BIT Life Sciences’ 8th Annual Congress of International Drug Discovery Science and Technology (IDDST) Theme: Supporting Systems for Major Innovative Drugs Time: October 23-26, 2010 Venue: Beijing International Convention Center (BICC), Beijing, China Website: http://www.iddst.com/2010

NOTE: IDDST2010 is comprised of TEN Chapters and One Inaugurate Symposium designed to offer comprehensive sessions that address current issues in Drug Discovery Science and Technology. You can register a whole conference or select a single track or register for special service package that you want for your participation. Now the program is under developing from viewing submitted abstracts. Proposed topics or related as below are accepted. Abstract Submission LANGUAGE NOTE: This meeting will be conducted in English.

Scientific Program

Opening Ceremony and Keynote Forum Opening Addresses Welcome Speeches from Organizers Executive Representative from Local Governmental Officers Governmental Regulatory Officers Industrial Leaders in Drug Discovery and Development on Major Diseases Leading Scientists in Drug Discovery

Keynote Forum Time: October 23, 2010, Saturday, 08:20-11:45 Place: Room No. 2, 2F, BICC, Beijing, China Opening Ceremony Moderator   Dr. Ming-Q Zhang, VP/CTO, Roche R&D China, China 08:20-08:40 Group Photo(Place: Gate of BICC) 09:00-09:05 Chair' s Opening Remark 09:05-09:35 VIP' s Address Keynote Forum 09:40-10:05   Title: Signals and Signalling Molecules in the Central Nervous System Dr. Erwin Neher, Nobel Prize Laureate in Physiology or Medicine 1991, Max Planck Institute for Biophysical Chemistry, Germany 10:05-10:30   Title: Investigation of Oxidative Stress at Single Cells with Ultramicroelectrodes: A New Platform for Drug Testing Dr. Christian Amatore, Director of the Research Unit “PASTEUR”, CNS Full Professor, CNRS, ENS and UPMC, France 10:30-10:55   Title: Current Targets in Resp Disease and Next Generation Resp Medicines Dr. Bertil Lindmark, Vice President and Head Clinical Division AstraZeneca KK, Japan 10:55-11:20 Title: Innovation Driven Collaborative Research – Future for CRO Dr. Andreas Tschirky, Leader of BioDuro, A PPD® Company, China 11:20-11:45   Title: Opportunities for R&D innovation in China and Asia Dr. Steve Yang, Vice President and Head of R&D in Asia, Pfizer, USA 18:30-20:30 Welcome Banquet and Art Performance

Chapter 1: Basic Sciences and Technologies of Drug Discovery

Section 1-1: Oncology and Drug Discovery (Part I) Time: October 23, 2010, Saturday, 13:30-17:35 Place: Room No. 301, 3F, BICC

Chair: Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada Co-Chair: Dr. Wanguo Liu, Associate Professor, Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, USA 13:30-13:55 Title: Belinostat a Novel HDAC Inhibitor Dr. Rajesh C Shrotriya, Chairman and CEO, Spectrum Pharmaceuticals, Inc.,  USA 13:55-14:20 Title: Natural Polyphenols in the Treatment of Cancer-preclinical Investigations Dr. Jose M Estrela, Scientific Director, Green Molecular S.L., University of Valencia, Spain 14:20-14:45 Title: Targeting a Novel AHI-1-BCR-ABL-JAK2 Interaction Complex in Chronic Myeloid Leukemia Stem/Progenitor Cells Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada 14:45-15:10 Title: A Novel Wnt Signaling Target as an Attractive Candidate for Drug Targeting in Colorectal Cancer Dr. Wanguo Liu, Associate Professor, Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, USA 15:10-15:30 Coffee Break 15:30-15:55 Title: Cancer Stem Cells as Therapeutic Targets Dr. Dean G. Tang, Professor, Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, USA 15:55-16:20 Title: Mechanisms of Apoptosis Induction by Novel and Classical Taxanes in Sensitive and Resistant Cancer Cells Dr. Jan Kovar, Professor and Head, Department of Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Czech Republic 16:20-16:45 Title: Targeting CREB-CBP Interaction as a Novel Strategy for Cancer Therapy Dr. Xiangshu Xiao, Assistant Professor, Department of Physiology and Pharmacology, Oregon Health & Science University, USA 16:45-17:10 Title: In Vitro Anti-leukaemia Activity of Pyrrolo[1,2-b][1,2,5]Benzothiadiazepines (PBTDs) Dr. Gabriella Marfe, Molecular Biologist, Department of Experimental Medicine and Biochemical Sciences, College of Medicine, University of Rome "Tor Vergata", Italy 17:10-17:35 Title: A Powerful Genetic Strategy to Screen for Inhibitors of Map Kinase Signaling and Its Application to Genomic Drug Discovery Dr. Reiko Sugiura, Professor, School of Pharmaceutical Sciences, Kinki University, Japan

Section 1-1: Oncology and Drug Discovery (Part II) Time: October 24, 2010, Sunday, 13:30-17:35 Place: Room No. 305C, 3F, BICC

Chair: Dr. Hwa-Chain Robert Wang, Professor, Comparative Medicine Department, College of Veterinary Medicine, University of Tennessee, USA 13:30-13:55 Title: Percutaneous Thermal Ablation of Advanced Hepatocellular Carcinoma in Patients with Cirrhosis Dr. Antonio Giorgio, Professor, Director of Infectious Diseases and Interventional Ultrasound Unit, D. Cotugno Hospital, Italy 13:55-14:20 Title: Development of Cancer Chemopreventive Agents on Betulonic Acid Platform Dr. Irina Sorokina, Senior Scientist, Laboratory of Pharmacological Researches, N.N.Voroztsov Institute of Organic Chemistry SB RAS, Russia 14:20-14:45 Title: ROS-mediated Selective Apoptosis of Oncogenic Ras-expressing Cancer Cells Dr. Hwa-Chain Robert Wang, Professor, Comparative Medicine Department, College of Veterinary Medicine, University of Tennessee, USA 14:45-15:10 Title: The Role of Drug Combination, Metabolism, Pharmacokinetics, Transport and Growth Factors on the Anticancer and Toxic Effects of Classical and New Generation Taxanes in Man, Animals and Tumor Cell Lines Dr. Ivan Gut, Senior Scientist, National Institute of Public health Biotransformation Group, Czech Republic Funding and support by IGA MHCZ: Internal Grant Agency of the Ministry of Health, Czech Republic, Grant No. NS/9803-4 15:10-15:30 Coffee Break 15:30-15:55 Title: The Four-decade War on Cancer: Are We Winning? Why? And How to Win Dr. Lee Jia, Senior Project Officer, Developmental Therapeutics Program,National Cancer Institute/NIH, USA 15:55-16:20 Title: The Anti-tumor Effects of Alkaloids from the Seeds of Strychnos Nux-vomica on HepG2 Cells and its Possible Mechanism Dr. Xunkun Deng, Director, South-Central University for Nationnalities, China 16:20-16:45 Title: Cytochromes P450 as Targets for Drug Development Dr. Klaus Pors, Lecturer in Medicinal Chemistry, Institute of Cancer Therapeutics, University of Bradford, UK 16:45-17:10 Title: Magnetic Anti-cancer Drug for Hyperthermal and Chemotherapy Dr. Yoshihiro Ishikawa, Professor and Chair, Cardiovascular Research Institute, Graduate School of Medicine, Yokohama City University, Japan 17:10-17:35 Title: Modulation of Insulin-like Growth Factor-I Receptor Signalings by Anti-cancer Agent HSP90 Inhibitors Dr. Toshihiko Yanagita, Associate Professor, Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Japan

Section 1-1: Oncology and Drug Discovery (Part III) Time: October 25, 2010, Monday, 08:30-12:10 Place: Room No. 305B, 3F, BICC

Chair: Dr. Yi-Qiang (Eric) Cheng, Associate Professor, Department of Biological Sciences, Department of Chemistry and Biochemistry, University of Wisconsin – Milwaukee, USA Co-Chair: Dr. Guoli Zhang, Director, The Laboratory of Biotechnological Application, The Military Veterinary Institute, Academy of Military Medical Sciences, China 08:30-08:55 Title: The Current Status of Anticancer Drugs Discovery and Development in World Wide Dr. Changnian Liu, Senior Vice President, Pharmaron, Inc., USA 08:55-09:20 Title: Platform for Discovery and Combinatorial Biosynthesis of Histone Deacetylase Inhibitors as Anticancer Agents Dr. Yi-Qiang (Eric) Cheng, Associate Professor, Department of Biological Sciences, Department of Chemistry and Biochemistry, University of Wisconsin – Milwaukee, USA 09:20-09:45 Title: Identification of a Potent and Selective Cofactor Binding Inhibitor of the Estrogen Receptor Alpha Dr. Koen Dechering, Section Head Nuclear Receptors, Department of Molecular Pharmacology, Merck Research Laboratories, The Netherlands 09:45-10:10 Title: Repurposing: Convert an Old Anti-alcoholism Medicine into Cancer Therapeutics Dr. Weiguang Wang, Associate Professor, Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, UK 10:10-10:30 Coffee Break 10:30-10:55 Title: Fusion Protein of the Luteinizing Hormone Releasing Hormone and Pseudomonas Aeruginosa Exotoxin A as a New Drug for Cancer Therapy Dr. Guoli Zhang, Director, The Laboratory of Biotechnological Application, The Military Veterinary Institute, Academy of Military Medical Sciences, China 10:55-11:20 Title: Targeting the Tumor Microenvironment Dr. Mark Pines, Senior Scientist, Institute of Animal Science, ARO, Volcani Center, Israel 11:20-11:45 Title: Anti EGFR Combined with Irinotecan for Treatment of Elderly Patients with Metastatic Colorectal Cancer Dr. Sherif Abdelwahab, Associate Professor of Clinical Oncology, Ain Shams University, Egypt 11:45-12:10 Title: HER2 Induces the Binding with GEP100 and the Activation of Arf6 to Promote Cancer Invasion and Metastasis Dr. Toshi Menju, Research Associate, Department of Thoracic Surgery, Gradutate School of Medicine, Kyoto University, Japan

Section 1-2: Endocrinology and Drug Discovery Time: October 24, 2010, Sunday, 08:30-10:55 Place: Room No. 305A, 3F, BICC

Chair:    Dr. Huixiao Hong, Senior Scientist, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, USA Co-Chair: Dr. Donna Seto-Young, Director of Endocrinology & Metabolism Laboratory, Associate Professor of Medicine, Albert Eintein College of Medicine, Beth Israel Medicine, USA 08:30-08:55 Keynote Speech Title: Drug or Endocrine Disruptor Structure Analysis of Estrogen Receptor Binding Chemicals Dr. Huixiao Hong, Senior Scientist, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, USA 08:55-09:20 Title: Thiazolinediones Inhibit Bone Formation Dr. Donna Seto-Young, Director of Endocrinology & Metabolism Laboratory, Associate Professor of Medicine, Albert Eintein College of Medicine, Beth Israel Medicine, USA 09:20-09:45 Title: Influence of Insulin Sensitizers on Polycystic Ovary Syndrome Outcome Dr. Daniela Jakubowicz,Professor of Medicine & Endocrinology, Virginia Commonwealth University, USA; Professor of Medicine VCU, Wolfson Hospital  University of Tel Aviv, Israel 09:45-10:10 Title: Endocrinal Functions of Sulfotransferases Dr. Guangping Chen, Associate Professor, Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, USA 10:10-10:30 Coffee Break 10:30-10:55 Title: Neural Regulation of Glucose Dependent Insulinotropic Peptide Secretion Dr. Maria Yavropoulou, Endocrinologist, Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, Greece

Section 1-3: Personalized Medicine and Drug Discovery Time: October 24, 2010, Sunday, 08:30-11:20 Place: Room No. 305B, 3F, BICC

