Opening Ceremony

08:20-08:40

Group Photo(Place: Gate of BICC)

09:00-09:05

Chair' s Opening Remark

09:05-09:35

VIP' s Address

Keynote Forum

09:40-10:05

Title: Signals and Signalling Molecules in the Central Nervous System
Dr. Erwin Neher, Nobel Prize Laureate in Physiology or Medicine 1991, Max Planck Institute for Biophysical Chemistry, Germany

10:05-10:30

10:30-10:55

Title: Opportunities for R&D innovation in China and Asia
Dr. Steve Yang, Vice President and Head of R&D in Asia, Pfizer, USA

10:55-11:20

Title: Current Targets in Resp Disease and Next Generation Resp Medicines
Dr. Bertil Lindmark, Vice President and Head Clinical Division AstraZeneca KK, Japan

11:20-11:45

Keynote Speech Delivered by Leading Scientist from Domestic Organization

11:45-12:10

Reserved for Representative from BioDuro

18:30-20:30

Welcome Banquet and Art Performance

Chair:

Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada

Co-Chair:

Dr. Wanguo Liu, Associate Professor, Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, USA

13:30-13:55

Title: Belinostat a Novel HDAC Inhibitor
Dr. Rajesh C Shrotriya, Chairman and CEO, Spectrum Pharmaceuticals, Inc.,  USA

13:55-14:20

Title: Natural Polyphenols in the Treatment of Cancer-preclinical Investigations
Dr. Jose M Estrela, Scientific Director, Green Molecular S.L., Spain

14:20-14:45

Title: Targeting a Novel AHI-1-BCR-ABL-JAK2 Interaction Complex in Chronic Myeloid Leukemia Stem/Progenitor Cells
Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada

14:45-15:10

Title: A Novel Wnt Signaling Target as an Attractive Candidate for Drug Targeting in Colorectal Cancer
Dr. Wanguo Liu, Associate Professor, Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, USA

15:10-15:30

Coffee Break

15:30-15:55

Title: Cancer Stem Cells as Therapeutic Targets
Dr. Dean G. Tang, Professor, Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, USA

15:55-16:20

Title: Mechanisms of Apoptosis Induction by Novel and Classical Taxanes in Sensitive and Resistant Cancer Cells
Dr. Jan Kovar, Professor and Head, Department of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Czech Republic

16:20-16:45

Title: Targeting CREB-CBP Interaction as a Novel Strategy for Cancer Therapy
Dr. Xiangshu Xiao, Assistant Professor, Department of Physiology and Pharmacology, Oregon Health & Science University, USA

16:45-17:10

Title: In Vitro Anti-leukaemia Activity of Pyrrolo[1,2-b][1,2,5]Benzothiadiazepines (PBTDs)
Dr. Gabriella Marfe, Molecular Biologist, Department of Experimental Medicine and Biochemical Sciences, College of Medicine, University of Rome "Tor Vergata", Italy

17:10-17:35

Title: A Powerful Genetic Strategy to Screen for Inhibitors of Map Kinase Signaling and Its Application to Genomic Drug Discovery
Dr. Reiko Sugiura, Professor, School of Pharmaceutical Sciences, Kinki University, Japan

Chair:

Dr. Bill Cham, Head of Australasian Medical Research; Professor, Department of Medicine, University of Queensland, Australia

Co-Chair:

Dr. Hwa-Chain Robert Wang, Professor, Comparative Medicine Department, College of Veterinary Medicine, University of Tennessee, USA

13:30-13:55

Title: Solasodine Rhamnosyl Glycosides from Test Tube Observations to Clinical Application for the Treatment of Malignant Skin Cancers
Dr. Bill Cham, Head of Australasian Medical Research; Professor, Department of Medicine, University of Queensland, Australia

13:55-14:20

Title: Percutaneous Thermal Ablation of Advanced Hepatocellular Carcinoma in Patients with Cirrhosis
Dr. Antonio Giorgio, Professor, Director of Infectious Diseases and Interventional Ultrasound Unit, D. Cotugno Hospital, Italy

14:20-14:45

Title: Activation of the Unfolded Protein Response in Solid Tumors and Its Targeting as a Novel Anti-tumor Strategy
Dr. Constantinos Koumenis, Associate Professor, Department of Radiation Oncology, University of Pennsylvania School of Medicine, USA

14:45-15:10

Title: The Role of Drug Combination, Metabolism, Pharmacokinetics, Transport and Growth Factors on the Anticancer and Toxic Effects of Classical and New Generation Taxanes in Man, Animals and Tumor Cell Lines
Dr. Ivan Gut, Senior Scientist, National Institute of Public health Biotransformation Group, Czech Republic

15:10-15:30

Coffee Break

15:30-15:55

Title: ROS-mediated Selective Apoptosis of Oncogenic Ras-expressing Cancer Cells
Dr. Hwa-Chain Robert Wang, Professor, Comparative Medicine Department, College of Veterinary Medicine, University of Tennessee, USA

15:55-16:20

Title: Development of Cancer Chemopreventive Agents on Betulonic Acid Platform
Dr. Irina Sorokina, Senior Scientist, Laboratory of Pharmacological Researches, N.N.Voroztsov Institute of Organic Chemistry SB RAS, Russia

16:20-16:45

Title: Cytochromes P450 as Targets for Drug Development
Dr. Klaus Pors, Lecturer in Medicinal Chemistry, Institute of Cancer Therapeutics, University of Bradford, UK

16:45-17:10

Title: Magnetic Anti-cancer Drug for Hyperthermal and Chemotherapy
Dr. Yoshihiro Ishikawa, Professor and Chair, Cardiovascular Research Institute, Graduate School of Medicine, Yokohama City University, Japan

17:10-17:35

Title: Modulation of Insulin-like Growth Factor-I Receptor Signalings by Anti-cancer Agent HSP90 Inhibitors
Dr. Toshihiko Yanagita, Associate Professor, Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Japan

Chair:

Dr. Yi-Qiang (Eric) Cheng, Associate Professor, Department of Biological Sciences, Department of Chemistry and Biochemistry, University of Wisconsin – Milwaukee, USA

Co-Chair:

Dr. Guoli Zhang, Director, The Laboratory of Biotechnological Application, The Military Veterinary Institute, Academy of Military Medical Sciences, China

13:30-13:55

Title: The Current Status of Anticancer Drugs Discovery and Development in World Wide
Dr. Changnian Liu, Senior Vice President, Pharmaron, Inc., USA

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: Platform for Discovery and Combinatorial Biosynthesis of Histone Deacetylase Inhibitors as Anticancer Agents
Dr. Yi-Qiang (Eric) Cheng, Associate Professor, Department of Biological Sciences, Department of Chemistry and Biochemistry, University of Wisconsin – Milwaukee, USA

14:45-15:10

Title: Identification of a Potent and Selective Cofactor Binding Inhibitor of the Estrogen Receptor Alpha
Dr. Koen Dechering, Section Head Nuclear Receptors, Department of Molecular Pharmacology, Schering-Plough Research Institute, The Netherlands

15:10-15:30

Coffee Break

15:30-15:55

Title: The Gonadotropin Releasing Hormone and Pseudomonas Aeruginosa Exotoxin a Fusion Protein as a New Drug for Cancer Therapy
Dr. Guoli Zhang, Director, The Laboratory of Biotechnological Application, The Military Veterinary Institute, Academy of Military Medical Sciences, China

15:55-16:20

Title: Repurposing: Convert an Old Anti-alcoholism Medicine into Cancer Therapeutics
Dr. Weiguang Wang, Associate Professor, Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, UK

16:20-16:45

Title: Targeting the Tumor Microenvironment
Dr. Mark Pines, Senior Scientist, Institute of Animal Science, ARO, the Volcani Center, Israel

16:45-17:10

Title: Anti EGFR Combined with Irinotecan for Treatment of Elderly Patients with Metastatic Colorectal Cancer
Dr. Sherif Abdelwahab, Associate Professor of Clinical Oncology, Ain Shams University, Egypt

17:10-17:35

Title: HER2 Induces the Binding with GEP100 and the Activation of Arf6 to Promote Cancer Invasion and Metastasis
Dr. Toshi Menju, Research Associate, Department of Thoracic Surgery, Gradutate School of Medicine, Kyoto University, Japan

Chair:

Co-Chair:

Dr. Jenny Xie, Principal Scientist, Bristol Myers Squibb, USA

13:30-13:55

Speech Opportunity Available

13:55-14:20

Title: High-dose Cyclophosphamide: A 25 Year History of Treating Autoimmune Illnesses
Dr. Douglas Gladstone, Co-Director, Bone Marrow Transplant Unit, Stony Brook University, USA

14:20-14:45

Speech Opportunity Available

14:45-15:10

15:10-15:30

Coffee Break

15:30-15:55

Title: TBD
Dr. Jenny Xie, Principal Scientist, Bristol Myers Squibb, USA

15:55-16:20

Title: Ipilimumab Monoclonal Antibody Therapy of Malignant Melanoma
Dr. Peter Boasberg, Associate Physician, Melanoma Program, The Angeles Clinic and Research Institute, USA

16:20-16:45

Title: Drug-inducing Activation of Regulatory Network: A New Approach for Immunomediated Diseases?
Dr. Camila Figueiredo, Professor, Department of Biorregulação, Institute of Ciências da Saúde, Federal University of Bahia, Brazil

16:45-17:10

Title: Immuno-nutrition in Neonatology: Role of Omega 3 Fatty Acids
Dr. Amit Tagare, Neonatologist, Department of Pediatrics, KEM Hospital, India

Chair:

Dr. Marcus Hompesch, President and CEO, Profil Institute for Clinical Research Inc., USA

Co-Chair:

Dr. Donna Seto-Young, Director of Endocrinology & Metabolism Laboratory, Associate Professor of Medicine, Albert Eintein College of Medicine, Beth Israel Medicine, USA

08:30-08:55

Keynote Speech
Title: Drug or Endocrine Disruptor Structure Analysis of Estrogen Receptor Binding Chemicals
Dr. Huixiao Hong, Senior Scientist, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, USA

08:55-09:20

Title:Investigating Pharmacodynamic Characteristics of Diabetes Drugs in Early Phase Clinical Development
Dr. Marcus Hompesch, President and CEO, Profil Institute for Clinical Research Inc., USA

09:20-09:45

Speech Opportunity Available

09:45-10:10

Title: Thiazolinediones Inhibit Bone Formation
Dr. Donna Seto-Young, Director of Endocrinology & Metabolism Laboratory, Associate Professor of Medicine, Albert Eintein College of Medicine, Beth Israel Medicine, USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Influence of Insulin Sensitizers on Polycystic Ovary Syndrome Outcome
Dr. Daniela Jakubowicz,Professor of Medicine & Endocrinology, Virginia Commonwealth University, USA; Professor of Medicine VCU, Wolfson Hospital  University of Tel Aviv, Israel

