BIT's 18th Annual Congress of International Drug Discovery Science and Technology (IDDST-2023)
Scientific Program

Program

 

Time: July 12-July 14, 2023

Venue: Amsterdam, the Netherlands

 

Registration

Time: 10:00-21:00, July 11, 2023 (Tuesday); Place: In Front of Rembrandt Room, Ground Floor, Holiday Inn Amsterdam Arena Towers

Opening Ceremony

Time: 09:00-09:10, July 12, 2023 (Wednesday); Place: Rembrandt Room, Ground Floor, Holiday Inn Amsterdam Arena Towers

Keynote Forum (Sponsored by Wyatt Technology)

Time: 09:10-12:10, July 12, 2023 (Wednesday); Place: Rembrandt Room, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Moderator

Dr. Matthew He, Professor, Halmos College of Arts and Sciences, Nova Southeastern University, USA

 

09:10-09:15

Chair's Introduction

09:15-09:40

Title: Advanced Cellular Models and Future Applications
Dr. Stefan Platz, SVP & Global Head Clinical Pharmacology & Safety Sciences, AstraZeneca, UK

09:40-10:05

Title: The Academia-CRO Tandem: The Drug Discovery Engine of the Future?
Dr. Luc Van Hijfte, Senior VP Drug Discovery, Symeres B.V., the Netherlands

10:05-10:30

Title: From Informatics to Intelligence: Bioinformatics, Bioengineering, And Brain Science

Dr. Matthew He, Professor, Halmos College of Arts and Sciences, Nova Southeastern University, USA

10:30-10:55

Title: The Role of ABC Membrane Transporters in Personalized Diagnostics and Drug Treatment
Dr. Balazs Sarkadi, Professor Emeritus, Research Centre for Natural Sciences, Institute of Enzymology, Hungary

10:55-11:20

Title: Nanoparticles for Gene and Drug Delivery: Applying Light Scattering to Screening and Characterization
Dr. Roger Scherrers, Head of Analytical Service, Water, Wyatt Technology Division, Germany

11:20-11:45

Title: Protein-DNA Recognition and Target Location Studied by NMR Spectroscopy

Dr. Robert Kaptein, Emeritus Professor, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands

11:45-12:10

Title: Building Better Treatments for Type 1 Diabetes Based on Understanding Human Pathogenesis

Dr. Matthias von Herrath, Scientific Director of the Diabetes Research Institute, University of Miami School of Medicine; Vice President, Novo Nordisk, USA (Video)

IDDST 211: Innovative Drug Discovery Technology---Part I

Time: 13:30-17:10, July 12, 2023 (Wednesday); Place: Rembrandt 1, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Barry Morgan, Chief Scientific Officer, HitGen Inc., USA

Co-Chair

Dr. Fabian Mohr, Vice President Research and Development, IBA Lifesciences GmbH, Germany

 

13:30-13:35

Chair's Introduction

13:35-13:55

Title: Novel Small Molecule Tocolytic Development

Dr. Iain L. O. Buxton, Foundation Professor, University of Nevada, USA

13:55-14:15

Title: Ice-free Vitrification for Cryopreservation and Nanowarming for Rapid Warming of Tissues and Organs as an Alternative to Freezing

Dr. Kelvin G.M. Brockbank, Professor & CEO, Clemson University and Tissue Testing Technologies LLC, USA

14:15-14:35

Title: Demystifying DEL: DNA-Encoded Library Technology is Not (That) Complicated!

Dr. Barry Morgan, Chief Scientific Officer, HitGen Inc., USA

14:35-14:55

Title: The Importance of Physicochemical Properties for the Bioavailability of Pharmaceutical Compounds

Dr. Rebeca Ruiz, Principal Scientist, Pion Inc., UK

14:55-15:15

Title: Label-free Readout in 1536 Format with MALDI-TOF Mass-spectrometry

Ms. Maaike Bras, Scientist, Pivot Park Screening Centre, the Netherlands

15:15-15:30

Coffee Break

15:30-15:50

Title: Developing a Robust Affinity Tag Platform Using Engineered Streptavidin

Dr. Fabian Mohr, Vice President Research and Development, IBA Lifesciences GmbH, Germany

15:50-16:10

Title: Three-Dimensional (3D) Imaging of Whole Single Cells: Using Synchrotron Light for Innovative Drug Discovery