Chair: Dr. Neil K. Warma, President & CEO, Opexa Therapeutics, Inc., USA Co-Chair: Dr. Jenny Liao Persson, Head of the Experimental Cancer Research, Clinical Reasearch Center, Lund University, Sweden 08:30-08:55 Title: Tovaxin®: A Personalized Autologous Immunotherapy for the Treatment of Multiple Sclerosis Dr. Neil K. Warma, President & CEO, Opexa Therapeutics, Inc., USA 08:55-09:20 Title: Tracer Induced Therapy in Cancer Dr. Manfred George Krukemeyer, Professor, Department of Radio-Oncology, Paracelsus-Hospital, Germany 09:20-09:45 Title: Nanomagnetic Sensing System and Biomarker Quantification for Personal Medicine Dr. Jian-Ping Wang, Professor, Electrical and Computer Engineering Department, University of Minnesota; Associate Director, The Center for Micromagnetics and Information Technologies (MINT), USA 09:45-10:10 Title: Personalized Genotype-guided Anticoagulant and Anti-aggregant Therapy Dr. Ronen Loebstein, Head, Institute of Clinical Pharmacology & Toxicology, Sheba Medical Center, Israel 10:10-10:30 Coffee Break 10:30-10:55 Title: Identification and Development of Biomarkers for Targeted and Effective Delivery of Therapies and for Predicting Drug Risk for Treatment of Metastatic Cancer Dr. Jenny Liao Persson, Head of the Experimental Cancer Research, Clinical Reasearch Center, Lund University, Sweden 10:55-11:20 Title: Cancer Chemo-gene Therapy Using Target Molecule-inhibiting Vectors Against Anti-tumor Drug Resistant Tumors Dr. Cheng-long Huang, Associate Professor, Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Japan

Section 1-4: Pharmacology and Drug Discovery Time: October 24, 2010, Sunday, 13:30-15:55 Place: Room No. 305A, 3F, BICC

Chair: Dr. Paul B. Tchounwou, Associate Dean & Presidential Distinguished Professor, Director, NIH RCMI-Center for Environmental Health, College of Science, Engineering & Technology, Jackson State University, USA Co-Chair: Dr. Georgi V. Petkov, Associate Professor of Pharmacology, University of South Carolina, USA 13:30-13:55 Title: Pharmacokinetics in the Design of Proof of Concept and Phamacodynamic Studies in Drug Discovery Dr. Norman Huebert, Team Leader, ADME, J&J PRD, USA 13:55-14:20 Title: Trisenox Modulation of p53, c-fos, RARE, Cyclin A and Cyclin D Expression in Human Leukemia (HL60) Cells Dr. Paul B. Tchounwou, Associate Dean & Presidential Distinguished Professor, Director, NIH RCMI-Center for Environmental Health, College of Science, Engineering & Technology, Jackson State University, USA 14:20-14:45  Title: Calcium-activated Potassium Channels as Novel Pharmacological Targets for Overactive Bladder Dr. Georgi V. Petkov, Associate Professor of Pharmacology, University of South Carolina, USA 14:45-15:10 Title: Targeting Signal Compartmentalization and Enzyme Allostery for New Drug Development Dr. Bing Zhu, Assistant Professor, Department of Pharmacology, University of South Alabama, USA 15:10-15:30 Coffee Break 15:30-15:55 Title: Assessment of Antioxidant Property for Development of Drugs Using by Electron Spin Resonance (ESR) Spectroscopy Dr. Masaichi-Chang-il Lee, Professor and Acting Chairman, Department of Critical Care Medicine, Division of Pharmacology, Kanagawa Dental College, Japan

Section 1-5: Neurosciences and Drug Discovery (Part I) Time: October 24, 2010, Sunday, 13:30-17:10 Place: Room No. 305B, 3F, BICC

Chair: Dr. Wandong Zhang, Senior Research Officer/Adjunct Professor (University of Ottawa), Institute for Biological Sciences, National Research Council of Canada, Canada Co-Chair:   Dr. Sonja Stoelzle, Senior Scientist, Nanion Technologies GmbH, Germany 13:30-13:55 Title: Excitement over Automated Patch Clamp: Action Potentials of Stem Cell-derived Cardiomyocytes and Heat Activation of TRPV1 Dr. Sonja Stoelzle, Senior Scientist, Nanion Technologies GmbH, Germany 13:55-14:20 Title: Testing the Effects of Drugs on Brain Connectivity : A New Data Processing Method Dr. Xavier Noguès, Professor, Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, France 14:20-14:45 Title: Effects of a Novel Chinese Herbal Formula on Neuroprotection and Neurorestoration after Spinal Cord Injury in Rats Dr. Shucui Jiang, Associate Professor, Head of Hamilton NeuroRestorative Group (NRG), Department of Surgery (Neurosurgery, Neuroscience and Neurobiology), McMaster University, Canada 14:45-15:10 Title: Influence of Transgenic Neurotrophic Factors on the Development of Mammalian Neural Tissue Dr. Galina Pavlova, Head, Group of Developmental Genetics and Neurogenetics, Institute of Gene Biology, Russia 15:10-15:30 Coffee Break 15:30-15:55 Title: Targetting Altered Cholesterol Metabolism for Alzheimer's Dsiease Dr. Wandong Zhang, Senior Research Officer/Adjunct Professor (University of Ottawa), Institute for Biological Sciences, National Research Council of Canada, Canada 15:55-16:20 Title: Depression and Neurogenesis; Implications for Balancing the Scales of Emotion and Memory Dr. William Ogle, Assistant Professor, Pruitt Family Department of Biomedical Engineering, Evelyn F. and William L. McKnight Brain Institute, Institute on Aging, University of Florida, USA 16:20-16:45 Title: Novel Approach to Treat Neurodegenerative Diseases Dr. Eunsook Lee, Assistant Professor, Meharry Medical College, USA 16:45-17:10 Title: Neu2000, An NR2B Selective, Moderative NMDA Antagonist and Potent Spin Trapping Molecule, Paves the Way for New Stroke Therapy Dr. Byoung Joo Gwag, Professor, Department of Pharmacology, Ajou University School of Medicine, Korea

Section 1-5: Neurosciences and Drug Discovery (Part II) Time: October 25, 2010, Monday, 13:30-15:10 Place: Room No. 305A, 3F, BICC

Chair: Dr. Francis Choy, Professor, Department of Biology, Centre for Biomedical Research, University of Victoria, Canada Co-Chair: Dr. Naiming Zhou, Professor, College of Life Sciences, and College of Pharmaceutical Sciences, Zhejiang University, China 13:30-13:55 Title: Peptide and Protein Neurotoxins: Mapping Binding Sites in Ion Channels and Ways to New Drugs Dr. Victor Tsetlin, Professor, Corresponding Member of the Russian Academy of Sciences, Humboldt Awardee; Head of the Department of Molecular Basis of Neurosignaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia 13:55-14:20 Title: Expression of Human Recombinant Fusion N-acetylglucosaminidase-PTD for Potential Therapeutic Treatment of Sanfilippo Syndorme Dr. Francis Choy, Professor, Department of Biology, Centre for Biomedical Research, University of Victoria, Canada 14:20-14:45 Title: Identification and Functional Characterization of ZEL-H16, A Novel Partial Agonist of Human Histamine H3 Receptor Dr. Naiming Zhou, Professor, College of Life Sciences, and College of Pharmaceutical Sciences, Zhejiang University, China 14:45-15:10 Title: New Radiopharmaceuticals in Diagnosis of Alzheimer Disease Dr. Elzbieta Mikiciuk-Olasik, Professor of Pharmacy, Head of Department of Pharmaceutical CHemistry and Drug Analyses, Medical University of Lódz, Poland

Section 1-6: Toxicology, Drug Safety Evaluation and Drug Discovery Time: October 25, 2010, Monday, 15:30-17:35 Place: Room No. 305A, 3F, BICC

Chair: Dr. Michael Swedberg, Associate Director, Safety Pharmacology, AstraZeneca R&D, Sweden Co-Chair: Dr. Rosemarie Lichtner, Principal Scientist, PMI Research & Development, Philip Morris Research Laboratories GmbH, Germany 15:30-15:55 Title: Drug Abuse and Dependence Liability Assesment in Safety Pharmacology Dr. Michael Swedberg, Associate Director, Safety Pharmacology, AstraZeneca R&D, Sweden 15:55-16:20 Title: Cardiovascular Safety: How to Develop Risk Assessments Dr. Jufeng Wang, Chief Scientific Officer, Waylandgreen, Inc., USA 16:20-16:45 Title: Explorative Toxicological Assessment of Consumer Products Dr. Rosemarie Lichtner, Principal Scientist, PMI Research & Development, Philip Morris Research Laboratories GmbH, Germany 16:45-17:10 Title: Direct Measurement of the QT Interval in Stem Cell Derived Cardiomyocytes for the Assessment of QT Liability Dr. Yasuyuki Asai, CTO, ReproCELL, Japan 17:10-17:35 Title: Optimum Patient Care Through Appropriate Drug Safety Monitoring Dr. Dhanalakshmi Iyer, IP Consultant, Vidarbha Youth Welfare Society, Institute of Pharmaceutical Education and Research, India

Section 1-7: Formulation in Drug Discovery Time: October 25, 2010, Monday, 08:30-12:10 Place: Room No. 305A, 3F, BICC

Chair: Dr. Elizabeth Kwong, Senior Scientific Director, Basic Pharmaceutical Sciences, Merck & Co., USA Co-Chair: Dr. Yingqing Ran, Scientist, Small Molecule Pharmaceutics, Genentech, Inc., USA 08:30-08:55 Keynote Speech Title: Significance of Formulation Development to Support Drug Discovery Dr. Elizabeth Kwong, Senior Scientific Director, Basic Pharmaceutical Sciences, Merck & Co., USA 08:55-09:20 Title: Investigation of Different Formulations for Drug Delivery through the Nail Plate Dr. Ivana Vejnovic, Industrial Pharmacy Lab, Department of Pharmaceutical Sciences, University of Basel, Switzerland 09:20-09:45 Title: Transcriptional Regulation of Glyco-genes by Apoptotic Agents: Potential Therapy for Breast and Colon Cancers Dr. Subhash C. Basu, Professor, Department of Chemistry and Biochemistry, University of Notre Dame, USA 09:45-10:10 Title: In Situ Gel Formulations for the Effective Treatment of Vaginal Candidiasis Dr. Esra Baloglu, Associate Professor, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Turkey 10:10-10:30 Coffee Break 10:30-10:55 Title: Spray-dried Amorphous Dispersion in Drug Discovery Dr. Yingqing Ran, Scientist, Small Molecule Pharmaceutics, Genentech, Inc., USA 10:55-11:20 Title: Formulation Strategies to Enhance Protein and Peptide Drugs Oral Bioavailability Dr. Jingyuan Wen, Senior Lecturer in Pharmaceutics, School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand 11:20-11:45 Title: Polymers Act as a Scaffold of Functional Peptides Dr. Chie Kojima, Assistant Professor, Nanoscience and Nanotechnology Research Center, Research Institutes for the Twenty First Century, Osaka Prefecture University, Japan 11:45-12:10 Title: Lipid Nanoparticles for Improved safety and Enhanced Targeting to deeper skin layers for treatment of Atopic Dermatitis , Dr. K. K. Singh, Professor in Pharmaceutics, C. U. Shah College Of Pharmacy, SNDT Women's University, India

Section 1-8: Stem Cell and Regenerative Medicine Time: October 24, 2010, Sunday, 15:55-16:45 Place: Room No. 305A, 3F, BICC

Chair: Dr. Sachin S. Devi., Director, Laboratory of Experimental and Clinical Toxicology, Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA 15:55-16:20 Title: Understanding Liver Regeneration to Treat Liver Failure Dr. Sachin S. Devi., Director, Laboratory of Experimental and Clinical Toxicology, Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA 16:20-16:45 Title: A PLAG1 Transgenic Mouse Model to Assess the Importance of Number and Balance of Endocrine Hormonal Cells for Stem Cell Based Therapy of Diabetes Dr. Jeroen Declercq, Postdoctoral Fellows, Laboratory for Molecular Oncology, Department of Human Genetics, Katholieke Universiteit Leuven, Belgium

