BIT's 15th Annual Congress of International Drug Discovery Science & Technology - 2017 (IDDST-2017)
★ Scientific Program

BIT's 15th Annual Congress of

International Drug Discovery Science and Technology - 2017

Theme: From Innovation to Translational Medicine

Time: November 9-11

Venue: Xi’an, China

 

 

Opening Ceremony and Keynote Forum
Sponsored by NanoTemper Technologies

Time: 09:25-12:00, Nov. 9, 2017

Moderator: Dr. Fengzhi Li, Chief Scientist, Roswell Park Cancer Institute; Chief Scientific Officer, Canget BioTekpharma, USA

09:25-09:30

Moderator's Introduction

09:30-10:00

Title: Structural Biology and Biophysics Technologies in Integrated Drug Discovery
Dr. Alexey Rak, Director, Bio Structure and Biophysics, Sanofi R&D, France

10:00-10:30

Title: Geometric Calibration on a Preclinical Cone-Beam Computed Tomography
Dr. Jyh-Cheng Chen, Professor, National Yang-Ming University, Taiwan

10:30-11:00

Title: The Development and Implementation of Stroke Risk Prediction Model in National Health Insurance Service’s Personal Health Record
Dr. Kyunghee Cho, President, Asia Pacific Association for Medical Informatics, South Korea

11:00-11:30

Title: Biomedical Engineering - Highlights from Near Infrared Spectroscopy and Laser Medicine
Dr. Gerhard Litscher, President of International Society for Medical Laser Applications, Austria

11:30-12:00

Sponsor
Title: MST: The Powerful Automated Screening Approach for Drug Discovery
Dr. Zhuo Li, General Manager of Greater China, NanoTemper Technologies, China

  

Track 1: Drug Discovery at the Cellular Molecular Level
Time: 13:30-15:40, Nov. 9, 2017

Chair

Dr. Francis Choy, Professor, Department of Biology, Biomedical Research Centre, University of Victoria, Canada

Co-Chair

Dr. Shuhua Yue, Associate Professor, School of Biological Science and Medical Engineering, Beihang University, China

13:30-13:35

Chair’s Introduction

13:35-14:00

Title: Sanfilippo B Syndrome: CRISPR-Cas9 Correction of Naglu Gene Mutations in Induced Pluripotent Stem Cellsderived from Skin Fibroblasts of Patients
Dr. Francis Choy, Professor, Department of Biology, Biomedical Research Centre, University of Victoria, Canada

14:00-14:25

Title: Novel Mutations in Quinolone Resistance-Determining Regions of gyrA, gyrB, parC and parE in Shigella Flexneri Clinical Isolates from Eastern Chinese Populations Between 2001 and 2015
Dr. Bing Gu, Deputy Director, Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, China

14:25-14:50

Title: rLj-RGD3 Induces Apoptosis via the Mitochondrial-dependent Pathway and Inhibits Adhesion, Migration and Invasion of Human HeyA8 Cells via FAK Pathway
Dr. Rong Xiao, Associate Professor, School of Life Sciences, Liaoning Normal University, China

14:50-15:15

Title: Deciphering Single Cell Metabolism by Coherent Raman Scattering Microscopy
Dr. Shuhua Yue, Associate Professor, School of Biological Science and Medical Engineering, Beihang University, China

15:15-15:40

Title: Epigenetic Regulation on Sonic Hedgehog Signaling Pathway in NTDs
Dr. Li Wang, Associate Researcher, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, China

 

Track 2: Drug Discovery at the Basic Sciences
Time: 15:50-17:35, Nov. 9, 2017

Chair

Dr. Rakesh Ranjan, Executive Medical Director, Charak Clinical Research Center, USA

15:50-15:55

Chair’s Introduction

15:55-16:20

Title: Neuroreceptors and Neurotransmitters:  Latest Frontiers for Psychotropic Drug Development
Dr. Rakesh Ranjan, Executive Medical Director, Charak Clinical Research Center, USA

