IDDST-2023
Scientific Program

 

 

Time: May 8-May 10, 2023

Venue: Tokyo, Japan

 

Registration

Time: 09:00-21:00, May 07, 2023 (Sunday); Place: Public Space, 3F, Shinagawa Prince Hotel

Opening Ceremony

Time: 09:00-09:10, May 8, 2023 (Monday); Place: Aquamarine, 32F, Shinagawa Prince Hotel

Keynote Forum

Time: 09:10-11:45, May 8, 2023 (Monday); Place: Aquamarine, 32F, Shinagawa Prince Hotel

 

Moderator

Dr. Arne Staby, Scientific VP, Novo Nordisk A/S, Denmark

 

09:10-09:15

Moderator’s Introduction

09:15-09:40

Title: Homeostatic and Pathogenic Roles of Ganglioside GM3 Molecular Species

Dr. Jin-ichi Inokuchi, Professor, Osaka University, Japan 

09:40-10:05

Title: How to Make the Bio Revolution a Reality? How will Bayer Become one of the Leaders in Cell and Gene Therapies?

Dr. Wolfram Carius, Executive Vice President, Bayer AG, Germany

10:05-10:30

Title: AI, Digital Revolution & New Avenues in Drug Discovery
Dr. Hans Leuenberger, Former Executive Vice President of the Swiss Academy of Engineering Sciences; Prof. Emeritus in Pharm. Technology (University of Basel) at the University of Florida, USA

10:30-10:55

Title: Influence of Production Process Methodology and Scale on Polypeptide Drug Quality: Case Study on GLP-1 Derivatives
Dr. Arne Staby, Scientific VP, Novo Nordisk A/S, Denmark

10:55-11:20

Title: An Unusual Metastatic Tumor to the Heart
Dr. Neda Zarrin-Khameh, Professor, Baylor College of Medicine, USA

11:20-11:45

Title: Characterization of Co-formulation of Therapeutics Antibodies
Dr. Methal Albarghouthi, Senior Director, AstraZeneca, USA

Section 2: Latest Development in Drug Discovery S & T

IDDST 211: Frontiers in Pharmacology, Toxicology and Drug Metabolism

Time: 09:00-11:05, May 9, 2023 (Tuesday) ; Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Urban Fagerholm, Founder & CEO, Prosilico AB, Sweden

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: Pediatric Formulation Development: The Utility of the Juvenile Porcine Model for Preclinical Pharmacokinetic Assessment

Dr. Gregory T. Knipp, Associate Professor, Purdue University, USA

09:25-09:45

Title: Presentation of Software - ANDROMEDA by Prosilico - that Outperforms and Complements Laboratory Methods for the Prediction of Human Clinical Pharmacokinetics

Dr. Urban Fagerholm, Founder & CEO, Prosilico AB, Sweden

09:45-10:05

Title: Serial Cerebrospinal Fluid Collection in Early Clinical Development May Provide Pharmacokinetic and Pharmacodynamic Insights for CNS Drugs

Dr. Hiroshi Yamanouchi, Clinical Pharmacologist, Scientific Affairs, Parexel International, Japan

10:05-10:25

Title: Triterpenoid Antitumor Agents on ATL Cells and their Mechanism

Dr. Yasuhiro Yoshida, Associate Professor, University of Occupational and Environmental Health, Japan

10:25-10:45

Title: Three Things to Consider before Conducting your ADME Study

Dr. Kazuko Aoyagi, Senior Director, Business Development, Celerion Inc, USA

10:45-11:05

Title: Withholding of M-CSF Supplement Reprograms Macrophages to M2-Like via Endogenous CSF-1 Activation

Mr. Yu-Chih Chen, Orthopedic Surgeon, National Pingtung University, Taiwan

IDDST 212: Innovative Drug Discovery Technology

Time: 09:00-11:25, May 10, 2023 (Wednesday) ; Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Dmitry G. Vassylyev, Professor, University of Alabama at Birmingham, USA

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: Application of a Novel CL7/Im7 Affinity System in Purification of Complex and Pharmaceutical Proteins

Dr. Dmitry G. Vassylyev, Professor, University of Alabama at Birmingham, USA

09:25-09:45

Title: Ketamine / Propofol Admixture (Ketofol) for Sedation: The Real Deal or Not?

Dr. Nathan Smischney, Associate Professor, Mayo Clinic, USA

09:45-10:05

Title: BIOMIMESYS® Hydroscaffold, A Ready-to-use Organ-specific Extracellular Matrix for Relevant Phenotypic Screening

Dr. Nathalie Maubon, CEO & CSO, HCS Pharma, France

10:05-10:25

Title: Transformation of Medicinal Chemistry towards Modern Era

Dr. Leena Otsomaa, Vice President, R&D, Head of Medicine Design, Orion Corporation, Orion Pharma, Finland

10:25-10:45 

Title: Luminescence Technologies to Enable Discovery & Optimization of Effective Targeted Protein Degraders

Mr. Steven Edenson, Strategic Collaborations Manager, Promega Corporation, USA

10:45-11:05

Title: Parenteral Nutrition Admixtures for Paediatric Patients Compounded with Highly Refined Fish Oil-Based Emulsion: Assessment of Physicochemical Stability