Section 1-9: Microbiology, Virology and Drug Discovery Time: October 25, 2010, Monday, 13:30-16:20 Place: Room No. 305B, 3F, BICC

Chair: Dr. Yinduo Ji, Associate Professor, Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, USA 13:30-13:55 Title: Electron Transfer in Therapeutic Alkaloids Triggers Anastomosis in Traumatized Liver Blood Flow Dr. Pauli Virtanen, Laboratory Manager and Vice Director, Turku University, Finland 13:55-14:20 Title: Nus Transcription Factors – Targets for New Antibiotics? Dr. Paul Rosch, Professor, Research Center for Bio-Macromolecules, University of Bayreuth, Germany 14:20-14:45 Title: Whole Cell-based Validation and Identification of Mode of Action for Antibacterial Agents Dr. Yinduo Ji, Associate Professor, Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, USA 14:45-15:10 Title: Human in vitro Neural Models for Human Cytomegalovirus Neuropathogenesis and Drug Screening Study Dr. Min Hua Luo, Group Leader of Neurovirology, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China 15:10-15:30 Coffee Break 15:30-15:55 Title: Auto-bactericidal Surfaces Obtained by Covalent Grafting Dr. Elisabeth Taffin de Givenchy, Assistant Professor, University of Nice Sophia Antipolis, France 15:55-16:20 Title: Overcoming Antibiotic Resistance by Overcoming Antibiotic Resistance Factor Dr. Hyung Jong Jin, Professor and President of The Korean RNA Society, Department of Bioscience and Biotechnology, College of Natural Science, The University of Suwon, South Korea

Session 1-10: Clinical Medicine and Drug Discovery Time: October 26, 2010, Tuesday, 08:30-10:10 Place: Room No. 305A, 3F, BICC

Chair: Dr. Robert Levy, Senior Partner, Okapi Consultants, LLC; Director of Clinical Development, Primus Pharmaceuticals, Inc., USA 08:30-08:50 Title: Knowledge Management to accelerate translational biology Dr. Lina Yip Sonderegger, Knowledge Management Scientist, Research Informatics and Knowledge Management, Merck Serono International S.A., Switzerland 08:50-09:10 Title: Can Evolutionary Clues be Used to Develop Platforms for New Drug Discovery? Dr. Robert Levy, Senior Partner, Okapi Consultants, LLC; Director of Clinical Development, Primus Pharmaceuticals, Inc., USA 09:10-09:30 Title: The Nicotinic CHRNA4 Gene and Schizophrenia - Function and Symptom Association Dr. Georg Winterer, Head, Translational Neurogenetics Group, Cologne Center for Genomics, University of Cologne, Germany 09:30-09:50 Title: How to Help Medication Adherence with New Drug Discovery? Results of the Survey Conducted in Europe Dr. Przemyslaw Kardas, Associate Professor and Head, The First Department of Family Medicine, Medical University of Lodz, Poland 09:50-10:10 Title: Polygonatum Cyrtonema Lectin: Targeting Apoptotic and Autophagic Pathways as a Potential Anti-tumor Drug Dr. Bo Liu, Lecturer, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, China

Chapter 2: Emerging New Technologies and Key Platform Infrastructure for New Drug Discovery

Part I: Recent Technology Breaking

Section 2-1: Genomics, Proteomics and Metabolomics in Drug Discovery and Target Validation Time: October 23, 2010, Saturday, 13:30-14:45 Place: Room No. 315, 3F, BICC

Chair: Dr. Andrew Kasarskis, Pacific Biosciences, USA Co-Chair: Dr. Kristiina Iljin, Team Leader / Senior Research Scientist, Cancer Systems Biology Team, VTT Medical Biotechnology, Finland 13:30-13:55 Title: Applications of SMRT™ Sequencing Outside the Performance Envelope of First and Second Generation Sequencing Dr. Andrew Kasarskis, Chief Technology Officer, Pacific Biosciences, USA 13:55-14:20 Title: High-throughput Compound and siRNA Screening to Identify Novel Treatment Options for ERG Oncogene Positive Prostate Cancers Dr. Kristiina Iljin, Team Leader / Senior Research Scientist, Cancer Systems Biology Team, VTT Medical Biotechnology, Finland 14:20-14:45 Title: In Silico Genetic Network Models for Pre-clinical Drug Prioritization Dr. Jiang-Hui Xiong, Associate Professor, China Astronaut Research and Training Center (ACC), China

Section 2-2: Advancing Molecular Target Discovery and Drug Screening Time: October 23, 2010, Saturday, 13:30-16:45 Place: Room No. 305C, 3F, BICC

Chair: Dr. Jean-Philippe Stephan, Research Senior Scientist (Technology), Genentech, Inc., USA Co-Chair: Dr. Jianxin Duan, Sr. Director of Med. Chem., Threshold Pharmaceuticals Inc., USA 13:30-13:55 Keynote Speech Title: Electrophysiology in the Fast Lane: Automated Patch Clamp in Research and Drug Discovery Dr. Niels Fertig, CEO, Nanion Technologies GmbH, Germany 13:55-14:20 Title: Today's Screenings to Discover Tomorrow's Targets Dr. Jean-Philippe Stephan, Research Senior Scientist (Technology), Genentech, Inc., USA 14:20-14:45 Title: High Throughput Motif Analysis for Drug Discovery Research Dr. Arun Datta, Director (Technology R & D) & Senior Faculty, National University, USA 14:45-15:10 Title: Electrophysiological Platforms in Ion Channel Drug Screening Dr. Qiang Lu, VP, Discovery Biology, WuXiAppTec, China 15:10-15:30 Coffee Break 15:30-15:55 Title: 14-Aminocamptothecins: Synthesis, Preclinical Activity, and Potential Use for Cancer Treatment Dr. Jianxin Duan, Sr. Director of Med. Chem., Threshold Pharmaceuticals Inc., USA 15:55-16:20 Title: Broad-spectrum Anti-toxin Compounds Identified by High Throughput Screeningg Dr. Daniel Gillet, Group Leader, iBiTec-S – SIMOPRO, CEA-Saclay, France 16:20-16:45 Title: Screening Strategy for Cholesterol Lowering Drugs Dr. Hiroshi Suzuki, Professor and Chair, Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Japan

Section 2-3: Biomarkers for Drug Discovery Time: October 23, 2010, Saturday, 15:30-18:00 Place: Room No. 315, 3F, BICC

Chair: Dr. Jingjing Ye, Mathematical Statistician, Food and Drug Administration (FDA), USA Co-Chair: Dr. Farideh Z. Bischoff, Sr. Director, Translational Research and CLIA Development, Biocept, Inc., USA 15:30-15:55 Title: Discovery of Histamine H3 Receptor PET Tracer Dr. Nagaaki Sato, Director, Department of Medicinal Chemistry, Taisho Research Laboratories, Taisho Pharmaceutical Co., Ltd., Japan 15:55-16:20 Title: Evaluation of Copy Number Variation in Cancer as Biomarkers for Patient Population Selection Dr. Jingjing Ye, Mathematical Statistician, Food and Drug Administration (FDA), USA 16:20-16:45 Title: Enumeration and Sequential Molecular Analysis of CTCs Using a Microfluidic (CEETM) Platform Dr. Farideh Z. Bischoff, Sr. Director, Translational Research and CLIA Development, Biocept, Inc., USA 16:45-17:10 Title: 4b-Hydroxycholesterol is a New Endogenous Biomarker for CYP3A Activity Dr. Ulf Diczfalusy, Associate Professor, Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Sweden 17:10-17:35 Title: Utilizing Toxicogenomics and Urinary Biomarkeres for Nephrotoxicity into Drug Safety Screening Dr. Takeki Uehara, Team Leader, Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co., Ltd., Japan 17:35-18:00 Title: Specific Recognition of Cancer Cells by Novel Biocompatible Nanocomposites Dr. Xuemei Wang, Professor, State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, China

Section 2-4: Bioinformatics/Chemoinformatics and Bio-IT/Pharm-IT for Drug Discovery Time: October 24, 2010, Sunday, 08:30-11:45 Place: Room No. 305C, 3F, BICC

Chair: Dr. Jacob de Vlieg, Global Head Molecular Design & Informatics, MSD, Merck; Head of Computational Drug Discovery, Radboud University, The Netherlands 08:30-08:55 Title: The Role of Informatics and Genomics to Drive Innovation in Pharma – How Far Have We Come? Dr. Jacob de Vlieg, Global Head Molecular Design & Informatics, MSD, Merck; Head of Computational Drug Discovery, Radboud University, The Netherlands 08:55-09:20 Title: Importance of Integrating Blood-brain-barrier and PBPK Simulation for CNS Drug Development Dr. Tomi Heiskanen, Chairman and CEO, Xemet Co., Finland 09:20-09:45 Title: Digitization of Fingerprint for Drug Binding Sites Dr. Jiaan Yang, Vice President, Drug Discovery Technology, Sundia MediTech, China 09:45-10:10 Title: Synthetic Biology and Drug Discovery in the 21st Century: An Emerging, Disruptive Technology Dr. Wayne Mitchell, Group Leader, Bioinformatics, Experimental Therapeutics Centre, A*STAR, Singapore 10:10-10:30 Coffee Break 10:30-10:55 Title: In Silico Models for Estimating Skin Penetration Dr. Michael Heisig, Senior Scientist, Goethe University Frankfurt, Germany 10:55-11:20 Title: Detection of Structurally Conserved Protein Binding Sites Dr. Dusanka Janezic, Professor, National Institute of Chemistry, Slovenia 11:20-11:45 Title: Prediction of Xenobiotics Metabolism in Humans Dr. Fangping Mu, Staff Scientist, Theoretical Biology & Biophysics, Theoretical Division, National Laboratory, USA

Section 2-5: Biochips, Microarray and Molecular Imaging for Drug Discovery Time: October 24, 2010, Sunday, 13:30-14:45 Place: Room No. 301, 3F, BICC

Chair: Dr. Po Ki Yuen, Research Manager, Bioengineering, Corning Incorporated, Biochemical Technologies, Science and Technology, USA 13:30-13:55 Title: Perfusion-based Microfluidic Device for Three-dimensional Dynamic Primary Human Hepatocyte Cell Culture Dr. Po Ki Yuen, Research Manager, Bioengineering, Corning Incorporated, Biochemical Technologies, Science and Technology, USA 13:55-14:20 Title: Microarray Assisted Gene Discovery in Ulcerative Colitis Dr. Klaus Brusgaard, Senior Researcher, Department of Clinical Genetics, Odense University Hospital, Denmark 14:20-14:45 Title: All-polymer Microdevice for Drug Screening Dr. Claus R. Poulsen, Researcher, Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark

Section 2-6: miRNA, siRNA/RNAi and Small RNA Technology in Drug Discovery Time: October 24, 2010, Sunday, 15:30-17:10 Place: Room No. 301, 3F, BICC

Chair: Dr. Xiaoli You, Senior Research Scientist, Department of Discovery Medicine & Clinical Pharmacology, Bristol-Myers Squibb Co., USA 15:30-15:55 Title: Asymmetric RNA, Next Generation Technology for Designing RNA Drugs Dr. Chiang Li, President and Chief Executive Officer, Boston Biomedical, Inc., USA 15:55-16:20 Title: Targeting PI3K/AKT by siRNAs and miRNAs to Regulate Tumor Growth and Angiogenesis Dr. Bing-Hua Jiang, Professor of Medicine, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA 16:20-16:45 Title: Pharmacokinetics of Belatacept in Renal Transplant Patients Dr. Xiaoli You, Senior Research Scientist, Department of Discovery Medicine & Clinical Pharmacology, Bristol-Myers Squibb Co., USA 16:45-17:10 Title: Functional Regulation of b-actin in Cancer: Role of MicroRNAs Dr. Stella Aronov, Senior Scientist, Department for Molecular Biology, Ariel University Center of Samaria, Israel