16:20-16:45

Title: The Lack of Raf-1 Kinase Feedback Regulation Enhances Anti-apoptosis in Cancer Cells
Dr. Changmin Chen, Director, Department of Basic Research, Sichuan Cancer Hospital/Institute, China

16:45-17:10

Title: Effects and Mechanisms of Cold-induced Rat White/Brown Adipose Tissue Changes on Plasticity and Metabolism by SiO2 Nanoparticles
Dr. Danfeng Yang, Professor, Tianjin Institute of Health and Environmental Medicine, China

17:10-17:35

Title: New ABC Chronic Kidney Disease Classification
Dr. Jaime Arturo Jojoa, Nephrologist, Fundacion Hospital San Pedro (Pasto) and Hospital Universitario Departamental de Narino, Colombia

  

Track 3: Drug Discovery at the Pharmacological/Toxicological/ Pathological Level
Time: 13:30-17:35, Nov. 9, 2017

Chair

Dr. Alexey Rak, Director, Bio Structure and Biophysics, Sanofi R&D, France

Co-Chair

Dr. Wenhua Zheng, Professor, Faculty of Health Sciences, University of Macau, Macau, China

13:30-13:35

Chair’s Introduction

13:35-14:00

Title: Integrating New Technologies - MST and NanoDSF in the Modern Drug Discovery Workflow
Dr. Alexey Rak, Director, Bio Structure and Biophysics, Sanofi R&D, France

14:00-14:25

Title: Evaluation of Heavy-chain C-terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies
Dr. Guoying Jiang, Senior Scientist and Group Leader, Analytical Development and Quality Control, Genentech (Member of the Roche Group), USA

14:25-14:50

Title: Rolapitant Absolute Bioavailability and PET Imaging Studies in Healthy Adult Volunteers
Dr. Xiaodong Wang, Senior Director, Tesaro Inc., USA

14:50-15:15

Title: Immunotoxicity Testing of Nano-drugs, Biologicals and Development of Safe Application of Them
Dr. Rudolf Urbanics, Head of In Vivo Laboratories, SeroScience Ltd., Hungary

15:15-15:30

Coffee Break

15:30-15:55

Title: Interactions of Glutamate and IGF-1 Receptor Signaling and Its Underlying Mechanisms
Dr. Wenhua Zheng, Professor, Faculty of Health Sciences, University of Macau, Macau, China

15:55-16:20

Title: New Use of Old Drug: Introduction of the Rapid Antidepressant Effects of Ketamine and the Underlying Mechanism
Dr. Jianjun Yang, Professor, Department of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, China

16:20-16:45

Title: T-patterns and Self-similarity from DNA to Neuronal and Human Scales
Dr. Magnus S. Magnusson, Research Professor, University of Iceland, Iceland

16:45-17:10

Title: Induction Chemotherapy Followed by Concurrent Radio-chemotherapy Versus Concurrent Radio-chemotherapy Alone as Treatment of Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC): A Meta-analysis of Randomized Trials
Dr. Edwin Bolke, Professor, Department of Radiation Oncology, Heinrich Heine University, Germany

17:10-17:35

Title: New Aspects Regarding Neoadjuvant Radiochemotherapy in Locally Advanced Noninflammatory Breast Cancer and Predictive Factors for a Pathologic Complete Remission
Dr. Christiane Matuschek, Senior Attending, Heinrich Heine University, Germany

  

Track 4: Innovative Drug Discovery Technology
Time: 08:30-12:35, Nov. 10, 2017

Chair

Dr. Jean-Claude G. Bunzli, Professor, Department of Chemistry, Hong Kong Baptist University (HKBU), Hong Kong, China; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Switzerland

08:30-08:35

Chair’s Introduction

08:35-09:00

Title: ALIS Affinity Selection in Pharmaceutical Discovery
Dr. Peter J. Dandliker, Director, Merck Sharp & Dohme, USA

09:00-09:25

Title: Understanding Grinding Stress in Monoclonal Antibody Drug Production Manufacturing Process - Application of QbD Approach
Dr. Yuh-Fun Maa, Senior Principal Engineer, Genentech, USA

