BIT's 16th Annual Congress of International Drug Discovery Science and Technology-2018 | ||||
Theme: Rethinking the Next Big Things in Pharma Innovations | ||||
Time: August 16-19, 2018 Place: Boston Marriott Cambridge, USA |
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Scientific Program | ||||
Stream 1 | Stream 2 | Stream 3 | Stream 4 | Stream 5 |
Stream 2: Drug Discovery X-Hubs -New Vision on Drug Discovery Science and Technology |
Substream 2-1: Dynamic Bio X-Hub |
Substream 2-1: Dynamic Bio X-Hub |
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Session 2101: Decoding Mechanism of Diseases and Drug Discovery Day 1: Afternoon, Thursday, August 16, 2018 Place: Discovery Room, 3rd Floor 13:30-17:30 |
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Chair: Dr. Jack Rogers, Director, Neurochemistry Laboratory, Massachusetts General Hospital, USA | |||
Co-Chair: Dr. Yaakov Naparstek, Professor of Medicine, Hadassah University Hospital, Israel | |||
Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-13:55 |
Title: Cooperative RNA Modulation to Improve Iron Homeostasis Specific to Neurons While Providing Anti-amyloid Efficacy as a Potential Alzheimer’s Disease Therapy Dr. Jack Rogers, Director, Neurochemistry Laboratory, Massachusetts General Hospital, USA |
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13:55-14:15 | Title: The Use of Isotopic Ratio Outlier Analysis for Metabolomic Target Discovery in Model Organisms Dr. Irwin Kurland, Associate Professor & Director, Albert Einstein College of Medicine, USA |
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14:15-14:35 | Title: Chatting with a Neuron Dr. Frank Elsen, Electrophysiology Application Scientist, Harvard Bioscience, USA |
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14:35-14:55 |
Title: Berberine Protects Cytokine Induced Inflammation through Multiple Pathways Dr. Lixin Li, Associate Professor, Central Michigan University, USA |
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14:55-15:15 |
Title: Novel Combinational Therapy for Multiple Food Allergic Patients Dr. R. Sharon Chinthrajah, Medical Director, Clinical Translational Research Unit, Sean N. Parker Center for Allergy & Asthma Research, Stanford University, USA |
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15:15-15:30 | Coffee Break | ||
15:30-15:50 | Title: Protective Antibodies Against HSP60 for Autoimmune Inflammatory Diseases Dr. Yaakov Naparstek, Professor of Medicine, Hadassah University Hospital, Israel |
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15:50-16:10 | Title: The Development and Application of New PET Neuroimaging Probes Dr. Changning Wang, Assistant Professor of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA |
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16:10-16:30 |
Title: Molecular Mechanisms Underlying Vitamin D Deficiency-induced Hypertension Dr. Songcang Chen, Senior Scientist, University of California, San Francisco, USA |
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16:30-16:50 | Title: Cancer-derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor Dr. Cheng-Chin Kuo, Associate Investigator, Institute of Cellular and System Medicine, National Health Research Institutes, Taiwan |
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16:50-17:10 |
Title: A Non-tight Junction Function of Claudin-7 in Lung Cancer Cell Progression Dr. Do Hyung Kim, Postdoctoral Fellow, Johns Hopkins School of Medicine, USA
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17:10-17:30 |
Title: Newly Elicited Pluripotent Stem Cells (nEPS) Ms. Mindy Min Sun Oh, CEO, bBHC Stem Cell Treatment & Research Institute, South Korea |
Session 2102: Toxicology and Drug Discovery Day 1: Afternoon, Thursday, August 16, 2018 Place: Endeavor Room, 3rd Floor 13:30-15:15 |
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Chair: Dr. Tamara Fridman, CEO, Vanasyl LLC., USA | |||
Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-13:55 | Title: The Crucial Role Process Equipment Plays in the Shift from Drug Discovery to Mass Drug Production; Ensuring Production is Successful Dr. Tamara Fridman, CEO and Engineer, Vanasyl LLC., USA |