Dr. Barbara M. Calisto, Industrial Liaison Officer, ALBA Synchrotron, Spain

16:10-16:30

Title: Navigating Through the Critical Path for Chemistry, Manufacturing and Controls (CMC)

Dr. Elizabeth Kwong, Consultant, Kwong Eureka Solutions, Canada

16:30-16:50

Title: Induction of Neo-angiogenesis to Control the Gangrenous Changes in Complex Wounds by Platelet Rich Plasma

Dr. Sandeep Shrivastava, Director & Professor of Orthopedics, JLN Medical College, Datta Meghe Institute of Higher Education & Reserach (DU), India

16:50-17:10

Title: The Crucial Conserved Residues' Effect on Drug Discovery

Dr. Azhar Salari-Jazi, Head of Drug Development and Innovation Center, Behban Pharmed Lotus Pharmaceutical Company, Iran

IDDST 212: Frontiers in Pharmacology and Toxicology

Time: 08:30-11:50, July 13, 2023 (Thursday); Place: Rembrandt 1, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Roberta Bursi, Executive Vice President R&D, InSilicoTrials Technologies, the Netherlands

Co-Chair

Dr. Alessandro Di Cerbo, Researcher, School of Biosciences and Veterinary Medicine, University of Camerino, Italy

 

08:30-08:35

Chair's Introduction

08:35-08:55

Title: Lessons Learned from BIA 10–2474; Consequences of Irreversible Target Binding for Interpretation of IC50, Selectivity, and Multiple Dose Toxicity

Dr. Mattheus (Thijs) van Iersel, Senior Director of Clinical Pharmacology, Drug Development Solutions, ICON, the Netherlands

08:55-09:15

Title: Accelerating Drug Discovery Science & Technology with the Cloud-based InSilicoTrials Platform

Dr. Roberta Bursi, Executive Vice President R&D, InSilicoTrials Technologies, the Netherlands

09:15-09:35

Title: Towards a More Sustainable Way to Conduct Drug Metabolism Studies: Use of Human and Bacterial Enzymes as the Sole Source of Metabolites

Dr. Gianluca Catucci, Assistant Professor, University of Torino, Italy

09:35-09:55

Title: Protective Effects of Borago Officinalis (Borago) on Cold Restraint Stress-induced Gastric Ulcers in Rats

Dr. Alessandro Di Cerbo, Researcher, School of Biosciences and Veterinary Medicine, University of Camerino, Italy

09:55-10:15 

Title: Drug Delivery Through the Physiological Barriers - Assessment of Transporter Interactions in vivo and ex vivo

Dr. Franciska Erdo, Associate Professor, Pazmany Peter Catholic University, Hungary

10:15-10:30

Coffee Break

10:30-10:50

Title: Aurora Kinase A Inhibitor (VX 680) Inhibits Cell Migration, Invasion, Proliferation and Viability and Promotes Cell Apoptosis in Human Prostate Cancer (PC3) Cells

Dr. Ahmad Al-Azayzih, Associate Professor, Department of Clinical Pharmacy-Faculty of Pharmacy, Jordan University of Science and Technology, Jordan

10:50-11:10

Title: Alternate Approach to Demonstrate Bioequivalence for Locally Applied and Acting Lozenges

Dr. Anuradha Kulasekaran, Global Medical Affairs Manager - Respiratory, Reckitt Health Ltd., UK

11:10-11:30

Title: Successful Outcome Following a Loading Dose of N-acetylcysteine to Treat Hepatotoxicity after Repeated Therapeutic Doses of Paracetamol

Dr. Abdullah Altamimi, Children Hospital - King Fahad Medical City, Saudi Arabia

11:30-11:50

Title: Translating Aging Discoveries to Delay Human Aging and Extend Healthspan

Dr. Brian Kennedy, Distinguished Professor, Yong Loo Lin School of Medicine, National University Singapore, Singapore

IDDST 213: Innovative Drug Discovery Technology---Part II

Time: 08:30-11:50, July 14, 2023 (Friday); Place: Rembrandt 1, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Csaba Hetenyi, Associate Professor, Head of the Pharmacoinformatics Unit, University of Pecs, Hungary

Co-Chair

Dr. Urban Fagerholm, Founder & CEO, Prosilico AB, Sweden

 

08:30-08:35

Chair's Introduction

08:35-08:55

Title: Computer-aided Drug Discovery in CRO: Innovative Approaches Using Open-Source Software