09:25-09:50

Title: Lanthanide Helicates for Optical Bioimaging and Theranostics
Dr. Jean-Claude G. Bunzli, Professor, Department of Chemistry, Hong Kong Baptist University (HKBU), Hong Kong, China; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Switzerland

09:50-10:15

Title: Status of Mo-99 Supply and the Role of IAEA in Supporting Member States
Dr. Joao Alberto Osso Junior, Section Head, RPRT-NAPC, International Atomic Energy Agency, Austria

10:15-10:30

Coffee Break

10:30-10:55

Title: Semiempirical Quantum Mechanics (SQM)-based Scoring Functions for Native Protein-Ligand Pose Recognition and Virtual Screening
Dr. Pavel Hobza, Distinguished Chair, Institute of Organic Chemistry and Biochemistry AS CR, Czech Republic

10:55-11:20

Title: Zebrafish: A Predictive Model for Drug Discovery and Reprofiling
Dr. Yong Zhang, Assistant President and Marketing Director, Hunter Biotechnology Inc., China

11:20-11:45

Title: Double Strand DNA Recognition by Peptides Consisting of Pyrrole and Imidazole Moiety for Diagnosticprobes and/or Gene Control Drugs
Dr. Kiyoshi Nokihara, CEO  and CSO, HiPep Laboratories and PIPLS Pharme Inc., Japan; Professor, Nanjing Medical University, China

11:45-12:10

Title: New Tools for Drug Target Identification and Prioritization
Mr. Alexey Dubovenko, Product Manager, Discovery Sciences Solutions, Clarivate Analytics, USA

12:10-12:35

Title: Deciphering Single Cell Metabolism by Coherent Raman Scattering Microscopy
Dr. Shuhua Yue, Associate Professor, School of Biological Science and Medical Engineering, Beihang University, China

  

Track 5: New Biotherapy and Biopharmaceuticals Discovery

Time: 08:30-11:20, Nov. 10, 2017

Chair

Mr. Mark Naivar, FPGA Manager, Owl Biomedical, USA

Co-Chair

Dr. Weisen Zeng, Professor, Southern Medical University, China

08:30-08:35

Chair’s Introduction

08:35-09:00

Title: An Easy-to-Use, Sterile, High-Speed Cell Sorter for Clinical Production of Therapeutic Cells
Mr. Mark Naivar, FPGA Manager, Owl Biomedical, USA

09:00-09:25

Title: Intestinal Tract as Bioreactor for Therapeutic Proteins Production Baised on a Fructose Inducible Expression System of Lactic Acid Bacteria
Dr. Weisen Zeng, Professor, Southern Medical University, China

09:25-09:50

Title: Rapidly Effective IVIG Therapy Has Corticosteroid-Sparing and Immunomodulatory Effects in Autoimmune Bullous Disease Pemphigus Vulgaris
Dr. Danka Svecova, Professor, Comenius University in Bratislava, Slovakia

09:50-10:15

Title: Establishment and Therapeutic Application of Universal hESC Lines
Dr. Geeta Shroff, Founder & Medical Director, Nutech Mediworld, India

10:15-10:30

Coffee Break

10:30-10:55

Title: Oral Administration of Chitosan/DNA Nanoparticles Containing DNA Coding for FVIII and IL-10 for the Modulation of Antibody Responses to FVIII in Hemophilia Mice
Dr. Gonzalo Hortelano, Professor, Department of Biology, School of Science & Technology, Nazarbayev University, Republic of Kazakhstan

10:55-11:20

Title: Optimizing the Property of Nano-hydroxyapatite Gene Vectors with Variety of Surface-modification
Dr. Fengjun Wang, Doctor, Xiangya Hospital, Central South University, China

    

Track 6: Glamorous Nature Products and Traditional Chinese Medicine

Section 601: Isolation and Synthesis of Bioactive Natural Products
Time: 08:30-10:15, Nov. 10, 2017

Chair

Dr. Boris V. Nemzer, Senior Director of R & D, FutureCeuticals, Inc.; Adjunct Professor, University of Illinois at Urbana-Champaign, USA