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13:55-14:15 |
Title: Antifungal Activity, Lipophilicity, Phyto and Cytotoxicity of Homo and Heteroleptic Complexes of Ag(I) with Sulfonamides and Albendazole Dr. Marcela Rizzotto, Chair, Department of Chemistry-Physics, Facultad de Bioquímica y Farmacia, Universidad Nacional de Rosario, Argentina |
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14:15-14:35 | Title: Kidney Organoids for Nephrotoxicity Testing and Drug Discovery Dr. Ryuji Morizane, Assistant Professor, Harvard Medical School; Associate Biologist, Renal Division, Brigham and Women’s Hospital; Affiliated Faculty, Harvard Stem Cell Institute, USA |
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14:35-14:55 | Title: Genetic Polymorphism and Prediction of Drug Toxicity from Protein Structures Dr. Kyonghee Son, Visiting Scientist, University of Massachusetts Medical School, USA |
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14:55-15:15 |
Title: Predictive Toxicology Tools and Applications in Drug Discovery – Mutagenicity Assessment of Pharmaceutical Impurities and Estimation of Skin Sensitization Potency Dr. Joel Cohen, Senior Toxicologist, Gradient, USA |
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15:15-15:30 | Coffee Break |
Session 2103: Microbiology and Drug Discovery Day 2: Morning, Friday, August 17, 2018 Place: Enterprise Room, 3rd Floor 08:30-09:50 |
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Chair: Dr. Claudia Gallert, Full Professor, University of Applied Science Emden Leer, Germany | |||
Time | FaceOn | Speeches and Speakers | |
08:30-08:35 | Chair's Introduction | ||
08:35-09:00 | Title: Staphylococci from Aquatic Environments with Inducible Resistance to Macrolides, Lincosamides and Streptogramin B (MLSB) - Induction of Cross-resistance against MLSB by the Omnipresent Metabolite Anhydroerythromycin Dr. Claudia Gallert, Full Professor, University of Applied Science Emden Leer, Germany |
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09:00-09:25 | Title: Learning from Ecology. Controlling Pathogens as Nature Does: By Their Self-DNA Dr. Stefano Mazzoleni, Full Professor,Applied Ecology and Modelling, University of Napoli “Federico II”, Italy |
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09:25-09:50 | Title: Immunization against Newcastle Disease and Bird Flu H5N1 CDC Strain Using Cinnamon Fraction Dr. Michael Ovadia, Professor Emeritus, Department of Zoology, Tel-Aviv University, Israel |
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09:50-10:05 | Coffee Break |
Session 2104: Oncology and Drug Discovery Day 3: Morning, Saturday, August 18, 2018 Place: Discovery Room, 3rd Floor 08:30-12:10 |
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Chair: Dr. Michael R. Briggs, Woodland Pharmaceuticals LLC; Tufts Cummings School of Veterinary Medicine, USA |
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Co-Chair: Dr. Ping Xie, Associate Professor, Rutgers University, USA | |||
Time | FaceOn | Speeches and Speakers | |
08:30-08:35 | Chair's Introduction | ||
08:35-08:55 | Keynote Speech Title: Cancer Stem Cells: Challenges and Opportunities for Drug Discovery Dr. Bakhos A. Tannous, Associate Professor of Neurology and Director, Harvard Medical School and Massachusetts General Hospital, USA |
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08:55-09:15 |
Title: Metabolic Disease Drivers of Hepatocellular Carcinoma, A New Disease Paradigm Dr. Michael R. Briggs, Woodland Pharmaceuticals LLC; Tufts Cummings School of Veterinary Medicine, USA |
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09:15-09:35 | Title: Comparison between HER2 Expression in Primary Breast Cancer before and after Neoadjuvant Therapy Dr. Jamal Zidan, Head, Oncology Division, Ziv Medical Center, Faculty of Medicine, Bar-Ilan University, Israel |
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09:35-09:55 | Title: Perioperative Use of NSAID Might Prevent Early Relapses in Breast and Other Cancers: An Upstream Approach Dr. Michael Retsky, Research Associate,Harvard TH Chan School of Public Health, USA; Honorary Reader, University College London, UK |