Dr. Germana Bersani, Consulting Pharmacist, University of Bologna, Italy

11:05-11:25

Title: Breaking the Pathological Aggregation Cascade of Intrinsically Disordered Proteins

Dr. Subha Kalyaanamoorthy, Assistant Professor, University of Waterloo, Canada

Section 3: Breaking Preclinical Research and Development

IDDST 311: Advances in Medicinal Chemistry, Drug Design and Synthesis

Time: 09:00-12:40, May 9, 2023 (Tuesday) ; Place: Kinrenka, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Timor Baasov, Professor Emeritus, Technion-Israel Institute of Technology, Israel

Co-Chair

Mr. Yann Gaston-Mathe, CEO & Co-Founder, Iktos, France

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: The Rapid and Long Lasting Antidepressant Effects of Agents Acting on Group II Metabotropic Glutamate (Mglu2/3) Receptors in Combination With Hallucinogenic Drugs

Dr. Andrzej Pilc, Professor, Institute of Pharmacology, Polish Academy of Sciences, Poland

09:25-09:45

Title: To Fix Nature's Mistake: Repairing Human Faulty Genes by Small Molecules

Dr. Timor Baasov, Professor Emeritus, Technion-Israel Institute of Technology, Israel

09:45-10:05

Title: Discovery of Molidustat (Musredo®), A Small Molecule Oral HIF-PH Inhibitor for Renal Anemia

Dr. Hartmut Beck, Senior Science Fellow, Bayer AG, Germany

10:05-10:25

Title: Discovery of the ‘Mitotic MTH1 Inhibitor’ OXC-101 and It’s Unique Dual Mechanism of Action

Dr. Martin Scobie, Team Leader Medicinal Chemistry, Thomas Helleday Laboratory, Karolinska Institute, Sweden

10:25-10:45

Title: Design, Synthesis, and Biological Evaluation of Optically Active Cyclometalated Iridium(III) Complex-Peptide Hybrids Obtained by Optical Resolution via Diastereomeric Stereoisomers

Dr. Shin Aoki, Professor, Tokyo University of Science, Japan

10:45-11:00

Coffee Break

11:00-11:20

Title: How a Small Drug, Methylene Quinuclidinone, Stabilizes the p53 DNA Binding Domain and its Interaction with its DNA Response Elements

Dr. Haim Rozenberg, Research Associate, Weizmann Institute of Science, Israel

11:20-11:40

Title: Rational Design and Synthesis of Drug Candidate TRPM8 Antagonist: Antinociceptive Effect in Acute and Chronic Pain Preclinical Models

Dr. Andrea Aramini, Head of Research and Early Development - VP, Dompe S.p.A, Italy

11:40-12:00

Title: Innovative Chemistry Toward Novel Tetrapyrrolic Macrocycles: Photodynamic Therapy and Imaging of Cancer

Dr. Teresa M. V. D. Pinho e Melo, Associate Professor, University of Coimbra, Portugal

12:00-12:20

Title: Yes, You should Use AI for Medicinal Chemistry

Mr. Yann Gaston-Mathe, CEO & Co-Founder, Iktos, France

12:20-12:40

Title: Photoswitchable Diarylethene-modified Peptides: Promising Drug Candidates for Photopharmacology

Dr. Igor V. Komarov, Scientific Advisor, Lumobiotics GmbH, Germany

IDDST 312: CNS and Neurodegenerative Drug Discovery & Targets

Time: 14:00-16:40, May 9, 2023 (Tuesday); Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Eduard Korkotian, Professor, The Weizmann Institute of Science, Israel

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: Potential of Circulating Biomarkers in Neuro-Oncology

Dr. Manfred Westphal, Professor, University Hospital Hamburg Eppendorf, Germany

14:25-14:45

Title: Mitophagy in Neurons and Astrocytes Promotes Cell Survival and Longevity

Dr. Eduard Korkotian, Professor, The Weizmann Institute of Science, Israel

14:45-15:05

Title: The Pro-apoptotic Protein FAF1 as a Novel Target for Parkinson’s Disease and Multiple System Atrophy: Preclinical and Clinical Development of its Inhibitor KM-819

Dr. Jae Moon Lee, President, Kainos Medicine Inc., South Korea; President, FAScinate Therapeutics, Inc., USA

15:05-15:25

Title: Targeting Posttranslational Modifications (PTMs) to Reduce Mutant Huntingtin Toxicity: Therapeutic Potentials of Kinase Inhibitors in Huntington’s Disease Treatment

Dr. Jing Jin, Assistant Professor, Johns Hopkins University School of Medicine, USA

15:25-15:45

Title: C9ORF72 Dipeptide Repeat Proteins Disrupt Formation of GEM Bodies and Induce Aberrant Accumulation of Survival of Motor Neuron Protein

Dr. Hitomi Tsuiji, Professor, Aichi Gakuin University, Japan  

15:45-16:00

Coffee Break

16:00-16:20

Title: Explainable Artificial Intelligence for Drug Discovery

Dr. Michele Migliore, Research Director, Institute of Biophysics, National Research Council, Italy

16:20-16:40

Title: Development of Positive and Negative Allosteric Modulations of the M1, M4, and M5 Muscarinic Acetylcholine Receptors for the Treatment of Neuropsychiatric Disorders