10:55-11:20

Title: New Insights into Bacterial Transcription Reveal Potential Drug Targets
Dr. Paul Rosch, Professor, Research Center for Bio-Macromolecules, University of Bayreuth, Germany

11:20-11:45

Title: Endocrinal Functions of Sulfotransferases
Dr. Guangping Chen, Associate Professor, Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, USA

11:45-12:10

Title: Neural Regulation of Glucose Dependent Insulinotropic Peptide Secretion
Dr. Maria Yavropoulou, Endocrinologist, Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, Greece

Chair:

Co-Chair:

08:30-08:55

Title: Tovaxin®: A Personalized Autologous Immunotherapy for the Treatment of Multiple Sclerosis
Dr. Neil K. Warma, President & CEO, Opexa Therapeutics, Inc., USA

08:55-09:20

Speech Opportunity Available

09:20-09:45

Title: Tracer Induced Therapy in Cancer
Dr. Manfred George Krukemeyer, Professor, Department of Radio-Oncology, Paracelsus-Hospital, Germany

09:45-10:10

Title: Development of Theranostic Agents to Detect Human Cancer Xenografts, Determine Biological Dose, in vivo Visualize Biodistribution and Reduce Systematic Toxicity
Dr. Shi Ke, Technical Director, Division of Molecular Imaging, Frensley Center for Imaging Research; Assistant Professor, Department of Radiology, Baylor College of Medicine, USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Novel Tools for Diagnostics and Targeted Therapeutics for Metastatic Cancer
Dr. Jenny Liao Persson, Head of the Experimental Cancer Research, Clinical Reasearch Center, Lund University, Sweden

10:55-11:20

11:20-11:45

Title: Personalized Genotype-guided Anticoagulant and Anti-aggregant Therapy
Dr. Ronen Loebstein, Head, Institute of Clinical Pharmacology & Toxicology, Sheba Medical Center, Israel

11:45-12:10

Title: Cancer Chemo-gene Therapy Using Target Molecule-inhibiting Vectors Against Anti-tumor Drug Resistant Tumors
Dr. Cheng-long Huang, Associate Professor, Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Japan

Chair:

Dr. Paul B. Tchounwou, Associate Dean & Presidential Distinguished Professor, Director, NIH RCMI-Center for Environmental Health, College of Science, Engineering & Technology, Jackson State University, USA

Co-Chair:

Dr. Georgi V. Petkov, Associate Professor of Pharmacology, University of South Carolina, USA

13:30-13:55

Title: Pharmacokinetics in the Design of Proof of Concept and Phamacodynamic Studies in Drug Discovery
Dr. Norman Huebert, Team Leader, ADME, J&J PRD, USA

13:55-14:20

Title: The Role of Pharmacokinetics in Developing Protein/Peptide and High Molecular Weight Drugs
Dr. Chyung S. Cook, Principal Scientist, Pharmacokinetics and Bioanalytical Sciences, Baxter Healthcare Corporation, USA

14:20-14:45

Title: Trisenox Modulation of p53, c-fos, RARE, Cyclin A and Cyclin D Expression in Human Leukemia (HL60) Cells
Dr. Paul B. Tchounwou, Associate Dean & Presidential Distinguished Professor, Director, NIH RCMI-Center for Environmental Health, College of Science, Engineering & Technology, Jackson State University, USA

14:45-15:10

Speech Opportunity Available

15:10-15:30

15:30-15:55

Title: Calcium-activated Potassium Channels as Novel Pharmacological Targets for Overactive Bladder
Dr. Georgi V. Petkov, Associate Professor of Pharmacology, University of South Carolina, USA

15:55-16:20

Title: Developing Novel Mutipathway Modulating Anticancer Agents
Dr. Bingliang Fang, Associate Professor, MD Anderson Cancer Center, USA

16:20-16:45

Title: Targeting Signal Compartmentalization and Enzyme Allostery for New Drug Development
Dr. Bing Zhu, Assistant Professor, Department of Pharmacology, University of South Alabama, USA

16:45-17:10

Title: Assessment of Antioxidant Property for Development of Drugs Using by Electron Spin Resonance (ESR) Spectroscopy
Dr. Masaichi-Chang-il Lee, Professor and Acting Chairman, Department of Critical Care Medicine, Division of Pharmacology; Vice Dean, Graduate School, Department of Pharmacology, Kanagawa Dental College, Japan

Chair:

Dr. Pierre Guertin, President and CEO, Nordic Life Science Pipeline; Professor, Laval University, Canada

Co-Chair:

Dr. Wandong Zhang, Senior Research Officer/Adjunct Professor (University of Ottawa), Institute for Biological Sciences, National Research Council of Canada, Canada

13:30-13:55

Title: Excitement over Automated Patch Clamp: Action Potentials of Stem Cell-derived Cardiomyocytes and Heat Activation of TRPV1
Dr. Sonja Stoelzle, Senior Scientist, Nanion Technologies GmbH, Germany

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: Effects of a Novel Chinese Herbal Formula on Neuroprotection and Neurorestoration after Spinal Cord Injury in Rats
Dr. Shucui Jiang, Associate Professor, Head of Hamilton NeuroRestorative Group (NRG), Department of Surgery (Neurosurgery, Neuroscience and Neurobiology), McMaster University, Canada

14:45-15:10

Title: Rationale Behind the Development of Combination Products in Neurology
Dr. Pierre Guertin, President and CEO, Nordic Life Science Pipeline; Professor, Laval University, Canada

15:10-15:30

Coffee Break

15:30-15:55

Title: Targetting Altered Cholesterol Metabolism for Alzheimer's Dsiease
Dr. Wandong Zhang, Senior Research Officer/Adjunct Professor (University of Ottawa), Institute for Biological Sciences, National Research Council of Canada, Canada

15:55-16:20

Title: Depression and Neurogenesis; Implications for Balancing the Scales of Emotion and Memory
Dr. William Ogle, Assistant Professor, Pruitt Family Department of Biomedical Engineering, Evelyn F. and William L. McKnight Brain Institute, Institute on Aging, University of Florida, USA

16:20-16:45

Title: Novel Approach to Treat Neurodegenerative Diseases
Dr. Eunsook Lee, Assistant Professor, Meharry Medical College, USA

16:45-17:10

Title: Neu2000, An NR2B Selective, Moderative NMDA Antagonist and Potent Spin Trapping Molecule, Paves the Way for New Stroke Therapy
Dr. Byoung Joo Gwag, Professor, Department of Pharmacology, Ajou University School of Medicine, Korea

Chair:

Dr. Yona Geffen, Executive Drug Development Director, BioLineRx, Ltd., Israel

Co-Chair:

Call for Co- Host

13:30-13:55

Title: Network Compression: Theory, Algorithms, and Applications in Neurodegeneration and Cancer
Dr. Michael Schroeder, Professor in Bioinformatics, BIOTEC and Department of Computing, TU Dresden; CSO, Transinsight.com, Germany

13:55-14:20

Title: Peptide and Protein Neurotoxins: Mapping Binding Sites in Ion Channels and Ways to New Drugs
Dr. Victor Tsetlin, Professor, Corresponding Member of the Russian Academy of Sciences, Humboldt Awardee; Head of the Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia

14:20-14:45

Speech Opportunity Available

14:45-15:10

Title: BL-1020 a GABA Enhanced Antipsychotic from Bench to Bedside
Dr. Yona Geffen, Executive Drug Development Director, BioLineRx, Ltd., Israel

15:10-15:30

Coffee Break

15:30-15:55

Title: Expression of Human Recombinant Fusion N-acetylglucosaminidase-PTD for Potential Therapeutic Treatment of Sanfilippo Syndorme
Dr. Francis Choy, Professor, Department of Biology, Centre for Biomedical Research, University of Victoria, Canada

15:55-16:20

Title: Testing the Effects of Drugs on Brain Connectivity : A New Data Processing Method
Dr. Xavier Noguès, Professor, Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, France

16:20-16:45

Title: New Radiopharmaceuticals in Diagnosis of Alzheimer Disease
Dr. Elzbieta Mikiciuk-Olasik, Associate Professor，Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland

16:45-17:10

Title: Identification and Functional Characterization of ZEL-H16, a Novel Partial Agonist of Human Histamine H3 Receptor
Dr. Naiming Zhou, Professor, College of Life Sciences, and College of Pharmaceutical Sciences, Zhejiang University, China

Chair:

Dr. Michael Swedberg, Associate Director, Safety Pharmacology, AstraZeneca R&D, Sweden

Co-Chair:

08:30-08:55

Title: Genetic Toxicology in Drug Safety Evaluation
Dr. Jianyong (Jerry) Wang, Pharmacology/Toxicology Reviewer, Office of New Drug, Center for Drug Evaluation and Research, US FDA, USA

08:55-09:20

Speech Opportunity Available

09:20-09:45

Title: Drug Abuse and Dependence Liability Assesment in Safety Pharmacology
Dr. Michael Swedberg, Associate Director, Safety Pharmacology, AstraZeneca R&D, Sweden

09:45-10:10

Title: Cardiovascular Safety: How to Develop Risk Assessments
Dr. Jufeng Wang, Chief Science Officer, Waylandgreen, Inc., USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Explorative Toxicological Assessment of Consumer Products
Dr. Rosemarie Lichtner, Principal Scientist, PMI Research & Development, Philip Morris Research Laboratories GmbH, Germany

10:55-11:20

Speech Opportunity Available

11:20-11:45

Title: Direct Measurement of the QT Interval in Stem Cell Derived Cardiomyocytes for the Assessment of QT Liability
Dr. Yasuyuki Asai, CTO, ReproCELL, Japan

11:45-12:10

Title: Optimum Patient Care Through Appropriate Drug Safety Monitoring
Dr. Dhanalakshmi Iyer, IP Consultant, Vidarbha Youth Welfare Society, Institute of Pharmaceutical Education and Research, India

Chair:

Dr. Weijia Zheng, Project Leader, Medicines Evaluation, AstraZeneca Pharmaceuticals LP, USA

Co-Chair:

Dr. Yingqing Ran, Scientist, Small Molecule Pharmaceutics, Genentech, Inc., USA

08:30-08:50

Keynote Speech
Title: Significance of Formulation Development to Support Drug Discovery
Dr. Elizabeth Kwong, Senior Scientific Director, Basic Pharmaceutical Sciences, Merck & Co., USA