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09:55-10:15 |
Title: Targeting the Epigenome in High Grade Ovarian Cancer Dr. Daniela Dinulescu, Assistant Professor, Harvard Medical School, USA |
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10:15-10:30 | Coffee Break | ||
10:30-10:50 |
Title: TRAF3 Specifically Targets the Phosphocholine-phosphatidylcholine-phosphatidylethanolamine Metabolic Pathway in B Lymphocytes Dr. Ping Xie, Associate Professor, Rutgers University, USA |
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10:50-11:10 | Title: Lonidamine Induced Selective Acidification and De-energization Enhances Tumor Response to Chemo and Radiation Therapy Dr. Kavindra Nath, Research Assistant Professor, University of Pennsylvania, USA |
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11:10-11:30 | Title: A Big Data Analysis Unveils the Gene Interactions in Cancer for Drug Development Dr. Benjamin Yat Ming Yung, Chair Professor of Biomedical Science, Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China |
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11:30-11:50 |
Title: An ‘out of the box’ Approach towards Eliminating Mammary Epithelial Carcinoma from Its Root Dr. Tanya Das, Senior Professor, Division of Molecular Medicine; Dean, Research and Development, Bose Institute, India |
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11:50-12:10 |
Title: Immune-rejuvenation Therapy of Cancer Dr. Gaurisankar Sa, Senior Professor & Chairman of Molecular Medicine, Bose Institute, India |
Session 2105: Molecular Biomedicine in Drug Discovery Day 3: Afternoon, Saturday, August 18, 2018 Place: Endeavor Room, 3rd Floor 13:30-15:15 |
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Chair: Dr. Johnathan R. Whetstine, Associate Professor of Medicine, Harvard Medical School and Massachusetts General Hospital Cancer Center, USA | |||
Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-13:55 |
Title: Small Molecular Inhibitors for Prostate Cancer and Bacterial Biofilms Dr. Hai-Feng Ji, Professor, Department of Chemistry, Drexel University, USA |
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13:55-14:15 | Title: Epigenetics is a Gatekeeper to DNA Amplification Dr. Johnathan R. Whetstine, Associate Professor of Medicine, Harvard Medical School and Massachusetts General Hospital Cancer Center, USA |
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14:15-14:35 | Title: Exploring Applications of Thio-phosphate in Drug Development Dr. Elizabeth G. Frayne, Associate Faculty Member, University of Phoenix, USA |
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14:35-14:55 |
Title: Exploring the Ligand Recognition Properties of the Human Vasopressin Receptors by Using Molecular Modeling and Molecular Dynamics Simulations Dr. Marlet T. Martinez Archundia, Researcher, Superior School of Medicine, National Polytechnic Institute (IPN), Mexico |
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14:55-15:15 |
Title: Using Mesenchymal Stem Cells as a Platform for ZFN Mediated Artificial Gene Knock-in Dr. Krissanapong Manotham, Advisor, SS Manufacturing Co.,Ltd; Lerdsin General Hospital, Thailand |
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15:15-15:30 | Coffee Break |
Substream 2-2: Enabled Technologies for Drug Discovery |
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Session 2201: Novel Analytical Technology for Drug Discovery Day 1: Afternoon, Thursday, August 16, 2018 Place: Enterprise Room, 3rd Floor 13:30-17:10 |
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Chair: Dr. Kerstin Walke, Head of Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany | |||
Co-Chair: Dr. Robert G. Lowery, President & CEO, BellBrook Labs, USA |
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Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-13:55 | Title: World's First Fully (Hybrid) Integrated and Waferscale Manufacturable Photonic Interferometric Biosensor-array Chip-module with Unparalleled Sensitivity and Reproducibility, Applicable in Both Drug Screening/Optimization and Companion Diagnostics Dr. Henk Leeuwis, Senior Vice President, Strategy and Innovation, LioniX International BV, The Netherlands |