Section 2-7: Advanced Cell-based to Tissue-based Assays Time: October 25, 2010, Monday, 08:30-09:20 Place: Room No. 305C, 3F, BICC

Chair: Dr. Pingfu Feng, Assistant Professor, Division of Pulmonary and Critical Care, Department of Medicine and Psychiatry, Case Western Reserve University, Louis Stokes Cleveland VA Medical Center, USA 08:30-08:55 Title: Assay Development in the OX2R Cell Line Dr. Pingfu Feng, Assistant Professor, Division of Pulmonary and Critical Care, Department of Medicine and Psychiatry, Case Western Reserve University, Louis Stokes Cleveland VA Medical Center, USA 08:55-09:20 Title: A Cell-based Assay for Screening Drugs Using Glioma Cells and Astrocytes Dr. Ramon dos Santos El-Bachá, Associate Professor, Laboratory of Neurochemistry and Cell Biology (LabNq), Department of Biochemistry and Biophysics, Health Science Institute, Federal University of Bahia, Brazil

Section 2-8: HPLC/GC, LC/GC-MS, Maldi-TOF and Structure Biology for Drug Discovery (Part I) Time: October 24, 2010, Sunday, 08:30-12:10 Place: Room No. 301, 3F, BICC

Chair: Dr. Janice Yau Yi Lau, Senior Group Leader, GPRD, Drug Metabolism, Abbott, USA Co-Chair: Dr. Xiaoli (Shirley) Wang, Senior Scientist, Analytical Development, Vertex Pharmaceuticals Incorporated, USA 08:30-08:55 Title: Application of LC-MSn in Conjunction with Mechanism-based Stress Studies in the Rapid Elucidation of Drug Degradation Products and Degradation Pathways Dr. Min Li, Manager, ACDS - Supply Analytical Sciences, Merck & Co., Inc., USA 08:55-09:20 Title: Ultra-high-performance nanoLC-MS/MS Analysis of Complex Proteomic Samples Dr. Wulff Niedner, LC Product Manager, Dionex Corporation, Germany 09:20-09:45 Title: High Speed HPLC/MS for Reactive Metabolite Screening Dr. Janice Yau Yi Lau, Senior Group Leader, GPRD, Drug Metabolism, Abbott, USA 09:45-10:10 Title: Cutting Edge Technologies Assisted Bioanalysis Using LC-MS/MS in Drug Discovery and Development Dr. Wei Song, Research Scientist, Pfizer Global Research and Development, USA 10:10-10:30 Coffee Break 10:30-10:55 Title: High-resolution Mass Spectrometry for Structural Characterization and Identification in Pharmaceutical Drug Discovery and Development Dr. Xiaoli (Shirley) Wang, Senior Scientist, Analytical Development, Vertex Pharmaceuticals Incorporated, USA 10:55-11:20 Title: New Chiral Phase for HPLC and SFC – Kromasil AmyCoat CelluCoat Dr. Shi Lei, Director, HPLC Column Department, Beijing Zhenxiang Company, China 11:20-11:45 Title: Structural and Functional Glycomics Based on HPLC Database, Sugar Library, and NMR Spectroscopy Dr. Koichi Kato, Professor, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan 11:45-12:10 Title: Combination of Cell-based Bioassays with LC-MS/MS Analysis for Herbal Drug Discovery Dr. Yinhan Gong, Assistant Professor, National University of Singapore, Singapore

Section 2-8: HPLC/GC, LC/GC-MS, Maldi-TOF and Structure Biology for Drug Discovery (Part II) Time: October 25, 2010, Monday, 10:30-12:10 Place: Room No. 305C, 3F, BICC

Chair: Dr. Xiaoliang Cui, Technical Director, Esensing Analytical Technology Co., Ltd., China 10:30-10:55 Title: Increased Ion Sampling Efficiency Using the Agilent 6490 LC/MS Instrument Simplifies the Determination of Fluticasone Propionate in Human Plasma Dr. Lester Taylor, LC/MS Platforms & Programs Manager, Life Sciences and Chemical Analysis, Agilent Technologies, USA 10:55-11:20 Title: The Use of High Resolution Mass Spectrometry (UPLC-Orbitrap) for the Quantification of Some One Hundred Veterinary Drugs at Trace Levels in Various Animal Tissues Dr. Anton Kaufmann, President of the Swiss Federal Working Group "Analytical Methods for Residues of Pharmaceutical Drugs in Food", Kantonales Labor Zürich, Switzerland 11:20-11:45  Title: On-line Generic Solid Phase Extraction-liquid Chromatography-tandem Mass Spectrometry Methodology for Fast Determination of Drugs in Biological Fluids Dr. Xiaoliang Cui, Technical Director, Esensing Analytical Technology Co., Ltd., China 11:45-12:10 Title: Identification of Cavities on Protein Surface Using Multiple Computational Approaches for Drug Binding Site Prediction Dr. Bingding Huang, Associate Professor, Division of Systems Biology, Zhejiang-California International NanoSystems Institute, Zhejiang University, China; Senior Scientist, Biotechnology Center, Technical University of Dresden, Germany

Section 2-9: Novel DMPK and ADMET Technologies Time: October 25, 2010, Monday, 13:30-17:35 Place: Room No. 305C, 3F, BICC

Chair: Dr. Hinnerk Boriss, CEO, Sovicell GmbH, Germany Co-Chair: Dr. Tove Tuntland, Director of Metabolism and Pharmacokinetics (MAP), Genomics Institute of the Novartis Research Foundation (GNF), Novartis Institute of Biomedical Research (NIBR), USA 13:30-13:55 Title: Balancing Potency, Pharmaceutical and ADME Properties Dr. Cornelis Hop, Head, Small Molecule Drug Metabolism & Pharmacokinetics Department, Genentech Inc., USA 13:55-14:20 Title: Predicting Neurotoxicity by Early Assessment of the Free Concentration of Drug in Brain Dr. Hinnerk Boriss, CEO, Sovicell GmbH, Germany 14:20-14:45 Title: Applications of Hepatocyte System in Drug Discovery and Development Dr. Yi-An Bi, Senior Scientist, Pfizer Inc., USA 14:45-15:10 Title: Translational Drug Discovery and Development – An Expedition from Preclinical ADMET to Clinical PK/PD Dr. Dongzhou (Jeffery) Liu, Principle Clinical Investigator, Medical Affairs and Clinical Development, GlaxoSmithKline, USA 15:10-15:30 Coffee Break 15:30-15:55 Title: The Use of Rapid in Vivo PK Screening in Drug Discovery Dr. Tove Tuntland, Director of Metabolism and Pharmacokinetics (MAP), Genomics Institute of the Novartis Research Foundation (GNF), Novartis Institute of Biomedical Research (NIBR), USA 15:55-16:20 Title: Accelerating Lead Optimization: DBS & HRMS Applications for in vivo Fast PK Applications Dr. Rohan A. Thakur, Associate Director, Specialized Mass Spectrometry, Taylor Technology – a PharmaNet Company, USA 16:20-16:45 Title: Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using Caco-2 Model Dr. Xuena Lin, Scientist II, Novartis, USA 16:45-17:10 Title: Identification of Metabolic and Bioreactive Pathways in Lead Optimization Dr. Haizhi Bu, CEO, 3D BioOptima Co., Ltd., China 17:10-17:35 Title: Assessing Brain Free Fraction in Early Drug Discovery Dr. Kevin Read, Head of DMPK, University of Dundee, UK

Section 2-10: Validated Animal Models in Drug Discovery Time: October 25, 2010, Monday, 13:30-14:20 Place: Room No. 301, 3F, BICC

Chair: Dr. Z. David Luo, Associate Professor, Department of Anesthesiology & Perioperative Care, Department of Pharmacology, Irvine Medical Center, University of California, USA 13:30-13:55 Title: A Non-invasive Model for Neuropathic Pain Drug Discovery Dr. Z. David Luo, Associate Professor, Department of Anesthesiology & Perioperative Care, Department of Pharmacology, Irvine Medical Center, University of California, USA 13:55-14:20 Title: Application of Hippocampal Theta Rhythm in Rodents to Drug Discovery Science Dr. Yuji Takano, Research Associate, NTT Communication Science Laboratories, NTT Corporation, Japan

Section 2-11: New Kinase Inhibitors Time: October 25, 2010, Monday, 15:30-17:35 Place: Room No. 301, 3F, BICC

Chair: Dr. Yi Liu, Vice President of Drug Discovery, Intellikine, Inc., USA 15:30-15:55 Title: Selective TORC1/2 Inhibitors for Cancer Therapy Dr. Yi Liu, Vice President of Drug Discovery, Intellikine, Inc., USA 15:55-16:20 Title: Biologically Relevant Identification of Type I, II, and III Kinase Inhibitors Using a Simplified Biochemical Assay Format Dr. Kurt W. Vogel, Director, R&D, Cell Systems Division, Life Technologies Corporation, USA 16:20-16:45 Title: SKIL and Judgement in Kinase Inhibitor Discovery Dr. Tim Mitchell, CEO, Sareum Ltd, UK 16:45-17:10 Title: ICA-1: A Novel PKC-ι Inhibitor Induces Apoptosis In Neuroblastoma Cells Dr. Mildred Acevedo-Duncan, Research Associate Professor, Department of Chemistry, University of South Florida, USA 17:10-17:35 Title: Multicolor Monitoring of Imatinib- and Dasatinib-Inhibited Dysregulated Protein Kinases in Chronic Myelogenous Leukemia Dr. Qunzhao Wang, Research Assistand Professor, University of North Carolina at Chapel Hill, USA

Section 2-12: GPCR-based Drug Discovery Time: October 26, 2010, Tuesday, 08:30-11:50 Place: Room No. 305B, 3F, BICC

Chair: Dr. Huailing Zhong, Senior Research Scientist, Department of Biological Research, Lundbeck Research, USA Co-Chair: Dr. Olaf Schroeder, Managing Director, NeuroProof GmbH, Germany 08:30-08:50 Title: Screening of Compounds Acting on GPCRs with MEA-neurochip Technology Dr. Olaf Schroeder, Managing Director, NeuroProof GmbH, Germany 08:50-09:10 Title: ACTOne, A Real Time cAMP Assay for GPCR and PDE HTS Dr. Jimmy Lu, President and CEO, CodexBiosolutions, USA 09:10-09:30 Title: Screening Strategies for Discovery of Allosteric Modulators Dr. Robert Lütjens, Head of Core Biology, Addex Pharmaceuticals, Switzerland 09:30-09:50 Title: Current Challenges and Perspectives in GPCR Allosteric Modulator Discovery Dr. Stephan Schann, Head of Research, Domain Therapeutics, France 09:50-10:10 Title: Integrated Platforms to Support GPCR- and ion Channel-targeted Drug Discovery Dr. Suke (Stanley) Wang, Director, Department of Discovery Biology, GenScript Corporation, USA 10:10-10:30 Coffee Break 10:30-10:50 Title: Allosteric Modulation of GPCRs and Transporters – A Novel Approach for Treating Depression and other CNS Disorders Dr. Huailing Zhong, Senior Research Scientist, Department of Biological Research, Lundbeck Research, USA 10:50-11:10 Title: GPCR Anterograde Trafficking Dr. Guangyu Wu, Associate Professor, Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, USA 11:10-11:30 Title: Structure Based Drug Design for Complex GPCR Targets; Studies on Relaxin Family Peptide Receptors Dr. Ross A. D. Bathgate, Associate Professor, Leader, Howard Florey Institute, University of Melbourne, Australia 11:30-11:50 Title: Computational Approaches to Prediction of G-protein Coupled Receptors Oligomerization Dr. Agnieszka Kaczor, Reseacher, Medical University of Lublin, Poland; Research Unit for Biomedical Informatics, Spain