08:50-09:10

Speech Opportunity Available

09:10-09:30

Title: Early Formulation Selection and Optimization with a Minimal Amount of Compound
Dr. Weijia Zheng, Project Leader, Medicines Evaluation, AstraZeneca Pharmaceuticals LP, USA

09:30-09:50

Title: Investigation of Different Formulations for Drug Delivery through the Nail Plate
Dr. Gabriele Betz, Group Leader, Industrial Pharmacy Lab, Department of Pharmaceutical Sciences, University of Basel, Switzerland

09:50-10:10

Title: Transcriptional Regulation of Glyco-genes by Apoptotic Agents: Potential Therapy for Breast and Colon Cancers
Dr. Subhash C. Basu, Professor, Department of Chemistry and Biochemistry, University of Notre Dame, USA

10:10-10:30

Coffee Break

10:30-10:50

Title: Spray-dried Amorphous Dispersion in Drug Discovery
Dr. Yingqing Ran, Scientist, Small Molecule Pharmaceutics, Genentech, Inc., USA

10:50-11:10

Title: In Situ Gel Formulations for the Effective Treatment of Vaginal Candidiasis
Dr. Esra Baloglu, Associate Professor, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Turkey

11:10-11:30

Title: Formulation Strategies to Enhance Protein and Peptide Drugs Oral Bioavailability
Dr. Jingyuan Wen, Senior Lecturer in Pharmaceutics, School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand

11:30-11:50

Title: Polymers Act as a Scaffold of Functional Peptides
Dr. Chie Kojima, Assistant Professor, Nanoscience and Nanotechnology Research Center, Research Institutes for the Twenty First Century, Osaka Prefecture University, Japan

11:50-12:10

Title: Antidiabetic Activity of Polyherbal Formulation “PanCure”
Dr. Anand Krishnamurthy, Director, Five Natures Power health care Pvt Ltd, India

Chair:

Dr. Alex F. Chen, Director, VA Vascular Surgery Research, Department of Surgery, Vascular Medicine Institute, McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, USA

Co-Chair:

Dr. Sachin S. Devi., Director, Laboratory of Experimental and Clinical Toxicology, Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA

13:30-13:55

Speech Opportunity Available

13:55-14:20

Title: Understanding Liver Regeneration to Treat Liver Failure
Dr. Sachin S. Devi., Director, Laboratory of Experimental and Clinical Toxicology, Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA

14:20-14:45

Title: Endothelial Progenitor Cells and Regenerative Medicine
Dr. Alex F. Chen, Director, VA Vascular Surgery Research, Department of Surgery, Vascular Medicine Institute, McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, USA

14:45-15:10

Title: Spinal Transplantation of Pre-differentiated Embryonic Stem Cells Alleviates Spinal Cord Injury Pain by Remyelination
Dr. Feng Tao, Assistant Professor, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, USA

15:10-15:30

Coffee Break

15:30-15:55

Title: ABCG2 is Involved in Self Renewal of Melanoma Cancer/Initiating Cells and Major Tumor Associated Antigens are Expressed by ABCG2-positive Cells
Dr. Caterina La Porta, Professor, University of Milan, Italy

15:55-16:20

Title: Non-coding RNA in Biology of Adult Meshenchymal Stem Cells
Dr. Victoria Lunyak, Associate Professor, Epigenetics and Cell Fate Determination, Buck Institute for Age Research, USA

16:20-16:45

Title: The Role of bFGF to Maintain Stemness of Embryonic Stem Cells
Dr. Byung Soo Kim, Cahirperson, Division of Hemato-Oncology, Anam Hospital, KUMC, Korea

16:45-17:10

Title: A PLAG1 Transgenic Mouse Model to Assess the Importance of Number and Balance of Endocrine Hormonal Cells for Stem Cell Based Therapy of Diabetes
Dr. Jeroen Declercq, Postdoctoral Fellows, Laboratory for Molecular Oncology, Department of Human Genetics, Katholieke Universiteit Leuven, Belgium

Chair:

Mr. Geert Verdonk, Senior Research Scientist Quality, QA Schering Plough Corporation, The Netherlands

Co-Chair:

13:30-13:55

Title: Discovery and Functional Validation of Novel Class Non-protein-coding Trans-regulatory RNAs Contributing to Increased Risk of Developing 24 Common Human Disorders: Implications for Development of the Population-based Personalized Disease Chemoprevention Programs
Dr. Gennadi V. Glinsky, Senior Scientist, Ordway Research Institute, Albany Medical College, USA

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: Determination of LOD of a Rapid Microbiological Method (RMM)
Mr. Geert Verdonk, Senior Research Scientist Quality, QA Schering Plough Corporation, The Netherlands

14:45-15:10

Title: Electron Transfer in Therapeutic Alkaloids Triggers Anastomosis in Traumatized Liver Blood Flow
Dr. Pauli Virtanen, Laboratory Manager and Vice Director, Turku University, Finland

15:10-15:30

Coffee Break

15:30-15:55

Title: Whole Cell-based Validation and Identification of Mode of Action for Antibacterial Agents
Dr. Yinduo Ji, Associate Professor, Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, USA

15:55-16:20

Title: Human in vitro Neural Models for Human Cytomegalovirus Neuropathogenesis and Drug Screening Study
Dr. Min Hua Luo, Group Leader of Neurovirology, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China

16:20-16:45

Title: Auto-bactericidal Surfaces Obtained by Covalent Grafting
Dr. Elisabeth Taffin de Givenchy, Lecturer in organic chemistry, Chemistry Laboratory of Organic and Metallic Materials (JCOMM), University of Nice Sophia Antipolis, France

16:45-17:10

Title: Overcoming Antibiotic Resistance by Overcoming Antibiotic Resistance Factor
Dr. Hyung Jong Jin, Professor and President of The Korean RNA Society, Department of Bioscience and Biotechnology, College of Natural Science, The University of Suwon, South Korea

Chair:

Dr. Robert Levy, Senior Partner, Okapi Consultants, LLC; Director of Clinical Development, Primus Pharmaceuticals, Inc., USA

Co-Chair:

Call for Co- Host

08:30-08:55

Speech Opportunity Available

08:55-09:20

Title: Can Evolutionary Clues be Used to Develop Platforms for New Drug Discovery?
Dr. Robert Levy, Senior Partner, Okapi Consultants, LLC; Director of Clinical Development, Primus Pharmaceuticals, Inc., USA

09:20-09:45

Speech Opportunity Available

09:45-10:10

Title: Doping Control, Sport, and Drug Development
Dr. Richard L. Hilderbrand, Science Director, United States Anti-Doping Agency, USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Knowledge Management to accelerate translational biology
Dr. Lina Yip Sonderegger, Knowledge Management Scientist, Research Informatics and Knowledge Management, Merck Serono International S.A., Switzerland

10:55-11:20

Title: Drug Development and Discovery for Use in Human Pregnancy
Dr. Antoine Malek, Head, Placental Research Group, Obstetrics Department, University Hospital Zurich, Switzerland

11:20-11:45

Title: How to Help Medication Adherence with New Drug Discovery? Results of the Survey Conducted in Europe
Dr. Przemyslaw Kardas, Associate Professor and Head, The First Department of Family Medicine, Medical University of Lodz, Poland

11:45-12:10

Title: Polygonatum Cyrtonema Lectin: Targeting Apoptotic and Autophagic Pathways as a Potential Anti-tumor Drug
Dr. Bo Liu, Lecturer, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, China

Chair:

Dr. Stephen Turner, Chief Technology Officer, Pacific Biosciences, USA

Co-Chair:

13:30-13:55

Speech Opportunity Available

13:55-14:20

Title: Discovery and Functional Validation of Novel Class Non-protein-coding Trans-regulatory RNAs Contributing to Increased Risk of Developing 24 Common Human Disorders: Implications for Development of the Population-based Personalized Disease Chemoprevention Programs
Dr. Gennadi V. Glinsky, Senior Scientist, Ordway Research Institute, Albany Medical College, USA

14:20-14:45

Title: TBD
Dr. Stephen Turner, Chief Technology Officer, Pacific Biosciences, USA

14:45-15:10

Title: Codeine as an Example for Implications of Cytochrome P450 Genetic Polymorphisms on the Toxicity of a Substance
Dr. Maren Hermanns-Clausen, Leader, Poison Information Center VIZ-Freiburg, Center for Paediatrics and Adolescent Medicine, Germany

15:10-15:30

Coffee Break

15:30-15:55

Title: High-throughput Compound and siRNA Screening to Identify Novel Treatment Options for ERG Oncogene Positive Prostate Cancers
Dr. Kristiina Iljin, Team Leader / Senior Research Scientist, Cancer Systems Biology Team, VTT Medical Biotechnology, Finland

15:55-16:20

Title: Mass Spectrometry for Microbial Proteomics
Dr. Haroun N. Shah, Head, Molecular Identification Services Unit., Department for Bioanalysis and Horizon Technologies, Health Protection Agency, Centre for Infections, UK

16:20-16:45

Title: In Silico Genetic Network Models for Pre-clinical Drug Prioritization
Dr. Jiang-Hui Xiong, Associate Professor, School of Computer Science, Wuhan University, China

16:45-17:10

Speech Opportunity Available

Chair:

Dr. Jean-Philippe Stephan, Research Senior Scientist (Technology), Genentech, Inc., USA

Co-Chair:

13:30-13:55

Keynote Speech
Title: Electrophysiology in the Fast Lane: Automated Patch Clamp in Research and Drug Discovery
Dr. Niels Fertig, CEO, Nanion Technologies GmbH, Germany

13:55-14:20

Title: Role and Function of Biophysical Methods in Supporting the Drug Disovery Process
Dr. Matthias Frech, Head, Molecular Interactions & Biophysics, Merck KGaA, Germany

14:20-14:45

Title: Today's Screenings to Discover Tomorrow's Targets
Dr. Jean-Philippe Stephan, Research Senior Scientist (Technology), Genentech, Inc., USA

14:45-15:10

Speech Opportunity Available

15:10-15:30

Coffee Break

15:30-15:55

Title: Hypoxia Active Prodrugs for Cancer Treatment
Dr. Jianxin Duan, Sr. Director of Med. Chem., Threshold Pharmaceuticals Inc., USA

15:55-16:20

Title: High Throughput Motif Analysis for Drug Discovery Research
Dr. Arun Datta, Director (Technology R & D) & Senior Faculty, National University, USA

16:20-16:45

Title: Broad-spectrum Anti-toxin Compounds Identified by High Throughput Screeningg
Dr. Daniel Gillet, Group Leader, iBiTec-S – SIMOPRO, CEA-Saclay, France