Dr. Ricardo J. Ferreira, Head of Computational Chemistry, Red Glead Discovery AB, Sweden

08:55-09:15

Title: Optimization of Drug-Target Interactions Using Fast Pharmacoinformatics Protocols

Dr. Csaba Hetenyi, Associate Professor, Head of the Pharmacoinformatics Unit, University of Pecs, Hungary

09:15-09:35

Title: Structural Elucidation of Ligand Binding Mechanisms to Somatostatin Receptors

Dr. Rita Borzsei, Senior Lecturer, Department of Pharmacology and Pharmacotherapy, Medical School, University of Pecs, Hungary

09:35-09:55

Title: BIOMIMESYS® Hydroscaffold, A Ready-to-use Organ-specific Extracellular Matrix for Relevant Phenotypic Screening

Dr. Nathalie Maubon, CEO & CSO, HCS Pharma, France

09:55-10:15 

Title: Details of ABCG2 Multidrug Transporter Function Revealed by Molecular Dynamics

Dr. Tamas Hegedus, Senior Research Fellow, Semmelweis University, Hungary

10:15-10:30

Coffee Break

10:30-10:50

Title: Computational Methodology Outperforms Laboratories in Predicting Human Clinical Biopharmaceutics

Dr. Urban Fagerholm, Founder & CEO, Prosilico AB, Sweden

10:50-11:10

Title: AlphaSelect, A Viral Replicon-based Screening Platform for the Identification of Primary Self-antigens of Autoimmune Diseases
Dr. Peter de Haan, CSO, Amarna Therapeutics, the Netherlands

11:10-11:30

Title: Innovative Methodologies and New Data for Predictive Oncology Model Evaluation (IMPROVE)

Dr. Alexander Partin, Computational Scientist, Argonne National Laboratory, USA

11:30-11:50

Title: Small But Mighty; The Cutting-Edge Role of PD-L1 Small Molecule Inhibitors in Cancer

Dr. Hend M. El Tayebi, Associate Professor, German University in Cairo, Egypt

IDDST 311: Open Innovation & Drug Design and Synthesis

Time: 08:30-11:50, July 13, 2023 (Thursday); Rembrandt 2, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Florian Montel, Head of opnMe.com and the Open Science Group, Boehringer Ingelheim, Germany

Co-Chair

Dr. Concettina La Motta, Associate Professor of Medicinal Chemistry, University of Pisa, Italy

 

08:30-08:35

Chair's Introduction

08:35-08:55

Title: Design and Development of Agonists Selectively Activating BMP Signalling Using the Three-Dimensional Structure of BMP7. Prevention of Cellular Injury

Dr. William Carlson, Associate Professor, Harvard Medical School, USA

08:55-09:15

Title: OpnMe.com: The Boehringer Ingelheim's Open Innovation Portal to Foster Academic Innovation 

Dr. Florian Montel, Head of opnMe.com and the Open Science Group, Boehringer Ingelheim, Germany

09:15-09:35

Title: Identification and Biological Role of Novel Catecholamines

Dr. Gilberto De Nucci, Professor, Sao Leopoldo Mandic Medical School, Brazil

09:35-09:55

Title: Positive Allosteric Modulators of GluN2B-Containing NMDARs as Enhancers of Synaptic Plasticity

Dr. Jose Maria Cid Nunez, Scientific Director, Janssen Research and Development, Spain

09:55-10:15 

Title: Revealing the Molecular Factors that Govern the Activation/Inhibition AMPK Mechanism by Direct Activators: Towards a New Drug Design

Dr. Carolina Estarellas, Lecturer Professor, University of Barcelona, Spain

10:15-10:30

Coffee Break

10:30-10:50

Title: Making Headway with a New Class of Ferroptotic Agents

Dr. Viranga Tillekeratne, Professor, Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA

10:50-11:10

Title: AMP-activated Protein Kinase: A Viable Target in Inflammatory Bowel Diseases

Dr. Concettina La Motta, Associate Professor of Medicinal Chemistry, University of Pisa, Italy

11:10-11:30

Title: Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: In Silico Approach

Dr. Michael Shapi, Head of Department of Chemistry, Mangosuthu University of Technology, South Africa

11:30-11:50

Title: A New Criterion for Systematization of Organic Compounds

Dr. Dumitru Petru Iga, Professor, University of Bucharest, Romania

IDDST 312: Novel Targets Discovery

Time: 13:30-16:30, July 13, 2023 (Thursday); Rembrandt 1, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Yong Li, Professor and Chief of BioMedical Engineering, Western Michigan University, USA

