BIT's 16th Annual Congress of International Drug Discovery Science & Technology-China 2018

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★ Scientific Program

BIT's 16^th Annual World Congress of

Drug Discovery Science & Technology - Jinan 2018

Theme: Focusing on Biomedical Frontiers, Driving Industrial Innovative Development

Time: November 6-8, 2018

Place: Jinan, China

Preliminary Scientific Program

Session times on those days will not be finalized until the overall program schedule is completed.

Program Sessions (Please click each Forum for detailed program information)

Stream 1: Masters' Mind Honor Hall

Stream 2: High-end Dialogue

Stream 3: Breaking Research of Drug Discovery

Stream 4: New Drug R & D for Major Diseases

Stream 5: Industrial Art Gallery

Stream 6: Young Pharmacists’ Nexus

Stream 7: Projects Matchmaking

Stream 3101: Advancing Molecular Target Discovery
Time:13:30-15:15, Nov. 6, 2018 Place: Han Room, 1^st Floor, Sheraton Jinan Hotel, Jinan, China
Chair	Dr. Kevin Liu, Head of Chemistry, Global Discovery Chemistry, Novartis Institute of Biomedical Research, China
Co-Chair	Dr. Xiangbing Qi, Director of Chemistry Center, National Institute of Biological Sciences, China
13:30-13:35	Chair's Introduction
13:35-13:55	*Title:* Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors *Dr. Xiangbing Qi*, Director of Chemistry Center, National Institute of Biological Sciences, China
13:55-14:15	*Title:* Is Pyruvate Dehydrogenase Complex a Legitimate Drug Target for Prostate Cancer? *Dr. Mu Wang,* Professor, Xi'an Jiaotong-Liverpool University, China
14:15-14:35	*Title:* DNA Encoded Library Technology & Applications in Innovative Drug Discovery *Dr. Jinqiao Wan,* Vice President, Discovery Chemistry Unit, HitGen, China
14:35-14:55	Title: Cancer Target Atlas Enabled by a Massively Parallel Monoclonal Antibody Array (MabArrayTM) Dr. Bing Hou, VP of Cell therapy Department, Abmart Inc, China
14:55-15:15	Title: Innovative Drug Based on Zebrafish Model: Third-generation ALK Inhibitors Dr. Jack. Li, President, Hangzhou REX Pharmaceutical Co., Ltd, China

Stream 3102: PK/PD, ADMET, In Vitro Efficacy and Toxicity
Time: 08:30-10:15, Nov. 7, 2018 Place: Yan Room, 1^st Floor, Sheraton Jinan Hotel, Jinan, China
Chair	Dr. Jeffery Liu, Director, GSK, USA
Co-Chair	Dr. Josef Jampilek, Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Slovakia
08:30-08:35	Chair's Introduction
08:35-08:55	*Title:* Pharma AI Application in Accessing Drugability - ADME/DMPK Profile *Dr. Jeffery Liu,* Director, GSK, USA
08:55-09:15	Title: Applications of Preclinical Pharmacokinetic-pharmacodynamic Modeling and Human Pharmacokinetic Prediction in First-in-human Clinical Trials Design for Anti-cancer Drug Development: Case Study Dr. Hong-Can Ren, Principal Scientist, Hutchison Medipharma Ltd., China
09:15-09:35	*Title:* Antibacterial Naphthalene-Based Agents *Dr. Josef Jampilek,* Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Slovakia
09:35-09:55	*Title:* Identification and Isolation of Toad Toxins and Their Toxic Mechanism *Dr. Haiyan Tian,* Associate Professor, Jinan University, China
09:55-10:15	Title: The Biological Characteristics of PJP1 Peptide and Its Anti-cancer Efficacy *Dr. Jianwei Zhou,* Professor, Nanjing Medical University, China