Dr. Carrie K. Jones, Associate Professor of Pharmacology, Vanderbilt University, USA

IDDST 313: Autoimmune and Inflammation Drug Targets (Cancel)

 

IDDST 314: Cancer Drug Targets

Time: 11:25-13:10, May 10, 2023 (Wednesday); Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Stephen T. C. Wong, Chair Professor, Houston Methodist Hospital and Weill Cornell Medical College, USA

 

11:25-11:30

Chair’s Introduction

11:30-11:50

Title: Pleiotropic Impacts of Chloroquine Encompass Concurrent Activation of Pro-survival and Pro-death Signaling in Glioblastoma Stem Cells: Implications for Chloroquine-mediated Radiosensitization

Dr. Ella L. Kim, Laboratory Director, Johannes Gutenberg University Medical Centre Mainz, Germany

11:50-12:10

Title: A Novel Rationale for the Drug Targeting of the KRAS Surrogate Target PDE6D

Dr. Daniel Abankwa, Professor, University of Luxembourg, Luxembourg

12:10-12:30

Title: Anti-fibrotic Immunotherapy by MFAP5 Targeting Ovarian and Pancreatic Cancer and Idiopathic Pulmonary Fibrosis

Dr. Stephen T. C. Wong, Chair Professor, Houston Methodist Hospital and Weill Cornell Medical College, USA

12:30-12:50

Title: SkewingTowards Neuroendocrine Phenotype in High Grade or High Stage Androgen-Responsive Primary Prostate Cancer

Dr. Luca Puccetti, Senior Urologist, Hospital Michele & Pietro Ferrero, Italy

12:50-13:10

Title: Emerging Target Discovery at a US Leading Cancer Center: Nuclear Medicine Perspective

Dr. Rick Wray, Nuclear Medicine Physician, Memorial Sloan Kettering Cancer Center, USA

Section 4: From Clinical Applications to Drug Manufacturing

IDDST 411: Cancers/Tumors

Time: 14:00-18:00, May 8, 2023 (Monday); Place: Shakunage, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Fan-Gang Tseng, Distinguished Professor, National Tsing Hua University, Taiwan

Co-Chair

Dr. Chao Han, Vice President, Tavotek Biotherapeutics, USA

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: Potential of 5-aminolevulinic Acid as a Radiotherapy Drug

Dr. Junko Takahashi, Professor, Waseda University, Japan

14:25-14:45

Title: From Technology to Clinical Applications of High Dose Rate Image Guided Brachytherapy for Patients with Rectal Cancer

Dr. Te Vuong, Professor, McGill University, Canada

14:45-15:05

Title: Image-Guided Brachytherapy for Rectal Cancer: A Technological Overview

Dr. Aurelie Garant, Assistant Professor, UT Southwestern Medical Center, USA

15:05-15:25

Title: The Discovery and Development of the Hec1 Inhibitor T-1101 as an Anticancer Drug__From Bench to Clinical Development

Dr. Chieh-Hua Lee, Project Manager, Taivex Therapeutics Corporation, Taiwan

15:25-15:45

Title: Automatic SACA System for Single Circulating Tumor Cells/Microembolis (CTCs/CTMs) Rapid Diagnosis/Prognosis

Dr. Fan-Gang Tseng, Distinguished Professor, National Tsing Hua University, Taiwan

15:45-16:00

Coffee Break

16:00-16:20

Title: Discovery of a Novel Multi-specific cMET x EGFR x VEGF Antibody Against Difficult-to-Treat Cancers

Dr. Chao Han, Vice President, Tavotek Biotherapeutics, USA

16:20-16:40

Title: Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation Measured by 31P MRS

Dr. Ruth Steiger, Senior Scientist/Univ.-Assistant, Department of Neuroradiology, Medical University of Innsbruck, Austria

16:40-17:00

Title: Feasibility of a Smart Bra to Screen Breast Cancer

Dr. Marie-Valerie Moreno, R&D Director, HzCare SAS, France

17:00-17:20

Title: Controversies, Consensus and Collaboration in the Use of -I-131 Therapy in the Differentiated Thyroid Cancer

Dr. Ciprian Draganescu, Head of Nuclear Medicine Dept., University Hospital of Martinique, France

17:20-17:40

Title: Tumor Markers of Orbital Cavernous Hemangioma: Possible Therapeutic Opportunities?