 

13:30-13:35

Chair's Introduction

13:35-13:55

Title: Epitomics: A New Proteomics Approach for the Discovery of Drug Targets and Diagnostics

Dr. Laszlo Takacs, Professor, University of Debrecen; CEO/CSO Biosystems Immunolab Zrt, Hungary

13:55-14:15

Title: Correct Identification of Cell of Origin is Essential for Rational Cancer Treatment

Dr. Helge Waldum, Professor, Norwegian University of Science and Technology, Norway

14:15-14:35

Title: Bortezomib is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation and Mitotic Catastrophe

Dr. Chun-Fung Sin, Clinical Assistant Professor, Department of Pathology, University of Hong Kong, Hong Kong, China

14:35-14:55

Title: Cerebral-autoregulation Guided Therapeutic Targets to Improve Outcomes from Sepsis and Sepsis-associated Encephalopathy

Dr. Kathryn Rosenblatt, Assistant Professor of Anesthesiology, Johns Hopkins University School of Medicine, USA

14:55-15:15

Title: Epigenetic Machineries from Basic Research to Pre-clinical

Dr. Indrabahadur Singh, Emmy Noether Research Group Leader, German Cancer Research Center, Germany

15:15-15:30

Coffee Break

15:30-15:50

Title: Two Mechanisms That Drive Uncontrolled Proliferation of Lung Cancer Cells 

Dr. Changmin Chen, Chief Scientific Officer, Chengdu Precision Medicine Laboratory Co., LTD., China

15:50-16:10

Title: Breaking Steroid Resistance by Targeted Compounds in Pediatric T-cell Acute Lymphoblastic Leukemia

Dr. Jules P. P. Meijerink, Principal Investigator, Princess Maxima Center for Paediatric Oncology, the Netherlands

16:10-16:30

Title: The Role of Extracellular Vesicles Secreted by Colon Cancer Cells in Mediating the Nuclear Translocation of PD-L1 in a Model of Human Healthy Hepatocytes: New Insights on Immune Checkpoint Pathways

Dr. Marzia Pucci, Researcher, University of Palermo, Italy

IDDST 411: Cancers/Tumors

Time: 13:30-17:50, July 12, 2023 (Wednesday); Place: Rembrandt 2, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Hidemitsu Nakagawa, President, Nozaki Tokushukai Hospital & Research Institute of Nozaki Tokushukai, Japan

Co-Chair

Dr. Valerie Vouret-Craviari, Director of Research, Institute for Research on Cancer and Aging, France

 

13:30-13:35

Chair's Introduction

13:35-13:55

Title: Melatonin Modulates Tumor Metabolism and Mitigates Metastasis

Dr. Russel J. Reiter, Professor, UT H San Antonio Health, USA

13:55-14:15

Title: Image-based Analysis of the Myeloid Cell landscape in the 3D Co-culture with Tumor Cells

Dr. Gera Goverse, Director Immuno-Oncology, Crown Bioscience, the Netherlands

14:15-14:35

Title: Intrathecal Sodium Butyrate for Leptomeningeal Metastasis (LM) of Malignant Tumors-experimental Research and Clinical Trial

Dr. Hidemitsu Nakagawa, President, Nozaki Tokushukai Hospital & Research Institute of Nozaki Tokushukai, Japan

14:35-14:55

Title: Cervical Cancer After Almost a Decade of HPV Vaccination Program in Brazil

Dr. Leandro Santos A. Resende, Gynecologist Oncologist, Oncoclinicas Brasil, Brazil

14:55-15:15

Title: HA Conjugated Drugs in Cancer Therapy

Dr. James Neil Hunter, International Healthcare Activities Director, Holy Stone Biotech Co Ltd, UK

15:15-15:30

Coffee Break

15:30-15:50

Title: Anti-inflammatory, General and Specific Functions of Human Red Blood Cells (hRBCs / erythrocytes), Their Role in Health and PATHOGENS Elimination

Dr. Mehrdad Ghashghaeinia, Vice President, Physiological Institute I, Department of Vegetative and Clinical Physiology, Germany

15:50-16:10

Title: Small Molecule Inhibitors of Nuclear MAPK Translocation as Novel Anti-cancer and Inflammation Drugs

