Session 1-2: Structural Biology and Drug Discovery Time: November 3, 2011, Thursday Place: Rose 1 Hall, 5F, SCEC

Chair: Dr. Michael Hennig, Vice Director & Head, Discovery Technologies, F. Hoffmann-La Roche Ltd., Switzerland 13:30-13:55 Title: Drug Discovery Facilitated by Screening & Biophysical Methods Dr. Michael Hennig, Vice Director & Head, Discovery Technologies, F. Hoffmann-La Roche Ltd., Switzerland 13:55-14:20 Title: Crystal Structure of the Acid-activated Urea Channel from the Human Pathogen Helicobacter Pylori Dr. Hartmut Luecke, Director, Center for Biomembrane Systems, Department of Biochemistry, Biophysics & Computer Science, University of California, USA 14:20-14:45 Title: The Design and Synthesis of Drugs Based on Self-Organizing Quasi-Live Systems Dr. Sonya Sophya Farber, Chief Communications Officer, Noigel, Inc, USA 14:45-15:10 Title: GA-Modified Polymers for Liver Targeting Drug Delivery Dr. Zhi Yuan, Vice Dean, Institute of Polymer Chemistry, Nankai University, China 15:10-15:35 Title: Use of Targeted Library for Efficient Identification of Fragments to Start Medicinal Chemistry Dr. Takaaki Miura, Group Leader, Biostructure Research Group, Discovery Research Department, Chugai Pharmaceutical Co.,Ltd., Japan

 

Session 1-3: Oncology and Drug Discovery Time: November 3, 2011, Thursday Place: Peony Hall, 5F, SCEC

Chair: Dr. Rob Howes, R&D Director, Horizon Discovery, UK Co-Chair: Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada 13:30-13:55 Title: Development of Antibody-based Therapies for Cancer Dr. Steve Coats, Director of Oncology Research - MedImmune/AstraZeneca of MedImmune, USA 13:55-14:20 Title: Human ‘Knock-In’ and ‘Kock-Out’ Cell-Lines for Precision Functional Genomics and Targeted Drug Discovery Dr. Rob Howes, R&D Director, Horizon Discovery, UK 14:20-14:45 Title: New Marine Anticancer Agents and Their Mechanisms of Action Dr. Hendrik Luesch, Associate Professor, Department of Medicinal Chemistry, University of Florida, USA 14:45-15:10 Title: Targeting Lipid Signal Required for Cell Cycle Re-entry by Quiescent Cancer Cells Dr. Qihan Dong, Associate Professor, School of Biomedical and Health Sciences, The University of Western Sydney, Australia 15:10-15:30 Coffee Break 15:30-15:55 Title: A Novel Approach to Target an AHI-1-BCR-ABL-JAK2 Interaction Complex in Leukemic Stem Cells Dr. Xiaoyan Jiang, Senior Scientist, Terry Fox Laboratory, BC Cancer Research Centre, Canada 15:55-16:20 Title: 99mTc-MDP Bone Scan as a Molecular Imaging Technique for Diagnostic Studying in Parathyroid Tumors, HPT Metabolic Bone Disease and Related Orthopedic Disorders Dr. Jing jing Peng, Professor, Beijing Ji Shui-Tan Hospital, The 4th Clinical Hospital of Peking University, China 16:20-16:45 Title: Do Statins Prevent Oesophageal Cancer? – Evidence from Epidemiology and Its Potential Clinical Implications Dr. Andrew R. Hart, Senior Lecturer in Gastroenterology, The University of East Anglia, UK 16:45-17:10 Title: Design and Synthesis of Modified Resveratrol Analogues Dr. Thet H THET, Lecturer, Jeffrey Cheah School of Medicine and Health Sciences, Monash University (Sunway Campus), Malaysia

  

Session 1-4: Neurosciences and Drug Discovery Time: November 3, 2011, Thursday Place: Chrysanthemum Hall, 5F, SCEC

Chair: Dr. Pierre A. Guertin, Associate Professor, Laval University, Canada 15:30-15:55 Title: Carbon Nanotubes: Promising Nanovectors for Targeted Intracellular Drug Delivery Dr. Silvana Fiorito, Professor, Department of Clinical Medicine, “Sapienza” University of Rome, Italy 15:55-16:20 Title: Cortical Oscillations in Animal Models of Schizophrenia Dr. Bernat Kocsis, Associate Professor of Psychiatry, Harvard Medical School, USA 16:20-16:45 Title: Rationale behind the Development of Combination Products in Neurology Dr. Pierre A. Guertin, Associate Professor, Laval University, Canada 16:45-17:10 Title: Translational Research Strategies in Drug Development for Neurodegenerative Disorders Dr. Piu Chan, President and CEO, Wincon TheraCells Biotechnologies Co., Ltd., China 17:10-17:35 Title: Early Lesion of The Medial Dorsal Nucleus of the Thalamus Leads to Alterations in Cell Density in the Dentate Gyrus: Possible Animal Model for Schizophrenia Dr. Liesl B. Jones, Biological Sciences and Associate Professor, Lehman College, USA