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13:55-14:15 | Title: Formulation of NBE: The Polysorbat Discussion Current Overview Relates Issues Degradation Pathways and Potential Solutions Challenges in Analytics Dr. Kerstin Walke, Head of Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Germany |
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14:15-14:35 |
Title: Advances in Capillary Zone Electrophoresis for Charge Heterogeneity Testing of Monoclonal Antibodies Dr. Mark Lies, Senior Manager, CE & BioPharma, SCIEX, USA |
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14:35-14:55 | Title: Advances in NGS Library Prep QC : Automated Pulsed-field Capillary Electrophoresis with Femtogram Level Detection Dr. Kit-Sum Wong, Director, Advanced Analytical Technologies Inc., USA |
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14:55-15:15 |
Title: Solutions for Automation of GMP Assays by Catalent Biologics Mr. Christopher Hepler, Group Leader, Biologics Analytical Services, Catalent Biologicss, USA |
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15:15-15:30 | Coffee Break | ||
15:30-15:50 | Title: Appliction of Multiple Configurations of a Photonic Based Microscale Calorimeter in the Drug Discovery Process
Dr. Gregory Kowalski, Associate Professor, Department of Mechanical and Industrial Engineering, Northeastern University, USA |
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15:50-16:10 |
Title: Measuring Drug Residence Times in an HTS Format with the Transcreener® ADP2 Kinase Assay Dr. Robert G. Lowery, President & CEO, BellBrook Labs, USA |
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16:10-16:30 |
Title: Drugging the Undruggable: Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Inhibitor of Cadherin Homophilic Interaction Dr. Emilio Parisini, Group Leader, Istituto Italiano di Tecnologia, Italy |
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16:30-16:50 |
Title: Microfluidic Impedance Cytometry for Prediction of Patient Response to Targeted Cancer Therapy: A Data-driven Approach Dr. Mehdi Javanmard, Assistant Professor, Rutgers University, USA |
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16:50-17:10 | Title: Following Fluorinated Drugs by Molecular Absorption Spectrometry – From Cancer Cells to Body Fluids Mr. Carlos Abad Andrade, Research Associate, Federal Institute for Materials Research and Testing -BAM, Germany |
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18:00-20:00 | Welcome Banquet & Art Performance |
Session 2202: Other Enabled Technologies for Drug Discovery Day 2: Afternoon, Friday, August 17, 2018 Place: Discovery Room, 3rd Floor 13:30-17:10 |
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Chair: Dr. Chengcang C. Wu, CEO & Founder, Intact Genomics, Inc., USA | |||
Co-Chair: Mr. Lekhram Changoer, CTO/Director, AXIM Biotechnologies, USA/The Netherlands | |||
Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-13:55 |
Title: Chemical Biology Approach for Biologics Drug Discovery and the Identification of Antibody-drug Conjugate T-CE-040
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13:55-14:15 | Title: Retrosynthetic Software for Practicing Chemists: Novel and Efficient in Silico Pathway Design Validated at the Bench Dr. Lindsey Hess Rickershauser, Technical Application Scientist, Cheminformatics Technologies, MilliporeSigma (a Business of Merck KGaA, Germany), USA |
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14:15-14:35 | Title: Revive Large-scale Natural Product and Drug Discovery from Microbes and Soil Metagenomes Dr. Chengcang C. Wu, CEO & Founder, Intact Genomics, Inc., USA |
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14:35-14:55 | Title: Novel Natural Product-based Macrocyclic Platform: MacroEvoLution Dr. Dietmar Wolf, Executive Vice President, AnalytiCon Discovery, LCC, Germany |