Dr. Galia Maik-Rachline, Associate Staff Scientist, The Weizmann Institute of Science, Israel

16:10-16:30

Title: A Novel Screen for Expression Regulators of TRF2 Identified Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

Dr. Julien Cherfils-Vicini, PI Team Immune Sureveillance in Aging & Cancer, IRCAN, University Cote d'Azur, France

16:30-16:50

Title: Reshaping Immune Lung Populations to Inhibit Lung Cancer and Fibrosis by Activation of Purinergic Receptor P2RX7

Dr. Valerie Vouret-Craviari, Director of Research, Institute for Research on Cancer and Aging, France

16:50-17:10

Title: OXC-101 (TH1579): A Novel Way to Treat Acute Myeloid Leukemia by Inducing Mitotic Arrest, ROS and Oxidative Damage

Dr. Ulrika Warpman Berglund, CEO, Oxcia AB, Sweden

17:10-17:30

Title: Models of Cancer Growth

Dr. Jens Christian Larsen, Retired Assistant Professor, Private Investigator, Denmark

17:30-17:50

Title: Imaging in Radiation Therapy

Dr. Despina Katsochi, Radiation Oncologist, Hygeia Hospital Athens, Greece

IDDST 412: Precision Medicine, Immunotherapy, Cell and Gene Therapy

Time: 13:30-17:30, July 12, 2023 (Wednesday); Place: Rembrandt 3, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Godefridus J Peters, Professor in Pharmacology of Cytostatics, Amsterdam University Medical Centers, the Netherlands; Professor in Biochemistry, Medical University of Gdansk, Poland

Co-Chair

Dr. Barbara Wolff-Winiski, Co-CEO & CSO, AKRIBES Biomedical GmbH, Austria

 

13:30-13:35

Chair's Introduction

13:35-13:55

Title: Personalized and Precision Medicine (PPM) as a Unique Healthcare Model to be Set Up via Biodesign-driven Translational Applications and Business Modeling to Secure the Human Healthcare and Biosafety

Dr. Sergey Suchkov, Professor, Institute for Biotech & Global Health of RosBioTech & A.I. Evdokimov MGMSU, Russia

13:55-14:15

Title: Novel Technologies Aiding Drug Discovery for Precision Medicine

Dr. Peter Staller, Director of Functional Genomics, Nuvisan - Innovation Campus Berlin, Germany

14:15-14:35

Title: Role of Pharmacogenetics and Drug Discovery

Dr. Godefridus J Peters, Professor in Pharmacology of Cytostatics, Amsterdam University Medical Centers, the Netherlands; Professor in Biochemistry, Medical University of Gdansk, Poland

14:35-14:55

Title: Testing Complex Activity Profiles of Human Immune Cells Using a Highly Standardised Bed-Side Whole Blood Culture Model (TruCulture®)

Dr. Katja Kirschbaum, Scientist, HOT Screen GmbH, Germany

14:55-15:15

Title: Targeted Therapy for Acute Lymphoblastic Leukemia

Dr. William J. Hogan, Associate Professor of Medicine, Mayo Clinic, USA

15:15-15:30

Coffee Break

15:30-15:50

Title: Personalized Treatment of Chronic Wounds

Dr. Barbara Wolff-Winiski, Co-CEO & CSO, AKRIBES Biomedical GmbH, Austria

15:50-16:10

Title: Novel Alginate-based Hydrogel Technology for the Preservation of Cells, Tissues, Viruses, And Apheresis at Hypothermic Temperatures

Ms. Anastassia Kostenko, Research & Development Scientist, Atelerix, UK

16:10-16:30

Title: Biomimetic Membrane-Based Drug Delivery Systems

Dr. Aharon (Roni) Azagury, Assistant Professor, Ariel University, Israel

16:30-16:50

Title: Tolerance Induction for Transplantation of Hypoxic Cells to Enhance Cell Therapy

Dr. Yong Li, Professor and Chief of BioMedical Engineering, Western Michigan University, USA

16:50-17:10

Title: A Thermostable Tetanus/Diphtheria (Td) Vaccine in the StablevaXTM Pre-Filled Delivery System

Ms. Juana de la Torre Arrieta, Senior Manager, R&D Operations Stablepharma Ltd., Spain