Session 1-5: Molecular Biology and Drug Discovery Time: November 3, 2011, Thursday Place: Rose 2 Hall, 5F, SCEC

Chair: Dr. Donna Seto-Young, Director of Endocrinology Laboratory, The Friedman Diabetes Institute, Division of Endocrinology, Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, USA 13:30-13:55 Title: Thiazolidinediones Affect Bone Biomarkers and Osteoblast Growth Independently of Their Effects on Aromatase Dr. Donna Seto-Young, Director of Endocrinology Laboratory, The Friedman Diabetes Institute, Division of Endocrinology, Department of Medicine, Beth Israel Medical Center and Albert Einstein College of Medicine, USA 13:55-14:20 Title: Chain Reaction of Conformational Changes of Ribosomal RNAs and tRNAs Leading to Accuracy in Translation Dr. Kozo Nagano, Professor and Director, Nagano Research Institute of Molecular Biology, Japan 14:20-14:45 Title: How to Use Large Scale Sequence Data from NGS to Understand Genetics and Biology Dr. Kazuho Ikeo, Professor, Center for Information Biology, National Institute of Genetics, Japan 14:45-15:10 Title: The Luminal Environment and Glucose Behavior in the Small Intestine Dr. Toru Takahashi, Associate Professor, Department of Nutrition and Health Science, Faculty of Human Environmental Sciences, Fukuoka Women’s University, Japan 15:10-15:30 Coffee Break 15:30-15:55 Title: MRP1-Targeting Therapy as a New Strategy for Eradication of Resistant Cancer Cells Overexpressing the Multidrug Drug Transporter Dr. Helene Baubichon-Cortay, Assistant Professor, Institute of Biology and Chemistry of Proteins (IBCP), Team Drug Resistance Mechanism and Modulation, UMR 5086 CNRS - University Lyon 1, France 15:55-16:20 Title: Polyadenylation as a Therapeutic Target Dr. Cornelia H. de Moor, Lecturer, RNA Biology, School of Pharmacy, University of Nottingham, UK

 

Session 1-6: Cell Biology and Drug Discovery Time: November 3, 2011, Thursday Place: Rose 3 Hall, 5F, SCEC

Chair: Dr. Michael R. Briggs, Senior Director, Biology, Vertex Pharmaceuticals, Inc., USA 13:30-13:55 Title: From the Patient to the Bench to the Patient, a Tumor’s Tale Dr. Michael R. Briggs, Senior Director, Biology, Vertex Pharmaceuticals, Inc., USA 13:55-14:20 Title: FreezFect Cells - HT Nucleofector™ Ready Frozen Primary Cells for HTS/HCS Applications Dr. Konstantin Matentzoglu, Managing Director, External Group Leader, Department of Biology, Trenzyme GmbH, Germany 14:20-14:45 Title: Induction of Neural Differentiation of Mammalian Adipogenic Stem Cells (ASCs), and the Cell Behavior after Transplantation into Mouse Brain Dr. Galina Pavlova, Head, Group of Developmental Genetics and Neurogenetics, Institute of Gene Biology, Russia 14:45-15:10 Title: New Strategies to Tackle Necrotic Cell Death Dr. Ilana Nathan, Associate Professor, Ben-Gurion University and Soroka University Medical Center, Israel 15:10-15:30 Coffee Break 15:30-15:55 Title: Phoretic Motions of Bioparticles Dr. Po-Yuan Chen, Assistant Professor, Department of Biological Science and Technology, China Medical University, Taiwan 15:55-16:20 Title: Characterisation of the Molecular Targets in Leptin-Mediated Renal Tubule Signalling Dr. Andrew J. McAinch, Senior Lecturer Nutrition, Biomedical and Lifestyle Diseases (BioLED) Unit, School of Biomedical and Health Sciences, Victoria University, Australia 16:20-16:45 Title: An Integrated Antibacterial Drug Discovery and Development Platform at Wuxi AppTec Dr. Deming Xu, Director, Wuxi Apptec Co.,Ltd., China

 

Session 1-7: Immunology and Drug Discovery Time: November 3, 2011, Thursday Place: Rose 1 Hall, 5F, SCEC

Chair: Dr. Sandeep Mukherjee, Associate Professor, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, USA 15:55-16:20 Title: Novojoint - Smart Cartilage Transplants with Regenerative and Anti-inflammatory Activity Dr. Michael F.G. Schmidt, Professor and Chairman, Institute of Immunology and Molecular Biology, Freie University in Berlin, Germany 16:20-16:45 Title: Treatment of Hepatitis C after Liver Transplantation Dr. Sandeep Mukherjee, Associate Professor, Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, USA 16:45-17:10 Title: Host-pathogen Interaction in Screening for Natural Products with Anti-Infective Activity Dr. Tengku Sifzizul Tengku Muhammad, Dean, Faculty of Science and Technology, University Malaysia Terengganu, Malaysia

Session 1-8: Endocrinology and Drug Discovery Time: November 3, 2011, Thursday Place: Room No. 316, 3F, SCEC