Dr. Mizhir Atallah, Retina Consultant, Ophthalmology Department, Emek Medical Center, Affiliated to the Technion-Institute of Technology, Israel

17:40-18:00

Title: Effects of Physical Activity on Sleep Problems in Breast Cancer Survivors: A Meta-analysis

Dr. Hongchang Yang, Associate Professor, Hohai University, China

IDDST 412: Immunotherapy, Cell and Gene Therapy 

Time: 14:00-17:20, May 8, 2023 (Monday); Place: Lavender, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Ganna Bilousova, Associate Professor, University of Colorado Anschutz Medical Campus, USA

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: Retinal Pigment Epithelium for Treatment of Macular Degeneration: from Discovery to First in Human Clinical Trials

Dr. Irina Klimanskaya, Senior Director, Astellas Institute for Regenerative Medicine, USA

14:25-14:45

Title: Innovative Combination Cancer Immunotherapy (iCCI): Activation of Th1-immunity by Helper/Killer Hybrid Epitope Long Peptides (H/K-HELP)

Dr. Takashi Nishimura, President, NPO Immmuno Support Center (Hokkaido Univ. Precision Clinic Group), Japan

14:45-15:05

Title: Curation and Integration of Single-cell RNA-Seq Data for Advancing Immuno-oncology Target Discovery

Dr. Frank Staubli, Business Development Manager, Nebion AG, Switzerland

15:05-15:25

Title: Development of Artificial RNA Editing Enzymes to Treat Diseases Caused by Point mutations

Dr. Toshifumi Tsukahara, Professor Emeritus, Japan Advanced Institute of Science and Technology; CEO, GeCoRT Co. Ltd., Japan

15:25-15:45

Title: Developing an Induced Pluripotent Stem Cell-based Therapy for Inherited Skin Blistering Diseases

Dr. Ganna Bilousova, Associate Professor, University of Colorado Anschutz Medical Campus, USA

15:45-16:00

Coffee Break

16:00-16:20

Title: Biotherapy in the Management of Metabolic Disorders

Dr. Hassan M. Heshmati, Consultant and Senior Scientific Advisor, Endocrinology Metabolism Consulting, LLC, USA

16:20-16:40

Title: Small Molecules Agonists of CD206 Induce M2 to M1-like Switching and Activation of Tumor-associated Macrophages, Triggering Anti-tumor Immune Responses

Dr. Juan Jose Marugan, Leader, National Center for Advancing Translational Sciences, National Institutes of Health, USA

16:40-17:00

Title: Breaking Barriers and Expediting Marketing Approvals: Pioneering Strategies for Cell and Gene Therapies

Dr. Chia-Hua Maggie Ho, Chief Operating Officer, Amarex Taiwan, LLC, Taiwan

17:00-17:20

Title: Novel Small Molecule MRGPRX2 Antagonists Inhibit a Murine Model of Allergic Reaction

Dr. Billy K. C. Chow, Professor, Chair of Endocrinology, University of Hong Kong, Hong Kong, China

IDDST 413: CNS and Neurodegenerative Disorders

Time: 11:05-12:50, May 9, 2023 (Tuesday) ; Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Wilfried Schupp, Senior Lecturer, Friedrich Alexander University, Germany

 

11:05-11:10

Chair’s Introduction

11:10-11:30

Title: Often and off Label Used Drugs in Neurorehabilitation - An Overview

Dr. Wilfried Schupp, Senior Lecturer, Friedrich Alexander University, Germany

11:30-11:50

Title: PPAR β/δ Antagonism Counteracts Pro-oxidant Effects Induced by 6-OHDA in both in Vivo and in Vitro Models of Parkinson's Disease

Dr. Vanessa Castelli, Assistant Professor, University of L'Aquila, Italy

11:50-12:10

Title: Bone Marrow-derived Mesenchymal Stem Cells Improve Cognitive Impairment in Alzheimer's Disease Model by Increasing the Expression of MicroRNA-146a in Hippocampus

Dr. Masako Nakano, Assistant Professor, Sapporo Medical University, Japan

12:10-12:30

Title: Determination of the Intramuscular Motor Endpoints for Effective Administration of Botulinum Toxin in the Treatment of Spasticity

Dr. Alexandr Kovalenko, Assistant Professor, Military Medical Academy, Russia

12:30-12:50 

Title: Duloxetine and 8-OH-DPAT, rather than Fluoxetine, Relievedepressive Behavior in Animal with Chronic Neuropathic Pain

Dr. Bing Hu, Scientist, Department of Neurology, University of California, San Francisco, USA

IDDST 414: Development of Therapeutic Antibodies, Vaccines, Protein and Peptide

Time: 09:00-13:00, May 9, 2023 (Tuesday) ; Place: Ajisai, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Kiyoshi Nokihara, CEO & CSO, HiPep Laboratories, Japan; Professor, The First Affiliated Hospital with Nanjing Medical University, China

Co-Chair

Dr. Ofir Schuster, Head of National Biological Laboratory, Israel Institute for Biological Research, Israel

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: Fighting SARS-CoV-2 and Other Infectious Diseases with Recombinant Antibodies

Dr. Michael Hust, Professor, Braunschweig University of Technology, Germany

09:25-09:45

Title: Development of Novel Peptide-libraries Immobilized on Gel-type Supports Focusing on Rapid Discovery of Medicinal Middle Molecules to Overcome Display Strategies and/or Sophisticated Deconvolution Method

Dr. Kiyoshi Nokihara, CEO & CSO, HiPep Laboratories, Japan; Professor, The First Affiliated Hospital with Nanjing Medical University, China

09:45-10:05

Title: Non-cognate Ligands of Broadly Neutralizing Antibody Paratopes as Potential Vaccine Immunogens

Dr. Petr Maly, Head of Laboratory of Ligand Engineering, Institute of Biotechnology of Czech Academy of Sciences, Czech Republic

10:05-10:25

Title: Design and Development of SVF-001, A Therapeutic Vaccine for the Treatment of Chronic Hepatitis B