16:45-17:10

Title: Screening Strategy for Cholesterol Lowering Drugs
Dr. Hiroshi Suzuki, Professor and Chair, Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Japan

Chair:

Dr. Jingjing Ye, Mathematical Statistician, Food and Drug Administration (FDA), USA

Co-Chair:

Dr. Farideh Z. Bischoff, Sr. Director, Translational Research and CLIA Development, Biocept, Inc., USA

08:30-08:55

Title: Discovery of Histamine H3 Receptor PET Tracer
Dr. Nagaaki Sato, Director, Department of Medicinal Chemistry, Taisho Research Laboratories, Taisho Pharmaceutical Co., Ltd., Japan

08:55-09:20

Title: Evaluation of Copy Number Variation in Cancer as Biomarkers for Patient Population Selection
Dr. Jingjing Ye, Mathematical Statistician, Food and Drug Administration (FDA), USA

09:20-09:45

Speech Opportunity Available

09:45-10:10

Title: Development of Lipid-based Oral Therapeutics for Treatment and Prevention of Liver/GI Cancer
Dr. Stanislav Svetlov, Sr. Principal Scientist/Associate Director, Center Operations Manager, Center of Innovative Research, Banyan Biomarkers, Inc., USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Enumeration and Sequential Molecular Analysis of CTCs Using a Microfluidic (CEETM) Platform
Dr. Farideh Z. Bischoff, Sr. Director, Translational Research and CLIA Development, Biocept, Inc., USA

10:55-11:20

Title: 4b-Hydroxycholesterol is a New Endogenous Biomarker for CYP3A Activity
Dr. Ulf Diczfalusy, Associate Professor, Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Sweden

11:20-11:45

Title: Utilizing Toxicogenomics and Urinary Biomarkeres for Nephrotoxicity into Drug Safety Screening
Dr. Takeki Uehara, Team Leader, Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd., Japan

11:45-12:10

Title: Specific Recognition of Cancer Cells by Novel Biocompatible Nanocomposites
Dr. Xuemei Wang, Professor, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, China

Chair:

Co-Chair:

Dr. Ning Yu, Principal Scientist, Pfizer Global Research & Development, USA

08:30-08:50

Title: The Role of Informatics and Genomics to Drive Innovation in Pharma – How Far Have We Come?
Dr. Jacob de Vlieg, Global Head Molecular Design & Informatics, MSD, Merck; Head of Computational Drug Discovery, Radboud University, The Netherlands

08:50-09:10

Speech Opportunity Available

09:10-09:30

Title: Modeling Ligand and Protein Interaction for Drug Discovery
Dr. Yong-Liang Zhu, Group Leader, Molecular Design, Elan Pharmaceuticals Inc., USA

09:30-09:50

Title: In Silico Models for Estimating Skin Penetration
Dr. Michael Heisig, Senior Scientist, Goethe University Frankfurt, Germany

09:50-10:10

Speech Opportunity Available

10:10-10:30

Coffee Break

10:30-10:50

Title: Efficient Exploration of Large Combinatorial Chemistry Spaces by Monomer-based Similarity Searching
Dr. Ning Yu, Principal Scientist, Pfizer Global Research & Development, USA

10:50-11:10

Title: Digitization of Fingerprint for Drug Binding Sites
Dr. Jiaan Yang, Vice President, Drug Discovery Technology, Sundia MediTech, China

11:10-11:30

Title: Synthetic Biology and Drug Discovery in the 21st Century: An Emerging, Disruptive Technology
Dr. Wayne Mitchell, Group Leader, Bioinformatics, Experimental Therapeutics Centre, A*STAR, Singapore

11:30-11:50

Title: Detection of Structurally Conserved Protein Binding Sites
Dr. Dusanka Janezic, Professor, National Institute of Chemistry, Slovenia

11:50-12:10

Title: Prediction of Xenobiotics Metabolism in Humans
Dr. Fangping Mu, Staff Scientist, Theoretical Biology & Biophysics, Theoretical Division, National Laboratory, USA

Chair:

Co-Chair:

Call for Co- Host

13:30-13:55

Title: TBD
Dr. Shintaro Nishimura, Vice President, Bioimaging Research Laboratories, Astellas Pharma Inc.; Professor, Institute of Basic Medical Science, University of Tsukuba; Visiting Professor, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Japan

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: Employment of Quantitative Light Microscopy in Identification of a Novel Metastasis Suppressor, Protein 4.1B, Controlling Morphology, Motility, Chemotaxis and Invasion
Dr. Daniel Zicha, Head of Imperial Cancer Research Fund, London Research Institute, Lincoln’s Inn Fields Laboratories, UK

14:45-15:10

Title: In Vivo MR Imaging and Spectroscopy in Drug Discovery: It's Much More Than Just Pretty Pictures
Dr. Haiying Liu, Senior Research Fellow, Merck & Co., USA

15:10-15:30

Coffee Break

15:30-15:55

Title: Perfusion-based Microfluidic Device for Three-dimensional Dynamic Primary Human Hepatocyte Cell Culture
Dr. Po Ki Yuen, Research Manager, Bioengineering, Corning Incorporated, Biochemical Technologies, Science and Technology, USA

15:55-16:20

Title: New technology Platforms for Healthcare and Nanomedicine
Dr. Salvo Coffa, Research Director, Soft Computing, STMicroelectronics, Itay

16:20-16:45

Title: Microarray Assisted Gene Discovery in Ulcerative Colitis
Dr. Klaus Brusgaard, Senior Researcher, Department of Clinical Genetics, Odense University Hospital, Denmark

16:45-17:10

Title: Automated Multi-well Device to Measure Transepithelial Electrical Conductance and Capacity
Dr. Yuchun Gu, Reader, Department of Physiology, The Medical School, University of Birmingham, UK

Chair:

Dr. Chiang Li, President and Chief Executive Officer, Boston Biomedical, Inc., USA

Co-Chair:

13:30-13:55

Title: Asymmetric RNA, Next Generation Technology for Designing RNA Drugs
Dr. Chiang Li, President and Chief Executive Officer, Boston Biomedical, Inc., USA

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: siRNA-based Gene Therapy for Skin Disorders
Dr. Qinwei (James) Yin, Professor, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, China

14:45-15:10

Title: Application of Tetraspanin CD81 RNAi for Diagnosis and Therapy of Rheumatoid Arthritis (RA)
Dr. Tohru Nakanishi, Professor and Chairman, Department of Molecular Diagnosis, Shujitsu University School of Pharmacy, Japan

15:10-15:30

Coffee Break

15:30-15:55

Title: Pharmacokinetics of Belatacept in Renal Transplant Patients
Dr. Xiaoli You, Senior Research Scientist, Department of Discovery Medicine & Clinical Pharmacology, Bristol-Myers Squibb Co., USA

15:55-16:20

Speech Opportunity Available

16:20-16:45

Title: TBD
Dr. Qing Jing, Principal Investigator, Professor, Lab of Nucleic Acid & Molecular Medicine, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

16:45-17:10

Title: Functional Regulation of b-actin in Cancer: Role of MicroRNAs
Dr. Stella Aronov, Senior Scientist, Department for Molecular Biology, Ariel University Center of Samaria, Israel

Chair:

Dr. Alessandra Pani, Professor, Department of Biomedical Science & Technology, University of Cagliari, Italy

Co-Chair:

Dr. Chieh-Hsi Wu, Professor and Chairman, School of Pharmacy, China Medical University, Taiwan

08:30-08:55

Speech Opportunity Available

08:55-09:20

Title: Human ‘Knock-in’ and ‘knock-Out’ Cell-Lines for Precision Functional Genomics and Targeted Drug Discovery
Dr. Rob Howes, R&D Director, Horizon Discovery, UK

09:20-09:45

Title: Cholesterol Ester Accumulation in Peripheral Blood Mononuclear Cells: A Novel Biomarker for the Early Diagnosis of Alzheimer and a Potential Drug Target for the Effective Control of Neurodegeneration
Dr. Alessandra Pani, Professor, Department of Biomedical Science & Technology, University of Cagliari, Italy

09:45-10:10

Title: Assay Development in the OX2R Cell Line
Dr. Pingfu Feng, Assistant Professor, Division of Pulmonary and Critical Care, Department of Medicine and Psychiatry, Case Western Reserve University, Louis Stokes Cleveland VA Medical Center, USA

10:10-10:30

Coffee Break

10:30-10:55

Title: Cell- and Tissue-based Assay for Quantification of Apoptosis and Necrosis Coexisting in a Single Cell
Dr. Alexei G. Basnakian, Associate Professor, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, USA

10:55-11:20

Title: A Cell-based Assay for Screening Drugs Using Glioma Cells and Astrocytes
Dr. Ramon dos Santos El-Bachá, Associate Professor, Laboratory of Neurochemistry and Cell Biology (LabNq), Department of Biochemistry and Biophysics, Health Science Institute, Federal University of Bahia, Brazil

11:20-11:45

Speech Opportunity Available

11:45-12:10

Title: The Role of Autophagy and Endoplasmic Reticulum Stress in Brain Ischemic Preconditioning and Drug Intervention
Dr. Sheng Rui, Associate Professor, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, China

Chair:

Dr. Janice Yau Yi Lau, Senior Group Leader, GPRD, Drug Metabolism, Abbott, USA

Co-Chair:

08:30-08:55

Title: Increased Ion Sampling Efficiency Using the Agilent 6490 LC/MS Instrument Simplifies the Determination of Fluticasone Propionate in Human Plasma
Dr. Lester Taylor, LC/MS Platforms & Programs Manager, Life Sciences and Chemical Analysis, Agilent Technologies, USA

08:55-09:20

Title: Application of LC-MSn in Conjunction with Mechanism-based Stress Studies in the Rapid Elucidation of Drug Degradation Products and Degradation Pathways
Dr. Min Li, Manager, ACDS - Supply Analytical Sciences, Merck & Co., Inc., USA

09:20-09:45

Speech Opportunity Available

09:45-10:10

Title: High Speed HPLC/MS for Reactive Metabolite Screening
Dr. Janice Yau Yi Lau, Senior Group Leader, GPRD, Drug Metabolism, Abbott, USA

10:10-10:30

Coffee Break

10:30-10:55

Title: High-resolution Mass Spectrometry for Structural Characterization and Identification in Pharmaceutical Drug Discovery and Development
Dr. Xiaoli (Shirley) Wang, Senior Scientist, Analytical Development, Vertex Pharmaceuticals Incorporated, USA

