Session 411: Cancer/Tumor

Day 1: Afternoon, Thursday, July 25, 2019

Place: Room K, 2nd Floor

Chair: Dr. Luana Pesco Koplowitz, Chief Medical & Scientific Officer, DUCK FLATS Pharma, USA

Chair’s Introduction

Keynote Speech

Title: Exploiting a ‘Kiss of Death’ Therapy for Nonsmall Cell Lung and Pancreatic Cancers

Dr. David A. Boothman, Professor, Department of Biochemistry, Indiana University, USA

Title: Cardiac Safety Issues in Oncology Trials
Dr. Luana Pesco Koplowitz, Chief Medical & Scientific Officer, DUCK FLATS Pharma, USA

Title: Nucleophilic Selectivities of Aliphatic Electrophile Candidates for Swain-Scott Analysis: Fully Protic and Aqueous, Green Media, Including Hypoxia, and Non-nucleophilic Solvents
Dr. Colin Paul Spears, Professor, California Northstate University College of Medicine, USA

Title: Inhibition of Histone Methyltransferases for Novel Childhood Cancer Therapies

Dr. Karim Malik, Cancer Epigenetics Lab, University of Bristol, UK

Coffee Break

Title: Methylglyoxal as a Potent Nontoxic Cancer Therapeutics: Its Past, Present and Future

Dr. Manju Ray, Professor, Department of Biophysics, Bose Institute, India

Title: Oncolytic Engineered Measles Virus Strains as Novel Therapeutic Agents in Cancer Treatment

Dr. Evanthia Galanis, Professor of Oncology, Mayo Clinic College of Medicine and Science, USA

Title: Cold Atmospheric Plasma New Tool for Cancer Therapy

Dr. Nofel Merbahi, Professor, University Toulouse III Paul Sabatier, France

Title: Clinical Significance of Circulating Tumor Cells (CTCs) Undergoing EMT in the Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma

Dr. Lu-Nan Qi, Associate Professor, Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, China

Title: Exploring the Therapeutic Efficacy of Engineered Heme-sequestering Peptides for Treating Non-small Cell Lung Cancer

Dr. Li Liu, Assistant Professor, The University of Texas Southwestern Medical Center, USA

Session 412: CNS and Neurodegenerative Disorders

Day 2: Morning, Friday, July 26, 2019

Place: Room J, 2nd Floor

Chair: Dr. Kiminobu Sugaya, Professor and Head of Neuroscience, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, USA

Chair’s Introduction

Keynote Speech

Title: Development of Highly Efficient BBB Transport of Biological Therapeutics to the CNS Using in vivo Phage Display with Single Domain VNAR to the Transferrin Receptor

Dr. Frank S. Walsh, Chief Executive Officer, Ossianix, Inc., USA

Title: Small Molecular Compound to Increase Neural Stem Cells: Promising Therapy for Alzheimer’s and Parkinson’s Diseases
Dr. Kiminobu Sugaya, Professor and Head of Neuroscience, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, USA

Title: From Translational Research to a New Molecule for the Treatment of Multiple Sclerosis

Dr. Anat Achiron, Professor, Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel

Title: Improving Function after Nerve Injury via Microparticles Releasing Growth Factors

Dr. Amgad Hanna, Professor of Neurological Surgery, University of Wisconsin, USA

Title: Leveraging Machine Learning and the Free-Wilson Approach in Lead Optimization: Efficient Discovery of a New Chemical Class Modulating the GABAA α5 Receptor

Dr. Florian Montel, Head of opnMe.com and CNS Project Leader in Medicinal Chemistry, Boehringer Ingelheim, Germany

Coffee Break

Title: Approaching Neurodegenerative Disease as an Immunological Disease: Role of Biomarkers

Title: RAM-589.555 a New Polymerase-1 Inhibitor as Innovative Targeted-treatment for Multiple Sclerosis

Panel Discussion

Session 413: Cardiovascular Disease and Metabolic Diseases

Day 2: Afternoon, Friday, July 26, 2019

Place: Room I, 2nd Floor

Chair: Dr. John Setaro, Associate Professor of Medicine, Yale University, USA

Chair’s Introduction

Title: Lactated Ringer's Solution for Cardioprotection in ST-segment Elevation Myocardial Infarction

Dr. Takashi Koyama, Vice Director, Saitama Municipal Hospital, Japan

Title: Management of Hypertension in Patients with Ischemic Heart Disease: Genetic Foundation and Therapeutic Advances

Dr. John Setaro, Associate Professor of Medicine, Yale University, USA

Title: Oxysterols as a Drug Target

Dr. Michihisa Umetani, Assistant Professor, Center for Nuclear Receptors and Cell Signaling, University of Houston, USA

Dr. Akiko Taguchi, Chair, National Center for Geriatrics and Gerontology, Japan

Title: Potassium Citrate is an Effective Prophylaxis against Recurrent Calcium Oxalate Nephrolithiasis. A Retrospective Study of Five Hundred Cases

Dr. Michel Normand, Nephrologist, Service De Néphrologie, Hôpital Privé Saint-Martin, France

Title: Whole Organism Chemical Screening Identifies Stimulators of Pancreatic β Cell Function

Dr. Hiroki Matsuda, Assistant Professor, Ritsumeikan University, Japan

Title: A Six-month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Apotential Candidate and a Candidatemodified Risk Tobacco Product, Chtp 1.2 and Ths 2.2 Respectively, Compared with Cigarettes
Dr. Nikolai V Ivanov, Global Head of Biomarker & Biosensor Research Department, Philip Morris International R&D Innovation Cube, Philip Morris Products S.A., Switzerland