08:30-08:35

Chair’s Introduction

08:35-09:00

Title: Identification, Quantitation and Bioavailability of Calcium Fructo-borate Natural Complex Using Multinuclear NMR and LC-MS(n)
Dr. Boris V. Nemzer, Senior Director of R & D, FutureCeuticals, Inc.; Adjunct Professor, University of Illinois at Urbana-Champaign, USA

09:00-09:25

Title: Antibacterial Agents from Chinese Medicinal Plants
Dr. Weidong Pan, Professor, The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, China

09:25-09:50

Title: Novel Triptolide-related Compounds as Potential Anticancer and Antivirus Clinical Trial Candidates
Dr. Jinghong Zhang, Professor, School of Biomedical Science, Huaqiao University, China

09:50-10:15

Title: Preliminary Study on Analgesic Mechanism of Three Components of Dragon’s Blood
Dr. Xiangming Liu, Professor, South-Central University for Nationalities, China

  

Track 6: Glamorous Nature Products and Traditional Chinese Medicine

Section 602: Biological Activity of Natural Products
Time: 13:30-15:40, Nov. 10, 2017

Chair

 Dr. Yanmin Zhang, Professor, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, China

13:30-13:35

Chair’s Introduction

13:35-14:00

Title: Tocotrienols from Red Palm Oil; An Important New Supplement for Aging Populations
Dr. Joseph Keenan, Professor, Department of Family Medicine, University of Minnesota, USA

14:00-14:25

Title: A New Way of Drug R & D - Methodology of Reverse Pharmacology
Dr. Jun Li, Vice Dean, College of Pharmacy, South-Central University for Nationalities, China

14:25-14:50

Title: Screening and Application of Active Compounds Targeting on Tyrosine Kinase Receptors
Dr. Yanmin Zhang, Professor, School of Pharmacy, Xi'an Jiaotong University, China

14:50-15:15

Title: 5-hydroxy-equol, A Microbial Metabolite of Isoflavone Genistein, Enhanced Lifespan and Stress Resistance in Caenorhabditis Elegans
Dr. Xiuling Wang, Professor, Agricultural University of Hebei, China

15:15-15:40

Title: Artemisinin Protected Various Cell Types from Oxidative Stress Injury and Its Underlying Mechanism
Dr. Wenhua Zheng, Professor, Faculty of Health Sciences, University of Macau, Macau, China

  

Track 7: Challenges and Solutions of Drug Delivery
Time: 15:50-17:10, Nov. 10, 2017

Chair

Dr. Deepak Hegde, Director, Product Development, Platform Technology Science China, GSK Shanghai R & D, China

15:50-15:55

Chair’s Introduction

15:55-16:20

Title: Oral Delivery Using Nanoparticles
Dr. Deepak Hegde, Director, Product Development, Platform Technology Science China, GSK Shanghai R & D, China

16:20-16:45

Title: IVIVC/IVIVR Development in the Pharmaceutical Industry – Past Experience and Current Perspectives
Dr. Rong Li, Associate Research Fellow, Pharmaceutical Research and Development, Pfizer Inc., USA

16:45-17:10

Title: Multipurpose Prevention Technologies: What Does the Future Hold?
Dr. David R. Friend, Chief Scientific Officer, Evofem Biosciences, USA

  

Track 8: Practice and Drug Innovation

Section 801: New Anti-Cancer Drugs
Time: 13:30-17:35, Nov. 10, 2017

Chair

Dr. Georgia Z. Chen, Professor, Emory University, USA

Co-Chair

Dr. Chunsheng Li, Assistant Professor, University of Pennsylvania, USA

13:30-13:35

Chair’s Introduction

13:35-14:15

Keynote Speech
Title:
Substituted and Fused 7-deazapurine Nucleosides – New Type of Potent Cytostatics with a Complex Mechanism of Action
Dr. Michal Hocek, Professor, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Czech Republic

14:15-14:40

Title: Targeted Therapies  Pave a Way towards the Precision Treatment of Head and Neck Cancer
Dr. Georgia Zhuo Chen, Professor, Emory University, USA