Dr. Richard Bethell, CEO, SVF Vaccines, Sweden

10:25-10:45

Title: The Role of Robotic Surgery in Urooncology

Dr. Anton Ponholzer, Guest Professor and Chair, Hospital Saint John of God Vienna, Austria

10:45-11:00

Coffee Break

11:00-11:20

Title: Specific and Rapid SARS-CoV2 Proteins Identification and Quantification using LC-MS/MS Analysis

Dr. Ofir Schuster, Head of National Biological Laboratory, Israel Institute for Biological Research, Israel

11:20-11:40

Title: Evolving Reactogenicity in Vaccine Development

Dr. Mohamed Al-Ibrahim, Principal Investigator, Pharmaron CPC, USA

11:40-12:00

Title: Effects of PACAP on Dry Eye Syndrome and Possible Use for Therapeutic Application  

Dr. Seiji Shioda, Professor, Shonan University of Medical Sciences, Japan

12:00-12:20

Title: Cracking the Code of Main Protease- The AchillesHeel of SARS-CoV-2

Dr. Aravindhan Ganesan, Research Assistant Professor, School of Pharmacy, University of Waterloo, Canada

12:20-12:40

Title: Detection of Organophosphate Bound Butytylcholinesterase Using aMonoclonal Antibody

Dr. Yoon-Won Kim, CEO, ImmuneMed; Professor, Hallym University, South Korea

12:40-13:00

Title: New Monoclonal Antibodies for Therapy of Covid 19 and Malaria

Dr. Rolf G. Werner, COO, Pacific Meinuoke Biopharmaceutical Co., Ltd., China

IDDST 415: Emerging Infectious Diseases

Time: 14:00-15:45, May 9, 2023 (Tuesday) ; Place: Ajisai, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Jan Carlo Morais Oliveira Bertassoni Delorenzi, Head of Center of Biological and Health Sciences, Mackenzie Presbyterian University; Chief Scientific Officer, Neguebe Chemical and Biology LLC., Brazil

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: The Stereoselective Synthesis of an Anti-Influenza Agent and the Trend of Influenza Patients

Dr. Tomoko Mineno, Professor, Takasaki University of Health and Welfare, Japan

14:25-14:45

Title: Medicinal Chemistry Campaign on Privileged Natural Products, and Their Pre-clinical Developments

Dr. Hee-Jong Hwang, CEO, A&J Science Co., Ltd, South Korea

14:45-15:05

Title: Combining in Silico and Experimental Techniques to Develop Next Generation Drug Like Molecules for Neglected Diseases - Leishmaniasis

Dr. Jan Carlo Morais Oliveira Bertassoni Delorenzi, Head of Center of Biological and Health Sciences, Mackenzie Presbyterian University; Chief Scientific Officer, Neguebe Chemical and Biology LLC., Brazil

15:05-15:25

Title: Anti-virulence-antibiotic Combinatorial Treatments - A New Paradigm in Combating Bacterial Infections

Dr. Richard Yi Tsun KAO, Associate Professor, The University of Hong Kong, Hong Kong, China

15:25-15:45

Title: Continuous Activation of Kinases, A Novel Mode of Action for Antimicrobial Agent

Dr. Wei Huang, Associate Professor, Shenzhen People’s Hospital, China

IDDST 416: Cardiovascular Disease and Metabolic Diseases

Time: 16:00-18:05, May 9, 2023 (Tuesday) ; Place: Ajisai, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Kenneth L. Byron, Professor Emeritus, Loyola University Chicago, USA

 

16:00-16:05

Chair’s Introduction

16:05-16:25

Title: RNA Inhibition - A New Class of Medicines: The Story of Primary Hyperoxaluria Type 1

Dr. Yaacov Frishberg, Pediatric Nephrologist & Professor of Pediatrics, Hebrew University of Jerusalem, Israel

16:25-16:45

Title: Challenge for the Development of Novel Anti-inflammatory Drug by Ganglioside GM3 Molecular Species

Dr. Jin-ichi Inokuchi, Professor, Osaka University, Japan

16:45-17:05

Title: Kv7 Channels in Smooth Muscle as Therapeutic Targets for Vascular and Airway Diseases

Dr. Kenneth L. Byron, Professor Emeritus, Loyola University Chicago, USA

17:05-17:25

Title: Metformin's Effects on Mitochondrial Respiration

Dr. Ling He, Associate Professor, Johns Hopkins University School of Medicine, USA

17:25-17:45

Title: Landmark for Chest Compression During CPR: Where Should It Be?