Chair: Dr. Juergen Engel, President & CEO, AEterna Zentaris, Germany Co-Chair: Dr. Hua Zhu (David) Ke, Scientific Executive Director, Metabolic Disorders Research, Amgen Inc., USA 13:30-13:55 Title: LHRH Receptors as Targets for Drug Development in Cancer Dr. Juergen Engel, President & CEO, AEterna Zentaris, Germany 13:55-14:20 Title: Development of Novel Drug, Selective Androgen Receptor Modulator (SARM42) with Metabolic Effect, but no Effect on Prostate Dr. Hajime Nawata, President and Director, Fukuoka Prefectural University, Japan 14:20-14:45 Title: Targeting Wnt Signaling in Drug Discovery for Skeletal Diseases Dr. Hua Zhu (David) Ke, Scientific Executive Director, Metabolic Disorders Research, Amgen Inc., USA 14:45-15:10 Title: Stress Release Aldosterone Modulation: Aiming More Than One Target Dr. Milan Radovic, Associate Professor of Internal Medicine, School of Medicine, University of Belgrade, Serbia 15:10-15:30 Coffee Break

 

Session 1-9: Microbiology, Virology and Drug Discovery Time: November 3, 2011, Thursday Place: Room No. 314, 3F, SCEC

Chair: Dr. Jonathan Wong, Defence Scientist, Defence Research and Development Canada Suffield, Canada 13:30-13:55 Title: Development of a Novel “Intracellular Immunization” Strategy to Restrict HIV-1 Infection and Dissemination Dr. Xiaojian Yao, Associate Professor and MMSF Professor, Director, Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada 13:55-14:20 Title: Toll-like Receptor Agonists as Broad-spectrum Antivirals Against Respiratory Viruses Dr. Jonathan Wong, Defence Scientist, Defence Research and Development Canada Suffield, Canada 14:20-14:45 Title: In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence Dr. Tatsuaki Tsuruyama, Assistant Professor, Department of Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University, Japan

Session 1-10: Toxicology and Pathology in Drug Discovery Time: November 3, 2011, Thursday Place: Room No. 314, 3F, SCEC

Chair: Dr. Sachin S. Devi, Director, Laboratory of Experimental and Clinical Toxicology; Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA 15:05-15:30 Title: Drugs & Environment – Ecopharmacovigilance Dr. Giampaolo Velo, Professor and Director, Clinical Pharmacology Unit, Veneto Region Pharmacovigilance Centre, Reference Centre for Education and Communication within the WHO Programme for International Drug Monitoring, Italy 15:30-15:55 Title: Lessons from Autoprotection Model to Treat Acute Liver Failure Dr. Sachin S. Devi, Director, Laboratory of Experimental and Clinical Toxicology; Assistant Professor of Pharmacology, School of Pharmacy, Lake Erie College of Osteopathic Medicine, USA 15:55-16:20 Title: Toxicology and Improving Drug Development; A Discussion on Extractables and Leachables Dr. Tamara Fridman, CEO, Vanasyl LLC., USA 16:20-16:45 Title: Detoxification of Organochlorine Compounds by Non-absorbable Dietary Fat Dr. Patrick Tso, Professor, Pathology and Laboratory Medicine, Pathology and Laboratory Medicine, University of Cincinnati, USA 16:45-17:10 Title: Drug Discovery and Personalized Medecine in Cystic Fibrosis and other Misfolding Diseases Dr. Frederic Becq, Professor of Physiology, Director of the Institute of Cellular Physiology and Biology, CNRS/University of Poitiers, France

Session 1-11: Epidemiology and Biostatistics for Drug Discovery Time: November 3, 2011, Thursday Place: Room No. 316, 3F, SCEC

Chair: Dr. Jerzy E Tyczynski, Director, Epidemiology, Global Surveillance & Pharmacoepidemiology, Global Medical Services, Global Pharmaceutical R&D, Abbott Laboratories, USA 15:30-15:55 Title: The Role of Epidemiology in Evaluating Safety Issues throughout the Drug Development Process Dr. Paul Beninger, Vice President, Global Patient Safety, Genzyme, USA 15:55-16:20 Title: Pharmacoepidemiology Observational Studies in Supporting Patient Safety: Focus on Oncology Therapeutic Area Dr. Jerzy E Tyczynski, Director, Epidemiology, Global Surveillance & Pharmacoepidemiology, Global Medical Services, Global Pharmaceutical R&D, Abbott Laboratories, USA 16:20-16:45 Title: Translating the New Discovery into a Clinical and Commercial Success in the New Health – the Statistical Contribution Dr. Jorgen Seldrup, Development Director, Biostatistics, Quintiles, France 16:45-17:10 Title: Statistical Modeling of Vaccine Safety Dr. Jie Chen, Head of Statistics, Merck Serono, China 17:10-17:35 Title: Clinical Significance in Statistical Hypothesis Testing: A Regulatory Point of View Dr. Chenguang Wang, Assistant Professor,Johns Hopkins University, USA