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14:55-15:15 | Title: Metabolic Detection of Bruton’s Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells Dr. Seung-Cheol Lee, Research Assistant Professor,Department of Radiology, University of Pennsylvania, USA |
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15:15-15:30 | Coffee Break | ||
15:30-15:50 |
Title: Novel cGMP Technologies for Extraction, Purification and Conversion of Cannabinoids for the Pharmaceutical Industry Mr. Lekhram Changoer, CTO/Director, AXIM Biotechnologies, USA/The Netherlands
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15:50-16:10 | Title: Heterogeneous Catalysis for Drug Synthesis Dr. Antonio Leyva-Perez, Distinguished Researcher, Universidad Politécnica de Valencia-Consejo Superior de Investigaciones Científicas, Spain |
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16:10-16:30 | Title: Organolithium Chemistry Using Flow Microreactors Dr. Aiichiro Nagaki, Associate Professor, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan |
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16:30-16:50 |
Title: Hollow Fiber Model - in vivo Screening in Cancer Drug Discovery Dr. Bettina Stahnke, Business Development Manager, ProQinase GmbH, Germany |
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16:50-17:10 |
Title: Responsive Molecular Imaging Biosensors for Precise Therapeutic Solutions in Regenerative Medicine Dr. Ethel J. Ngen, Research Faculty, Johns Hopkins University School of Medicine, USA |
Substream 2-3: Computer-aided Drug Discovery |
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Session 2301: Computer-aided Drug Discovery Day 2: Afternoon, Friday, August 17, 2018 Place: Endeavor Room, 3rd Floor 13:30-17:10 |
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Chair: Dr. Zhenhong Li, Senior Principal Scientist, Medicine Design Modeling and Simulation, Pfizer Global Research and Development, USA | |||
Co-Chair: Dr. Pavel Pospisil, PMI R&D, Philip Morris Products S.A., Switzerland |
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Time | FaceOn | Speeches and Speakers | |
13:30-13:35 | Chair's Introduction | ||
13:35-14:00 |
Title: Translational ADME and PBPK/PD Sciences to Impact Drug Discovery and Development
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14:00-14:25 |
Title: Big Data Driven Drug Development Strategy for Alzheimer Disease Dr. Gyungah Jun, Assistant Professor, Boston University School of Medicine, USA |
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14:25-14:50 | Title: A Model-based Assessment of Plasma Citrate Flux into the Liver: Implications for NaCT as a Therapeutic Target Dr. Zhenhong Li, Senior Principal Scientist, Medicine Design Modeling and Simulation, Pfizer Global Research and Development, USA |
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14:50-15:15 | Title: Using DILIsym, A Quantitative Systems Toxicology Modeling Tool of Drug-induced Liver Injury (DILI), to Assess DILI Risk in Drug Development Dr. Brett A. Howell, President, DILIsym Services Inc., a Simulations Plus Company; Associate Director, DILI-sim Initiative, USA |
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15:15-15:30 | Coffee Break | ||
15:30-15:55 | Title: Integrated Informatics Platform for Drug R&D Dr. Jinbo Lee, Chief Scientific Officer, Scilligence Corporation, USA |
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15:55-16:20 |
Title: Software Tool for Population Pharmacokinetic Analysis and Model Preparation with Usage of Iterative Two-Stage Bayesian Technique Dr. Jiří Douša, Head of Medical Softtware Development Team, Mediware Company, Czech Republic |
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16:20-16:45 |
Title: Building an Efficient R & D Chemo-centric Data Repository System that Leads to Knowledge Discovery Dr. Pavel Pospisil, PMI R&D, Philip Morris Products S.A., Switzerland |
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16:45-17:10 |
Title: Discovery and Development of Novel Inhibitors of the MDMs Proteins for Cancer Therapy Dr. Valeria La Pietra, Assistant Professor, University of Naples "Federico II", Italy |
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