Stream 3103: New Formulation, Drug Delivery and Nanotechnology
Time: 13:30-17:30, Nov. 7, 2018 Place: Qi Room, 1^st Floor, Sheraton Jinan Hotel, Jinan, China
Chair	Dr. Gerald J. Yakatan, Chairman & CEO, IriSys, LLC,.USA
Co-Chair	*Dr. Li Li,* Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Australia
13:30-13:35	Chair's Introduction
13:35-13:55	Title: RNA Nanotechnology Dr. Eric Westhof, Professor, University of Strasbourg, France
13:55-14:15	*Title:* Are Copies of Nanomedicines Generics or Nanosimilars? *Dr. Beat Fluhmann,* Global Head Non-Biological Complex Drugs, Vifor Pharma Ltd, Switzerland
14:15-14:35	*Title:* Development of pH Sensitive Liposomal Delivery Systems for Anticancer Drugs *Dr. Gerald J. Yakatan,* Chairman & CEO, IriSys, LLC,.USA
14:35-14:55	Title: Engineering Hydrogels for Drug Deleivery Dr. Hossein Hosseinkhani, Founder & Chief Scientific Officer, Innovation Center for Advanced Technology, Matrix, Inc., USA
14:55-15:15	*Title:* Succeeding at Innovation: Generating Value from New Technology at Each Stage of Development and Implementation *Mr. Howard J. Stamato,* Consultant, Stamato Solutions LLC, USA
15:15-15:35	*Title:* Cost Effective Solution for Injectable Drug Delivery Devices *Dr. Menachem Zucker,* Vice President of Injectable Drug Delivery Devices, Elcam Medical, Israel
15:35-15:50	Coffee Break
15:50-16:10	*Title:* Targeted Drug Delivery in Cancer Therapy *Dr. Yunmei Song,* Scientist, University of South Australia, Australia
16:10-16:30	*Title:* Bioinspired Materials and Microstructures for Drug Delivery and Separation *Dr. Meiling Zheng,* Associate Professor, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China
16:30-16:50	*Title:* Nanoparticle-facilitated Combination Cancer Therapy *Dr. Li Li,* Postdoctoral research fellow in the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Australia
16:50-17:10	*Title:* Development of Technetium-99m Labelled Trihydroxystilbene Loaded Gold Nanoparticles as an Imaging Tool for the Detection of Colon Tumors *Dr. Devinder Kumar Dhawan,* Professor, Department of Biophysics and Centre for Nuclear Medicine, Panjab University Chandigarh, India
17:10-17:30	Title: Engineered Nanoparticles and Autophagy Assisted Cancer Therapy: A New Insights in Drug Delivery *Dr. Yamini Sudha Lakshmi,* Assistant Professor, Department of Medical Biochemistry, University of Madras, India

Stream 3104: Drug Discovery at Cell and Molecular Level
Time: 13:30-17:50, Nov. 7, 2018 Place: Yan Room, 1^st Floor, Sheraton Jinan Hotel, Jinan, China
Chair	Dr. Amr El-Shazly, Professor, Liege University Hospital, Belgium
Co-Chair	*Dr. Jung S. Huang,* Professor, Saint Louis University School of Medicine, USA
13:30-13:35	Chair's Introduction
13:35-13:55	*Title:* Renewed Interest in Natural Products with Natural Fragment Library-A Disruptive Innovation Programme for Drug Discovery *Mr. Yves Barbin,* Director, Pierre Fabre Research Institute, France
13:55-14:15	*Title:* Learn from Microbial Intelligence for Avermectins Overproduction *Dr. Lixin Zhang,* Director, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, China
14:15-14:35	*Title:* Tyrosine Kinase Inhibition is Important Factor for Gene Expression of CRTH2 in Human Eosinophils and Lymphocytes. *Dr. Amr El-Shazly,* Professor, Liege University Hospital, Belgium
14:35-14:55	*Title:* Novel High-throughput Drug Screening Assays for Identifying Potential Novel Phytochemical-based Therapeutics *Dr. Amandio Vieira,* Associate, Professor, Simon Fraser University, Canada
14:55-15:15	*Title:* Placebo Effect During Cognitive-behavioral Therapy of Aggressiveness-CInnovative Agonology in Practice *Dr. Roman Maciej Kalina,* Professor, Archives of budo, Poland
15:15-15:35	*Title:* Using a Combined NMR-fragment based Screening and Virtual Screening for the Development of Anti-tuberculosis Agents *Dr. Barak Akabayov,* Assistant Professor, Ben-Gurion University of the Negev, Israel
15:35-15:50	Coffee Break
15:50-16:10	*Title:* Supramolecular Epigenetics: The Vital Role of Magnesium *Dr. Anthony W. Coleman*, Research Director, University of Lyon, France
16:10-16:30	*Title:* Activation of Innate Immunity for Cancer Immunotherapy *Dr. Yuxun Wang,* Vice President of Biology, Denovo Pharmatech, China
16:30-16:50	*Title:* Targeting the Nuclear Translocation of MAPKs as a Novel Anti-inflammatory and Anti-cancer Therapy *Dr. Rony Seger,* Professor, Weizmann Institute of Science, Israel
16:50-17:10	*Title:* Development of the LYVE-1 Gene with an Acidic-amino-acid-rich Domain in Evolution is Associated with Acquisition of Lymph Nodes and Efficient Adaptive Immunity: Implications of Mammalian LYVE-1 as an Emerging Immune-oncology Target *Dr. Jung S. Huang,* Professor, Saint Louis University School of Medicine, USA
17:10-17:30	Title: High-throughput Imaging of Zebrafish Brain Activities for Systems Neuropharmacology Dr. Xin Wang, Assistant Professor, City University of Hong Kong, Hong Kong, China
17:30-17:50	*Title:* The Oncogene PAX3 Promotes Solid Tumour Growth through TGF-beta and CD105 Signalling Pathway *Dr. Wen-Hui Fang,* Senior Research Associate, Manchester Metropolitan University, UK