Section 2-13: Novel Drug Delivery from New Materials to Nanotechnology (Part I) Time: October 24, 2010, Sunday, 13:30-17:30 Place: Room No. 302, 3F, BICC

Chair: Dr. Hassan Benameur, Senior Director, Global Pharmaceutical Sciences, Capsugel, Pfizer Inc., France Co-Chair: Dr. Xian-Ming Zeng, Senior Director, Global Respiratory R&D, TEVA Branded Pharmaceutical Products R&D, Inc., USA 13:30-13:50 Title: Biopharmaceutic of Functional Excipients Used in Self Auto Nanoemulsions to Enhance Oral Drug Delivery Dr. Hassan Benameur, Senior Director, Global Pharmaceutical Sciences, Capsugel, Pfizer Inc., France 13:50-14:10 Title: The Role of Material Science in Inhalation Drug Delivery Dr. Xian-Ming Zeng, Senior Director, Global Respiratory R&D, TEVA Branded Pharmaceutical Products R&D, Inc., USA 14:10-14:30 Title: Carbon Nanotubes as Diagnostic and Drug Delivery Tools: Molecular Bases for Their Interaction with Human Cells Dr. Silvana Fiorito, Professor, Department of Medicine, ClinicaInstitute of Neurobiology and Molecular Medicine, National Research Council (CNR), Italy 14:30-14:50 Title: Lipid-based Nanostructures: Functionalization with Cell Penetrating Peptides Dr. Margitta Dathe, Professor, Peptide Lipid Interaction / Peptide Transport, Leibniz Institute of Molecular Pharmacology, Germany 14:50-15:10 Title: Evaluation of Implantable Drug Delivery Systems – From Benchtop to Animal Dr. Lisa Ferrara, President, OrthoKinetic Technologies, LLC, USA 15:10-15:30 Coffee Break 15:30-15:50 Title: Towards Clinically-feasible Macromolecular Contrast Agents for Cancer Imaging Dr. Yanjun Fu, Chief Research Chemist, Contrast Material Research Group, Department of Radiology and Biomedical Imaging, University of California at San Francisco (UCSF), USA 15:50-16:10 Title: Ionogels: Confined Ionic Liquids for New Drug Delivery System Dr. Corine Tourné-Péteilh, Research Engineer, Charles Gerhardt Institute of Montpellier, France 16:10-16:30 Title: The Delivery of Drugs from Moldable Polymeric Bone Replacements Dr. Gary A. Leeke, Lecturer, Chemical Engineering, University of Birmingham, UK 16:30:16:50 Title: Drug Delivery Opportunities with Novel Particulate Formulations: A Case Study for Oral Colonic Drug Delivery Dr. Rachel Bridson, Lecturer, School of Chemical Engineering, University of Birmingham, UK 16:50-17:10 Title: Spectroscopic Characterization of Hydrophiic Fine Particles Dr. Tatsuya Fujino, Associate Professor, Tokyo Metropolitan University, Japan 17:10-17:30 Title: Amino-acid Derivative-mediated Multifunctionalization of Biomaterial for Bone Regeneration Dr. Masahiro Yamada, Assistant Professor, Oral Health Science Center and Department of Removable Prosthodontics & Gerodontology, Tokyo Dental College, Japan

Section 2-13: Novel Drug Delivery from New Materials to Nanotechnology (Part II) Time: October 25, 2010, Monday, 13:30-17:10 Place: Room No. 302, 3F, BICC

Chair: Dr. Jean-Marie Devoisselle, Professor and Team Leader, Institute Charles Gerhardt, France Co-Chair: Dr. Peihong Ni, Professor in Macromolecular Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, China 13:30-13:50 Title: Nanostructured Inorganic/lipid-based Drug Delivery Systems Dr. Jean-Marie Devoisselle, Professor and Team Leader, Institute Charles Gerhardt, France 13:50-14:10 Title: Hydrogel Microspheres as Amphibious Carriers for Nanoparticle Phase Transfer Dr. Dayang Wang, Professor, Ian Wark Research Institute, University of South Australia, Australia 14:10-14:30 Title: Magnetic Nanohybride Organic-inorganic Material Platform for Drug Delivery Dr. Paulo Morais, Professor, University of Brasilia, Brazil 14:30-14:50 Title: Preparation of Uniform-sized Mico- and Nano-particles and Their Applications in Drug Delivery Systems Dr. Lianyan Wang, Associate Professor, Institute of Process Engineering, CAS, China 14:50-15:10 Title: Uniform-sized Chitosan Microspheres with Interesting Structures for Protein Drug Carrier Dr. Wei Wei, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, China 15:10-15:30 Coffee Break 15:30-15:50 Title: Design of Stimuli-responsive Polymer Systems Relevant to Biomedical Applications Dr. Peihong Ni, Professor in Macromolecular Science, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, China 15:50-16:10 Title: A Novel Polysaccharide Carrier for Functional Oligonucleotides: APS Targeting DDS with Dectin-1 Dr. Kazuo Sakurai, Professor, Department of Chemical Process and Environments, The University of Kitakyushu, Japan 16:10-16:30 Title: Design of Functionalized Liposomal Nanocarrier and Its Applications Dr. Young Wook Choi, Dean and Professor, College of Pharmacy, Chung-Ang University, Korea 16:30-16:50 Title: Novel Nanotechnology-based Drug Delivery in Treating Age-related Macular Degeneration Dr. Yasuhiro Tamaki, Associate Professor, Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Japan 16:50-17:10 Title: Gene Delivery by DNA-chitosan Nanoparticles; Novel Chitosans with Improved Structural and Functional Properties Dr. Nina K Reitan, Postdoctoral Fellow, Department of Physics, The Norwegian University of Science and Technology, Norway

Part II: Roles of Emerging China Innovation Technology Platforms

Section 2-14: Supporting Systems for Major Innovative Drugs (Conference Official Language: Chinese) Time: October 26, 2010, Tuesday, 10:30-11:45 Place: Room No. 305A, 3F, BICC

Chair: Dr. Yanhuai Liu, President, Beijing East Linden Science & Technology Co., Ltd., China 10:30-10:55 Title: Advancement and Challenge of Chemistry in Drug Discovery Dr. Joseph (Jiawang) Zhu, Vice President, Medicinal Chemistry/Drug Discovery, Sundia MediTech, Inc, China 10:55-11:45 Title: The Application of World Traditional/Natural Medicine Patent Database in Drug Design Dr. Yanhuai Liu, President, Beijing East Linden Science & Technology Co., Ltd., China

Chapter 3: Advances in Anti-Major Disease Drug R & D Section 3-1: Cardiovascular Diseases   Section 3-1-1: Novel Target and Biomarker of Cardiovascular Diseases Time:  October 23, 2010, Saturday, 15:30-17:10 Place: Room No. 309, 3F, BICC Chair:   Dr. Jan Torzewski, Professor, Head of Cardiovascular Center Oberallgaeu, Germany Co-Chair: Dr. Bing-Hua Jiang, Professor of Medicine, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA 15:30-15:55 Title: Targeting Cholesterol: Redesign Signaling Pathways Dr. Ching Song, Professor, University of Science and Technology Beijing, China 15:55-16:20 Title: Inhibiting C-reactive Protein for the Treatment of Cardiovascular Disease Dr. Jan Torzewski, Professor, Head of Cardiovascular Center Oberallgaeu, Germany 16:20-16:45 Title: Successful Translation from Rodents to Humans of a Novel Drug targeting Hypertensive Genetic Abnormalities Dr. Giuseppe Bianchi, Professor, Division of Nephrology Dialysis and Hypertension, S. Raffaele Hospital, Italy 16:45-17:10 Title: Akt/mTOR Signaling Pathway in Tumor Angiogenesis Dr. Bing-Hua Jiang, Professor of Medicine, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA Section 3-1-2: The Cholesterol and Lipid Management New Drug Discovery Time: October 25, 2010, Monday, 08:30-11:45 Place:Room No. 301, 3F, BICC Chair: Dr. Guorong Xu, Professor, Department of Medicine, University of Medicine & Dentistry of New Jersey and VA Medical Center, USA 08:30-08:55 Title: Heat Shock Protein 27: A Novel Treatment for Lowering Blood and Vessel Wall Cholesterol Content Dr. Edward O'Brien, Professor & Research Chair, University of Ottawa Heart Institute, Canada 08:55-09:20 Title: A Highly Selective ACAT-1 Inhibitor, K-604, Accelerates Plaque Stabilization in Atherogenic Lesion Dr. Kimiyuki Shibuya, Medicinal Chemist, Tokyo New Drug Research Laboratories, Kowa Company Ltd., Japan 09:20-09:45 Title: New Targets for Lipid Management Dr. Allen Adolphe, Physician, Professor of Medicine, Department of Internal Medicine, University of New Mexico, USA 09:45-10:10 Title: To Reduce Plasma Cholesterol Levels by Blocking the Function of Ileal Apical Sodium-dependent Bile Acid Transporter (ASBT) Dr. Guorong Xu, Professor, Department of Medicine, University of Medicine & Dentistry of New Jersey and VA Medical Center, USA 10:10-10:30 Coffee Break 10:30-10:55 Title: Adipose Tissue as a Novel Target for Cholesterol Management? Dr. Régis Roche, Scientific Director, Adip'Sculpt; GEICO, La Reunion University, France 10:55-11:20 Title: Hypolipidemic Effects of Melissa Officinalis Essential Oil in Human Apolipoprotein E2 Transgenic Mice and HepG2 Cells Dr. Sung-Joon Lee, Associate Professor, College of Life Sciences and Biotechnology, Korea University, South Korea 11:20-11:45 Title: Process Development of PF-04240791, a Drug Candidate of SPT Inhibitor Dr. Yong Tao, Associate Research Fellow, Research API, Pfizer Global R&D, USA