10:55-11:20

Title: Structural and Functional Glycomics Based on HPLC Database, Sugar Library, and NMR Spectroscopy
Dr. Koichi Kato, Professor, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan

11:20-11:45

Title: Combination of Cell-based Bioassays with LC-MS/MS Analysis for Herbal Drug Discovery
Dr. Yinhan Gong, Assistant Professor, National University of Singapore, Singapore

11:45-12:10

Speech Opportunity Available

Chair:

Dr. William Shi, Senior Product Manager, Esensing Analytical Technology Co., Ltd., China

Co-Chair:

Call for Host

08:30-08:55

Title: Ultra-high-performance nanoLC-MS/MS Analysis of Complex Proteomic Samples
Dr. Wulff Niedner, LC Product Manager, Dionex Corporation, Germany

08:55-09:20

Title: The Use of High Resolution Mass Spectrometry (UPLC-Orbitrap) for the Quantification of Some One Hundred Veterinary Drugs at Trace Levels in Various Animal Tissues
Dr. Anton Kaufmann, President of the Swiss Federal Working Group "Analytical Methods for Residues of Pharmaceutical Drugs in Food", Kantonales Labor Zürich, Switzerland

09:20-09:45

Title: Cutting Edge Technologies Assisted Bioanalysis Using LC-MS/MS in Drug Discovery and Development
Dr. Wei Song, Research Scientist, Pfizer Global Research and Development, USA

09:45-10:10

Title: On-line Generic Solid Phase Extraction-liquid Chromatography-tandem Mass Spectrometry Methodology for Fast Determination of Drugs in Biological Fluids
Dr. William Shi, Senior Product Manager, Esensing Analytical Technology Co., Ltd., China

10:10-10:30

Coffee Break

10:30-10:55

Title: TBD
Dr. Yuan-Qing Xia, Senior Research Scientist, Bioanalytical and Discovery Analytical Sciences, Bristol-Myers Squibb Company, USA

10:55-11:20

Title: Identification of Cavities on Protein Surface Using Multiple Computational Approaches for Drug Binding Site Prediction
Dr. Bingding Huang, Associate Professor, Division of Systems Biology, Zhejiang-California International NanoSystems Institute, Zhejiang University, China; Senior Scientist, Biotechnology Center, Technical University of Dresden, Germany

11:20-11:45

Title: Discovery of  a New Type Anti-cancer Compounds ---Thiochroman-4-one Derivatives by LC-MS
Dr. Gengliang Yang, Professor and Dean, College of Pharmaceutical Sciences, Hebei University, China

11:45-12:10

Speech Opportunity Available

Chair:

Dr. Hinnerk Boriss, CEO, Sovicell GmbH, Germany

Co-Chair:

Dr. Tove Tuntland, Director of Metabolism and Pharmacokinetics (MAP), Genomics Institute of the Novartis Research Foundation (GNF), Novartis Institute of Biomedical Research (NIBR), USA

13:30-13:55

Title: Balancing Potency, Pharmaceutical and ADME Properties
Dr. Cornelis Hop, Head, Small Molecule Drug Metabolism & Pharmacokinetics Department, Genentech Inc., USA

13:55-14:20

Title: Predicting Neurotoxicity by Early Assessment of the Free Concentration of Drug in Brain
Dr. Hinnerk Boriss, CEO, Sovicell GmbH, Germany

14:20-14:45

Speech Opportunity Available

14:45-15:10

Title: Applications of Hepatocyte System in Drug Discovery and Development
Dr. Yi-An Bi, Senior Scientist, Pfizer Inc., USA

15:10-15:30

Coffee Break

15:30-15:55

Title: The Use of Rapid in Vivo PK Screening in Drug Discovery
Dr. Tove Tuntland, Director of Metabolism and Pharmacokinetics (MAP), Genomics Institute of the Novartis Research Foundation (GNF), Novartis Institute of Biomedical Research (NIBR), USA

15:55-16:20

Title: DBS and HRMS for in vivo Fast PK Studies – The Value and Advantage for Pre-clinical Studies
Dr. Rohan A. Thakur, Associate Director, Specialized Mass Spectrometry, Taylor Technology – a PharmaNet Company, USA

16:20-16:45

Title: Translational Drug Discovery and Development – An Expedition from Preclinical ADMET to Clinical PK/PD
Dr. Dongzhou (Jeffery) Liu, Principle Clinical Investigator, Medical Affairs and Clinical Development, GlaxoSmithKline, USA

16:45-17:10

Title: Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using Caco-2 Model
Dr. Xuena Lin, Scientist II, Novartis, USA

17:10-17:35

Title: Assessing Brain Free Fraction in Early Drug Discovery
Dr. Kevin Read, Head of DMPK, University of Dundee, UK

Chair:

Co-Chair:

Dr. Z. David Luo, Associate Professor, Department of Anesthesiology & Perioperative Care, Department of Pharmacology, Irvine Medical Center, University of California, USA

13:30-13:55

Speech Opportunity Available

13:55-14:20

Title: TBD
Dr. Andreas A. Linninger, Director, Laboratory for Product and Process Design, University of Illinois, USA

14:20-14:45

Title: Animal Models: A  Gap between Present in Reality
Dr. Sayed Nour, Consultant Cardiac Surgeon,  R & D Manager, Laboratory of Biosurgical Research, France

14:45-15:10

Speech Opportunity Available

15:10-15:30

Coffee Break

15:30-15:55

Title: A Non-invasive Model for Neuropathic Pain Drug Discovery
Dr. Z. David Luo, Associate Professor, Department of Anesthesiology & Perioperative Care, Department of Pharmacology, Irvine Medical Center, University of California, USA

15:55-16:20

Title: Experimental Animal Models for Drug Studies
Dr. Badiaa Lyoussi, Director UFR : Physiology-Pharmacology, President Deputy of Arab Union of Pharmacology, Head of Physiology-Pharmacology and environmental Health Laboratory, Morocco

16:20-16:45

Title: Application of Hippocampal Theta Rhythm in Rodents to Drug Discovery Science
Dr. Yuji Takano, Research Associate, NTT Communication Science Laboratories, NTT Corporation, Japan

16:45-17:10

Title: Nude Mice with Human Cancer as Animal Model: Potential Role in Molecular Target Therapy
Dr. Anwar Tawfik Amin, Surgical Oncologist and Lecturer of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Egypt

Chair:

Dr. Huailing Zhong, Senior Research Scientist, Department of Biological Research, Lundbeck Research USA, USA

Co-Chair:

08:30-08:50

Title: Screening of Compounds Acting on GPCRs with MEA-neurochip Technology
Dr. Olaf Schroeder, Managing Director, NeuroProof GmbH, Germany

08:50-09:10

Title: ACTOne, A Real Time cAMP Assay for GPCR and PDE HTS
Dr. Jimmy Lu, President and CEO, CodexBiosolutions, USA

09:10-09:30

Speech Opportunity Available

09:30-09:50

Title: Screening Strategies for Discovery of Allosteric Modulators
Dr. Robert Lütjens, Head of Core Biology, Addex Pharmaceuticals, Switzerland

09:50-10:10

Title: Neutralizing GPCR Ligands with Small Molecules as a New Therapeutic Approach
Dr. Jean-Luc Galzi, Research Director, Centre National de la Recherche Scientifique (CNRS), France

10:10-10:30

Coffee Break

10:30-10:50

Title: Allosteric Modulation of GPCRs and Transporters – A Novel Approach for Treating Depression and other CNS Disorders
Dr. Huailing Zhong, Senior Research Scientist, Department of Biological Research, Lundbeck Research USA, USA

10:50-11:10

Title: Current Challenges and Perspectives in GPCR Allosteric Modulator Discovery
Dr. Stephan Schann, Head of Research, Domain Therapeutics, France

11:10-11:30

Title: GPCR Anterograde Trafficking
Dr. Guangyu Wu, Associate Professor, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, USA

11:30-11:50

Title: Structure Based Drug Design for Complex GPCR Targets; Studies on Relaxin Family Peptide Receptors
Dr. Ross A. D. Bathgate, Associate Professor, Leader, Howard Florey Institute, University of Melbourne, Australia

11:50-12:10

Title: Computational Approaches to Prediction of G-protein Coupled Receptors Oligomerization
Dr. Agnieszka Kaczor, Reseacher, Medical University of Lublin, Poland; Research Unit for Biomedical Informatics, Spain

Chair:

Dr. Yi Liu, VP of Drug Discovery, Intellikine, Inc., USA

Co-Chair:

Dr. Yongxin Han, Vice President of Chemistry, General Manager of China Operations, Chemizon, Inc., China

13:30-13:55

Title: INK128 – A Selective TORC1/2 Inhibitor for Cancer Therapy
Dr. Yi Liu, VP of Drug Discovery, Intellikine, Inc., USA

13:55-14:20

Title: Discovery of a New Class of Kinase Inhibitor that Selectively Kills Leukemic Stem Cells
Dr. Mark  A. Guthridge, Head, Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, Australia

14:20-14:45

Speech Opportunity Available

14:45-15:10

Title: ICA-1: A Novel PKC-ι Inhibitor Induces Apoptosis In Neuroblastoma Cells
Dr. Mildred Acevedo-Duncan, Research Associate Professor, Department of Chemistry, University of South Florida, USA

15:10-15:30

Coffee Break

15:30-15:55

Title: A Highly Potent and Selective Agent as Targeted Anti-cancer Therapy
Dr. Yongxin Han, Vice President of Chemistry, General Manager of China Operations, Chemizon, Inc., China

15:55-16:20

Title: Multicolor Monitoring of Imatinib- and Dasatinib-Inhibited Dysregulated Protein Kinases in Chronic Myelogenous Leukemia
Dr. Qunzhao Wang, Research Assistand Professor, University of North Carolina at Chapel Hill, USA

16:20-16:45

Title: TBD
Dr. Swethajit Biswas, Consultant and Clinical Senior Lecturer, Northern Centre for Cancer Care (BICCC), Freeman Hospital, UK

16:45-17:10

Speech Opportunity Available

Chair:

Dr. Hassan Benameur, Senior Director, Global Pharmaceutical Sciences, Capsugel, Pfizer Inc., France

Co-Chair:

Dr. Xian-Ming Zeng, Senior Director, Global Respiratory R&D, TEVA Branded Pharmaceutical Products R&D, Inc., USA

13:30-13:50

Title: Biopharmaceutic of Functional Excipients Used in Self Auto Nanoemulsions to Enhance Oral Drug Delivery
Dr. Hassan Benameur, Senior Director, Global Pharmaceutical Sciences, Capsugel, Pfizer Inc., France