17:10-17:30

Title: Next Generation of Cell based Therapies for Cancer

Dr. Khalid Shah, Associate Professor, Harvard Medical School; Vice Chairman, Department of Neurosurgery, Brigham and Women's Hospital; Principal Faculty, Harvard Stem Cell Institute, Harvard University, USA

IDDST 413: Breakthrough of Therapeutic Antibodies, Vaccines, Protein and Peptide

Time: 08:30-12:30, July 13, 2023 (Thursday); Place: Rembrandt 3, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Immanuel Lerner, Chief Executive Officer, Pepticom LTD, Israel

Co-Chair

Dr. Monica Berrondo, CEO, Macromoltek, Inc., USA

 

08:30-08:35

Chair's Introduction

08:35-08:55

Title: Schistosomiasis: Basic Requirements for the Development of a Molecularly Defined Vaccine

Dr. Gul Ahmad, Professor, School of Arts & Sciences, Peru Staste College, USA

08:55-09:15

Title: Induction and Potential Reversal of a T Cell Exhaustion-Like State

Dr. Pirouz Daftarian, Director of Scientific Engagement, Crown Bioscience; Director of Senior Manager, Immuno-Oncology and Vaccines' Applications, JSR Life Sciences, USA

09:15-09:35

Title: A Universal Tool for Stability Predictions of Biotherapeutics, Vaccines and In Vitro Diagnostic Products

Mr. Didier Clenet, Principal Scientist, Sanofi, France

09:35-09:55

Title: Application of Artificial Intelligence in Peptide Drug Discovery: Opportunities and Challenges

Dr. Immanuel Lerner, Chief Executive Officer, Pepticom LTD, Israel

09:55-10:15 

Title: Effectively Meeting the Needs in Today's Antibody Discovery: Methods to Address Narrow Diversity Targets and Functionality

Dr. Volker Lang, Managing Director, AbCheck, Czech Republic

10:15-10:30

Coffee Break

10:30-10:50

Title: De novo Computational Antibody Design Against Mycobacteria and Other Antigens

Dr. Monica Berrondo, CEO, Macromoltek, Inc., USA

10:50-11:10

Title: Application of an Antibiotic-free Selection System and Use of an AI-assisted Process Optimization Approach

Dr. Marinka Gudelj-Wyletal, Scientist, Boehringer-Ingelheim RCV GmbH & CoKG, Austria

11:10-11:30

Title: Clinical Update on Anti-IL-17A Antibody and Beyond

Dr. Xiangyang Zhu, CEO, Shanghai Huaota Biopharmaceutical Co., Ltd., China

11:30-11:50

Title: LYZ-A3, The 8-mer Fragment Peptide Derived from Lysozyme Ameliorates α-Syn61-84 Peptide-induced Short Memory Impairment and Motor Dysfunction by Suppressing Aggregation of α-Syn61-84 Peptide

Dr. Toshifumi Akizawa, Professor, Kochi University; CEO, O-Force Co. Ltd., Japan

11:50-12:10

Title: Five-mer Peptides GSGFK and GSGNR Suppress and Resolve the Aggregation of Aβ25-35

Dr. Rina Nakamura, Lecturer, Kochi University; Director of Catalytide Institute, O-Force Co. Ltd., Japan

12:10-12:30

Title: Endoplasmatic Reticulum Shaping by Generic Mechanisms and Protein-induced Spontaneous Curvature

Dr. Erich Sackmann, Professor, Physics Department, Technical University of Munich, Germany

IDDST 414: CNS, Infectious, Cardiovascular and Other Diseases

Time: 13:30-18:10, July 13, 2023 (Thursday); Rembrandt 2, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

 Dr. Tamas Alexy, Associate Professor of Medicine, University of Minnesota, USA

Co-Chair

Dr. Robert W. W. Biederman, Director, Cardiovascular Magnetic Resonance Imaging, Allegheny General Hospital, USA

 

13:30-13:35

Chair's Introduction

13:35-13:55

Title: The Causes of Dyspnea in Post-COVID-19 Syndrome in the Absence of Organ Damage: Potential Role of Skeletal Muscle Pathophysiology and Autonomic Dysfunction

Dr. Klaus Wirth, Professor, Goethe-University Frankfurt, Germany

13:55-14:15

Title: Developing Novel Alternative Delivery Strategies for Pediatric HIV Antiretroviral Therapy to Improve Adherence in Kenya

Dr. Sarah Finocchario-Kessler, Professor, University of Kansas Medical Center, USA