Section 3-2: Neurodegenerative Diseases   Section 3-2-1: Drug Discovery Targeting Alzheimer's Disease (Part I) Time: October 23, 2010, Saturday, 13:30-17:10 Place: Room No. 302, 3F, BICC Chair: Dr. Wellington Gibson Wood, Professor of Pharmacology, University of Minnesota, USA 13:30-13:55 Title: Inhibition of Glutaminyl Cyclase – A new approach to Alzheimer's therapy Dr. Hans-Ulrich Demuth, Professor, Director Research & Development, Probiodrug AG, Germany 13:55-14:20 Title: The NGF-target Neuron Model to Induce and Analyze an Alzheimer-like Molecular Syndrome Dr. Pietro Calissano, Vice President, European Brain Research Institute; Rome Full Professor of Neurophysiology, II University of Roma, Italy 14:20-14:45 Title: Multi-Target Drugs For Neurodegenerative Disorders Treatment: Dimebon and Others Dr. Sergey O. Bachurin, Director, The Institute of Physiologically Active Compounds, Russian Academy of Sciences, Russia 14:45-15:10 Title: Cotinine: A Multiple Action Drug against Alzheimer’s Disease Dr. Valentina Echeverria Moran, Assistant Professor, University of South Florida; Scientist, Bay Pines VAHCS, USA 15:10-15:30 Coffee Break 15:30-15:55 Title: EVT 302: Clinical Development of a Novel Drug Targeting Alzheimer’ Disease Dr. Xiaolu Wang, Senior Scientist & Project leader, Evotec AG, Germany 15:55-16:20 Title: Discovery of New Chemical Entities (NCEs) with Memory Enhancing Potential Dr. Ruchi Malik, Professor and Associate Dean, Department of Pharmaceutical Sciences, Lovely Faculty of Applied Medical Sciences, Lovely Professional University, India 16:20-16:45 Title: Statins and Alzheimer's Disease Dr. Gail Li, Associate Professor, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, USA 16: 45-17:10 Title: Regulation of the HMG-CoA Reductase Pathway in Brain of Alzherimer’s Patients: Specific Targeting of Isoprenoids but Not Cholesterol Dr. Wellington Gibson Wood, Professor of Pharmacology, University of Minnesota, USA Section 3-2-2: Drug Discovery Targeting Parkinson's Disease Time: October 23, 2010, Saturday, 13:30-15:10 Place: Room No. 309, 3F, BICC Chair: Dr. Vincent Mutel, CEO, Addex Pharmaceuticals Ltd, Switzerland Co-Chair: Dr. Paolo Carloni, Full Professor, German Research School for Simulation Sciences GmbH, Germany 13:30-13:55 Title: 14-3-3 Isoforms and Phosphorylation-dependent Interaction with Proteins Involved in Neurodegenerative Disease Dr. Alastair Aitken, Professor of Protein Biochemistry, University of Edinburgh, ISB, School of Biological Sciences, UK 13:55-14:20 Title: Inhibition of Metabotropic Glutamate Receptors 5  as a Potential New Mechanism of Action in the Treatment of PD-LID Dr. Vincent Mutel, CEO, Addex Pharmaceuticals Ltd, Switzerland 14:20-14:45 Title: Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs Dr. Paolo Carloni, Full Professor, German Research School for Simulation Sciences GmbH, Germany 14:45-15:10 Title: Development of SynuclereTM: A Novel Disease-Modifying Drug for the Reduction of Brain Alpha-Synuclein Aggregates in Parkinson’s Disease Dr. Alan D. Snow, Chief Scientific Officer, ProteoTech Inc., USA Section 3-2-3: Drug Discovery Targeting Alzheimer's Disease (Part II) Time: October 24, 2010, Sunday, 08:30-09:45 Place: Room No. 302, 3F, BICC Chair: Dr. Russel J. Reiter, Professor, Department of Cellular & Structural Biology, UT Health Science Center, USA 08:30-08:55 Title: The Consequences of Mitochondrial Beta-Amyloid in Alzheimer's Disease Dr. Frank Gunn-Moore, Reader, Department of Neuroscience and Cell biology, School of Biology, University of St Andrews, UK 08:55-09:20 Title: Melatonin: It’s Efficacy in Targeting Alzheimer’s Disease Dr. Russel J. Reiter, Professor, Department of Cellular & Structural Biology, UT Health Science Center, USA 09:20-09:45 Title: The Molecular Neuropharmacology and Chinese Medicine Treatment in Healing with Alzheimer's Disease Dr. Po-Yuan Chen, Assistant Professor, Department of Biological Science and Technology, China Medical University, Member of R. O. C. Biophysics Association, Taiwan Section 3-2-4: Drug Discovery Targeting Amyotrophic Lateral Sclerosis Time: October 24, 2010, Sunday, 10:30-11:45 Place: Room No. 302, 3F, BICC Chair: Dr. Carmel Armon, Chief, Division of Neurology, Baystate Medical Center, Professor of Neurology, Tufts University School of Medicine, USA 10:30-10:55 Title: Therapeutic Benefits of Intrathecal Protein Therapy in a Mouse Model of Amyotrophic Lateral Sclerosis Dr. Koji Abe, Professor and Chairman, Department of Neurpology, Graduate School of Medicine, Dentistry, and Pharmacological Sciences, Okayama University, Japan 10:55-11:20 Title: Hypothesis: Acquired MicroRNA Changes May Trigger Sporadic ALS Initiation and Spread Dr. Carmel Armon, Chief, Division of Neurology, Baystate Medical Center, Professor of Neurology, Tufts University School of Medicine, USA 11:20-11:45 Title: The Neurovascular Link: a Source of Novel Therapies for ALS? Dr. Koen Poesen, Laboratory of Molecular Cell Biology, Katholieke Universiteit Leuven, Belgium

Section 3-3: Diabetes & Other Metabolic Diseases Section 3-3-1: Emerging Targets for Diabetes Drug Discovery Time: October 24, 2010, Sunday, 13:30-14:20 Place: Room No. 303, 3F, BICC Chair: Dr. Michael R. Hanley, Chief Scientific Officer, Amylin Pharmaceuticals, Inc., USA 13:30-13:55 Keynote Speech Title: Engineering Multifunctional Biologics for Diabetes Dr. Michael R. Hanley, Chief Scientific Officer, Amylin Pharmaceuticals, Inc., USA 13:55-14:20 Title: Hypothalamic Regulation of Energy Balance, Glucose Homeostasis and Hepatic Lipid Metabolism Dr. Allison W. Xu, Assistant Professor, Diabetes Center, University of California San Francisco, USA Section 3-3-2: Beyond Insulin Therapy Time: October 24, 2010, Sunday, 14:20-17:10 Place: Room No. 303, 3F, BICC Chair: Dr. Nobuhiko Katunuma, Professor, Tokushima Bunri University, Japan 14:20-14:45 Title: Potential Anti-diabetic Effect of Histamine Receptor 3 (H3R) Agonist on the Non-obese Type II Diabetic Goto-Kakizaki Rats Dr. Ling Kang, Senior Scientist, Diabetes & Obesity Research, Merck Research Laboratories, USA 14:45-15:10 Title: The Broad Spectrum of the Incretin System as Target for Diabetes and Obesity Management Dr. Luc Van Gaal, Professor of Medicine, Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Belgium 15:10-15:30 Coffee Break 15:30-15:55 Title: L-Tryptophan and Tryptamine as the most Ideal Type-2 Diabetes Drugs Dr. Nobuhiko Katunuma, Professor, Tokushima Bunri University, Japan 15:55-16:20 Title: Looking for Progress in Incretins and Insulin: The Next Generation Dr. Kelly Close, President, Close Concerns, Inc., USA 16:20-16:45 Title: Why We Need Second Generation Insulin Sensitizers? Dr. Mike Cawthorne, Professor, Director of Metabolic Research, Clore Laboratory, University of Buckingham, UK 16:45-17:10 Title: Adult Stem Cells providing a Promising Potential to Generate Insulin - Producing Cells in Canines Dr. Moghazy Aly Mahgoub, Professor of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University, Egypt Section 3-3-3: Progress in Non-insulin Antidiabetics – Targeting Type 2 diabetes Time: October 25, 2010, Monday, 08:30-10:10 Place: Room No. 302, 3F, BICC Chair: Dr. Frank Sundler, Professor, Department of Experimental Medical Science, Lund University, Sweden 08:30-08:55 Title: The Novel Thiazolidinedione Compound BLX-1002 preferentially Potentiates Insulin Secretion in Diabetic, but Not Non-diabetic Animal Models Dr. Qimin Zhang, Senior Researcher, Research Center, Karolinska Institutet, Sweden 08:55-09:20 Title: CART is a Regulator of Islet Function and a possible Incretin Hormone Dr. Frank Sundler, Professor, Department of Experimental Medical Science, Lund University, Sweden 09:20-09:45 Title: Pharmacogenomics of Pioglitazone Dr. Sandeep K Mathur, Professor & Head, Department of Endocrinology, S.M.S.Medical College, India 09:45-10:10 Title: Bioconjugated Incretin Analogues for Potential Type 2 Diabetes Therapeutics Dr. Kang Choon Lee, Professor and Chair, Department of Pharmaceutical Science; Director, Center of Excellence for Future Pharmaceutical Education and Research, SungKyunKwan University, Korea Section 3-3-4: Targeting Diabetes Related Metabolic Complications Time: October 25, 2010, Monday, 10:30-12:10 Place: Room No. 302, 3F, BICC Chair: Dr. Qiuhong Li, Associate Professor, Department of Ophthalmology, University of Florida, USA 10:30-10:50 Title: Understanding Diabetic Complications Using Animal Models Dr. Jason K. Kim, Professor of Molecular Medicine; Professor of Medicine and Ophthalmology, Division of Endocrinology, Metabolism and Diabetes; Director, UMass Mouse Phenotyping Center, University of Massachusetts Medical School, USA 10:50-11:10 Title: Rho Kinase Inhibition for Diabetic Nephropathy - beyond Blood Pressure Control Dr. Hartmut Ruetten, Head Translational Medicine, R&D Diabetes Division, Sanofi-Aventis Deutschland GmbH, Germany 11:10-11:30 Title: Targeting Ocular Renin-angiotensin System for Diabetic Retinopathy- Novel Mechanisms and Therapy Dr. Qiuhong Li, Associate Professor, Department of Ophthalmology, University of Florida, USA 11:30-11:50 Title: Diabetic Vascular Complications: A Real Need for a Specific Treatment Dr. Hany El-Bassossy, Lecturer of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt 11:50-12:10 Title: Discovery of DZCY06, a AMPK Activator for the Treatment of Diabetic Nephropathy and Non-alcoholic Fatty Liver Disease Dr. Wei Wu, Founder & General Manger, Hainan Deze Drug Research Co.,Ltd, China Section 3-3-5: Alternative Medicines for Anti-Diabetes Treatment Time: October 25, 2010, Monday, 13:30-15:10 Place: Room No. 303, 3F, BICC Chair: Dr. Takashi Kenmochi, Chairman of Department of Surgery & Director of Clinical Research Center, Chiba-East National Hospital, National Hospital Organization (NHO), Japan 13:30-13:55 Title: Clinical Islet Transplantation in Japan Dr. Takashi Kenmochi, Chairman of Department of Surgery & Director of Clinical Research Center, Chiba-East National Hospital, National Hospital Organization (NHO), Japan 13:55-14:20 Title: Synergy between Natural Product and Oral Hypoglycemic Drugs in Glucose Uptake Dr. Mukesh Doble, Professor, Department of Biotechnology, Indian Institute of Technology Madras, India 14:20-14:45 Title: From the Beduin Tent to the Laboratory Bench: Anti-diabetic Activity of Sarcopoterium Spinosum Dr. Tovit Rosenzweig, Senior Lecturer, Ariel University Center of Samaria, Israel 14:45-15:10 Title: Method of Treating Non-insullin Dependen Diabetes Mellitus and Related Complications Dr. Young Jeffrey Jay, President of  National Science of Human Life  Institute, USA Section 3-3-6: Drug Discovery Targeting Obesity Time: October 25, 2010, Monday, 15:30-17:10 Place: Room No. 303, 3F, BICC Chair: Dr. Linus Lin, Senior Research Fellow, Department of Medicinal Chemistry, Merck Research Laboratories, USA 15:30-15:55 Title: Selective Effects of the Thyroid Receptor b Subtype Selective Agonists KB-141 and GC-1 Metabolic Disease Models Dr. Gary J. Grover, Director, Product Safety Laboratories, Eurofins Scientific, USA 15:55-16:20 Title: Discovery of MK-5046, a BRS-3 agonist for the Treatment of Obesity through both Food Intake Reduction and Metabolic Rate Increase Dr. Linus Lin, Senior Research Fellow, Department of Medicinal Chemistry, Merck Research Laboratories, USA 16:20-16:45 Title: Therapeutic Application of Diacylglycerol for Obesity and Obesity-related Metabolic Disorders Dr. Hidekatsu Yanai, The Head Physician, Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, National Center for Global Health and Medicine, Kohnodai Hospital, Japan 16:45-17:10 Title: Effects of Long-Term Exenatide BID Treatment Combined with Lifestyle Modification in Patients with Type 2 Diabetes Dr. Alexander Dreval, Professor, Head of Department of Endocrinology, Moscow Regional Clinical Research Institute, Russia