13:50-14:10

Title: The Role of Material Science in Inhalation Drug Delivery
Dr. Xian-Ming Zeng, Senior Director, Global Respiratory R&D, TEVA Branded Pharmaceutical Products R&D, Inc., USA

14:10-14:30

Speech Opportunity Available

14:30-14:50

Title: Lipid-based Nanostructures: Functionalization with Cell Penetrating Peptides
Dr. Margitta Dathe, Professor, Peptide Lipid Interaction / Peptide Transport, Leibniz Institute of Molecular Pharmacology, Germany

14:50-15:10

Title: Evaluation of Implantable Drug Delivery Systems – From Benchtop to Animal
Dr. Lisa Ferrara, President, OrthoKinetic Technologies, LLC, USA

15:10-15:30

Coffee Break

15:30-15:50

Title: Carbon Nanotubes as Diagnostic and Drug Delivery Tools: Molecular Bases for Their Interaction with Human Cells
Dr. Silvana Fiorito, Professor, Department of Medicine, ClinicaInstitute of Neurobiology and Molecular Medicine, National Research Council (CNR), Italy

15:50-16:10

Title: Ionogels: Confined Ionic Liquids for New Drug Delivery System
Dr. Corine Tourné-Péteilh, Research Engineer, Charles Gerhardt Institute of Montpellier, France

16:10-16:30

Title: The Delivery of Drugs from Moldable Polymeric Bone Replacements
Dr. Gary A. Leeke, Lecturer, Chemical Engineering, University of Birmingham, UK

16:30:16:50

Title: Drug Delivery Opportunities with Novel Particulate Formulations: A Case Study for Oral Colonic Drug Delivery
Dr. Rachel Bridson, Lecturer, School of Chemical Engineering, University of Birmingham, UK

16:50-17:10

Title: Spectroscopic Characterization of Hydrophiic Fine Particles
Dr. Tatsuya Fujino, Associate Professor, Tokyo Metropolitan University, Japan

17:10-17:30

Title: Amino-acid Derivative-mediated Multifunctionalization of Biomaterial for Bone Regeneration
Dr. Masahiro Yamada, Assistant Professor, Department of Removable Prosthodontics & Gerodontology, Tokyo Dental College, Japan

Chair:

Dr. Jean-Marie Devoisselle, Professor and Team Leader, Institute Charles Gerhardt, France

Co-Chair:

Dr. Peihong Ni, Professor in Macromolecular Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, China

13:30-13:50

Speech Opportunity Available

13:50-14:10

Title: Nanostructured Inorganic/lipid-based Drug Delivery Systems
Dr. Jean-Marie Devoisselle, Professor and Team Leader, Institute Charles Gerhardt, France

14:10-14:30

Title: Hydrogel Microspheres as Amphibious Carriers for Nanoparticle Phase Transfer
Dr. Dayang Wang, Professor, Ian Wark Research Institute, University of South Australia, Australia

14:30-14:50

Title: Magnetic Nanohybride Organic-inorganic Material Platform for Drug Delivery
Dr. Paulo Morais, Professor, University of Brasilia, Brazil

14:50-15:10

Title: Preparation of Uniform-sized Mico- and Nano-particles and Their Applications in Drug Delivery Systems
Dr. Lianyan Wang, Associate Professor, Institute of Process Engineering, CAS, China

15:10-15:30

Coffee Break

15:30-15:50

Title: Design of Stimuli-responsive Polymer Systems Relevant to Biomedical Applications
Dr. Peihong Ni, Professor in Macromolecular Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, China

15:50-16:10

Title: A Novel Polysaccharide Carrier for Functional Oligonucleotides: APS Targeting DDS with Dectin-1
Dr. Kazuo Sakurai, Professor, Department of Chemical Process and Environments, The University of Kitakyushu, Japan

16:10-16:30

Title: Design of Functionalized Liposomal Nanocarrier and Its Applications
Dr. Young Wook Choi, Dean and Professor, College of Pharmacy, Chung-Ang University, Korea

16:30-16:50

Title: Novel Nanotechnology-based Drug Delivery in Treating Age-related Macular Degeneration
Dr. Yasuhiro Tamaki, Associate Professor, Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Japan

16:50-17:10

Title: Gene Delivery by DNA-chitosan Nanoparticles; Novel Chitosans with Improved Structural and Functional Properties
Dr. Nina K Reitan, Postdoctoral Fellow, Department of Physics, The Norwegian University of Science and Technology, Norway

Chair:

Call for Host

08:30-08:55

Speech Opportunity Available

08:55-09:20

Title: Advancement and Challenge of Chemistry in Drug Discovery
Dr. Joseph (Jiawang) Zhu, Vice President, Medicinal Chemistry/Drug Discovery, Sundia MediTech, Inc, China

09:20-10:10

Title: The Application of World Traditional/Natural Medicine Patent Database in Drug Design
Dr. Yanhuai Liu, President, Beijing East Linden Science & Technology Co., Ltd., China

10:10-10:30

Coffee Break

10:30-10:55

Title: Bioinformatical Approaches on TCM Database SAPHRON and Its Application in Drug Discovery
Dr. William Wei-guo Jia, Vice President (Research), Shanghai Innovative Research Centre of Traditional Chinese Medicine (SIRC-TCM), China

10:55-11:20

Speech Opportunity Available

11:20-11:45

Speech Opportunity Available

11:45-12:10

Speech Opportunity Available

Chair:

Call for Host

08:30-12:10

7~8 Speakers’ Profiles will be released soon

Dr. Jan Torzewski, Professor, Head of Cardiovascular Center Oberallgaeu, Germany

13:30-13:55

Title: Inhibiting C-reactive Protein for the Treatment of Cardiovascular Disease
Dr. Jan Torzewski, Professor, Head of Cardiovascular Center Oberallgaeu, Germany

13:55-14:20

Speech Opportunity Available

14:20-14:45

Title: TBD
Dr. Qinhui Song, Novartis Institutes for BioMedical, Research, Inc., USA

14:45-15:10

Title: Markers of Cholesterol Metabolism and Cardiovascular Diseases
Dr. Oliver Weingartner, Cardiology, Angiology and Intensive Care Medicine, University of the Saarland, Germany

Chair:

Dr. Qiang Lu, Vice President, WuXi AppTec, China

08:30-08:55

Title: Screening, Synthesis and Biological Activity of Novel Kv7/KCNQ/M-channel Activator for Neuropsychiatric Disorders
Dr. KeWei Wang, ChangJiang Professor, Department of Neurobiology and Neuroscience Research Institute, Peking University School of Medicine, China

08:55-09:20

Title: Amino Acid Analogs as Ca2+ Channel Modulators
Dr. Venkat Gopalakrishnan, Professor & Head, Department of Pharmacology, University of Saskatchewan, Canada

09:20-09:45

Title: Electrophysiological Platforms in Ion Channel Drug Screening
Dr. Haiheng Dong, Director, Discovery Biology, WuXi AppTec, China

09:45-10:10

Speech Opportunity Available

Chair:

Dr. Jeanne Mendell, Director, Clinical Pharmacology, Daiichi Sankyo Pharma Development, USA

Co-Chair:

Call for Co- Host

10:30-10:55

Speech Opportunity Available

10:55-11:20

Title: Manipulation of Hepatic Isozymes; Possible Treatment for Clopidogrel Resistance
Dr. Dan Hogan, Associate Professor, Cardiology, Purdue University, USA

11:20-11:45

Speech Opportunity Available

11:45-12:10

Title: Inhibition of Platelet Aggregation with Prasugrel and Clopidogrel: an Integrated Analysis in 846 Subjects
Dr. Ying Grace Li, Lilly Research Laboratories, Eli Lilly and Company, USA

Chair:

Dr. Brian L. Walton, Associate Director of Interventional Cardiology Research; Director, Cardiovascular Experimental Imaging and Therapeutics (CVEIT), Department of Atherosclerosis and Vulnerable Plaque Research, Texas Heart Institute at St. Luke's Episcopal Hospital, USA

Co-Chair:

Dr. Guorong Xu, Professor, Department of Medicine, University of Medicine & Dentistry of New Jersey and VA Medical Center, USA

08:30-08:55

Keynote Speech
Title: Cardiovascular Risk Reduction beyond Statins
Dr. Yale Mitchel, Vice President, Cardiovascular Disease Dept, Global Clinical and Quantitative Science, Merck Research Laboratories, USA

08:55-09:20

Title: Liposomes for Imaging and Therapies of Cardiovascular Diseases
Dr. Brian L. Walton, Associate Director of Interventional Cardiology Research; Director, Cardiovascular Experimental Imaging and Therapeutics (CVEIT), Department of Atherosclerosis and Vulnerable Plaque Research, Texas Heart Institute at St. Luke's Episcopal Hospital, USA

09:20-09:45

Title: New Targets for Lipid Management
Dr. Allen Adolphe, Physician, Professor of Medicine, Department of Internal Medicine, University of New Mexico, USA

09:45-10:10

Title: A Highly Selective ACAT-1 inhibitor, K-604, accelerates Plaque Stabilization in Atherogenic Lesion
Dr. Kimiyuki Shibuya, Medicinal Chemist, Tokyo New Drug Research Laboratories, Kowa Company Ltd., Japan

10:10-10:30

Coffee Break

10:30-10:55

Title: To Reduce Plasma Cholesterol Levels by Blocking the Function of Ileal Apical Sodium-dependent Bile Acid Transporter (ASBT)
Dr. Guorong Xu, Professor, Department of Medicine, University of Medicine & Dentistry of New Jersey and VA Medical Center, USA

10:55-11:20

Title: Hypolipidemic Effects of Melissa Officinalis Essential Oil in Human Apolipoprotein E2 Transgenic Mice and HepG2 Cells
Dr. Sung-Joon Lee, Research Professor, College of Life Sciences and Biotechnology, Korea University, Korea

11:20-11:45

Title: Process Development of PF-04240791, a Drug Candidate of SPT Inhibitor
Dr. Yong Tao, Associate Research Fellow, Research API, Pfizer Global R&D, USA

11:45-12:10

Speech Opportunity Available

Chair:

Dr. Antonio Delgado-Almeida, Professor, Emeritus Fellow, American Heart Association, USA

10:30-10:55

Title: Challenges and Opportunities for Discovery and Development of Novel Antihypertensive Drugs
Dr. Peter U. Feig, Senior Director, Merck Research Laboratories, Merck & Co. Inc., USA

10:55-11:20

Title: Erythrocyte K Transport and Hemoglobin-Oxygen Binding: A Novel Drug Discovery for Hypertensives with LVH and CAD
Dr. Antonio Delgado-Almeida, Professor, Emeritus Fellow, American Heart Association, USA