14:15-14:35

Title: Antibacterial Drug Discovery and Development Programs, Preclinical and Clinical Services at NIAID 

Dr. Zuoyu Xu, Program Officer, National Institute of Allergy and Infectious Diseases, NIH/DHHS, USA

14:35-14:55

Title: Association of Pulmonary Hypertension and Monoclonal Gammopathy of Undetermined Significance

Dr. Wayne Feyereisn, Assistant Professor, Mayo Clinic, USA

14:55-15:15

Title: A Double-Edged Sword: Thioxanthenes and Other Non-antibiotics Act on Both the Mind and the Microbiome

Dr. Marianne Ostergaard Poulsen, Medical Laboratory Technician, University of Southern Denmark, Denmark

15:15-15:30

Coffee Break

15:30-15:50

Title: The Challenging Route to a Potential Therapeutic Option for the Rare Disease Fibrodysplasia Ossificans Progressiva   

Dr. Elisabeth Marelise W. Eekhoff, Associate Professor, Amsterdam University Medical Center, the Netherlands

15:50-16:10

Title: The Additive Value of Pacemakers and ICDs in the MRI Environment Over 19 Years; A Large, Prospective, Longitudinal, Observational Study

Dr. Robert W. W. Biederman, Director, Cardiovascular Magnetic Resonance Imaging, Allegheny General Hospital, USA

16:10-16:30

Title: Novel, pH-neutral Furosemide Formulation for Subcutaneous Use: Transforming the Management of Congestion in Heart Failure

Dr. Tamas Alexy, Associate Professor of Medicine, University of Minnesota, USA

16:30-16:50

Title: Is Magnesium an Effective Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis?

Dr. Michel Normand, Nephrologist, Private Hospital, France

16:50-17:10

Title: Effect of tt-Farnesol and Myricetin on In Vitro Biofilm Formed by Streptococcus Mutans and Candida Albicans

Dr. Marlise Inez Klein, Assistant Professor, Piracicaba Dental School, State University of Campinas, Brazil

17:10-17:30

Title: Segmentation of Skin Lesion Using Color Histogram Clustering with Saliency Algorithm

Dr. Seena Joseph, Researcher & Lecturer, Durban University of Technology, South Africa

17:30-17:50

Title: In the Era of Digital Medicine: Using Technologies to Restore Functional Movement in Neurological Patients 

Dr. Paolo Milia, Neurologist, Istituto Clinico Tiberino, University of Perugia, Italy

17:50-18:10

Title: Obesity: Treatments, Conceptualizations, And Future Directions for a Growing Problem

Dr. Rashmi Supriya, Assistant Professor, Hong Kong Baptist University, Hong Kong, China

IDDST 415: Drug Bioprocessing & Manufacturing and Integrative Services

Time: 08:30-11:10, July 14, 2023 (Friday); Place: Rembrandt 2, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Tara Nealey, Chair - Biotechnology and Life Sciences Patents, Polsinelli PC, USA

Co-Chair

Dr. Andreas Seidl, Chairman of the Scientific Advisory Board, Leukocare AG; CSO, Formycon AG/Munich, Germany

 

08:30-08:35

Chair's Introduction

08:35-08:55

Title: Confounding Factors in Assessing Adverse Events in Clinical Trials: Examples from the COVID-19 Pandemic

Dr. James Buchanan, President, Covilance LLC, USA

08:55-09:15

Title: Strategies for Protecting Life Science Inventions Across the World

Dr. Tara Nealey, Chair - Biotechnology and Life Sciences Patents, Polsinelli PC, USA

09:15-09:35

Title: U.S. Efforts to Advance Pharmaceutical Innovations from the Early Stage Startup Phase to the Clinic

Dr. Todd Haim, Director of the Office of Strategic Extramural Programs, National Institute on Aging, USA

09:35-09:55

Title: Opportunities for Biosimilar Product Differentiation Through Drug Product Enhancement

Dr. Andreas Seidl, Chairman of the Scientific Advisory Board, Leukocare AG; CSO, Formycon AG/Munich, Germany

09:55-10:15 

Title: Outcome of Phase - 1 Studies 

Dr. Kiran Vithaldas Marthak, Director - Medical Affairs, Phase-1 and Regulatory Affairs, Veeda Clinical Research Limited, India