Stream 3105: New Biomarker, Big Data and Drug Discovery
Time: 08:30-10:15, Nov. 8, 2018 Place: Qi Room, 1^st Floor, Sheraton Jinan Hotel, Jinan, China
Chair	*Dr. Ken Aoshima,* Director of Data Science Laboratory, hhc Data Creation Center, Eisai Co., Ltd. Japan
Co-Chair	*Dr. Xavier Pillai,* Shareholder, Leydig, Voit & Mayer, Ltd., USA
08:30-08:35	Chair's Introduction
08:35-09:00	*Title:* A Quantitative Proteomic Study Revealed PXXX2 to be a Colon Cancer Early Biomarker *Dr. Lijun Zhang,* Professor, Shanghai Public Health Clinical Center, Fudan University, China
09:00-09:25	*Title:* Managing Complex and Disengaged Patients in Primary Care What Can Pharmaceutical Companies Learn from New Delivery of Care Models *Dr. Waqar Malik,* Consultant Diabetologist, Heartlands Hospital and Birmingham Community Healthcare Trust, UK
09:25-09:50	*Title:* Biomarker & Real World Data Based Decision Making in Drug Development *Dr. Ken Aoshima*, Director of Data Science Laboratory, hhc Data Creation Center, Eisai Co., Ltd. Japan
09:50-10:15	*Title:* Strategies for Obtaining U.S. Patents on Drug Discoveries with a View to Successfully Withstand Challenges at the Federal Courts and the Patent Trial and Appeal Board of the USPTO for their Validity and Enforceability *Dr. Xavier Pillai,* Shareholder, Leydig, Voit & Mayer, Ltd., USA

News Release

● Full Program Released

● Call for Supporting Organizations and Media Partners
● Call for Session Chairs and Speakers
● Call for Exhibitors and Sponsors

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	Format of Abstract
	Projects Matchmaking

Hosting Organizations

Information Research Center of International Talent, SAFEA

Jinan Innovation Zone

Supporting Organizations

Ji'nan Branch of China Council for The Promotion of International Trade

University of South Australia

School of Biological Engineering, Qilu University of Technology

Operating Organizations

Jinan Innovation Zone Life Science Development City

BIT Group Global Ltd.

Official Travel Agency

BIT World Travel Service, Inc.

Exhibition

Participating Organizations

Amgen, Inc.
Arrowhead Pharmaceuticals Inc.
Eisai Co., Ltd.
ChemDiv, Inc.
University of Queensland
Comenius University
Fountain Medical Development Ltd.,
McGill University
Pharmaron Inc.
Pfizer Inc.
Florida State University
Shanghai Jiaotong University School of Medicine
Leydig, Voit & Mayer, Ltd.
University of Pittsburgh
F. Hoffmann-La Roche
Tactical Therapeutics, Inc.
Leadscope Inc.
AbbVie Deutschland GmbH & Co. KG
Merck KGaA
Genentech, Inc.
Sanofi
Hamamatsu Photonics K.K.
University of Arizona
ChemDiv, Inc
AbMax Biotechnology Inc.
University Hospital Brno and Medical Faculty of Masaryk University
PSMMC, Riyadh
Boehringer Ingelheim Pharma GmbH & Co. KG
Global PKPD & Pharmacometrics, Eli Lilly and Company
Beijing Institute of Pharmacology and Toxicology
Auckland UniVersity
Cyclenium Pharma Inc.
Helmholtz Centre for Infection Research
University of Arizona
Medlab Clinical Pty Ltd.
National Institute of Biological Sciences, Beijing
Quinnipiac University/King Lee PhD, LCC
Novartis Institue of Biomedical Research
IriSys, LLC,
Private Clinic of Dermatovenerology Svidník
Saarland University
Cardiff University

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