14:40-15:05

Title: Recent Advances in Anti-tumour Berberine
Dr. Paolo Lombardi, President and Co-Founder, Naxospharma srl, Italy

15:05-15:30

Coffee Break

 15:30-15:55

Title: FL118, A Novel Anticancer Drug, for Personalized Medicine Using the Unexpected Kras Gene Status as a Biomarker
Dr. Fengzhi Li, Chief Scientist, Roswell Park Cancer Institute; Chief Scientific Officer, Canget BioTekpharma, USA

15:55-16:20

Title: The Development of Ingenol Disoxate for the Treatment of Actinic Keratosis and Other Non-Melanoma Skin Cancers
Dr. Thomas Hogberg, Senior Advisor, Mind the Byte, Denmark

16:20-16:45

Title: Metformin: A Drug for All Reasons - an Update on the Therapeutics Effects of Metformin
Dr. Christopher R. Triggle, Professor, Weill Cornell Medicine, Qatar

16:45-17:10

Title: Molecular Imaging and Immunotherapy of CD248-positive Cancer
Dr. Chunsheng Li, Assistant Professor, University of Pennsylvania, USA

17:10-17:35

Title: The Combined Use of Camellia Sinensis (Green Tea) and Metronomic Zoledronic Acid in Intratibial Breast Cancer-Induced Osteolysis Mouse Model against Tumor Metastasis and Bone Destruction
Dr. Ke-Wang Luo, Department Head, Research and Education Department, People’s Hospital of Longhua, China

  

Track 8: Practice and Drug Innovation

Section 802: New Anti-Infectious Drugs
Time: 08:30-10:15, Nov. 11, 2017

Chair

Dr. Kylie M. Wagstaff, Career Development Fellow and Head, Cancer Targeting and Nuclear Therapeutics Laboratory, Monash University, Australia

08:30-08:35

Chair’s Introduction

08:35-09:00

Title: Antivirals for Lethal RNA Virus Pathogens
Dr. Kylie M. Wagstaff, Career Development Fellow and Head, Cancer Targeting and Nuclear Therapeutics Laboratory, Monash University, Australia

09:00-09:25

Title: New Antifungal Agents Based on Carbazone or Carbamate Fragment
Dr. Josef Jampilek, Professor, Comenius University, Slovakia

09:25-09:50

Title: Dalbavancin – A New Lipoglycopeptide
Dr. Kimberly D. Leuthner, Clinical Specialist of Infectious Disease, University Medical Center of Southern Nevada, USA

09:50-10:15

Title: ALA-PDT Combined with Antibiotics for the Treatment of Multiple Skin Abscesses Caused by Mycobacterium Fortuitum
Dr. Yang Tan, Attending, Daping Hospital, Third Military Medical University, China

   

Track 9: Me-too to Me-Better Drug R & D and Biosimilars
Time: 10:25-12:10, Nov. 11, 2017

Chair

Dr. Teresa Brodniewicz, President and Director, MTZ Clinical Research Sp. z o.o., Poland

10:25-10:30

Chair’s Introduction

10:30-10:55

Title: Wax-Matrix Extended-Release Niacin versus Inositol Hexanicotinate in Persons with Mild to Moderate Hyperlipidemia
Dr. Joseph Keenan, Professor, Department of Family Medicine, University of Minnesota, USA

10:55-11:20

Title: Safety Aspects of Biosimilar Products
Dr. Teresa Brodniewicz, President and Director, MTZ Clinical Research Sp. z o.o., Poland

11:20-11:45

Title: Drug Delivery Systems as Critical Success Factors for Biosimilar Products
Dr. Dirk Kreder, CEO, Anteris Medical GmbH, Germany

11:45-12:10

Title: The Effect of Selective Estrogen Receptor Down-regulator (SERD) in the Treatment of Breast Cancer
Dr. Jin Zhang, BD Manager, Nanjing Sanhome Pharmaceutical Co., Ltd., China

 

Track 10: Clinical Trials, Market and Policy
Time: 13:30-17:35, Nov. 11, 2017

Chair

Dr. Wei Sun, Associate Director, Biostatistcs, Kyowa Kirin Pharmaceutical Development, Inc., USA