10:15-10:30

Coffee Break

10:30-10:50

Title: Metabolomics in the Development of Herbal and Traditional Medicine

Dr. Pulok Kumar Mukherjee, Director, Institute of Bioresources and Sustainable Development; Professor, Department of Pharmaceutical Technology, Jadavpur University, India

10:50-11:10

Title: Biosimilars in Europe, A Blueprint for Success

Dr. Michael Reilly, Executive Director, Alliance For Safe Biologic Medicines; Founding President, Tidwell Group, LLC, USA

Young Scientists' Forum

Time: 10:30-11:55, July 14, 2023 (Friday); Place: Rembrandt 3, Ground Floor, Holiday Inn Amsterdam Arena Towers

 

Chair

Dr. Adam Haimhoffer, Assistant Lecturer, University of Debrecen, Hungary

 

10:30-10:35

Chair's Introduction

10:35-10:55

Title: Glucose Sensing VIA the Skin_ From in vitro to in vivo: Translation Studies

Dr. Nsrein Ali, Senior Researcher, University of Oulu, Finland

10:55-11:15

Title: Develop Gastro-retentive Dosage Forms by Innovative Hot, Melt Technics

Dr. Adam Haimhoffer, Assistant Lecturer, University of Debrecen, Hungary

11:15-11:35

Title: The Role of the ABCG2 Efflux Transporter at the Blood-milk Barrier

Dr. Lydia Kuhnert, Postdoctoral Researcher, Faculty of Veterinary Medicine, University Leipzig, Germany

11:35-11:55

Title: Structure- And Ligand-based Virtual Screening Approaches for Identification of Novel TRPV4 Inhibitors

Ms. Atefeh Saadabadi, Ph.D. Candidate, Abo Akademi University, Finland

11:55-12:20

Title: Optimization of Luteolin-Loaded TPGS/Poloxamer 407 Nanomicelle: Effect of Copolymers, Hydration Temperature and Duration, And Freezing Temperature on Encapsulation Efficiency, Particle Size, And Solubility 

Mr. Muhammad Redza Fahmi Mod Razif, Ph.D. Candidate, University of Cyberjaya, Malaysia

Posters & Papers

 

IDDST 01 

Title: New Validated, Authority Approved Software for Prediction, Simulation & Optimization of Human Clinical ADME/PK

Dr. Sven Hellberg, Co-Founder, Prosilico AB, Sweden

IDDST 02 

Title: 1H and 13C NMR Spectra Characterization of a Partially Methylated Cerebroside [β-D-Glucopyranosyl (3-O-Methyl) - Ceramide] and Its Synthesis Intermediates

Mr. Valentin Ioan Remus Niculescu, Senior Researcher, University of Bucharest, Romania

 IDDST 03

Title: Examining Toxicity of MnO2 Aerosol Nanoparticles under Single Inhalation Exposure

Dr. Nina Zaitseva, Professor, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies Perm, Russia

IDDST 04

Title: Targeting Liver Diseases and Causes by Natural Traditional Remedies from Burkina Faso-Africa

Dr. Maelle Carraz, Researcher, Institute of Research for Development, France

IDDST 05

Title: Development of a Novel Tocotrienol Analogue, Tocoflexol, As a Radiomitigator

Ms. Shraddha Thakkar, Associate Director of Sales, MIMETAS B.V., the Netherlands

SDDS 01

Title: Using Indocyanine Green Liposomes for Diagnosis and Therapeutic Monitoring of Cerebral Malaria

Dr. Jacob Golenser, Professor Emeritus, The Hebrew University of Jerusalem, Israel

SDDS 02

Title: Recent Trends in Silver Nanoparticles Toxicity, Health Effects and Biomedical Applications

Dr. Jamila Kathoon Adam, Institutional Research Ethics Committee (IREC) Chairperson, Durban University of Technology, South Africa

SDDS 03

Title: Diallyl Trisulfide (DATS) Protects Cardiac Cells Against Advanced Glycation End-product-induced Apoptosis by Enhancing FoxO3A-dependent Upregulation of miRNA-210

Dr. Wei-Wen Kuo, Professor, China Medical University, Taiwan

SDDS 04

Title: Carboxyl Terminus of HSP70 Interacting Protein (CHIP) Engineered Wharton's Jelly-derived Mesenchymal Stem Cells Attenuates Hyperglycemia-induced P53/TGFβ1/SMAD2/3 Mediated Differentiation to Enhance Self-renewal

Dr. Chih-Yang Huang, Professor, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan

 



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