Session 414: Digestive System Diseases

Day 3: Morning, Saturday, July 27, 2019

Place: Room I, 2nd Floor

Chair: Dr. Monika Fischer, Associate Professor of Medicine, Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, USA

Chair’s Introduction

Title: Effects of Gender and Age on Prevalence of Cholelithiasis in Patients with Chronic HCV Infection
Dr. Jing-Hong Hu, Director, Department of Internal Medicine, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taiwan

Title: Guggulsterone and Its Role in Digestive Diseases

Dr. Takanori Yamada, Chief, Department of Gastorenteroligy and GI Endoscpcopy Unit, Iwata City Hospital, Japan

Title: Optimizing Fecal Microbiota Transplant for Ulcerative Colitis
Dr. Najwa El-Nachef, Associate Professor, University of California San Francisco, USA

Title: Fecal Microbiota Transplantation: Redefining Surgical Management of Refractory Clostridium difficile Infection

Dr. Monika Fischer, Associate Professor of Medicine, Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, USA

Coffee Break

Title: Case Presentation: Single-loop Nylon Snare Ligation for Treatment of Gastrointestinal Bleeding and Perforation

Dr. Zhenglei Xu, Associate Professor, Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, China

Title: Comparative Outcomes between Ligasure and THD Techniques for the Management of Haemorrhoidal Disease

Short Title: THD vs Ligasure

Dr. Jesus A. Bahena-Aponte, Angeles del Pedregal Hospital, Mexico

Session 415: Autoimmune and Inflammation Drug Targets and Diseases

Day 3: Morning, Saturday, July 27, 2019

Place: Room J, 2nd Floor

Chair’s Introduction

Title:  Relaxin Mitigates Microvascular Damage and Inflammation Following Cardiac Ischemia-reperfusion
Dr. Xiao-Ming Gao, Baker Heart and Diabetes Institute, Monash University, Australia; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, China

Title: Targeting Scavenger Receptor CD36 in the Treatment of Retinal Inflammation

Dr. Huy Ong, Professor, Faculty of Pharmacy, Universit de Montral, Canada

Coffee Break

Title: Role of Ultrasound in Carotidynia

Dr. Bhagyam Nagarajan-Monga, Consultant Radiologist and Joint Coordinator Radiology, Wockhardt Hospitals, India

Title: IL-6, IFN-g and IL-10 as Potencial Diagnostic Biomarker in Gastric Cancer: A Controlled Study

Dr. Norma Sanchez-Zauco, Research Associate,  Instituto Mexicano del Seguro Social, Mexico

Panel Discussion

Session 416: Emerging Infectious Diseases

Day 3: Afternoon, Saturday, July 27, 2019

Place: Room I, 2nd Floor

Chair: Dr. Martin Doležal, Professor, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic

Chair’s Introduction

Keynote Speech

Title: A New Target for bHLH/PAS Dioxin Receptor-Arnt Transcription Factor – Human Herpesviruses

Dr. Ilya B. Tsyrlov, President and CSO, Xenotox Inc, USA

Title: Large Anionic Macrocycles as Endonuclease PA Inhibitors: Towards a Treatment for Influenza

Dr. Anthony W. Coleman, Research Director, Université de Lyon, France

Title: The Challenges of Sample Collection with Limited Infrastructure: Active Chemical Protection Solutions

Dr. Shanavaz Nasarabadi, President & Director R&D, GenTegra LLC, USA

Title: Drug Repurposing in Tuberculosis Treatment Development

Dr. Martin Doležal, Professor, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic

Coffee Break

Title: Novel Small Molecules that Increase the Susceptibility of Neisseria Gonorrhoeae to Cationic Antimicrobial Peptides

Dr. Charlene M. Kahler, Associate Professor, The University of Western Australia, Australia

Title: Inhibition of Influenza A (H7N9) Virus Replication by the Novel Cap-dependent Endonuclease Inhibitor Baloxavir Marboxil

Mr. Keiichi Taniguchi, Researcher, Shionogi & Co., Ltd., Japan

Title: Targeting Post-translational Modifications to Abate the Beta-lactam Resistance and Biofilm-related Problems of Staphylococcus aureus

Dr. Vijay Pancholi, Associate Professor, Ohio State University College of Medicine, USA

Title: The in vitro Anti-hepatitis B Virus Activities of Aloe Vera Derived Anthraquinones

Dr. Mohammad Khalid Parvez, Associate Professor, King Saud University College of Pharmacy, Saudi Arabia

Session 417: Other Diseases and Orphan Diseases

Day 3: Afternoon, Saturday, July 27, 2019

Place: Room G, 1st Floor

Chair: Dr. William C. Maier, Chief Scientific Officer & Head, Rare Disease Research, Commercialisation and Outcomes Division, ICON Plc, UK

Chair’s Introduction

Title: Rare Disease Studies Facilitated by Taking Study Visits to the Patients
Dr. Gail Adinamis, CEO, GlobalCare Clinical Trials, LLC, USA

Title: MENA Orphan Drug Market Specificities and Potentials
Dr. Tony Zbeidy, General Manager, Recordati Rare Diseases Middle East Fz/LLC, UAE

Dr. William C. Maier, Chief Scientific Officer & Head, Rare Disease Research, Commercialisation and Outcomes Division, ICON Plc, UK

Title: Profiling Analysis of 10 Years of Rare Disease Research Using Scientific Literature

Dr. Hongmei Guo, Assistant Professor, National Science Library, Chinese Academy of Sciences, China