Dr. Pimpan Usawasuraiin, Emergency Physician, Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Thailand

17:45-18:05

Title: Optimal Pharmacological Treatment for Men and Momen with Peripheral Arterial Disease; What we Should do and What we Do

Dr. Birgitta Sigvant, Associate Professor, Orebro University, Sweden

IDDST 417: Inflammation and Immunological Diseases (Sponsored by Selvita Ltd)

Time: 09:00-13:00, May 10, 2023 (Wednesday) ; Place: Kinrenka, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Mike A. Royal, Chief Medical Officer, Sorrento Therapeutics, USA

Co-chair

Dr. Pierre-Francois Laterre, Head of the ICU, St Luc University Hospital, Catholic University of Louvain, Belgium

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: Dynamic Doppler Ultrasound Assessment of Tissue Perfusion Is a Better Tool than a Single Vessel Doppler Examination in Differentiating Malignant and Inflammatory Pancreatic Lesions

Dr. Maciej Gonciarz, Full Professor, Military Institute of Medicine-National Research Institute in Warsaw, Poland

09:25-09:45

Title: Arrest Acute Respiratory Failure; Ancillary Treatment of Pneumonia with Inhaled Medications

Dr. Emir Festic, Professor, Mayo Clinic, USA

09:45-10:05

Title: Clinical Development of an Antiviral for COVID-19 with a Dual Mechanism of Action and no Requirement for CYP3A4 Boosting

Dr. Mike A. Royal, Chief Medical Officer, Sorrento Therapeutics, USA

10:05-10:25

Title: Key to Life: Physiological Role and Clinical Implications of Progesterone

Dr. Bernadett Nagy, Assistant Professor, University of Pecs, Hungary

10:25-10:45

Title: Complex Regional Pain Syndrome (CRPS) in Children and Adolescents

Dr. Ludmyla Kachko, Lecturer, Schneider Children’s Medical Center of Israel, Israel

10:45-11:00

Coffee Break

11:00-11:20

Title: Morbidity and Mortality in 691 Offspring of Mothers with Type 1 Diabetes: A Danish Cohort Study with 8-35 Years Follow-up

Dr. Gunnar Lauge Nielsen, Associate Professor, Aalborg University Hospital & Aalborg University, Denmark

11:20-11:40

Title: Safety and Tolerability of Non-neutralizing Adrenomedullin Antibody Adrecizumab (HAM8101) in Septic Shock Patients: The AdrenOSS-2 Phase 2a Biomarker-guided Trial

Dr. Pierre-Francois Laterre, Head of the ICU, Saint Luc University Hospital, Belgium

11:40-12:00

Title: Immunobiological Analysis of Salivary Fluid before and after Dental Extraction in Patients with Type Two Diabetes

Dr. Liliana Foia, Professor of Biochemistry, Grigore T. Popa University of Medicine and Pharmacy, Romania

12:00-12:20

Title: Novel Immune Modulators of Acute Lung Inflammation

Dr. Gurpreet Kaur Aulakh, Assistant Professor, University of Saskatchewan, Canada

12:20-12:40

Title: Clinical Data on an Essential Biosimilar: Promising Results in Phase I and Phase III Studies of CinnoRA

Dr. Ahmadreza Jamshidi, Professor, Tehran University of Medical Sciences, Iran

12:40-13:00

Title: Infectious-immune as an Axis of Neuro-immune Disease

Dr. Isaac Melamed, Medical Director, IMMUNOe Health Centers, USA

13:00-13:20

Title: In Vivo Approaches for Preclinical Modelling of Systemic Lupus Erythematosus (SLE) and Sjogren's Syndrome

Dr. Anamarija Markota, Team Lead Scientist, In Vivo Pharmacology and Toxicology, Selvita Ltd, Croatia

IDDST 418: Orphan Diseases & Other Diseases

Time: 09:00-11:40, May 10, 2023 (Wednesday) ; Place: Ajisai, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Christian Jeleazcov, Professor, University Hospital Erlangen, Germany

Co-Chair

Dr. Silvia Gartner, Pediatric Pulmonologist, Vall d'Hebron University Hospital, Spain

 

09:00-09:05

Chair’s Introduction

09:05-09:25

Title: RWE (Real World Evidence)'s Impact to Rare Disease by Way of Data Sciences & Orphan Drug Discovery

Mr. Sanggoo Kang, CEO, MedySapiens, Inc., South Korea

09:25-09:45

Title: Intranasal Perioperative Pain Therapy

Dr. Christian Jeleazcov, Professor, University Hospital Erlangen, Germany

09:45-10:05

Title: Reducing Facility-Acquired Pressure Injuries Through Real-Time Monitoring of Turning Compliance Using a Wearable Device

Dr. Barbara Mayer, Clinical Assistant Professor, Stanford University, USA

Dr. Chungmei Shih, Director, Specialty Practice, Stanford Healthcare, USA

10:05-10:25

Title: Sexuality, Intimacy and the Brain in Older Age

Drs. Els Messelis, Gerontologist, Director Lachesis: Office of Expertise on Ageing and Gender, Belgium

10:25-10:45

Title: The Importance of Early Diagnosis and Treatment in Cystic Fibrosis

Dr. Silvia Gartner, Pediatric Pulmonologist, Vall d'Hebron University Hospital, Spain

10:45-11:00

Coffee Break

11:00-11:20

Title: Impact of Maternal Lateral Tilt on Cardiac Output during Caesarean Section under Spinal Anesthesia: A Prospective Observational Study

Dr. Chiara Sonnino, Registered Anesthesiologist, IRCCS Policlinico Universitario Agostino Gemelli, Italy

11:20-11:40

Title: The role of dehydroepiandrosterone (DHEA) and its metabolites in pathogenesis and development of Primary Biliary Cholangitis