Section 3-4: Severe Respiratory and Inflammation Diseases Section 3-4-1: Drug Discovery Targeting Asthma and Chronic Obstructive Pulmonary Disease (COPD) Time: October 23, 2010, Saturday, 13:30-16:45 Place: Room No. 303, 3F, BICC Chair: Dr. Michael Roth, Professor, Head, Pulmonary Cell Research, University Hospital Basel, Switzerland Co-Chair:   Dr. Richard Li-Cher LOH, Professor of Medicine & Chest Physician, Head, Department of Medicine, Penang Medical College, Malaysia 13:30-13:55 Title: Receptors, Co-receptors and Protein Kinases are all Potential Therapeutic Targets for Allergic Eosinophilic Airway Inflammation Dr. Amr El-Shazly, Professor of Rhinology, Liege University Hospital, Belgium 13:55-14:20 Title: New Aspects on Asthma and COPD Therapies Dr. Michael Roth, Professor, Head, Pulmonary Cell Research, University Hospital Basel, Switzerland 14:20-14:45 Title: New Inhaled Steroids –Ideal Kinetic and Deposition Parameters Dr. Andrzej M. Fal, Professor & Chair, Department of Public Health, Division of Allergology, Wroclaw Medical University, Poland 14:45-15:10 Title: Anti-inflammatory Effects of Cineol in COPD and Asthma Dr. Uwe Dethlefsen, Managing Director, MKL Institute of Clinical Research, Germany 15:10-15:30 Coffee Break 15:30-15:55 Title: Potential Therapeutic Targets and Strategies for COPD Dr. Richard Li-Cher LOH, Professor of Medicine & Chest Physician, Head, Department of Medicine, Penang Medical College, Malaysia 15:55-16:20 Title: Arginase: Master Switch in Allergic Athma? Dr. Harm Maarsingh, Lecturer, Department of Molecular Pharmacology, University of Groningen, The Netherlands 16:20-16:45 Title: Matrix Metalloprotease 12 as a Therapeutic Target for Potential Treatment of COPD and Asthma Dr. Wei Li, Vice President of Chemistry, Medicilon, Inc., China Session 3-4-2: Anti-Inflammatory Drugs Time: October 23, 2010, Saturday, 13:30-16:45 Place: Room No. 310, 3F, BICC Chair: Dr. Wai Keung Tam, Senior Clinical Lecturer, Imperial College Kidney and Transplant Institute, Imperial College London, UK Co-Chair: Dr. Kazuyuki Yoshizaki, Professor, Center for Advanced Science and Innovation, Osaka University, Japan 13:30-13:55 Title: Discovery of Anti-inflammatory Natural Compouds from Herbal Plants by Activity-guided Purification Dr. Young Whan Choi, Professor, Department of Horticultural Science, Pusan National University, South Korea 13:55-14:20 Title: Spleen Tyrosine Kinase Inhibitor Reverses Pathological Changes in Experimental Glomerulonephritis Dr. Wai Keung Tam, Senior Clinical Lecturer, Imperial College Kidney and Transplant Institute, Imperial College London, UK 14:20-14:45 Title: Protein S-glutathionylation as an Anti-inflammatory Strategy for Vascular Diseases Dr. Being-Sun Wung, Associate Professor, Department of Microbiology and Immunology, National Chiayi University, Taiwan 14:45-15:10 Title: The Differential Effects of TNF-α in LTP in Hippocampus and in Spinal Dorsal Horn Dr. Xian-Guo Liu, Professor, Vice Dean, Zhongshan School of Medicine of Sun Yat-sen University, China 15:10-15:30 Coffee Break 15:30-15:55 Title: Development and Function of an IL-6 Blocking Antibody, Tocilizumab, as an Anti-inflammatory Drug Dr. Kazuyuki Yoshizaki, Professor, Center for Advanced Science and Innovation, Osaka University, Japan 15:55-16:20 Title: Multiplex Cytokine Assay for Evaluating Anti-Inflammatory Effect of Herbal Medicine Dr. Wansu Park, Professor, Department of Pathology, College of Oriental Medicine, Kyungwon University, South Korea 16:20-16:45 Title: Biphasic Effects of Selective Inhibition of TGF-ß1 Activin Receptor - Like Kinase (ALK) on LPS-induced Lung Injury Dr. Xia Zhao-fan, Director, Department of Burn Surgery, Changhai Hospital, Second Military Medical University, China

Section 3-5: Mental Disease Drug Discovery Section 3-5: Mental Disease Drug Discovery Time: October 24, 2010, Sunday, 08:30-11:45 Place: Room No. 303, 3F, BICC Chair: Dr. Torgny Svensson, Professor of Pharmacology, A Member of the Nobel Assembly at the Karolinska Institutet, Past President of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Sweden Co-Chair: Dr. Katsunori Kobayashi, Senior Assistant Professor, Department of Pharmacology, Nippon Medical School, Japan 08:30-08:55 Title: Molecular Imaging of Psychotropic Drug Mechanisms in Human – Recent Learnings from Quetiapine Dr. Svante Nyberg, Principal Physician, Global Clinical Development, Neuroscience TA, AstraZeneca, Sweden 08:55-09:20 Title: Transcranial Magnetic Stimulation in the Treatment of Depression and Neuroimaging Dr. Shinsuke Kito, Psychiatrist, Assistant Professor, Department of Neuropsychiatry, Kyorin University School of Medicine, Japan 09:20-09:45 Title: Would Mirtazapine Added to Antipsychotics Challenge Clozapine? Dr. Joffe Grigori, Psychiatrist-in-Chief, Helsinki University Central Hospital, Finland 09:45-10:10 Title: Combined Utility of Antipsychotic and Antidepressant Drugs: Scientific Rationales Dr. Torgny Svensson, Professor of Pharmacology, A Member of the Nobel Assembly at the Karolinska Institutet, Past President of the Collegium Internationale Neuro-Psychopharmacologicum (CINP), Sweden 10:10-10:30 Coffee Break 10:30-10:55 Title: Transformation of Plant Metabolites is a Perspective Approach to the Development of New Psychotropic and Analgesic Agents Dr. Ekaterina Morozova, Scientist, Laboratory of Pharmacological Researches, N.N.Voroztsov Institute of Organic Chemistry SB RAS, Russia 10:55-11:20 Title: CRF Antagonist as Potential Drug for the Treatment of Depression Dr. Xiaohu Zhang, Senior Director, BioDuro (Beijing) Co.,Ltd, China 11:20-11:45 Title: Serotonergic Antidepressants Reverse Neuronal Maturation in Adult Hippocampus Dr. Katsunori Kobayashi, Senior Assistant Professor, Department of Pharmacology, Nippon Medical School, Japan

Section 3-6: Autoimmune and Other Severe Immune Diseases Section 3-6: Autoimmune and Other Severe Immune Diseases Time: October 25, 2010, Monday, 08:30-10:10 Place: Room No. 303, 3F, BICC Chair: Dr. Nathan Yee, Director, Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, USA Co-Chair: Dr. Jagat Kanwar, Associate Professor, Centre for Biotechnology and Interdisciplinary Biosciences, Institute for Technology Research and Innovation (ITRI), Deakin University, Australia 08:30-08:55 Title: The Link between Multiple Sclerosis, T Regulatory Cells and Japanese Rice Dr. Uri Wormser, Professor of Pharmacology, Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Israel 08:55-09:20 Title: Glucocorticoid-induced Osteoporosis in Collagen Vascular Diseases Dr. Ichiro Tatsuno, Associate Professor, Chiba University Graduate School of Medicine, Japan 09:20-09:55 Title: Tertiary Trifluoromethyl Alcohol Derivatives as Glucocorticoid Mimetics Drug Candidates Dr. Nathan Yee, Director, Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, USA 09:55-10:10 Title: Gap Junction Hemichannels: Novel Drug Targets for the Treatment of Diarrheal Diseases Dr. Julian Andrew Guttman, Assistant Professor, Biological Sciences, Simon Fraser University, Canada

Section 3-7: Antimicrobial Drug Discovery Section 3-7-1: Challenges and Opportunities Time: October 23,2010, Saturday, 13:30-15:10 Place: Room No. 311A, 3F, BICC Chair: Dr. Steve Mustapha Harakeh, Professor, Dr. Rath Reseasrch Institute, USA 13:30-13:55 Title: Medium Sized Molecules – Fertile or Futile Ground for Drug Discovery? Dr. Ming-Q Zhang, VP/CTO, Roche R&D China, China 13:55-14:20 Title: Benefits and Limitations of Intrapulmonary Pharmacokinetics Study by BAL Method for Antibiotics Development Dr. Hidetoshi Furuie, Clinical Pharmacologist, Osaka Pharmacology Clinical Research Hospital, Japan 14:20-14:45 Title: Antimicrobial Resistance of Gram Positive Bacteria Isolated from Dairy Products Dr. Steve Mustapha Harakeh, Professor, Dr. Rath Reseasrch Institute, USA 14:45-15:10 Title: High Rate of Antimicrobial Resistance in E. coli Isolated from Dairy Based Foods Dr. Ahmed Al-Hejin, Assistant Professor, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi Arabia Section 3-7-2: Antibacterial Drug Discovery Time: October 23,2010, Saturday, 15:30-17:10 Place: Room No. 311A, 3F, BICC Chair: Dr. Monika Konaklieva, Associate Professor, Department of Chemistry, American University, USA Co-Chair: Dr. Steven Polyak, Research Associate, School of Molecular and Biomedical Science, The University of Adelaide, Australia 15:30-15:55 Title: PCR Based Detection of Food Borne Pathogens Dr. Taha A. Kumosani, Professor, Vice Director, King Fahad Medical Research Centre, Saudi Arabia 15:55-16:20 Title: New life for old friends: Beta-lactams' Resurgence as Antimicrobials Dr. Monika Konaklieva, Associate Professor, Department of Chemistry, American University, USA 16:20-16:45 Title: Structure based approaches to target Biotin Protein Ligase: Towards Novel Antibiotics Dr. Steven Polyak, Research Associate, School of Molecular and Biomedical Science, The University of Adelaide, Australia 16:45-17:10 Title: Use of Bacteriophage Therapy to Combat Mutlidrug Resistance in Pathogenic Bacteria Dr. Archana Panchapakesan Iyer, Associate Professor, Deputy Head, Experimental Biochemistry Unit, King Fahd Medical Research Centre, King Abdulaziz University, Saudi Arabia Session 3-7-3: Antifungal and Antiviral Drug Discovery Time: October 24, 2010, Sunday, 10:55-12:10 Place: Room No. 305A, 3F, BICC Chair: Dr. Jonathan Wong, Defence Scientist, Defence Research and Development Canada Suffield, Canada 10:55-11:20 Title: Treatment Options for Human Cytomegalovirus Infection in High Risk Solid Organ Transplant Recipients Dr. Elisabeth Puchhammer, Professor, Institute of Virology, Medical University of Vienna, Austria 11:20-11:45 Title: Calcineurin Biological Implications in Candida Albicans Dr. Yuan-Ying Jiang, Director, Department of Pharmacology, College of Pharmacy, Second Military Medical University, China 11:45-12:10 Title: Respiratory Delivery of Experimental Antiviral Drug against Seasonal and Pandemic Influenza Dr. Jonathan Wong, Defence Scientist, Defence Research and Development Canada Suffield, Canada

Section 3-8: MDR/XDR-TB and Malaria Drug Discovery Section 3-8: MDR/XDR-TB and Malaria Drug Discovery Time: October 23, 2010, Saturday, 13:30-16:45 Place: Room No. 308, 3F, BICC Chair: Dr. Jorg J. Mohrle, Director Clinical Development and Head of Translational Medicine, Medicines for Malaria Venture, Switzerland Co-Chair: Dr. Edith Sim, Professor, Department of Pharmacology, University of Oxford, UK 13:30-13:55 Title: A Novel Pathway in Mycobacterium Tuberculosis - A Target for New Drugs Dr. Edith Sim, Professor, Department of Pharmacology, University of Oxford, UK 13:55-14:20 Title: New Generation of Respiratory Quinolone DC-159a for the treatment of TB and M(X)DR-TB Dr. Norio Doi, Senior Researcher & Chief of New Anti-TB Drugs Project, Japan Anti-Tuberculosis Association, Research Institute of Tuberculosis, Japan 14:20-14:45 Title: Nitrosyl Ruthenium(II) Complexes as Antimycobacterial Agents Dr. Alzir A. Batista, Professor, Federal University of Sao Carlos, Brazil 14:45-15:10 Title: Partnering to Develop New Medicines to Control and Eradicate Malaria Dr. Jorg J. Mohrle, Director Clinical Development and Head of Translational Medicine, Medicines for Malaria Venture, Switzerland 15:10-15:30 Coffee Break 15:30-15:55 Title: New Strategies to Develop Potential Antimalarials Dr. Venkata S. S. Kantamreddi, Assistant Professor (Analytical Chemistry and Pharmacognosy), Department of Engineering Chemistry, GITAM University, India  15:55-16:20 Title: Antiplasmodial Activity of Selected Plant-derived, Structurally Identified Substances Dr. Walther H. Wernsdorfer, Professor, Medical University of Vienna, Austria 16:20-16:45 Title: Solubility and Stability of Dihydroartemisinin Dr. Muhammad Tayyab Ansari, Professor of Pharmaceutical Chemistry, Department of Pharmacy, Bahauddin Zakariya University, Pakistan