11:20-11:45

Title: L-arginine Transporters in Hypertension: Opportunities for Development of Novel Therapeutic Targets
Dr. Niwanthi Rajapakse, CJ Martin Fellow (NHMRC), Department of Physiology, Monash University, Australia

11:45-12:10

Title: Successful Translation from Rodents to Humans of a Novel Drug targeting Hypertensive Genetic Abnormalities
Dr. Giuseppe Bianchi, Professor, Division of Nephrology Dialysis and Hypertension, S. Raffaele Hospital, Italy

Chair:

Dr. Xi-Long Zheng, Associate Professor and Senior Scholar of Alberta Heritage Foundation for Medical Research, Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta, The University of Calgary, Canada 

Co-Chair:

Dr. Bing-Hua Jiang, Professor of Medicine, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA

13:30-13:55

Title: Akt/mTOR Signaling Pathway in Tumor Angiogenesis
Dr. Bing-Hua Jiang, Professor of Medicine, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA

13:55-14:20

Title: The Regulation of Vascular Smooth Muscle Functions by microRNA1
Dr. Xi-Long Zheng, Associate Professor and Senior Scholar of Alberta Heritage Foundation for Medical Research, Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute of Alberta, The University of Calgary, Canada

14:20-14:45

Title: Targeting Cholesterol: Redesign Signaling Pathways
Dr. Ching Song, Professor, Member of CNPHARS; University of Science and Technology Beijing, China

14:45-15:10

Speech Opportunity Available

Chair:

Dr. Wellington Gibson Wood, Professor of Pharmacology, University of Minnesota, USA

13:30-13:55

Title: Inhibition of Glutaminyl Cyclase – A new approach to Alzheimer's therapy
Dr. Hans-Ulrich Demuth, Professor, Director Research & Development, Probiodrug AG, Germany

13:55-14:20

Title: Expedited Synthesis of Radiotracers for PET Imaging of Alzheimer’s Disease
Dr. Graham B. Jones, Professor and Chair, Department of Chemistry & Chemical Biology, Northeastern University, USA

14:20-14:45

Title: Multi-Target Drugs For Neurodegenerative Disorders Treatment: Dimebon and Others
Dr. Sergey O. Bachurin, Director of the Institute of Physiologically Active Compounds, Russia

14:45-15:10

Title: The NGF-target Neuron Model to Induce and Analyze an Alzheimer-like Molecular Syndrome
Dr. Pietro Calissano, Vice President, European Brain Research Institute; Rome Full Professor of Neurophysiology, II University of Roma, Italy

15:10-15:30

Coffee Break

15:30-15:55

Title: Clinical Development of a Novel Drug Targeting Alzheimer’ Disease
Dr. Xiaolu Wang, Senior Scientist & Project leader, Evotec AG, Germany

15:55-16:20

Title: Discovery of New Chemical Entities (NCEs) with Memory Enhancing Potential
Dr. Ruchi Malik, Professor and Associate Dean, Department of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, India

16:20-16:45

Title: Cotinine: A Multiple Action Drug against Alzheimer’s Disease
Dr. Valentina Echeverria Moran, Scientist, VA Healthcare System, Assistant Professor, University of South Florida, USA

16: 45-17:10

Title: New Paradigm Drug Candidate, Catalytic Drug Candidate against A-beta
Keunhong Jeong, Professor, Department of Chemistry, Korea Military Academy, Korea

17:10-17:35

Title: Statins and Alzheimer's Disease
Dr. Gail Li, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, USA

17:35-18:00

Title: Regulation of the HMG-CoA Reductase Pathway in Brain of Alzherimer’s Patients: Specific Targeting of Isoprenoids but not Cholesterol
Dr. Wellington Gibson Wood, Professor of Pharmacology, University of Minnesota, USA

Chair:

Dr. Vincent Mutel, CEO, Addex Pharmaceuticals Ltd, Switzerland

Co-Chair:

Dr. Paolo Carloni, Full Professor, German Research School for Simulation Sciences GmbH, Germany

13:30-13:55

13:55-14:20

Title: Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
Dr. Paolo Carloni, Full Professor, German Research School for Simulation Sciences GmbH, Germany

14:20-14:45

Title: 14-3-3 Isoforms and Phosphorylation-dependent Interaction with Proteins Involved in Neurodegenerative Disease
Dr. Alastair Aitken, Professor of Protein Biochemistry, University of Edinburgh, ISB, School of Biological Sciences, UK

14:45-15:10

15:10-15:30

Coffee Break

15:30-15:55

Title: Transcriptome and Proteome of PD Patient Cells and Mouse Models
Dr. Georg Auburger, Associate Professor, Goethe University Frankfurt/M, Germany

15:55-16:20

Title: Therapeutic Potential of Curcumin and it Conjugates in Parkinson's Disease and their Molecular Mechanism of Action
Dr. Krishna Misra, Hony Professor in Chemistry department University of Allahabad Allahabad; Coordinator, Indo-Russian Centre for Biotechnology, Indian Institute of Information Technology-A, India

16:20-16:45

16:45-17:10

Speech Opportunity Available

Chair:

08:30-08:55

Title:      New Therapeutic Strategies for Down Syndrome - Lessons Learned for Alzheimer’s Disease
Dr. Ahmad Salehi, Clinical Associate Professor, Department of Psychiatry, VA Palo Alto Health Care System, Stanford Medical School, USA

08:55-09:20

Title: Melatonin: It’s Efficacy in Targeting Alzheimer’s Disease
Dr. Russel J. Reiter, Professor, Department of Cellular & Structural Biology, UT Health Science Center, USA

09:20-09:45

Title: Mitochondrial Transition Pore is a  Therapautic Target for Alzheimer's Disease
Dr. ShiDu Yan, Professor of Clinical Pathology, Columbia University College of Physicians & Surgeons, USA

09:45-10:10

10:10-10:30

Coffee Break

10:30-10:55

Title: TBD
Dr. Frank Gunn-Moore, Reader, Department of Neuroscience and Cell biology, School of Biology, University of St Andrews, UK

10:55-11:20

Title: The Molecular Neuropharmacology and Chinese Medicine Treatment in Healing with Alzheimer's Disease
Dr. Po-Yuan Chen, Assistant Professor, Department of Biological Science and Technology, China Medical University, Member of R. O. C. Biophysics Association, Taiwan

11:20-11:45

11:45-12:10

Speech Opportunity Available

Chair:

Dr. Carmel Armon, Chief, Division of Neurology, Baystate Medical Center, Professor of Neurology, Tufts University School of Medicine, USA

8:30-8:55

Title: Therapeutic Benefits of Intrathecal Protein Therapy in a Mouse Model of Amyotrophic Lateral Sclerosis
Dr. Koji Abe, Professor and Chairman, Department of Neurpology, Graduate School of Medicine, Dentistry, and Pharmacological Sciences, Okayama University, Japan

8:55-9:20

Speech Opportunity Available

9:20-9:45

Title: Hypothesis: Acquired MicroRNA Changes May Trigger Sporadic ALS Initiation and Spread
Dr. Carmel Armon, Chief, Division of Neurology, Baystate Medical Center, Professor of Neurology, Tufts University School of Medicine, USA

9:45-10:10

Title: Biomarkers in Amyotrophic Lateral Sclerosis
Dr. Vincenzo La Bella, ALS Clinical Research Center, Bio.Ne.C, University of Palermo, Italy

10:10-10:30

Coffee Break

10:30-10:55

Speech Opportunity Available

10:55-11:20

Title: The Neurovascular Link: a Source of Novel Therapies for ALS?
Dr. Koen Poesen, Laboratory of Molecular Cell Biology, Katholieke Universiteit Leuven, Belgium

11:20-11:45

Speech Opportunity Available

11:45-12:10

Speech Opportunity Available

Chair:

Dr. Erik Hessen, Chief Psychologist, Department of Neurology, Akershus University Hospital, Norway

13:30-13:55

13:55-14:20

Title: Improvement in Verbal Memory after Withdrawal of Carbamazepine and Valproate in Well-controlled Epilepsy Patients: a Randomized, Double-Blind Study
Dr. Erik Hessen, Chief Psychologist, Department of Neurology, Akershus University Hospital, Norway

14:20-14:45

Title: Targetting Neuropeptides in Epilepsy
Dr. Alfred Meurs, Department of Pharmaceutical Chemistry, Drug Analysis, and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Belgium

14:45-15:10

Speech Opportunity Available

Chair:

Co-Chair:

Call for Co- Host

15:30-15:55

Keynote Speech
Title: Engineering Multifunctional Biologics for Diabetes
Dr. Michael R. Hanley, Chief Scientific Officer, Amylin Pharmaceuticals, Inc., USA

15:55-16:20

Title: Hypothalamic Regulation of Energy Balance, Glucose Homeostasis and Hepatic Lipid Metabolism
Dr. Allison W. Xu, Assistant Professor, Diabetes Center, University of California San Francisco, USA

16:20-16:45

Title: Antihypertensive Treatment with Beta-Blockers in the Metabolic Syndrome
Dr. Angelo Michele Carella, Department of Internal Medicine, “T. Masselli-Mascia” Hospital, Italy

16:45-17:10

Title: Pathophysiology of Diabetes Mellitus and its Modulation by Drugs
Dr. Manju Sharma, Senior Lecturer, Hamdard University, India

17:10-17:35

Speech Opportunity Available

Chair:

Dr. Nobuhiko Katunuma, Professor, Tokushima Bunri University, Japan

08:30-08:55

Title: Potential Anti-diabetic Effect of Histamine Receptor 3 (H3R) Agonist on the Non-obese Type II Diabetic Goto-Kakizaki Rats
Dr. Ling Kang, Senior Scientist, Diabetes & Obesity Research, Merck Research Laboratories, USA

08:55-09:20

Title: Why we need Second Generation Insulin Sensitizers?
Dr. Mike Cawthorne, Professor, Director of Metabolic Research, Clore Laboratory, University of Buckingham, UK

09:20-09:45

Title: The Broad Spectrum of the Incretin System as Target for Diabetes and Obesity Management
Dr. Luc Van Gaal, Professor of Medicine, Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Belgium

09:45-10:10

Title: L-Tryptophan and Tryptamine as the most Ideal Type-2 Diabetes Drugs
Dr. Nobuhiko Katunuma, Professor, Tokushima Bunri University, Japan

10:10-10:30

Coffee Break

10:30-10:55

Speech Opportunity Available

10:55-11:20

Title: Adult Stem Cells providing a Promising Potential to Generate Insulin - Producing Cells in Canines
Dr. Moghazy Aly Mahgoub, Professor of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University, Egypt

