholder, Banner & Witcoff, Ltd., USA

10:25-10:45

Title: Legal Issues about Legal Licensing Agreement Between Academia and Industry to Facilitate Collaboration and Commercialization of Scientific Ideas in Connection with Research and Development of Drugs
Mr. Philip Jun Wang, Principal, the Law Offices of Albert Wai-Kit Chan, PLLC, New York, USA

10:45-11:05

Title: The Importance of Global Patent Protection in Early Stage Drug Discovery
Mr. Michael W. Connelly, Partner, McDermott Will & Emery LLP, USA

¡¡11:05-11:25

Title: How to Balance Cost and Quality while Establishing Effective Patent Portfolio that Aligns with Corporate Strategy
Dr. Qian Huang, Attorney, The Global Law Firm of McDermott Will & Emery LLP, USA

11:25-11:45

Panel Discussion

 

 

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