Section 3-9: Drug Discovery Against Severe Virus Infectious Diseases Section 3-9-1: Anti-HCV Drug Discovery Time: October 25, 2010, Monday, 13:30-15:10 Place: Room No. 310, 3F, BICC Chair: Dr. Yutaka Kishida, Physician, Clinical Researcher, Hepatologist, Department of Internal Medicine, Osaka Kaisei Hospital; Osaka Prefectural General Medical Center, Japan 13:30-13:55 Title: Novel Macrocyclic Compounds Highly Potent as HCV Inhibitors Dr. Zheng-Yun Zhan, President & CEO, Zannan SciTech Co., Ltd., China 13:55-14:20 Title: Effect of Ribavir in and Pegin Terferon-Alpha-2B Using an Induction Approach with Natural Interferon-beta on Innate Immunity in Difficult-to-treat Chronic Hepatitisc C Dr. Yutaka Kishida, Physician, Clinical Researcher, Hepatologist, Department of Internal Medicine, Osaka Kaisei Hospital; Osaka Prefectural General Medical Center, Japan 14:20-14:45 Title: Evolving Therapies for Chronic Hepatitis C Virus Infection Dr. Petr Urbanek, Senior Hepatologist, Department of Internal Medicine, 1st Medical Faculty Charles University Prague and Central Military Hospital Prague, Czech Republic 14:45-15:10 Title: A Novel Luciferase and GFP Dual Reporter Virus for Rapid and Convenient Evaluation of Hepatitis C Virus Replication Dr. Xulin Chen, Professor, Wuhan Institute of Virology, Chinese Academy of Sciences, China   Section 3-9-2: Anti-AIDS, Anti-Avian Flu, and Anti-H1N1 Drug Discovery Time: October 25, 2010, Monday, 15:30-17:35 Place: Room No. 310, 3F, BICC Chair: Dr. Xiaojian Yao, Associate Professor, and the MMSF Professor, Director, Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada 15:30-15:55 Title: The Role of Alpha Interferon in the Treatment of Avian Influenza Dr. Kevin M. Boehm, Associate Program Director Emergency Medicine Residency, Department of Emergency Medicine, Henry Ford Wyandotte Hospital, USA 15:55-16:20 Title: Identification of a Novel Anti-HIV Molecule AH0109 and Characterization of the Mode of its Action Dr. Xiaojian Yao, Associate Professor, Director, Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada 16:20-16:45 Title: New Therapeutic Strategy for Influenza Virus Infection with a Novel Intravenous Neuraminidase Inhibitor, Peramivir Dr. Toshihiro Tanaka, Pediatrician, Department of Pediatrics, Shizuoka Kosei Hospital, Japan 16:45-17:10 Title: Perspectives of Sialodendrimer Hemagglutinin Inhibitors as New Therapeutic Agents against Influenza Virus Dr. Paraskevi Papaioannidou, Associate Professor of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Greece 17:10-17:35 Title: Synthesis and Microsomal Stability of Anti-HIV Entry Betulinic Acid Derivatives Dr. Li Huang, Assistant Professor, Surgery Department, Duke University Medical Center, USA

Chapter 4: Smart Medicinal Chemistry toward NCEs

Section 4-1: Receptors and Ion Channel Based Drug Design and Medicinal Chemistry Time: October 23, 2010, Saturday, 13:30-16:45 Place: Room No. 311B, 3F, BICC

Chair: Dr. Dan Marquess, Vice President, Medicinal Chemistry, Theravance, USA Co-Chair: Dr. Qiang Lu, Vice President, WuXi AppTec, China 13:30-13:55 Title: A Multivalent Approach to Novel Antibiotics for Resistant, Gram Positive Pathogens: The Discovery and Early Development of TD-1792 Dr. Dan Marquess, Vice President, Medicinal Chemistry, Theravance, USA 13:55-14:20 Title: Modulation of the Voltage Sensitivity of a Voltage-gated K Channel: A Potential Mechanism to Treat Epilepsy Dr. Fredrik Elinder, Professor of Molecular Neurobiology, Linkoping University, Sweden 14:20-14:45 Title: Synthesis and Characterization of Potent and Binding Selective GABAA 5 Selective Inverse Agonists Dr. Bernd Buettelmann, Scientific Specialist, Discovery Chemistry, Pharmaceutical Research Basel, F. Hoffmann-La Roche Ltd, Switzerland 14:45-15:10 Title: Targeting Potassium Channels for the Treatment of Rheumatoid Arthritis Dr. Christine Beeton, Assistant Professor, Baylor College of Medicine, USA 15:10-15:30 Coffee Break 15:30-15:55 Title: Discovery of Potent EDG5 Antagonist Dr. Hao Wu, Executive Director, Chemistry Department, WuXi AppTec, China 15:55-16:20 Title: Modulation of NMDA Receptor Channels by Lipid Bilayer Dr Anna (Ania) Kloda), Research Fellow, Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Australia 16:20-16:45 Title: The Pyrazolo-triazolo-pyrimidine Scaffold as a Versatile Platform to Design Potent and Highly Selective Human A3 Adenosine Receptor’s Antagonists Cheong Siew Lee, Department of Pharmacy, National University of Singapore, Singapore

Section 4-2: Computer Aided Drug Design and SAR Studies Time: October 25, 2010, Monday, 08:30-11:45 Place: Room No. 310, 3F, BICC

Chair: Dr. Huifen Chen, Scientist, Computational Drug Discovery, Genentech Inc., USA Co-Chair: Dr. Jiangli Yan, Sr. Principal Scientist, Global Research & Development, La Jolla Laboratories, Pfizer Inc., USA 08:30-08:55 Title: Structure-Guided Development of Coronavirus Protease Inhibitors as Therapeutics for SARS and Other Coronaviral Infections Dr. Michael E. Johnson, Professor and Director, Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, USA 08:55-09:20 Title: On a New Platinum Anticancer Drug, Picoplatin (ZD0473) and the Intrastrand Adduct with DNA: Theoretical Studies Dr. Danuta Michalska, Professor of  Chemistry, Wroclaw University of Technology, Poland 09:20-09:45 Title: Fragment Approach to Novel Lead Generation for HSP90 Dr. Jiangli Yan, Sr. Principal Scientist, Global Research & Development, La Jolla Laboratories, Pfizer Inc., USA 09:45-10:10 Title: Structure-based Discovery and Optimization of a Novel Class of Chk1 Inhibitors Dr. Huifen Chen, Scientist, Computational Drug Discovery, Genentech Inc., USA 10:10-10:30 Coffee Break 10:30-10:55 Title: Structure-activity Relationship Analysis of Small-Molecule Agonists for Human Formyl Peptide Receptors Based on Atom Pair Descriptors Dr. Andrei I. Khlebnikov, Medical Chemist, Altai State Technical University, Russia 10:55-11:20 Title: QSAR Studies on b-Raf Kinase Inhibitors Dr. Art E. Cho, Associate Professor, Department of Biotechnology and Bioinformatics, Korea University, Korea 11:20-11:45 Title: Fragment-based Drug Discovery: Strategy & Case Study Dr. Haihong Ni, Director, Computational Science, Bioduro, China

Section 4-3: Structure-Based Drug Design and Medicinal Chemistry Time: October 25, 2010, Monday, 13:30-17:45 Place: Room No. 311A, 3F, BICC

Chair: Dr. Gerald H. Lushington,  Associate Scientist & Director of Laboratories, Courtesy Associate Professor, University of Kansas, USA  Co-Chair: Dr. Yu Chen, Assistant Professor, Department of Molecular Medicine, College of Medicine, University of South Florida, USA 13:30-13:55 Title: Comparative Binding Energy Analysis as a Tool for Pharmacophore Rationalization and Validation Dr. Gerald H. Lushington,  Associate Scientist & Director of Laboratories, Courtesy Associate Professor, University of Kansas, USA 13:55-14:20 Title: Tests and Improvements of the MM/PBSA Method Dr. Ulf Ryde, Professor, Department of Theoretical Chemistry, Lund University, Chemical Centre, Sweden 14:20-14:45 Title: Antagonizing Drug-resistant Androgen Receptor Mutants by Molecular Design: Towards Novel Antiandrogens for Castration-resistant Prostate Cancer Dr. JianHui Wu, Assistant Professor, Department of Oncology, McGill University, Canada 14:45-15:10 Title: Fragment-based Molecular Docking in Inhibitor Discovery against CTX-M Class A beta-lactamase Dr. Yu Chen, Assistant Professor, Department of Molecular Medicine, College of Medicine, University of South Florida 15:10-15:30 Coffee Break 15:30-15:55 Title: Novel Medicinally Important 9-Anilinoacridine Conjugates and Their Biological Evaluation: From Solution to High Throughput Solid Phase Chemistry Dr. Gary Gellerman, Senior Lecturer, Department of Biological Chemistry, Ariel University Center In Samaria, Israel 15:55-16:20 Title: The CH/Hydrogen Bond. Implication In Host/Guest Chemistry, Conformation, and Biological Science Dr. Motohiro Nishio, The CHPI Institute, Japan 16:20-16:45 Title: Thalidomide Dithiocarbamate and Dithioate Derivatives Induce Apoptosis Through Inhibition of Histon Deacetylases and Induction of Caspases Dr. Magdy Zahran, Professor, Chemistry Department, Menoufyia University, Egypt

Section 4-4: Improving ADME/DMPK Profile, Reducing DDI/Toxicity, and Overcoming Formulation Difficulties Time: October 26, 2010, Tuesday, 08:30-10:55 Place: Room No. 305C, 3F, BICC

Chair: Dr. Yunsheng Hsieh, Senior Principal Scientist, Department of Drug Metabolism and Pharmacokinetic, Merck Research Laboratories, USA 08:30-08:55 Title: Drug Interactions While Battling Co-Morbidities: Buprenorphine, Methadone and Antiretrovirals Dr. David E. Moody, Associate Director, Center for Human Toxicology, Research Professor, Department of Pharmacology and Toxicology, University of Utah, USA 08:55-09:20 Title: Improving the ADME Profile of Benzimidazole-based Hydroxamates Led to the Discovery of SB939, a Histone Deacetylase Inhibitor in Phase 2 Clinical Trials Dr. Haishan WANG, Group Leader, Medicinal Chemistry,Chemistry Discovery, S*BIO Pte Ltd, Singapore 09:20-09:45 Title: Treatment of Anemia with Erythropoietin-Stimulating Agents vs. Cardiovascular Toxicities: A Modeling Perspective Dr. Wojciech Krzyzanski, Assistant Professor, Department of Pharmaceutical Sciences, University at Buffalo, USA 09:45-10:10 Title: Using rMetID as a Key Tool in Drug Discovery to Monitor and Minimize Metabolism-activated Toxicities Dr. Yaoqiu Zhu, Chief Research Investigator, MetabQuest Research and Consulting, China 10:10-10:30 Coffee Break 10:30-10:55 Title: Prediction of Developmental Toxicity Using Machine Learning Techniques A Comparative Study Dr. Sitarama B. Gunturi, Consultant, Tata Consultancy Services Limited, India