Dr. Ewa Kilanczyk, Post-docPomeranian Medical University in Szczecin, Poland

IDDST 419: Advanced Natural Products

Time: 14:00-17:20, May 10, 2023 (Wednesday) ; Place: Kinrenka, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Dulcie A Mulholland, Professor of Organic Chemistry, University of Surrey, UK

Co-Chair

Dr. Chen Situ, Lecturer, Queen’s University Belfast, UK

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: Vitamin A is an Important Mediator of Adipose Tissue Thermogenesis

Dr. Florian Kiefer, Associate Professor of Medicine, Medical University of Vienna, Austria

14:25-14:45

Title: Homoisoflavonoids for the Treatment of Retinopathy

Dr. Dulcie A Mulholland, Professor of Organic Chemistry, University of Surrey, UK

14:45-15:05

Title: The Concept of Zeolite in Fundamental Research and Medical Application

Dr. Wilfried Dathe, External Consultant and Head of Zeolite Research, Heck Bio-Pharma GmbH, Germany

15:05-15:25

Title: Comparing the Response of Narrowband UVB Therapy to Heliotherapy and a Topical Application of Lecithin and the Amino Acid L Tryptophan

Dr. Rowland Noakes, Visiting Dermatologist, Queensland Institute of Dermatology, Australia

15:25-15:45

Title: Preliminary Studies on Therapeutic Effect of Ethanolic Extract of Tylophora Villosa Leaves against Paracetamol-induced Hepatotoxicity in Mice

Dr. Aceng Ruyani, Professor of Developmental Biology, Bengkulu University, Indonesia

15:45-16:00

Coffee Break

16:00-16:20

Title: Palmitoleic Acid as New Agent for the Treatment of Obesity Complications

Dr. Maria Isabel C Alonso-Vale, Professor, Federal University of Sao Paulo, Brazil

16:20-16:40

Title: Elucidating Anti-aging and Antioxidant Activity of Hydnocarpus Anthelmintica on Skin Aging and Cosmeceutical Potentials: In Silico and in Vitro Study

Dr. Minjee Kim, Senior Researcher, Konkuk University, South Korea

16:40-17:00

Title: Antibacterial Multitarget Properties of Medicinal Plants

Dr. Chen Situ, Lecturer, Queen’s University Belfast, UK

17:00-17:20

Title: Ergosterol Peroxide Isolated from Oyster Medicinal Mushroom, Pleurotus ostreatus, Potentially Induces Radiosensitivity in Cervical Cancer

Dr. Thuluz Meza-Menchaca, Professor, University of Veracruz, Mexico

IDDST 420: Pharmacovigilance, Drug Manufacturing and Integrative Services

Time: 14:00-16:40, May 10, 2023 (Wednesday) ; Place: Ajisai, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Kanami Orihara, Associate Professor, Tokyo Institute of Technology, Japan

 

14:00-14:05

Chair’s Introduction

14:05-14:25

Title: Intrathecal Morphine Benefit and Risks

Drs. Aart Jan Teunissen, Associate Professor, Maasstad Hospital Rotterdam, The Netherlands

14:25-14:45

Title: Pharmacovigilance in China

Dr. Hualong Sun, Chief Operating Officer, Clinical Service Center, China

147:45-15:05

Title: Protective Effect of COVID-19 Vaccine in Saudi Arabia 

Dr. Haya F. Al-Salloum, Clinical Pharmacist, King Saud University, Saudi Arabia

15:05-15:25

Title: Regulating Peripheral Clocks to Restore Epithelial Immunity

Dr. Kanami Orihara, Associate Professor, Tokyo Institute of Technology, Japan

15:25-15:45

Title: Policy and Regulations Related to Patent Waiver and Government Use in Tackling Pandemics and National Health Emergencies in Indonesia

Dr. Ahmad M. Ramli, Professor, Padjadjaran University; Commissioner of PT Bio Farma, Indonesia

15:45-16:00

Coffee Break

16:00-16:20

Title: Roadmap for Practical Use of Continuous Manufacturing System “iFactory” by 2030

Mr. Yousuke Maezawa, Business Development Manager, Yokogawa Solution Service corporation, Japan

16:20-16:40

Title: Landscape of Biosimilars

Dr. S. D. Ravetkar, Executive Director, Serum Institute of India Pvt Ltd., India

Young Scientists’ Forum 

Time: 16:00-17:45, May 10, 2023 (Wednesday) ; Place: Suzuran, 3F, Shinagawa Prince Hotel

 

Chair

Dr. Melanie Dechamps, Associate Head of Clinic, Cardiovascular ICU, Saint Luc University Hospital, Belgium

 

16:00-16:05

Chair’s Introduction

16:05-16:30

Title: Antifungal Activity and Cytotoxicity Assessment of the Polyhydroxylated Polyketide Amphidinol-C Isolated from the Marine Dinoflagellate Amphidinium Carterae

Mrs. Maria Elena Barone, Ph.D student, Atlantic Technological University, Ireland

16:30-16:55

Title: Inflammation-induced Coagulopathy Substantially Differs between COVID-19 and Septic Shock

Dr. Melanie Dechamps, Associate Head of Clinic, Cardiovascular ICU, Saint Luc University Hospital, Belgium