Co-Chair

Dr. Giovanni Dondi Dall’Orologio, Professor and Director, University of Bologna, Italy

13:30-13:35

Chair’s Introduction

 13:35-14:00

Tilte: Critical Statistical Issues in the Design of a Non-inferiority Clinical Trial
Dr. Wei Sun, Associate Director, Biostatistcs, Kyowa Kirin Pharmaceutical Development, Inc., USA

14:00-14:25

Title: How to Achieve and Optimise a Long-term Relationship with a CRO Enabling Mutual Creation of Value
Ms. Lidia Cappellina, Head of R & D Outsourcing Management, Chiesi Group, Italy

14:25-14:50

Title: China Medical City – An Integrated Life Science Cluster in the Heart of Asia
Mr. Xiaobo Wu, Deputy Director, International Business Development Center, China Medical City, China

14:50-15:15

Title: Implications of Continuous Glucose Monitoring in Diabetes Research and Patient Management
Dr. Yong-Fu Xiao, Fellow and Professor, Crown Bioscience Inc., China; Rutgers University, USA

15:15-15:30

Coffee Break

15:30-15:55

Title: Handling Missing Data in Clinical Trials
Dr. Giovanni Dondi Dall’Orologio, Professor and Director, University of Bologna, Italy

15:55-16:20

Title: Effectiveness of Bibliographic Research from Scientific Databases
Dr. Loretta De Franceschi, Aggregate Professor, University of Urbino, Italy

16:20-16:45

Title: Hospitalizations and Economic Analysis in Psychotic Patients with Paliperidone Palmitate Long-Acting Injection
Dr. Jesus E. Mesones, Head of Psychiatry Service, Torrevieja University Hospital, Spain

16:45-17:10

Title: Quality Requirements in R & D
Dr. Allen Edward Goldenthal, Senior Quality Consultant, University of Macau, Macau, China

17:10-17:35

Title: Clinical Trial Design Issues and Market Access
Dr. Robert A. Freeman, Professor and Vice Chair of Research, University of Maryland Eastern Shore, USA

  

Track 11: Medicinal Chemistry and Drug Discovery
Time: 13:30-17:10, Nov. 11, 2017

Chair

Dr. Zack Zou, Vice President and Head of DMPK & Bionanlytical Chemistry, Sundia Meditech (Shanghai) Inc., China

13:30-13:35

Chair’s Introduction

13:35-14:00

Title: Drug ADME Profiling -- Understanding the Practical Examples
Dr. Zack Zou, Vice President and Head of DMPK & Bionanlytical Chemistry, Sundia Meditech (Shanghai) Inc., China

14:00-14:25

Title: Should CADD be Interpreted and also Applied Differently?
Dr. Thomas Hogberg, Senior Advisor, Mind the Byte, Denmark

14:25-14:50

Title: Chirality Determination of Organic Compounds and Chiral Drugs by Using Asymmetric Autocatalysis
Dr. Kenso Soai, Professor, Tokyo University of Science, Japan

14:50-15:15

Title: Replication of L- and D-Amino Acids via Strecker Synthesis with Asymmetric Amplification and Multiplication of L- and D-Aminonitriles
Dr. Tsuneomi Kawasaki, Associate Professor, Tokyo University of Science, Japan

15:15-15:30

Coffee Break

15:30-15:55

Title: A Novel Targeted Drug Enhancer for Liver Cancer
Dr. Shi Peng, R & D Director, Beijing YunHui Medical Technology Co. Ltd., China

15:55-16:20

Title: Overview of LH031, An Orallykinesinspindle Protein Eg5 Inhibitor for the Treatment of Cancer
Dr. Shiqun Zhang, Assistant General Manager, Guangzhou Link Heath Group, China

16:20-16:45

Title: Myelination and Demyelination - A Sphingolipid Mystery
Dr. Somsankar Dasgupta, Scientist Emeritus, Augusta University, USA

16:45-17:10

Title: Identification of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors
Dr. Shiow-Ju Lee, Associate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan

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