11:20-11:45

Speech Opportunity Available

11:45-12:10

Speech Opportunity Available

Chair:

Co-Chair:

8:30-8:55

Title: CART is a Regulator of Islet Function and a possible Incretin Hormone
Dr. Frank Sundler, Professor, Department of Experimental Medical Science, Lund University, Sweden

8:55-9:20

Title: The Novel Thiazolidinedione Compound BLX-1002 preferentially Potentiates Insulin Secretion in Diabetic, but Not Non-diabetic Animal Models
Dr. Qimin Zhang, Senior Researcher, Research Center, Karolinska Institutet, Sweden

9:20-9:45

Speech Opportunity Available

9:45-10:10

Title: Pharmacogenomics of Pioglitazone
Dr. Sandeep K Mathur, Professor & Head, Department of Endocrinology, S.M.S.Medical College, India

10:10-10:30

Coffee Break

10:30-10:55

Title: Bioconjugated Incretin Analogues for Potential Type 2 Diabetes Therapeutics
Dr. Kang Choon Lee, Professor and Chair, Department of Pharmaceutical Science; Director, Center of Excellence for Future Pharmaceutical Education and Research, SungKyunKwan University, Korea

10:55-11:20

Title: Newere Treatment on Type 2 Diabetes and Metabolic Syndrome
Dr. Shashank S. Shah, Associate Professor, Krishna Institute of Medical Sciences Ltd,, India

11:20-11:45

Title: Bile Acids as New Antidiabetic Drugs
Dr. Momir Mikov, Senior Lecturer, Pharmacy, Health Sciences, University of Otago, New Zealand

11:45-12:10

Speech Opportunity Available

Chair:

13:05-13:30

Title: Understanding Diabetic Complications Using Animal Models
Dr. Jason K. Kim, Professor of Molecular Medicine; Professor of Medicine and Ophthalmology, Division of Endocrinology, Metabolism and Diabetes; Director, UMass Mouse Phenotyping Center, University of Massachusetts Medical School, USA

13:30-13:55

Title: Understanding Diabetic Complications Using Animal Models
Dr. Jason K. Kim, Professor of Molecular Medicine; Professor of Medicine and Ophthalmology, Division of Endocrinology, Metabolism and Diabetes; Director, UMass Mouse Phenotyping Center, University of Massachusetts Medical School, USA

13:55-14:20

Title: Rho Kinase Inhibition for Diabetic Nephropathy - beyond Blood Pressure Control
Dr. Hartmut Ruetten, Head Translational Medicine, R&D Diabetes Division, Sanofi-Aventis Deutschland GmbH, Germany

14:20-14:45

Title: Targeting Ocular Renin-angiotensin System for Diabetic Retinopathy- Novel Mechanisms and Therapy
Dr. Qiuhong Li, Associate Professor, Department of Ophthalmology, University of Florida, USA

14:45-15:10

Title: Diabetic Vascular Complications: A real need for a specific treatment
Dr. Hany El-Bassossy, Lecturer of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt

Chair:

Dr. Martin H. Bluth, Associate Professor of Pathology, Director of Translational Research, Wayne State University School of Medicine, Detroit Medical Center, USA

15:30-15:55

Title: Clinical Islet Transplantation in Japan
Dr. Takashi Kenmochi, Chairman of Department of Surgery & Director of Clinical Research Center, Chiba-East National Hospital, National Hospital Organization (NHO), Japan

15:55-16:20

Speech Opportunity Available

16:20-16:45

Title: Synergy between Natural Product and Oral Hypoglycemic Drugs in Glucose Uptake
Dr. Mukesh Doble, Professor, Department of Biotechnology, Indian Institute of Technology Madras, India

16:45-17:10

Title: From the Beduin Tent to the Laboratory Bench: Anti-diabetic Activity of Sarcopoterium Spinosum
Dr. Tovit Rosenzweig, Ariel University Center of Samaria, Israel

17:10-17:35

Chair:

Dr. Linus Lin, Senior Research Fellow, Department of Medicinal Chemistry, Merck Research Laboratories, USA

8:30-8:55

Speech Opportunity Available

8:55-9:20

Title: Discovery of MK-5046, a BRS-3 agonist for the Treatment of Obesity through both Food Intake Reduction and Metabolic Rate Increase
Dr. Linus Lin, Senior Research Fellow, Department of Medicinal Chemistry, Merck Research Laboratories, USA

9:20-9:45

Title: TBD
Dr. Régis Roche, University of La Réunion Saint-Denis Messag Cedex, France

9:45-10:10

Title: Therapeutic Application of Diacylglycerol for Obesity and Obesity-related Metabolic Disorders
Dr. Hidekatsu Yanai, The Head Physician, Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, National Center for Global Health and Medicine, Kohnodai Hospital, Japan

10:10-10:30

Coffee Break

10:30-10:55

Title: The Role of Maternal Adipose Tissue during Pregnancy
Dr. George Mastorakos, Associate Professor of Endocrinology, Athens University School of Medicine, Greece

10:55-11:20

Speech Opportunity Available

11:20-11:45

Speech Opportunity Available

11:45-12:10

Speech Opportunity Available

Chair:

Dr. Michael Roth, Professor, Head, Pulmonary Cell Research, University Hospital Basel, Switzerland

13:30-13:55

Title: Can Mast Cells and Lymphoid Tissue be New Targets in the Therapy of COPD?
Dr. Claes-Goran Lofdahl, Professor, Head of Department of Respiratory Diseases and Allergology, Lund University, Sweden

13:55-14:20

Title: New Aspects on Asthma and COPD Therapies
Dr. Michael Roth, Professor, Head, Pulmonary Cell Research, University Hospital Basel, Switzerland

14:20-14:45

Title: New Inhaled Steroids –Ideal Kinetic and Deposition Parameters
Dr. Andrzej M. Fal, Professor & Chair, Department of Public Health, Division of Allergology, Wroclaw Medical University, Poland

14:45-15:10

Speech Opportunity Available

15:10-15:30

Coffee Break

15:30-15:55

Speech Opportunity Available

15:55-16:20

Title: Potential Therapeutic Targets and Strategies for COPD
Dr. Richard Li-Cher LOH, Professor of Medicine & Chest Physician, Head, Department of Medicine, Penang Medical College, Malaysia

16:20-16:45

Title: Arginase: Master Switch in Allergic Athma?
Dr. Harm Maarsingh, Lecturer, Department of Molecular Pharmacology, University of Groningen, The Netherlands

16:45-17:10

Speech Opportunity Available

Chair:

Dr. A. El-Shazly, Professor of Rhinology, Liege University Hospital, Belgium

08:30-08:55

Title: Looking to the Future: Clinical Research Pipeline for Respiratory Indications (Allergy, Asthma and COPD)
Dr. Paul H Ratner, Assistant Professor of Pediatrics, University of Texas Health Science Center at San Antonio; Medical Director of Sylvana Research, USA

08:55-09:20

Speech Opportunity Available

09:20-09:45

Speech Opportunity Available

09:45-10:10

Title: Receptors, Co-receptors and Protein Kinases are all Potential Therapeutic Targets for Allergic Eosinophilic Airway Inflammation
Dr. A. El-Shazly, Professor of Rhinology, Liege University Hospital, Belgium

Chair:

Dr. Wai Keung Tam, Senior Clinical Lecturer, Hon. Consultant Nephrologist, Imperial College Kidney and Transplant Institute, UK

Co-Chair:

Dr. Kazuyuki Yoshizaki, Professor, Center for Advanced Science and Innovation, Osaka University, Japan

13:30-13:55

Title: Inhalation Delivery Approaches form Lung Cancer Treatment
Dr. Mandip Singh Sachdeva, Professor of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, USA

13:55-14:20

Title: Spleen Tyrosine Kinase Inhibitor Reverses Pathological Changes in Experimental Glomerulonephritis
Dr. Wai Keung TAM, Senior Clinical Lecturer, Hon. Consultant Nephrologist, Imperial College Kidney and Transplant Institute, UK

14:20-14:45

Title: Protein S-glutathionylation as an Anti-inflammatory Strategy for Vascular Diseases
Dr. Being-Sun Wung, Associate Professor, Department of Microbiology and Immunology, National Chiayi University, Taiwan

14:45-15:10

15:10-15:30

Coffee Break

15:30-15:55

Title: Multiplex Cytokine Assay for Evaluating Anti-Inflammatory Effect of Herbal Medicine
Dr. Wansu Park, Professor, Department of Pathology, College of Oriental Medicine, Kyungwon University, Korea

15:55-16:20

Title: Newer Heterocycles as Anti-inflammatory Agents
Dr. Maninder Minu, Assistant Professor, Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, India

16:20-16:45

Title: Development and Function of an IL-6 Blocking Antibody, Tocilizumab, as an Anti-inflammatory Drug
Dr. Kazuyuki Yoshizaki, Professor, Center for Advanced Science and Innovation, Osaka University, Japan

16:45-17:10

Title: Discovery of Anti-inflammatory Natural Compouds from Herbal Plants by Activity-guided Purification
Dr. Young Whan Choi, Professor,Department of Horticultural Science, Pusan National University, South Korea

Speech Opportunity Available

Chair:

Dr. Jens D. Mikkelsen, Senior Scientist, Neurobiology Research Unit, 9201, Head, Department of Translational Neurobiology, NeuroSearch A/S, Denmark

13:30-13:55

13:55-14:20

14:20-14:45

14:45-15:10

Chair:

Dr. Torgny Svensson, Professor of Pharmacology, A Member of the Nobel Assembly at the Karolinska Institutet, Past President of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Sweden

Co-Chair:

Dr. Mohammed Shahid, Senior Scientist, Schering-Plough Research Institute, UK

08:30-08:55

Title: Combined Utility of Antipsychotic and Antidepressant Drugs: Scientific Rationales
Dr. Torgny Svensson, Professor of Pharmacology, A Member of the Nobel Assembly at the Karolinska Institutet, Past President of the Collegium Internationale

08:55-09:20

Title: Would Mirtazapine Added to Antipsychotics Challenge Clozapine?
Dr. Joffe Grigori, Psychiatrist-in-Chief, Helsinki University Central Hospital, Finland

09:20-09:55

Title: Molecular Imaging of Psychotropic Drug Mechanisms in Human – Recent Learnings from Quetiapine
Dr. Svante Nyberg, Principal Physician, Global Clinical Development, Neuroscience TA, AstraZeneca, Sweden

09:55-10:10

Speech Opportunity Available

10:10-10:30

Coffee Break