16:55-17:20

Title: High Throughput Screen Discovers Molecular Target Flagellum Attachment Zone 1 (FAZ1) Filament within Trypanosoma Brucei

Mr. Cody Orahoske, Student, Cleveland State University, USA

17:20-17:45

Title: MUC1 is Responsible for the Pro-metastatic Potential of Calycosin in Pancreatic Ductal Adenocarcinoma

Ms. Wenqing Chen, Ph.D. Candidate, Hong Kong Baptist University, Hong Kong, China

Video Forum

 

1

Title: SARS-CoV-2 Accelerated Clearance using a Novel Nitric Oxide Nasal Spray (NONS) Treatment: A Randomized Trial

Dr. Monika Tandon, Group Vice President, Clinical Development, Glenmark Pharmaceuticals, India

2

Title: Role of Sphingosine-1-phosphate in Physiological Condition and in Lung Cancer-associated Inflammatory Pathways

Dr. Michela Terlizzi, Research Scientist, University of Salerno, Italy

3

Title: Heart Signaling and Repair Through Extracellular Vesicles

Dr. David W Greening, Associate Professor, Baker Heart and Diabetes Institute, Australia

4

Title: Epigenetics PET Imaging Probes for Brain Research

Dr. Changning Wang, Assistant Professor, Massachusetts General Hospital, Harvard Medical School, USA

5

Title: Ring-Substituted Cinnamanilides - Effective Antimicrobial Agents

Dr. Josef Jampilek, Professor, Comenius University, Slovak Republic

6

Title: Thyroid Deficiency, The Silent Epidemic of our Time; The Journey in Creating a Novel Treatment

Dr. Eldon Dahl, Founder and Chief Executive Officer, Life Choice Ltd., Canada

7

Title: In Vivo Imaging of Rat Vascularity with FDG-labeled Erythrocytes and Positron Emission Tomography

Dr. Jung W. Choi, Associate Member, H. Lee Moffitt Cancer Center & Research Institute Tampa, USA

8

Title: Building a One-Stop-Shop Solution to Assist Drug Safety Reviewers’ Decision-Making

Dr. Taxiarchis Botsis, Assistant Professor, Johns Hopkins University, USA

9

Title: Cell-Penetrating Transcription Factors Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents

Dr. Qing Zhou, Associate Research Scientist, Columbia University, USA

10

Title: Multivariant Transcriptome Analysis Identifies Modules and Hub Genes Associated with Poor Outcomes in Newly Diagnosed Multiple Myeloma Patients

Dr. Olayinka O. Adebayo, Senior Scientist, Johnson & Johnson, USA

11

Title: Electron Spin Resonance Evaluation of Buccal Membrane Fluidity Alterations by Sodium Caprylate and L-Menthol

Dr. Shanthi Chede, Formulation Scientist -I, American Regent, Inc (A subsidiary of Daichi Sankyo, Japan), USA

12

Title: GLP-1 Secretagogues from the Marquesan Endemic Tree Oparanthus Teikiteetinii (Asteraceae)

Dr. Phila Raharivelomanana, Full Professor, University of French Polynesia, French Polynesia

Posters & Papers

 

IDDST 01

Title: Application of a Novel CL7/Im7 Affinity System in Purification of Complex and Pharmaceutical Proteins

Dr. Dmitry G. Vassylyev, Professor, University of Alabama at Birmingham, USA

IDDST 02

Title: The Future of Drugs is Digital: Improving Accuracy and Repeatability of Digital Drug

Mr. Roscop Frederic, Head of Aequil Lab, UK

IDDST 03

Title: SIVOMIXX® Probiotic Formulation as a Coadjuvant Therapy for Parkinsons Disease: Preclinical Evidence on 6-OHDA Models

Ms. Margherita Alfonsetti, PhD Student, University of L'Aquila, Italy

IDDST 04

Title: Severe Nervous System Damage in Long-term Professional Exposure to Phthalates

Dr. Wlodzislaw Kulinski, Professor, Military Institute of Medicine-National Research Institute, Poland

SDDS 01

Title: Anti-CD3scfv Stimulates Locoregional Immunotherapy Against Hepatocellular Carcinoma

Depending on the E1A-engineered HUMSC Homing

Dr. Yanjun Zhang, Associate Professor, State Key Laboratory of Experimental Hematology, Department of Pharmacy, Institute of Hematology & Hospital of Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, China

SDDS 02

Title: Recent Trends in Silver Nanoparticles Toxicity, Health Effects and Biomedical Applications

Dr. Jamila Khatoon Adam, Adjunct Professor, Durban University of Technology, South Africa

GSCF 01

Title: The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy
Dr. Oksana Koryakina, Ural State Medical University, Yekaterinburg, Regional Children Clinical Hospital,Yekaterinburg, Russia

GSCF 02

Title: Circulating Serum-Derived miRNAs: Minimally Invasive Predictors of Bladder Cancer Outcome
Dr. Andreas Scorilas, Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Greece

GSCF 03

Title: Next-generation Sequencing Reveals Altered Gene Expression and Enriched Pathways in Triple-Negative Breast Cancer Cells Treated with Oleuropein and Oleocanthal

Dr. Andreas Scorilas, Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Greece

 



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